Neurocytoma

A benign brain tumor composed of neural elements which most often arise from the SEPTUM PELLUCIDUM and the walls of the lateral ventricles. Immunohistochemistry and electron microscopy evaluations may reveal expression of neuron specific enolase and synaptophysin and cells containing microtubuli, neurosecretory granules, and presynaptic vesicles. (From Acta Med Port 1994 Feb;7(2):113-9)

Also Known As:

Networked: 124 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Oligodendroglioma
2.	Astrocytoma (Pilocytic Astrocytoma)
3.	Neoplasms (Cancer)
4.	Ependymoma
5.	Neuroepithelial Neoplasms (Gliomatosis Cerebri)

Experts

1.	Rades, Dirk: 8 articles (07/2006 - 10/2002)
2.	Schild, Steven E: 6 articles (07/2006 - 12/2004)
3.	Fehlauer, Fabian: 5 articles (01/2005 - 10/2002)
4.	Kim, Dong Gyu: 4 articles (01/2015 - 02/2003)
5.	Paek, Sun Ha: 4 articles (03/2013 - 02/2003)
6.	Jung, Hee-Won: 3 articles (03/2013 - 08/2005)
7.	Kim, Yong Hwy: 2 articles (01/2015 - 03/2013)
8.	Kim, Chae-Yong: 2 articles (01/2015 - 02/2003)
9.	Park, Sung-Hye: 2 articles (03/2013 - 08/2005)
10.	Sarkar, Chitra: 2 articles (12/2011 - 10/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neurocytoma:

