Ganglioneuroblastoma

A moderately malignant neoplasm composed of primitive neuroectodermal cells dispersed in myxomatous or fibrous stroma intermixed with mature ganglion cells. It may undergo transformation into a neuroblastoma. It arises from the sympathetic trunk or less frequently from the adrenal medulla, cerebral cortex, and other locations. Cervical ganglioneuroblastomas may be associated with HORNER SYNDROME and the tumor may occasionally secrete vasoactive intestinal peptide, resulting in chronic diarrhea.

Also Known As:

Networked: 169 relevant articles (0 outcomes, 9 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Neuroblastoma
2.	Pheochromocytoma
3.	Neoplasms (Cancer)
4.	Ganglioneuroma
5.	Vipoma (WDHA)

Experts

1.	Angelini, Paola: 2 articles (02/2015 - 06/2003)
2.	Kofler, Barbara: 2 articles (09/2013 - 01/2006)
3.	Shibahara, Shigeki: 2 articles (02/2003 - 06/2002)
4.	Murakami, Osamu: 2 articles (02/2003 - 06/2002)
5.	Hayashi, Yutaka: 2 articles (02/2003 - 06/2002)
6.	Totsune, Kazuhito: 2 articles (02/2003 - 06/2002)
7.	Takahashi, Kazuhiro: 2 articles (02/2003 - 06/2002)
8.	Noshiro, Takao: 2 articles (02/2003 - 06/2002)
9.	Totsune, K: 2 articles (01/2001 - 04/2000)
10.	Hayashi, Y: 2 articles (01/2001 - 04/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ganglioneuroblastoma:

