Intraductal Papilloma

A small, often impalpable benign papilloma arising in a lactiferous duct and frequently causing bleeding from the nipple. (Stedman, 25th ed)
Also Known As:
Papilloma, Intraductal; Intraductal Papillomas; Papillomas, Intraductal
Networked: 70 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Related Diseases

1. Breast Neoplasms (Breast Cancer)
2. Fibroadenoma
3. Hyperplasia
4. Carcinoma (Carcinomatosis)
5. Neoplasms (Cancer)


1. Tang, Jie: 2 articles (03/2015 - 12/2013)
2. Rizzo, Monica: 2 articles (03/2012 - 04/2008)
3. Mosunjac, Marina: 2 articles (03/2012 - 04/2008)
4. Mesurolle, Benoît: 2 articles (09/2009 - 10/2006)
5. Rakha, Emad A: 1 article (01/2016)
6. Yang, Hsin-Sheng: 1 article (12/2015)
7. Wang, Qing: 1 article (12/2015)
8. Zhu, Jiang: 1 article (12/2015)
9. Zhao, Song: 1 article (12/2015)
10. Ma, Rong: 1 article (12/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Intraductal Papilloma:
1. Biological Markers (Surrogate Marker)IBA
2. MicroRNAs (MicroRNA)IBA
3. hydroxide ionIBA
4. Inosine Diphosphate (IDP)IBA
5. Pseudoangiomatous stromal hyperplasiaIBA
6. Phenobarbital (Luminal)FDA Link
06/01/1994 - "Since solitary intraductal papillomas were shown to be monoclonal in origin, it was suggested that this disease originates from a common precursor that could differentiate into both luminal epithelial and myoepithelial cells."
01/01/2011 - "Intraductal papillomas of the breast were classified into 4 MR types: oval nodule in 14 patients; irregular nodule in 6, solid and cystic mass in 8; and occult lesion in 4. Each of the MR types reflected its unique pathologic features: oval nodule composed of papillary fronds surrounded by narrow luminal space inside the duct; irregular nodule of papillary fronds entirely filling up the luminal space and adhering to the duct wall, with irregular margins surrounded by fibrosis or collagenization of fibroglandular stroma; solid and cystic mass of solid nodular protrusion of papillary fronds attached to the dilated cystic duct wall; and occult lesion of 1 to 2 mm in diameter with dilated ducts. "
03/23/1995 - "Since this tumor is composed of two types of cells, luminal epithelial cells and myoepithelial cells, it was suggested that the origin of solitary intraductal papilloma is a precursor cell which is capable of differentiating into both luminal and myoepithelial cells. "
06/01/1994 - "Immunohistochemical staining of smooth muscle alpha-actin, a marker protein of myoepithelial cells, revealed that solitary intraductal papilloma was composed of approximately equal mixtures of luminal epithelial and myoepithelial cells. "
12/01/1998 - "In the cases of colloid carcinoma that showed mucin-filled ducts, luminal mucin was observed in 40% of the normal ducts and acini, 40% to 75% of the ducts involved by hyperplasia, atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS), respectively, and in 50% of the co-incidental areas of cysts (mucoceles), adenosis, fibroadenoma, and intraductal papilloma (P < .01). "
7. DNA (Deoxyribonucleic Acid)IBA
8. tranilast (N 5')IBA
9. Myosin Heavy Chains (Myosin Heavy Chain)IBA
10. HormonesIBA

Therapies and Procedures

1. Segmental Mastectomy (Lumpectomy)
2. Mastectomy (Mammectomy)
3. Mammaplasty (Breast Reconstruction)
4. Modified Radical Mastectomy (Mastectomy, Modified)
5. Lasers (Laser)