1.	2,6-dinitrotoluene (DNT)IBA 03/01/2004 - "In the group of neuronal and mixed glioneuronal neoplasms are lesions with distinctive morphological features that are still not included in a precise classification, including extraventricular neurocytoma, papillary glioneuronal tumor, rosette-forming glioneuronal of the fourth ventricle, glioneuronal with neuropil-like rosette, and DNT-like tumor of the septum pellucidum. " 10/01/2001 - "Tumor cells with immunoreactive bi- or multi-polar processes were mostly encountered in astroglial neoplasms, whereas the small cell component in neurocytomas and DNT was not labeled. " 12/01/2002 - "Because of their histological similarities, it is occasionally difficult to differentiate neurocytoma and dysembryoplastic neuroepithelial tumor (DNT) from oligodendroglial tumors. " 11/01/2008 - "Furthermore, six histological variants of well-known brain tumours have been added, partially because they show different biological behaviour and/or prognosis: pilomyxoid astrocytoma; atypical choroid plexus papilloma; medulloblastoma with extensive nodularity; anaplastic medulloblastoma; extraventricular neurocytoma; non-specific variant of dysembryoplastic neuroepithelial tumour (DNT). " 01/01/2003 - "PGNT may be regarded as a variant of ganglioglioma or as a complex variant of extraventricular neurocytoma and belongs to a wide group of benign, dysembryoplastic or even hamartomatous neuroepithelial tumors, which may differentiate into both, glial or neuronal direction: pleomorphic astrocytoma may posses neurocytic differentiation, desmoplastic infantile ganglioglioma may be regarded as complex superficial dural astrocytoma and DNT may present gliomatous areas (complex DNT). "
2.	ParaffinIBA 03/01/2006 - "Anti-NeuN immunohistochemistry was performed on paraffin-embedded biopsy specimens of 106 diffuse astrocytomas, 100 pilocytic astrocytomas, 107 ependymomas, 59 1p-aberrant oligodendroglial neoplasms, 115 glioblastomas, 115 medulloblastomas, 14 gangliogliomas/gangliocytomas and 10 central neurocytomas. " 01/01/2003 - "As the diagnostic criteria for central neurocytoma include immunohistochemical and/or ultrastructural evidence for neuronal differentiation, NeuN as a sensitive and specific neuronal marker in formalin-fixed, paraffin-embedded tissues may greatly facilitate the differential diagnosis of central neurocytomas." 10/01/2001 - "In the present study, we systematically analyzed the expression of MAP2 in a series of 237 human neuroepithelial tumors including paraffin-embedded specimens and tumor tissue microarrays from oligodendrogliomas, mixed gliomas, astrocytomas, glioblastomas, ependymomas, as well as dysembryoplastic neuroepithelial tumors (DNT), and central neurocytomas. " 04/01/1991 - "Western blots also revealed expression of the synaptic vesicle protein, synapsin I, neurofilament protein and glial fibrillary acidic protein in several neurocytomas which failed to exhibit immunoreactivity to these marker antigens on paraffin sections. "
3.	tebufenozide (Mimic)IBA 10/01/2006 - "Neurocytomas often mimic oligodendrogliomas when confirmation of diagnosis rests on immunohistochemistry, ultrastructure, and genetic studies. " 01/01/2012 - "Extraventricular neurocytomas mimic central neurocytomas histologically but are located outside the lateral and/or third ventricles. " 11/15/2003 - "Histologically, it may mimic oligodendroglioma, central neurocytoma, hemangioblastoma, and renal cell carcinoma. "
4.	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 08/01/2012 - "We therefore investigated the expression of activated leukocyte adhesion molecule in 9 malignant glial cell lines, 105 normal/reactive human brain specimens, 248 astrocytomas/glioblastomas, 98 ependymomas, 35 oligodendrogliomas, 10 neurocytomas, 10 primitive neuroectodermal tumors (PNET), and 36 medulloblastomas by immunohistochemistry and in selected cases by reverse transcriptase polymerase chain reaction. " 08/01/2005 - "For investigation of histogenesis of central neurocytomas (CNs), subependymoma (SEs), subependymal giant cell astrocytomas (SEGAs), we studied expression of various neuronal and glial biomarkers by immunohistochemical (IHC) study and reverse transcriptase-polymerase chain reaction (RT-PCR). "
5.	Glucose (Dextrose)FDA LinkGeneric 10/01/1995 - "To estimate proliferating activity of central neurocytoma, we measured kinetic rate constants and glucose metabolic rate (kinetic-rCMRGI) using dynamic positron emission tomography (PET), as well as autoradiographic rCMRG1 (arg-rCMRG1), in patients with histologically verified central neurocytoma. " 10/01/1995 - "[Kinetics of glucose metabolism in central neurocytomas]." 12/01/2004 - "Methionine and glucose metabolism of central neurocytoma: a PET study."
6.	Neurotransmitter Agents (Neurotransmitter)IBA 05/01/2001 - "In this study we analyzed neurotransmitters in an attempt to clarify the tumorigenesis of central neurocytomas. " 05/01/2001 - "Although past electron microscopic studies demonstrated synaptic vesicles in the synapse of central neurocytomas, the kinds of neurotransmitters in central neurocytomas have never been identified. " 05/01/2001 - "The biochemical analysis of neurotransmitters in central neurocytomas."
7.	Biological Markers (Surrogate Marker)IBA 08/01/2005 - "For investigation of histogenesis of central neurocytomas (CNs), subependymoma (SEs), subependymal giant cell astrocytomas (SEGAs), we studied expression of various neuronal and glial biomarkers by immunohistochemical (IHC) study and reverse transcriptase-polymerase chain reaction (RT-PCR). "
8.	Methionine (L-Methionine)FDA Link 12/01/2004 - "Methionine and glucose metabolism of central neurocytoma: a PET study."
9.	SynaptophysinIBA 01/01/2010 - "In the rare case of Synaptophysin-negative central neurocytoma, its neuronal differentiation should be substantiated by electron-microscopic examination. " 01/01/2010 - "Histology showed a picture consistent with central neurocytoma, but tumour was completely negative for Synaptophysin. " 01/01/2010 - "To report a case of a rare central neurocytoma with a complete loss of Synaptophysin expression and provide the differential diagnosis. " 01/01/2010 - "Synaptophysin negative central neurocytoma." 02/01/2008 - "Typical histologic features of recurrent neurocytoma include high proliferative activity (MIB-1 labeling index: 2.0-6.8%), prominent vascular proliferation and remarkable synaptophysin expression. "
10.	Protons (Proton)IBA 10/01/2014 - "Three cases of histopathologically confirmed central neurocytoma (CN) are presented, emphasizing diagnostic imaging issues: conventional magnetic resonance imaging with Proton magnetic resonance spectroscopy (MRS) and diffusion-weighted imaging (DWI) findings of CN. " 10/01/2014 - "Diffusion weighted MR imaging and proton MR spectroscopy findings of central neurocytoma with pathological correlation." 04/01/2009 - "To present proton magnetic resonance spectroscopy and diffusion-weighted imaging (DWI) findings of central neurocytoma (CN). " 04/01/2009 - "Central neurocytoma: proton MR spectroscopy and diffusion weighted MR imaging findings." 09/01/2005 - "3-T proton magnetic resonance spectroscopy of central neurocytoma: 3 case reports and review of the literature."

