Luteoma

An ovarian neoplasm composed of LUTEAL CELLS derived from luteinized GRANULOSA CELLS and THECA CELLS. Luteomas respond to GONADOTROPINS, and vary in their hormone production (PROGESTERONE; ESTROGENS; or ANDROGENS). During PREGNANCY, a transient type of luteoma may develop due to an exaggerated LUTEINIZATION of the OVARY.

Also Known As:

Networked: 55 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Virilism (Virilization)
3.	Hyperplasia
4.	Cysts
5.	Granulosa Cell Tumor

Experts

1.	Libertun, C: 2 articles (09/2005 - 09/2002)
2.	Roth, C: 2 articles (03/2000 - 03/2000)
3.	Pillai, G Rajasekharan: 1 article (09/2014)
4.	Gokhale, Uday A: 1 article (09/2014)
5.	Nanda, Annu: 1 article (09/2014)
6.	Carvalho, Davide: 1 article (12/2012)
7.	Sousa, Pedro F: 1 article (12/2012)
8.	Braga, Daniel C: 1 article (12/2012)
9.	Baptista, Pedro V: 1 article (12/2012)
10.	Barreto, Filomena: 1 article (12/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Luteoma:

1.	SteroidsIBA 06/01/1982 - "The concentrations in the ovarian vein were significantly greater than those in the peripheral vein, which indicates active secretion of these steroids by the luteoma. " 07/01/1977 - "[C19 urinary steroids in a pregnant ovarian luteoma]." 08/01/1953 - "Neutral steroids in the urine of a patient with a luteoma of the ovary." 01/01/1995 - "Estradiol and progesterone in portal blood, which collects the steroids secreted by the luteoma, were significantly reduced by GnRH-a treatment in both models. "
2.	Buserelin (Suprefact)IBA 09/09/2005 - "Although basal apoptosis levels were higher in SPO than in Luteoma cells, Buserelin-induced apoptosis was only detected in Luteoma cells after 48 h treatment. " 04/01/1997 - "Therefore, a direct effect of buserelin on luteoma cells can be postulated." 04/01/1997 - "In vivo treatment with buserelin did not modify luteoma GnRH receptors. " 08/01/1999 - "For GnRH receptor studies membranes were obtained from 4- to 6-week-old ovarian tumors (luteoma) and ovaries from prepubertal rats treated with 25 IU PMSG and 25 IU hCG (SPO) and were incubated with [125I]Buserelin. " 09/09/2005 - "Buserelin (GnRH analog) increased GnRH mRNA and peptide expression in SPO but not in Luteoma cells. "
3.	LHRH Receptors (Gonadotropin-Releasing Hormone Receptor)IBA 08/01/1999 - "These data provide evidence that the transformation of the ovary into a luteoma implies the acquisition of novel characteristics in the GnRH receptor second messenger-generating system." 08/01/1999 - "The number of GnRH receptors were increased in luteoma compared with that in SPO ovaries; dissociation constants were similar in both tissues. " 04/01/1997 - "GnRH receptors were present in luteoma in similar concentrations and dissociation constant (Kd) to control estrous ovaries. " 04/01/1997 - "Furthermore, they show that luteoma possess GnRH receptors similar to those in normal ovarian tissue, and that GnRH analogs have endocrine effects on these cells. " 04/01/1997 - "In vivo treatment with buserelin did not modify luteoma GnRH receptors. "
4.	Testosterone (Sustanon)FDA Link 01/01/1981 - "Finally, a review of the literature makes it possible to draw up a history of the usual behaviour of these virilising luteomas in pregnancy: they usually show up in the second trimester of pregnancy, and the overriding role is played by testosterone with virilisation of female fetuses." 09/01/2010 - "Luteomas present most commonly in the second half of pregnancy, with a solid ovarian mass that is frequently bilateral, elevated testosterone levels and some aspects of virilization. " 10/01/2007 - "High maternal serum testosterone levels due to a luteoma can result in virilization in the female newborn. " 01/01/1999 - "Testosterone was detected immunohistochemically in the hilus cell hyperplasia, stromal luteoma and hyperthecosis found in the hyperandrogenic patients. " 03/01/2000 - "Diagnostic workup findings showed a female karyotype, homozygous 21-hydroxylase deficiency, and excessive testosterone exposure prenatally as a consequence of maternal pregnancy luteoma, altogether causing this unusual phenotype. "
5.	LuteinIBA 02/01/2012 - "Additional lesions specific to the gravid state must be considered in the differential diagnosis when appropriate, such as hyperstimulated ovaries, hyperreactio luteinalis, theca lutein cyst, and luteomas." 06/01/2004 - "Uncommon adnexal lesions specific to pregnancy include hyperreactio luteinalis, theca lutein cysts with moles, and luteomas. " 10/01/2002 - "The most common etiologies include ovarian luteomas and theca-lutein-cysts. " 05/01/1997 - "Seven pregnancy luteomas (nodular theca lutein hyperplasia of pregnancy), 3 corpora lutea and 2 ovarian follicles were also studied. " 05/01/1967 - "Nodular theca-lutein hyperplasia of pregnancy (so-called "pregnancy luteoma"). "
