Capillary Hemangioma

A dull red, firm, dome-shaped hemangioma, sharply demarcated from surrounding skin, usually located on the head and neck, which grows rapidly and generally undergoes regression and involution without scarring. It is caused by proliferation of immature capillary vessels in active stroma, and is usually present at birth or occurs within the first two or three months of life. (Dorland, 27th ed)

Also Known As:

Networked: 250 relevant articles (12 outcomes, 16 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Pyogenic Granuloma
3.	von Hippel-Lindau Disease (von Hippel Lindau Disease)
4.	Retinal Detachment (Retinal Detachments)
5.	Hemangioma (Angioma)

Experts

1.	Shields, Jerry A: 6 articles (02/2011 - 03/2002)
2.	Shields, Carol L: 6 articles (02/2011 - 03/2002)
3.	Singh, Arun D: 5 articles (07/2010 - 03/2002)
4.	Murray, Timothy G: 2 articles (01/2016 - 01/2004)
5.	Meyer, David: 2 articles (10/2015 - 07/2012)
6.	Yang, Michael B: 2 articles (05/2015 - 10/2011)
7.	Hao, Jinsong: 2 articles (05/2015 - 10/2011)
8.	Li, S Kevin: 2 articles (05/2015 - 10/2011)
9.	Liu, Hongzhuo: 2 articles (05/2015 - 10/2011)
10.	Nicolai, Michele: 2 articles (05/2014 - 01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Capillary Hemangioma:

1.	Retinaldehyde (Retinal)IBA 01/01/2016 - "Atypical Exophytic Retinal Capillary Hemangioma and Diagnostic Modalities." 01/01/2014 - "The treatment of juxtapapillary retinal capillary hemangiomas (JRCHs) is still a therapeutic dilemma without established guidelines. " 01/01/2014 - "Juxtapapillary retinal capillary hemangioma: new therapeutic strategies." 01/01/2014 - "Various treatment modalities have been described for retinal capillary hemangioma. " 06/01/2013 - "Best corrected visual acuity in right eye was 20/50, and fundoscopic examination revealed juxtapapillary endophytic retinal capillary hemangioma. "
2.	Propranolol (Inderal)FDA LinkGeneric 12/01/2012 - "According to previous researches, propranolol seems to be an effective and safe drug to treat capillary hemangioma. " 10/01/2011 - "Oral propranolol has become a promising treatment of capillary hemangiomas (CHs) despite concerns of side effects associated with systemic beta-blockers. " 01/01/2011 - "To examine the shift in astigmatic error following the use of oral propranolol as first-line treatment for periocular capillary hemangioma. " 05/01/2015 - "Our previous study demonstrated that topical ocular instillation can deliver effective concentrations of propranolol in the periocular tissues, and may be superior to oral propranolol in the treatment of periocular capillary hemangiomas. " 05/01/2014 - "A single-center study of consecutive patients with capillary hemangiomas treated with systemic propranolol. "
3.	Timolol (Blocadren)FDA LinkGeneric 03/01/2012 - "Topical timolol maleate gel 0.25% is effective in treatment of nonvision-threatening infantile capillary hemangiomas with a superficial component. " 01/01/2015 - "Thus, we conclude that long-term use of topical 0.5% timolol maleate solution is safe and effective in treating superficial capillary hemangiomas." 01/01/2015 - "We present a case report of two children having large capillary hemangiomas who responded well to topical treatment by 0.5% timolol maleate solution. " 03/01/2012 - "To evaluate the efficacy of topical 0.25% timolol maleate gel for the treatment of cutaneous infantile capillary hemangiomas. " 03/01/2012 - "A controlled study of topical 0.25% timolol maleate gel for the treatment of cutaneous infantile capillary hemangiomas."
4.	Adrenal Cortex Hormones (Corticosteroids)IBA 11/01/1996 - "[Therapeutic effectiveness of local administration of corticosteroids in the treatment of orbital capillary hemangioma]." 08/01/1994 - "Surgical resection of pediatric capillary hemangiomas should be considered a treatment option in those that fail to respond to corticosteroids and/or are isolated and noninfiltrative in nature." 12/01/1992 - "Intralesional corticosteroids are often successful in reducing the size of functionally significant capillary hemangiomas. " 02/01/1991 - "Adrenal suppression and/or growth retardation were noted in two patients after injection of periocular capillary hemangiomas with corticosteroids. " 02/01/1991 - "Adrenal suppression and growth retardation after injection of periocular capillary hemangioma with corticosteroids."
5.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 07/01/2002 - "To evaluate the potential benefit and risks of photodynamic therapy (PDT) in the treatment of papillary capillary hemangioma. " 10/01/2014 - "According to our experience, the PDT with Visudyne appears as promising therapy method of juxtapapillary capillary hemangiomas. " 01/01/2012 - "To report a case of a large anterior retinal capillary hemangioma (RCH) treated successfully with photodynamic therapy (PDT). " 06/01/2014 - "Photodynamic therapy (PDT) is a common treatment on retinal capillary hemangioma. " 05/01/2014 - "A rare case of juxtapapillary retinal capillary hemangioma (JRCH) with tractional macular detachment that was managed successfully with minimally invasive 25-gauge vitreoretinal surgery, followed by two sessions of half-fluence photodynamic treatment (PDT) with good visual outcome, is presented. "
6.	verteporfin (Visudyne)FDA Link 10/01/2014 - "According to our experience, the PDT with Visudyne appears as promising therapy method of juxtapapillary capillary hemangiomas. " 03/01/2005 - "Verteporfin and photodynamic therapy were effective in achieving closure of large retinal capillary hemangiomas. " 03/01/2005 - "To investigate the efficacy of verteporfin and photodynamic therapy in the treatment of large retinal capillary hemangiomas. " 12/01/2005 - "Transient closure of a retinal capillary hemangioma with verteporfin photodynamic therapy." 03/01/2005 - "Case reports of 3 patients with large retinal capillary hemangiomas treated with photodynamic therapy using verteporfin. "
7.	Indocyanine Green (Cardio-Green)FDA LinkGeneric 03/01/2003 - "To describe the clinical, angiographic and optical coherence tomography (OCT) findings of a patient with a large retinal capillary hemangioma who was treated by indocyanine green-mediated photothrombosis. " 03/01/2003 - "Retinal capillary hemangioma treatment by indocyanine green-mediated photothrombosis." 03/01/2003 - "Photothrombosis using low-intensity, 810-nm light to direct laser energy continuously at the tumor after intravenous indocyanine green infusion was effective in restoring macular architecture and improving vision in a patient with a large peripheral retinal capillary hemangioma by means of substantial occlusion of the tumor vasculature and resolution of subretinal fluid." 01/01/2014 - "Fluorescein angiography and angiogram with indocyanine green confirmed the diagnosis of juxtapapillary retinal capillary hemangioma. " 07/01/2004 - "Fluorescein and indocyanine green angiography revealed exophytic juxtapapillary retinal capillary hemangioma. "
8.	Fluorescein (Funduscein)FDA LinkGeneric 11/01/1983 - "On the basis of ophthalmoscopy, fluorescein angiography, ultrasonography and other studies, the authors presume that the described lesion is a primary acquired benign vascular tumor, most likely a variant of capillary hemangioma. " 09/01/1996 - "We present five patients who developed luxury perfusion following anterior ischemic optic neuropathy in whom fluorescein angiography was misinterpreted as "capillary hemangioma" or neovascularization of the disc. " 09/01/1984 - "Ophthalmoscopic and fluorescein angiographic findings of capillary hemangiomas of the optic disc are summarized to aid in differentiating them from cavernous and racemose hemangiomas. " 01/01/2013 - "Fluorescein angiography demonstrated leakage from the tumor, and a 4-mm lesion of high density was seen on computed tomography, and we diagnosed it as retinal capillary hemangioma. " 06/01/2006 - "A patient presented with a unilateral decrease of visual acuity and was found to have a juxtapapillary capillary hemangioma by ophthalmoscopy (confirmed by fluorescein angiography) and atrophy in the retinal pigmentary epithelium with leakage points suggesting bilateral central serous retinopathy. "
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/01/2015 - "The ECs of capillary hemangiomas actively proliferated and were generally regulated by VEGF-A. " 01/01/2007 - "A potential therapeutic strategy for capillary hemangioma with new anti-vascular endothelial growth factor (anti-VEGF) agents." 03/01/2015 - "As compared with cavernous hemangiomas and normal controls, capillary hemangiomas had higher staining scores for CD105, VEGF-A, and COX-2. " 01/01/2004 - "In this study the expression of GLUT-1, VEGF, Ki-67, bcl-2 and apoptotic index in twenty-six cases of infantile capillary hemangioma (ICH), fifteen of lobular capillary hemangioma (LCH) and nine of epithelioid hemangioma were examined. " 04/01/1996 - "We studied 16 cases of AIDS-associated Kaposi's sarcoma (KS), 2 cases of cutaneous angiosarcoma, and 6 cases of capillary hemangioma by in situ hybridization for expression of VPF/VEGF, KDR, and flt-1 mRNAs. "
10.	bevacizumabFDA Link 02/01/2012 - "The purpose of this study is to report a case of retinal capillary hemangioma treated with ruthenium-106 brachytherapy combined with intravitreal bevacizumab. " 02/01/2012 - "Ruthenium-106 brachytherapy and intravitreal bevacizumab for retinal capillary hemangioma." 03/01/2010 - "Juxtapapillary capillary hemangioma treated by intravitreal injection of bevacizumab combined with posterior subtenon injection of triamcinolone acetonide." 04/01/2015 - "Massive exudative retinal detachment following photodynamic therapy and intravitreal bevacizumab injection in retinal capillary hemangioma." 01/01/2014 - "Persistent exudative retinal detachment after photodynamic therapy and intravitreal bevacizumab injection for multiple retinal capillary hemangiomas in a patient with von Hippel-Lindau disease."

Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy) 07/01/2002 - "Benefits and complications of photodynamic therapy of papillary capillary hemangiomas." 04/01/2004 - "[A case of von Hippel-Lindau disease with papillary capillary hemangioma treated by photodynamic therapy]." 11/01/2002 - "To describe a case of exudative retinal capillary hemangioma treated with photodynamic therapy that resulted in an improvement in clinical appearance and visual acuity. " 01/01/2014 - "In conclusion, photodynamic therapy offers promising anatomical and functional results for juxtapapillary retinal capillary hemangioma, providing visual acuity improvement or even stabilization and restriction of enlargement of the lesion. " 01/01/2014 - "Our purpose is to present a case of juxtapapillary retinal capillary hemangioma treated with photodynamic therapy. "
2.	Lasers (Laser) 01/01/1992 - "[Indications for laser in the treatment of capillary hemangioma]." 11/01/1989 - "Capillary hemangiomas: case study of a novel laser treatment and a review of therapeutic options." 05/01/1989 - "Methodological recommendations for applying three methods fo laser treatment of extensive capillary hemangiomas are suggested. " 07/01/2006 - "Laser treatment of vascular birthmarks remains one of the more common applications of dermatologic lasers and is the treatment of choice for port-wine stains (PWS) and superficial capillary hemangiomas. " 01/06/1986 - "[Treatment of capillary hemangiomas and telangiectases with laser]."
3.	Radiotherapy 03/01/2006 - "Stereotactic fractionated radiotherapy for recurrent capillary hemangioma of the cavernous sinus." 01/01/2005 - "CD/PD ultrasound is helpful in monitoring treatment of selected orbital tumors, enables evaluation of biological evolution of capillary hemangioma and assessment of vascularization degree of tumors treated with chemo- and radiotherapy." 07/01/2012 - "However, because partial removal is associated with a high recurrence rate, capillary hemangiomas that cannot be removed radically should be treated with radiotherapy, which offers the possibility of controlling lesion size and preventing tumor recurrence." 03/01/2006 - "Capillary hemangioma of the cavernous sinus is a rare benign skull base tumor that can successfully be treated with radiotherapy. " 07/01/2012 - "Periocular infantile capillary hemangiomas do not always respond well to conventional treatment modalities such as systemic or intralesional corticosteroids, radiotherapy or debulking surgery. "
4.	Intralesional Injections 06/01/1996 - "Diagnosis and treatment of an ophthalmic artery occlusion during an intralesional injection of corticosteroid into an eyelid capillary hemangioma." 12/01/1992 - "We believe these resulted from the hemodynamic continuity of capillary hemangiomas with the orbital and systemic circulation and that intralesional injections are intravascular. " 09/01/1999 - "Intralesional injection of corticosteroids is an effective treatment for capillary hemangiomas. " 05/01/2001 - "Injection pressures exceeding the systemic arterial pressures routinely occur during intralesional injections of corticosteroids into capillary hemangiomas. " 05/01/2001 - "High injection pressure during intralesional injection of corticosteroids into capillary hemangiomas."
5.	Injections 08/01/1984 - "The use of intralesional corticosteroid injections has been demonstrated to be a simple, safe, and effective method of treating capillary hemangiomas of the eyelid." 02/01/2004 - "To evaluate the effects of steroid injections for periocular capillary hemangioma on adrenal function and body composition. " 01/01/1995 - "Capillary hemangiomas have been treated with observation and intralesional corticosteroid injections. " 03/01/1990 - "Although many cases of atrophy following local corticosteroid injections for other lesions elsewhere in the body have been reported, the entity we describe is a rare complication in capillary hemangioma therapy."