Spindle Cell Nevus

A form of pigmented nevus showing intense melanocytic activity around the dermo-epidermal junction. Large numbers of spindle-shaped melanocytes proliferate downward toward the dermis and usually a large amount of pigment is present. It was first described in 1976 and the bulk of patients reported have been young females with the lesions presenting on the thighs. (From Rook et al., Textbook of Dermatology, 4th ed, 1992, p185)

Also Known As:

Nevus, Spindle Cell; Nevi, Spindle Cell; Spindle Cell Nevi

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Neoplasms: 1324753
- Neoplasms by Histologic Type: 2
  - Nevi and Melanomas: 63
    - Nevus: 2308
      - Pigmented Nevus: 750
        Spindle Cell Nevus: 5
        Epithelioid and Spindle Cell Nevus: 29

Related Diseases

1.	Nevus (Nevi)

Experts

1.	Belazarian, Leah: 1 article (12/2014)
2.	Senna, Maryanne Makredes: 1 article (12/2014)
3.	Strazzula, Lauren: 1 article (12/2014)
4.	Yasuda, Mariko: 1 article (12/2014)
5.	Elston, Carly A: 1 article (01/2011)
6.	Elston, Dirk M: 1 article (01/2011)
7.	Ferringer, Tammie C: 1 article (01/2011)
8.	Puri, Puja K: 1 article (01/2011)
9.	Tyler, William B: 1 article (01/2011)
10.	Botella-Estrada, Rafael: 1 article (10/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Spindle Cell Nevus:

1.	MART-1 AntigenIBA 01/01/2000 - "Expression of Melan-A in Spitz, pigmented spindle cell nevi, and congenital nevi: comparative immunohistochemical study." 01/01/2000 - "The expression of the antibody Melan-A in 27 benign melanocytic skin lesions (10 congenital nevi, 10 Spitz nevi, and 7 pigmented spindle cell nevi) was compared to that of S100 protein and HMB-45. "
2.	NAD (NADH)IBA 06/01/1992 - "This report describes 41 patients with lesions similar to those previously termed "deep penetrating" or "plexiform spindle cell" nevus (DPN). " 12/01/2014 - "The deep penetrating nevus (DPN), also known as the plexiform spindle cell nevus, is a pigmented lesion that commonly arises on the head and neck in the first few decades of life. "
3.	S100 Proteins (S 100 Protein)IBA 01/01/2000 - "The expression of the antibody Melan-A in 27 benign melanocytic skin lesions (10 congenital nevi, 10 Spitz nevi, and 7 pigmented spindle cell nevi) was compared to that of S100 protein and HMB-45. "
4.	Melanins (Melanin)IBA 10/01/2008 - "Hypopigmented Reed nevus shows all the typical features of conventional pigmented spindle cell nevus, but it does not contain abundant melanin. "
5.	S100 Calcium Binding Protein A6IBA 01/01/2011 - "The staining pattern of pigmented spindle cell nevi with S100A6 protein."