6.	HormonesIBA 01/04/2000 - "However, in hybrid mice generated by crossing CF-1 males with C57BL/6, SJL, or CD-1 females, elevated levels of this same hormone cause a completely different phenotype resembling a luteoma of pregnancy. " 01/01/2007 - "Usually symptoms are attributed to pregnancy luteomas, which are hormone-active benign neoplasms. " 01/01/2000 - "We report a case of female pseudohermaphroditism secondary to a maternal ovarian luteoma of pregnancy producing androgenic hormones. " 06/01/1973 - " Since tumor size decreased as did production of androgenic hormones following hypophysectomy, the luteoma is believed to have been dependent on pituitary tropic hormones; posthypophysectomy histologic changes supported this conclusion. " 01/01/1987 - "The use of hormones, castration and transplantation of the ovaries in a number of inbred strains results in a high incidence of ovarian tumors; in strain Maf/Sp gct and luteomas were induced in 82%. "
7.	ProgesteroneFDA LinkGeneric 12/03/1984 - "It is concluded that a high correlation between prolactinemia and LH binding, as well as between this last parameter and progesterone output exists in the experimental luteoma." 12/03/1984 - "Moreover, progesterone secreted by the luteoma increased as LH binding sites augmented (R:0,97). " 12/03/1984 - "High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma." 04/01/1997 - "Although luteinizing-hormone (LH)-stimulated progesterone in both kinds of cells, buserelin significantly inhibited LH-stimulated progesterone only in luteoma cells. " 04/01/1997 - "In organ incubations, luteoma secreted significantly higher estradiol and lower progesterone than estrous ovaries; addition of buserelin did not modify steroid secretion. "
8.	Gonadotropin-Releasing Hormone (GnRH)FDA Link 09/09/2005 - "Luteoma cells proliferate very weakly, express and secrete high amounts of GnRH, do not show an autoregulatory effect and respond to the decapeptide with apoptosis stimulation. " 09/09/2005 - "These results show that the two types of rat, luteinized tissues, Luteoma and SPO, markedly differed in some intrinsic properties and in their local GnRH systems. " 09/09/2005 - "In vitro cultures of Luteoma cells expressed 2-fold higher GnRH mRNA and 10-fold higher GnRH peptide than SPO cells. " 09/09/2005 - "GnRH mRNA was present in SPO, isolated corpora lutea from SPO and Luteoma from 1 week to 7 months of development. " 08/01/1999 - "GnRH stimulation of second messenger release was assessed in cells obtained from luteoma and SPO ovaries by collagenase treatment. "
9.	Steroid 21-Hydroxylase (21 Hydroxylase)IBA 03/01/2000 - "Diagnostic workup findings showed a female karyotype, homozygous 21-hydroxylase deficiency, and excessive testosterone exposure prenatally as a consequence of maternal pregnancy luteoma, altogether causing this unusual phenotype. " 03/01/2000 - "A newborn girl with manifestations of the Antley-Bixler syndrome showed severe virilization probably caused by the association of a mild 21-hydroxylase deficiency and maternal hyperandrogenism due to a pregnancy luteoma. " 08/15/2004 - "Evidence for this has included association with maternal luteomas, fetal 21-hydroxylase deficiency, early pregnancy exposure to high-dose fluconazole, lanosterol 14-alpha-demethylase deficiency, and a unique urinary steroid profile consistent with apparent pregnene hydroxylation deficiency (APHD). "
10.	Inhibins (Inhibin)IBA 09/01/2003 - "Using conventional tissue sections and a tissue microarray, we studied the immunoreactivities of 131 ovarian tumors for A103 and inhibin: 30 SCSTs, including fibrothecoma, luteoma, hilus cell tumor, granulosa cell tumor, Sertoli-Leydig cell tumor, and sex cord tumor with annular tubules, and a control group of 96 surface epithelial tumors. " 07/01/1998 - "Inhibin was present in the tumor cells in all 14 primary adult granulosa cell tumors (4 luteinized) plus 3 metastatic, all 10 primary juvenile granulosa cell tumors plus 1 metastatic, 10 of 11 thecomas, 3 of 11 fibromas, 4 of 11 sclerosing stromal tumors, 6 of 11 Sertoli cell tumors (1 oxyphilic), 7 of 11 Sertoli-Leydig cell tumors, 1 gynandroblastoma, 10 primary ovarian sex cord tumors with annular tubules plus 2 metastatic, 8 of 9 steroid cell tumors, both pregnancy luteomas, 1 of 2 unclassified sex cord tumors, 2 of 5 gonadoblastomas, 9 of 10 female adnexal tumors of probable wolffian origin, and in the non-neoplastic stroma of many carcinomas and germ cell tumors. " 02/01/2010 - "Granulosa cell component was lacking, and both luteal and Sertoli cell portions were entirely positive for inhibin alpha and neuron-specific enolase, whereas luteoma portion alone was positive for Wilms' tumor-1 (WT1), immunohistochemically. "

