Calcifying Odontogenic Cyst

A mixed radiolucent-radiopaque lesion of the jaws with features of both a cyst and a solid neoplasm. It is characterized microscopically by an epithelial lining showing a palisaded layer of columnar basal cells, presence of ghost cell keratinization, dentinoid, and calcification. (Stedman, 25th ed)

Also Known As:

Networked: 49 relevant articles (0 outcomes, 6 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Odontogenic Tumors (Dental Tissue Neoplasm)
2.	Ameloblastoma
3.	Odontogenic Cysts (Keratocyst)
4.	Cysts
5.	Fibroma (Fibromatosis)

Experts

1.	Nikai, H: 3 articles (08/2000 - 04/2000)
2.	Uchida, T: 3 articles (08/2000 - 04/2000)
3.	Zhao, M: 3 articles (08/2000 - 04/2000)
4.	Takata, T: 3 articles (08/2000 - 04/2000)
5.	Salehinejad, Jahanshah: 2 articles (05/2011 - 12/2010)
6.	Wang, T: 2 articles (08/2000 - 04/2000)
7.	Montague, Lindsay: 1 article (09/2015)
8.	Bhattacharyya, Indraneel: 1 article (09/2015)
9.	Islam, Nadim: 1 article (09/2015)
10.	Cohen, Donald: 1 article (09/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Calcifying Odontogenic Cyst:

1.	Keratins (Keratin)IBA 07/01/1997 - "Calcifying odontogenic cyst: a clinicopathologic study of 57 cases with immunohistochemical evaluation for cytokeratin." 03/01/2005 - "Expression of hard alpha-keratins in pilomatrixoma, craniopharyngioma, and calcifying odontogenic cyst." 03/01/2003 - "Calcifying odontogenic cysts showed odontogenic cytokeratin profile and bcl-2 and Mel-CAM expression indicate that these proteins may be involved in the development of COC. " 01/01/1988 - "Calcifying odontogenic cyst immunohistochemical detection of keratin and involucrin in cyst wall." 11/01/1983 - "The keratinizing and calcifying odontogenic cyst (KCOC), a lesion that features proliferating ameloblastic epithelium, ghost keratin, calcification, and cyst formation, may more precisely mimic the craniopharyngioma. "
2.	AntibodiesIBA 05/01/2003 - "The purpose of this study was to investigate a case of calcifying odontogenic cyst (COC) in which numerous calcifications were observed not only in the lining epithelium, but also in the cyst wall, using cytokeratins 13 (CK13), 19 (CK19), and core binding factor a-1 (cbfa-1) as primary antibodies. " 10/01/2002 - "Specimens of five tooth germs, 34 ameloblastomas, three calcifying epithelial odontogenic tumors (CEOTs), two clear cell odontogenic tumors (CCOTs), five adenomatoid odontogenic tumors (AOTs), six calcifying odontogenic cysts (COCs) and six malignant ameloblastomas were examined immunohistochemically with the use of antibodies against HGF, TGF-beta and their receptors. " 03/01/2005 - "To examine the properties of shadow and ghost cells, 3 kinds of antibodies were raised against human hair proteins and their immunoreactivity was examined in tumors expressing those cells: pilomatrixoma, 14 cases; craniopharyngioma, 17 cases; and calcifying odontogenic cyst (COC), 14 cases. " 04/01/2000 - "In the present study, we examined the immunoreactivity of ghost cells in calcifying odontogenic cysts and dermal calcifying epitheliomas, with antibodies against amelogenin, enamelin, sheath protein (sheathlin) and enamelysin, in an attempt to clarify the nature of this unique cell. "
3.	AdenoameloblastomaIBA 09/01/2003 - "The histologic specimen revealed the diagnosis of an adenomatoid odontogenic tumor (AOT) in a calcifying odontogenic cyst (COC). " 09/01/2003 - "[Adenomatoid odontogenic tumor in calcifying odontogenic cyst]." 04/01/2000 - "Immunoexpression of sheathlin was, furthermore, demonstrated in eosinophilic droplets in solid nests of adenomatoid odontogenic tumor (AOT) and ghost cells in the epithelial lining of calcifying odontogenic cyst (COC). " 05/01/1996 - "Adenomatoid odontogenic tumor arising in a calcifying odontogenic cyst." 02/01/2010 - "Hybrid odontogenic tumor with features of ameloblastic fibro-odontoma, calcifying odontogenic cyst, and adenomatoid odontogenic tumor: a case report and review of the literature."
4.	AmelogeninIBA 09/01/2001 - "In odontogenic tumors, positive reactions for amelogenin were localized in limited areas in adenomatoid odontogenic tumor, calcifying odontogenic cyst, primary intraosseous carcinoma and odontoma. " 04/01/2000 - "In the present study, we examined the immunoreactivity of ghost cells in calcifying odontogenic cysts and dermal calcifying epitheliomas, with antibodies against amelogenin, enamelin, sheath protein (sheathlin) and enamelysin, in an attempt to clarify the nature of this unique cell. " 03/01/1992 - "Amelogenin and enamelin were demonstrated in small mineralized foci and in the tumor cells surrounding them in adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), and calcifying odontogenic cyst (COC). "
5.	Matrix Metalloproteinase 20IBA 08/01/2000 - "Furthermore, enamelysin was also detected in globular amyloid masses and calcified foci in calcifying epithelial odontogenic tumors, hyaline droplets, small and large mineralized areas in adenomatoid odontogenic tumors, and a portion of ghost cells in calcifying odontogenic cysts. " 04/01/2000 - "In the present study, we examined the immunoreactivity of ghost cells in calcifying odontogenic cysts and dermal calcifying epitheliomas, with antibodies against amelogenin, enamelin, sheath protein (sheathlin) and enamelysin, in an attempt to clarify the nature of this unique cell. "
6.	tuftelin (enamelin)IBA 04/01/2000 - "In the present study, we examined the immunoreactivity of ghost cells in calcifying odontogenic cysts and dermal calcifying epitheliomas, with antibodies against amelogenin, enamelin, sheath protein (sheathlin) and enamelysin, in an attempt to clarify the nature of this unique cell. " 03/01/1992 - "Amelogenin and enamelin were demonstrated in small mineralized foci and in the tumor cells surrounding them in adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), and calcifying odontogenic cyst (COC). "
7.	MART-1 AntigenIBA 03/01/2012 - "Melan-A/Mart-1- or HMB-45-positive melanocytes are not present in calcifying cystic odontogenic tumors (calcifying odontogenic cysts): a study in 13 Caucasian patients."
8.	Versicans (Versican)IBA 09/01/2002 - "The present study investigated the localization of versican in odontogenic tumors by immunohistochemistry, using paraffin-embedded sections obtained from 27 patients with odontogenic tumors (17 ameloblastomas, 1 adenomatoid odontogenic tumor, 4 odontogenic keratocysts, 1 calcifying odontogenic cyst, 2 ameloblastic fibromas, and 2 malignant ameloblastomas). "
9.	Core Binding Factors (Core-Binding Factor)IBA 05/01/2003 - "The purpose of this study was to investigate a case of calcifying odontogenic cyst (COC) in which numerous calcifications were observed not only in the lining epithelium, but also in the cyst wall, using cytokeratins 13 (CK13), 19 (CK19), and core binding factor a-1 (cbfa-1) as primary antibodies. "
10.	Mucin-1 (CA 15-3 Antigen)IBA 01/01/1993 - "Two solid and two cystic forms of calcifying odontogenic cysts were stained immunohistochemically to study keratin, carcinoembryonic antigen, epithelial membrane antigen, and S-100 protein expression in ghost cells. "

Therapies and Procedures

1.	Oral Pathology 07/01/1997 - "A clinicopathologic study of all cases accessioned as calcifying odontogenic cyst (COC) from 1971 to 1996 from the files of the Oral Pathology Laboratory at Temple University School of Medicine was undertaken. " 05/01/2011 - "To reevaluate all cases previously diagnosed as calcifying odontogenic cyst (COC) from the archives of the Department of Oral Pathology at Mashhad Faculty of Dentistry from 1978 to 2008. " 01/01/2005 - "Oral pathology quiz # 47: case number 4. Calcifying odontogenic cyst."
2.	Lasers (Laser) 05/01/2011 - "Calcifying odontogenic cysts associated with odontomas: confocal laser scanning microscopy analysis of 13 cases."