Therapies and Procedures

1.	Radiotherapy 03/01/2006 - "After ITR of typical neurocytomas, LC is significantly improved by both conventional radiotherapy and SRS. " 01/01/2015 - "The management of central neurocytoma: radiotherapy." 06/01/2014 - "[Radiotherapy in central neurocytoma and review of literature]." 02/01/2014 - "To determine optimal treatment for recurrent or residual intraventricular neurocytomas (IVNs), a systematic review of PubMed and EMBASE was conducted comparing fractionated conventional radiotherapy (FCRT) versus stereotactic radiosurgery (SRS). " 12/01/2011 - "Gamma-knife surgery may be an effective alternative for treatment of central neurocytomas owing to its relative safety compared with conventional radiotherapy. "
2.	Drug Therapy (Chemotherapy) 09/01/1997 - "Central neurocytoma: a clinical study of response to chemotherapy." 05/01/2010 - "The use of intensive chemotherapy followed by autologous stem cell rescue for atypical neurocytoma may be considered as an adjunct to surgical therapy in young patients with atypical neurocytoma not amenable to radiation therapy." 05/01/2010 - "The authors describe a 9 month old female with recurrent atypical central neurocytoma and leptomeningeal spread treated with high dose chemotherapy, autologous stem cell rescue, and adjuvant therapy. " 05/01/2010 - "Treatment of atypical central neurocytoma in a child with high dose chemotherapy and autologous stem cell rescue." 02/01/2004 - "Chemotherapy may be useful for recurrent central neurocytomas that cannot be resected and have been radiated, although long-term responses have not been reported for chemotherapy. "
3.	Particle Accelerators 02/01/2003 - "This study presents a case of central neurocytoma successfully treated with linear accelerator (LINAC)stereotactic radiosurgery. " 09/01/2003 - "Between October 1996 and December 2001, four patients with central neurocytoma were treated by surgery and subsequently underwent linear accelerator (LINAC) radiosurgery. "
4.	Adjuvant Radiotherapy 04/21/2015 - "(P043) Central neurocytoma: impact of resection extent and adjuvant radiotherapy on survival outcomes." 01/01/2014 - "The role of adjuvant radiotherapy for central neurocytomas (CNs) is not clear. " 01/01/2014 - "Long-term outcomes of adjuvant radiotherapy after surgical resection of central neurocytoma." 01/01/2013 - "One of the greatest problems in the management of neurocytoma is the timing of adjuvant radiotherapy. " 10/01/2006 - "The role of adjuvant radiotherapy apparently seems to benefit patients with incomplete resection and in atypical neurocytoma. "
5.	Endoscopes 11/01/2010 - "We report that a working channel endoscope combined with a polypropylene endoscopic sheath facilitates the removal of intraventricular central neurocytoma. "