1.	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))IBA 06/01/2014 - "The patient was diagnosed with vasoactive intestinal peptide releasing ganglioneuroblastoma localized in the right surrenal gland. " 03/01/2014 - "[Vasoactive intestinal peptide-secreting ganglioneuroblastoma in a 20 month-old child]." 06/01/2011 - "In this case report we describe a case of mediastinal ganglioneuroblastoma-secreting vasoactive intestinal peptide (VIP), causing secretory diarrhoea in an 18-month-old child. " 06/01/2011 - "Mediastinal ganglioneuroblastoma-secreting vasoactive intestinal peptide causing secretory diarrhoea." 12/01/1984 - "The isolation and sequence analysis of vasoactive intestinal peptide from a ganglioneuroblastoma."
2.	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 08/20/1987 - "Immunohistochemical studies have demonstrated that immunoreactive vasoactive intestinal polypeptide is present in the ganglioneuroblastoma component, and that immunoreactive somatostatin is present in the pheochromocytoma component. " 01/01/1995 - "The results of in vivo somatostatin scintigraphy were correlated with those of MIBG from 14 patients, aged 22-66 yr, with metastatic pheochromocytoma (10 patients), malignant paraganglioma (3 patients) and metastatic ganglioneuroblastoma (1 patient). " 10/01/1989 - "Neuropeptide Y- and somatostatin-like immunoreactivities in ganglioneuroma, ganglioneuroblastoma and neuroblastoma." 10/01/1989 - "Neuropeptide Y (NPY)- and somatostatin (SS)-like immunoreactivities (LI) were investigated in tumor tissues of one ganglioneuroma (GN), 3 ganglioneuroblastomas (GNB) and one neuroblastoma (NB) by radioimmunoassay. " 01/01/1988 - "All the remaining tumors were neurogenic, showing either neurons and nerve fibers together with Schwann cells (ganglioneuromas and ganglioneuroblastomas) or endocrine cells (pheochromocytomas) reacting with VIP, PHM, NPY, enkephalin, somatostatin, neuron-specific enolase, synaptophysin, and MAP2 (but not cytokeratin, PP, or GRH) antibodies. "
3.	Adrenocorticotropic Hormone (ACTH)FDA Link 01/01/1993 - "Adrenocorticotropic hormone-secreting ganglioneuroblastoma associated with opsomyoclonic encephalopathy: a case report with immunohistochemical study." 09/01/2003 - "Findings on light microscopic and immunohistochemical examination of the retroperitoneal mass were consistent with a ganglioneuroblastoma that expressed CRH, pro-opiomelanocortin, and ACTH. " 01/01/1984 - "Treatment consisted in corticosteroids and adrenocorticotropic hormone respectively in all patients, the patient with ganglioneuroblastoma also had a resection of the tumor. "
4.	WDHA syndromeIBA 08/01/1982 - "WDHA syndrome caused by VIP-producing ganglioneuroblastoma." 01/01/1982 - "This is to report the rapid turnover of serum level of VIP after resection of ganglioneuroblastoma with WDHA syndrome in a child." 08/01/1982 - "This case was thought to be WDHA syndrome caused by VIPO-producing ganglioneuroblastoma (VIPoma)." 05/01/1993 - "Multiple-hormone gene expression in ganglioneuroblastoma with watery diarrhea, hypokalemia, and achlorhydria syndrome." 05/01/1993 - "The authors examined the distribution of several peptides--VIP, peptide histidine methionine (PHM), neuropeptide Y (NPY), methionine-enkephalin (M-EK), somatostatin (SS), substance-P (Sub-P), corticotropin-releasing hormone, and tyrosine hydroxylase--with immunohistochemical studies and an in situ hybridization method in three ganglioneuroblastomas with WDHA syndrome. "
5.	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 02/01/2003 - "We measured two genes simultaneously, tyrosine hydroxylase (TH) as the target gene and glyceraldehyde-3-phosphate dehydrogenase as a reference gene, in blood and bone marrow samples at diagnosis and after follow-up from six patients with neuroblastoma, one patient with ganglioneuroma, and one patient with ganglioneuroblastoma. " 05/01/1993 - "The authors examined the distribution of several peptides--VIP, peptide histidine methionine (PHM), neuropeptide Y (NPY), methionine-enkephalin (M-EK), somatostatin (SS), substance-P (Sub-P), corticotropin-releasing hormone, and tyrosine hydroxylase--with immunohistochemical studies and an in situ hybridization method in three ganglioneuroblastomas with WDHA syndrome. "
6.	Substance PIBA 06/09/1995 - "Both substance-P and somatostatin receptors were present in astrocytomas and in ganglioneuroblastomas, whereas little or no receptor was found in pancreatic and non-small-cell lung carcinomas. " 05/01/1993 - "The authors examined the distribution of several peptides--VIP, peptide histidine methionine (PHM), neuropeptide Y (NPY), methionine-enkephalin (M-EK), somatostatin (SS), substance-P (Sub-P), corticotropin-releasing hormone, and tyrosine hydroxylase--with immunohistochemical studies and an in situ hybridization method in three ganglioneuroblastomas with WDHA syndrome. "
