Inverted Papilloma

A mucosal tumor of the urinary bladder or nasal cavity in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded than in other papillomas. (Stedman, 25th ed)

Also Known As:

Networked: 169 relevant articles (2 outcomes, 15 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Squamous Cell Carcinoma (Epidermoid Carcinoma)
2.	Neoplasms (Cancer)
3.	Carcinoma (Carcinomatosis)
4.	Papilloma (Papillomatosis)
5.	Infection

Experts

1.	Danilewicz, Marian: 5 articles (11/2015 - 01/2010)
2.	Stasikowska-Kanicka, Olga: 4 articles (11/2015 - 01/2010)
3.	Kong, Hui: 3 articles (09/2014 - 03/2005)
4.	Cheng, Liang: 3 articles (08/2013 - 12/2007)
5.	Montironi, Rodolfo: 3 articles (08/2013 - 12/2007)
6.	Lopez-Beltran, Antonio: 3 articles (08/2013 - 12/2007)
7.	Lewy-Trenda, Iwona: 2 articles (11/2015 - 06/2015)
8.	Krześlak, Anna: 2 articles (11/2015 - 06/2015)
9.	Pietkiewicz, Piotr: 2 articles (11/2015 - 06/2015)
10.	Forma, Ewa: 2 articles (11/2015 - 06/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Inverted Papilloma:

1.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 12/01/2013 - "Evaluate the efficacy of 5-Aminolevulinic Acid Photodynamic Therapy (PDT) in medical treatment of nasal inverted papilloma (NIP). "
2.	DNA (Deoxyribonucleic Acid)IBA 01/01/1990 - "[Quantitative studies on nuclear DNA content and morphological features in inverted papillomas of the nasal cavities and paranasal sinuses]." 06/01/2010 - "Canine inverted papillomas associated with DNA of four different papillomaviruses." 11/01/2009 - "HPV DNA was detected in 14/20 patients with inverted papillomas (IPs) (70%). " 08/01/2005 - "Human papillomavirus (HPV) transcripts in malignant inverted papilloma are from integrated HPV DNA." 01/01/1999 - "DNA of papillomavirus origin has been identified in the cells of an inverted papilloma by using techniques of in situ hybridisation."
3.	Cyclin D1IBA 11/01/2013 - "Epidermal growth factor receptor, p16, cyclin D1, and p53 staining patterns for inverted papilloma." 11/01/2009 - "Expression of p53, p16INK4A, pRb, p21WAF1/CIP1, p27KIP1, cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papilloma." 01/01/2011 - "The aim of this study was to evaluate the relationships between HPV DNA presence and p16INK4a, p21waf1/cip1, p53 and cyclin D1 immunoexpression in heterogenous HPV-positive and HPV-negative groups of laryngeal cancers and inverted papillomas. " 01/01/2011 - "Effect of human papillomavirus on cell cycle-related proteins p16INK4A, p21waf1/cip1, p53 and cyclin D1 in sinonasal inverted papilloma and laryngeal carcinoma. " 11/01/2013 - "The aim of this study was better characterize the staining patterns of inverted papilloma (IP) with and without carcinoma by performing immunohistochemistry for p16, epidermal growth factor receptor (EGFR), p53, and cyclin D1 antibodies in a large patient cohort. "
4.	Epidermal Growth Factor Receptor (EGF Receptor)IBA 08/01/2008 - "The present study was undertaken to compare positive rate of immunostaining (PR) and positive intensity of immunostaining (PI) of epidermal growth factor receptor (EGFR) in inverted papilloma (IP), synchronous carcinoma with IP and metachronous carcinoma with IP of the nasal cavity. " 08/01/2008 - "Expression of epidermal growth factor receptor in the inverted papilloma and squamous cell carcinoma of nasal cavity." 11/01/2013 - "Epidermal growth factor receptor, p16, cyclin D1, and p53 staining patterns for inverted papilloma." 10/01/2005 - "To measure HPV status, epidermal growth factor receptor (EGFR) and transforming growth factor-alpha (TGF-alpha) expression and Ki-67 index in exophytic papilloma (EP), inverted papilloma (IP) with dysplasia, IP with carcinoma and invasive squamous cell carcinoma (SCC). " 11/01/2013 - "The aim of this study was better characterize the staining patterns of inverted papilloma (IP) with and without carcinoma by performing immunohistochemistry for p16, epidermal growth factor receptor (EGFR), p53, and cyclin D1 antibodies in a large patient cohort. "
5.	fascinIBA 09/01/2009 - "Fascin over expression is associated with dysplastic changes in sinonasal inverted papillomas: a study of 47 cases." 07/01/2012 - "To investigate the expression of Fascin in sinonasal inverted papilloma (SNIP) and the relationship between Fascin expression and microvessel density (MVD). " 07/01/2012 - "[Expression of fascin and correlation with MVD in sinonasal inverted papilloma]." 03/05/2007 - "Increased expression of fascin associated with malignant transformation of sinonasal inverted papilloma." 03/05/2007 - "In this study, we examined the expression of fascin by immunohistochemistry in sinonasal epithelium with chronic inflammation (control group), exophytic papilloma (EP), inverted papilloma (IP) with dysplasia and cancerated IP (including carcinoma in situ and invasive squamous cell carcinoma, SCC), and furthermore investigated the relationship between fascin expression and formation of malignant IP. "
6.	ParaffinIBA 09/01/1998 - "Paraffin-embedded tissues of 42 sinonasal inverted papillomas were subjected to polymerase chain reaction using type-specific primers pairs of HPV 6, 11, 16, 18, and 33. " 12/01/1997 - "Ten cases of inverted papilloma and 20 cases of papillary transitional cell carcinoma of the bladder from Chinese patients in Hong Kong were examined for the presence of HPV type 6, 11, 16, 18, 31, and 33 genomes using the polymerase chain reaction and HPV type specific primer probe combinations on paraffin wax embedded biopsy specimens. " 02/01/2011 - "Formalin-fixed and paraffin-embedded tissues from eight cases of inverted papilloma of the bladder were studied. " 02/01/1996 - "-Formalin fixed, paraffin wax embedded sections from 14 cases of inverted papilloma of the urinary bladder were studied retrospectively. " 11/01/1994 - "To determine the etiological role of human papillomavirus (HPV) in inverted papilloma and to clarify the relationship between the different types of human papillomavirus and malignant transformation, we analyzed retrospectively a series of 29 formalin - fixed, paraffin-embedded cases, 3 of which had squamous cell carcinoma. "
7.	Formaldehyde (Formol)FDA Link 12/01/1994 - "In addition, we demonstrated accumulation of formalin-sensitive mast cells at the tumor site of nasal inverted papilloma. " 05/01/1993 - "Serial staining of nasal inverted papilloma showed that the number of mast cells and the percentage of formalin sensitive mast cells within 50 microns of the tumor site and 50 microns above the basement membrane were 16576 +/- 5729/mm3 (90.8%) and 4697 +/- 304/mm3 (76.1%), respectively. " 02/01/2011 - "Formalin-fixed and paraffin-embedded tissues from eight cases of inverted papilloma of the bladder were studied. " 02/01/1996 - "-Formalin fixed, paraffin wax embedded sections from 14 cases of inverted papilloma of the urinary bladder were studied retrospectively. " 11/01/1994 - "To determine the etiological role of human papillomavirus (HPV) in inverted papilloma and to clarify the relationship between the different types of human papillomavirus and malignant transformation, we analyzed retrospectively a series of 29 formalin - fixed, paraffin-embedded cases, 3 of which had squamous cell carcinoma. "
8.	Keratins (Keratin)IBA 04/01/1997 - "[Inverted papilloma of the nose and paranasal sinuses--diagnosis, surgical procedure and studies of cytokeratin profile]." 12/01/2004 - "Cytokeratin (CK) 20 staining was negative in all cases of inverted papillomas. " 05/01/2001 - "Cytokeratin (CK) expression was studied in 22 sinonasal inverted papillomas. " 04/01/1997 - "The findings of immunohistochemical examinations suggest that inverted papilloma is derived from a cytokeratin 5-immunoreactive cell of the basal layer of the mucosa." 12/01/1992 - "Inverted papilloma were classified into two patterns according to their histological patterns, determined by immunohistochemical staining with anti-keratin antibody, namely a bladder tumor pattern and a urethral tumor pattern. "
9.	Proliferating Cell Nuclear Antigen (PCNA)IBA 03/01/2013 - "To explore the expression and significance of survivin and proliferating cell nuclear antigen (PCNA) on the occurrence, proliferation, recurrence and carcinogenesis of the sinonasal inverted papilloma (SNIP). " 03/01/2013 - "[Expression and significance of survivin and PCNA in sinonasal inverted papilloma]." 03/01/2007 - "Immunohistochemical analysis of PCNA, Ki67 and p53 in nasal polyposis and sinonasal inverted papillomas." 08/01/2004 - "To investigate the expression of CD34 and proliferating cell nuclear antigen (PCNA) and to study the relationship between tumor angiogenesis and cellular proliferation activity in nasal inverted papilloma (NIP). " 01/01/2014 - "Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell carcinoma transformation of sinonasal tract compared with inverted papilloma were revealed. "
10.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/01/2014 - "To investigate the quantification and significance of Msx2, topoII-α; HPV16 and VEGF in sinonasal inverted papilloma(SNIP), to study the correlation among the four factors,and to discover the relationship between Msx2 and topoII-α in the process of SNIP malignant transfomation. " 04/01/2012 - "[Significance and expression of VEGF and its receptor in nasal inverted papillomas and the correlation with malignant phenotype]." 02/01/2000 - "[The significance and expression of vascular endothelial growth factor on nasal inverted papillomas]." 12/01/2014 - "[The quantification and significance of muscle segment homeobox gene Msx2, human topoisomerase II-α, HPV16 and VEGF in sinonasal inverted papilloma]." 04/01/2012 - "To determine the expression of vascular endothelial growth factor (VEGF) and their receptor in nasal inverted papillomas (NIP) and to clarify the function of VEGF in the occurrence of NIPs and the correlation with malignant phenotype. "

Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy) 12/01/2013 - "5-Aminolevulinic Acid Photodynamic Therapy appears to be an effective treatment of nasal inverted papilloma. " 12/01/2013 - "Efficacy of 5-Aminolevulinic Acid Photodynamic Therapy in treatment of nasal inverted papilloma." 12/01/2013 - "After treated with 5-Aminolevulinic Acid Photodynamic Therapy, the nasal inverted papillomas were removed. " 12/01/2013 - "Three patients with nasal inverted papilloma were treated with 5-Aminolevulinic Acid Photodynamic Therapy at our department from April to September 2012. " 12/01/2013 - "Evaluate the efficacy of 5-Aminolevulinic Acid Photodynamic Therapy (PDT) in medical treatment of nasal inverted papilloma (NIP). "
2.	Lasers (Laser) 01/01/2007 - "Laser endoscopic coagulation seems to be an effective treatment for multicentric sinonasal inverted papilloma especially for lesions with a difficult surgical access." 01/01/2007 - "To describe a new method of treatment of multicentric sinonasal inverted papilloma by laser endoscopic coagulation. "
3.	Radiotherapy 03/01/2013 - "Radiotherapy for inverted papilloma: a case report and review of the literature." 09/01/2011 - "Focal malignancy in sinonasal inverted papilloma--is postoperative radiotherapy recommendable?" 10/01/2007 - "Definitive radiotherapy may be used to successfully treat patients with incompletely resectable inverted papilloma." 01/01/1994 - "Seven cases of inverted papilloma with malignant change, of the nasal cavity and paranasal sinuses, were referred to the department of radiotherapy in Newcastle between 1979 and 1990. " 05/01/1986 - "Radiotherapy was found to be a useful and effective adjunct in cases associated with malignancy or for multiply recurrent and inoperable benign inverted papillomas. "
4.	Endoscopes 06/01/2014 - "Nasal endoscope: an armamentarium in the management of sinonasal inverted papilloma." 04/01/2014 - "The clinical data of 104 patients with nasal inverted papilloma underwent endoscopic surgery u sing the plasma radiofrequency ablation at low temperature from July, 2008 to July, 2012 were analyzed,and the recovery of mucosa was observed under nasal endoscope. " 01/01/2007 - "The use of the endoscope in this type of surgical treatment is an important success factor in the treatment of inverted papilloma." 09/01/2004 - "Endoscopic and endoscope-assisted resections of inverted papilloma are effective techniques for managing inverted papilloma. "
5.	Catheters 04/01/1995 - "A case of inverted papilloma of the bladder in a 52-year-old man with a permanent bladder catheter is described. " 05/01/1990 - "Pathological findings revealed a grade 1 papillary carcinoma in 3 patients and a well differentiated inverted papilloma in 1. A single-J ureteral catheter was left in place after the procedure. "