Blue Nevus

Usually a benign tumor, that commonly presents as a solitary blue nodule with spindled MELANOCYTES covered by smooth SKIN. Several variants have been identified, one variant being malignant. The blue color is caused by large, densely packed melanocytes deep in the DERMIS of the nevus. In CHILDREN, they usually occur on the BUTTOCKS and LUMBOSACRAL REGION and are referred to as cellular blue nevi. Malignant blue nevi are more commonly found on the SCALP.
Also Known As:
Nevus, Blue; Blue Nevi; Blue Nevus, Cellular; Cellular Blue Nevi; Blue Nevi, Cellular; Nevi, Blue; Nevi, Cellular Blue; Nevus, Cellular Blue; Cellular Blue Nevus
Networked: 102 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasm Metastasis (Metastasis)
2. Seborrheic Keratosis
3. Monosomy
4. Fibrosis (Cirrhosis)
5. Cysts


1. Zembowicz, Artur: 2 articles (03/2011 - 11/2007)
2. Kutzner, H: 2 articles (11/2007 - 05/2000)
3. Requena, L: 2 articles (11/2007 - 05/2000)
4. Hoang, Mai P: 2 articles (05/2004 - 02/2003)
5. Requena, Luis: 2 articles (04/2004 - 02/2002)
6. Kutzner, Heinz: 2 articles (04/2004 - 02/2002)
7. Tsao, Hensin: 1 article (11/2015)
8. Roh, Mi Ryung: 1 article (11/2015)
9. Eliades, Philip: 1 article (11/2015)
10. Gupta, Sameer: 1 article (11/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Blue Nevus:
1. Melanins (Melanin)IBA
2. Uveal melanomaIBA
3. neodymium pyrocatechin disulfonate (NPD)IBA
4. S100 Proteins (S 100 Protein)IBA
5. Codon (Codons)IBA
6. G-substrate (protein G)IBA
7. ParaffinIBA
03/01/1989 - "The recently described method of staining nucleolar organizer regions (NOR) with colloidal silver nitrate was applied to the paraffin sections of five junctional nevi, 13 compound nevi, seven Spitz nevi, nine cellular blue nevi, 11 dysplastic nevi, seven malignant lentigines, 12 superficial spreading melanomas, and 14 secondary melanomas. "
04/01/1996 - "We have investigated immunohistochemically the expression of CD44S and the variant isoforms CD44v3 and CD44v6 in paraffin-embedded tissue from 5 Spitz nevi, 3 compound melanocytic nevi, 2 blue nevi, 6 primary melanomas, 15 cutaneous metastases (three epidermotropic, nine dermal and three ulcerated) and 10 lymph node metastases of melanoma. "
08/01/1991 - "Using a silver staining technique, we studied nucleolar organizer regions (AgNOR) in paraffin sections of junctional nevi, compound nevi, intradermal nevi, blue nevi, dysplastic nevi, Spitz nevi, lentigo maligna, malignant melanomas in nevus, superficial spreading melanomas, and nodular melanomas. "
04/01/1999 - "Tissue samples of 55 formalin-fixed, paraffin-embedded melanoma (primary n=32, metastatic n=23) and of 27 control cases (junctional dermal, compound, Spitz, Reed, blue nevi, balloon-cell nevus, lentigo maligna) were analyzed by immunohistochemistry with anti-cellular apoptosis susceptibility antibodies. "
12/01/1993 - "The proliferative activity of four malignant cellular blue nevi (MCBN) was assessed in routinely fixed, paraffin-embedded material using staining for the argyrophilic nucleolar organizer regions (AgNORs), immunohistochemical staining for proliferating cell nuclear antigen (PCNA [PC10]), and DNA flow cytometry. "
8. tebufenozide (Mimic)IBA
9. Neurocutaneous melanosisIBA
10. 9,10-Dimethyl-1,2-benzanthracene (DMBA)IBA

Therapies and Procedures

1. Semiconductor Lasers
2. Hysterectomy
3. Lasers (Laser)
4. Solid-State Lasers
5. Laser Therapy (Surgery, Laser)