7.	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 06/01/2002 - "In the present study, expression of PrRP receptor was studied in the human brain, pituitaries, adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas, a ganglioneuroblastoma and neuroblastomas by reverse transcriptase polymerase chain reaction (RT-PCR) and Northern blot analysis. " 02/01/2003 - "The reverse transcriptase polymerase chain reaction (RT-PCR) showed expression of urotensin II and its receptor mRNAs in all the samples examined; seven pheochromocytomas, nine adrenocortical adenomas (four with primary aldosteronism, four with Cushing syndrome and one with non-functioning adenoma), four adrenocortical carcinomas, one ganglioneuroblastoma and five neuroblastomas, as well as four normal portions of adrenal glands (cortex and medulla). "
8.	PeptidesIBA 09/01/1982 - "This report presents an adrenal ganglioneuroblastoma containing several kinds of neuronal peptides. " 09/01/1982 - "Ganglioneuroblastoma containing several kinds of neuronal peptides with watery diarrhea syndrome." 05/01/1993 - "The authors examined the distribution of several peptides--VIP, peptide histidine methionine (PHM), neuropeptide Y (NPY), methionine-enkephalin (M-EK), somatostatin (SS), substance-P (Sub-P), corticotropin-releasing hormone, and tyrosine hydroxylase--with immunohistochemical studies and an in situ hybridization method in three ganglioneuroblastomas with WDHA syndrome. "
9.	Corticotropin-Releasing HormoneIBA 09/01/2003 - "Cushing's syndrome due to ectopic production of corticotropin-releasing hormone in an infant with ganglioneuroblastoma." 09/01/2003 - "To report the first recognized case of Cushing's syndrome due to a corticotropin-releasing hormone (CRH)-secreting ganglioneuroblastoma, which was found in an 18-month-old boy with hypertensive encephalopathy. " 05/01/1993 - "The authors examined the distribution of several peptides--VIP, peptide histidine methionine (PHM), neuropeptide Y (NPY), methionine-enkephalin (M-EK), somatostatin (SS), substance-P (Sub-P), corticotropin-releasing hormone, and tyrosine hydroxylase--with immunohistochemical studies and an in situ hybridization method in three ganglioneuroblastomas with WDHA syndrome. "
10.	Cyclin D1IBA 10/01/2015 - "In the present study, we performed a microarray analysis in order to evaluate the expression of cyclin D1 in neuroblastoma as compared to ganglioneuroma and ganglioneuroblastoma. " 10/01/2015 - "In addition, we observed that neuroblastoma is associated to significantly higher levels of cyclin D1 as compared to both ganglioneuroma and ganglioneuroblastoma. " 10/01/2015 - "It was previously shown that cyclin D1 (CCDN1) in pediatric neuroblastic tumors (neuroblastoma, ganglioneuroblastoma, and ganglioneuroma) recapitulates its expression during the development of peripheral sympathetic nervous system (PSNS). "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 09/01/1993 - "Spinal ganglioneuroblastoma--complete response to chemotherapy alone." 06/01/2012 - "He had relapsed despite chemotherapy, plasma exchange with immunoadsorption, and resection of ganglioneuroblastoma, detected 3 years after OMS onset. " 01/01/1988 - "Histological examinations, performed on these 13 NB patients before and after chemotherapy, showed (1) differentiation of the NB to ganglioneuroblastoma (GNB) with predominance of mature atypical ganglion cells, development of stromal components and a few immature malignant cells in 10 of 13 and (2) differentiation of the NB to a more mature form than was seen histologically before treatment in the remaining 3. Our results indicate that the morphological differentiation of immature NB in advanced stage to more mature GNB can be induced by conventional cytotoxic chemotherapy with or without so-called 'maturation-inducing' agents. " 01/01/1983 - "Personal experiences with biochemical assessments of the urinary catecholamine metabolite excretion in 460 patients with neuroblastoma and 55 patients with ganglioneuroblastoma, as well as prognostic factors and selected data characterizing the role of surgery, radio- and chemotherapy in the treatment of neuroblastoma are reviewed. " 01/01/1983 - "The role of surgery, radio- and chemotherapy in the treatment of neuroblastoma and ganglioneuroblastoma."
2.	Adrenalectomy 01/01/2015 - "He underwent laparoscopic right adrenalectomy, and pathological examination revealed composite pheochromocytoma-ganglioneuroblastoma. " 01/01/1999 - "The patient underwent a right adrenalectomy at 20 days of age, and the resected tumor was diagnosed as a poorly-differentiated ganglioneuroblastoma. "
3.	Transplants (Transplant) 08/01/1981 - "Malignant conversion occurred in 6 of 118 transplants (5%); the tumors were a fibrosarcoma (1), a ganglioneuroblastoma (1), leiomyosarcomas (2) and squamous cell carcinomas (2). "
4.	Sympathectomy (Sympathectomies) 03/01/1988 - "False positive bone scan secondary to sympathectomy following resection of a ganglioneuroblastoma or affect of unilateral sympathectomy of bone scan in the pediatric patient."
5.	Radiotherapy 06/01/2014 - "Ventricular ganglioneuroblastoma in an adult and successful treatment with radiotherapy."