Therapies and Procedures

1.	Cesarean Section (Caesarean Section) 01/01/1999 - "A pregnancy luteoma (PL) was incidentally found at a term cesarean section in a 27-year-old black woman without any endocrine abnormality. " 01/01/1976 - "A case of luteoma gravidarum detected during cesarean section is reported for the first time in German literature. " 09/01/2014 - "Pregnancy luteoma is a non-neoplastic lesion of the ovary occurring during pregnancy and is usually discovered incidentally at the time of a cesarean section or during postpartum tubal ligation. " 02/01/1991 - "Luteomas in pregnancy are benign ovarian tumours which can occur uni- or bilaterally and are mostly detected during laparotomy or Caesarean section. " 01/01/1990 - "We have presented a case of luteoma of pregnancy, an uncommon ovarian lesion that is usually detected incidentally during cesarean section or postpartum tubal ligation. "
2.	Tubal Sterilization (Tubal Ligation) 09/01/2014 - "Pregnancy luteoma is a non-neoplastic lesion of the ovary occurring during pregnancy and is usually discovered incidentally at the time of a cesarean section or during postpartum tubal ligation. " 01/01/1990 - "We have presented a case of luteoma of pregnancy, an uncommon ovarian lesion that is usually detected incidentally during cesarean section or postpartum tubal ligation. " 06/01/1982 - "Even though both luteomas were discovered incidentally at the time of postpartum tubal ligation and cesarean section, they were found to be functionally active, secreting several androgens. "
3.	Transplants (Transplant) 06/01/1953 - "Evolution of luteoma in intrasplenic ovarian grafts in the guinea-pig." 01/01/1992 - "Dysgerminomas and luteomas were discovered only in intrasplenic grafts of rats of the young group. "
4.	Ovariectomy (Oophorectomy) 12/01/2012 - "The patient was submitted to bilateral laparoscopic oophorectomy, and histopathological examination revealed a luteoma of the left ovary. " 03/01/2008 - "A diagnostic laparotomy and a right salpingo-oophorectomy were performed, and the diagnosis of luteoma was made based on histology. "
5.	Laparotomy 03/01/2008 - "A diagnostic laparotomy and a right salpingo-oophorectomy were performed, and the diagnosis of luteoma was made based on histology. " 02/01/1991 - "Luteomas in pregnancy are benign ovarian tumours which can occur uni- or bilaterally and are mostly detected during laparotomy or Caesarean section. "