Mucinous Cystadenoma

A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.

Also Known As:

Networked: 182 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Cystadenoma
3.	Serous Cystadenoma
4.	Mucinous Cystadenocarcinoma
5.	Carcinoma (Carcinomatosis)

Experts

1.	Park, Ji Young: 2 articles (11/2015 - 01/2013)
2.	Qiu, Wanglong: 2 articles (05/2008 - 06/2006)
3.	Su, Gloria H: 2 articles (05/2008 - 06/2006)
4.	Remotti, Helen E: 2 articles (05/2008 - 06/2006)
5.	Schönleben, Frank: 2 articles (05/2008 - 06/2006)
6.	Tsunoda, Hajime: 2 articles (10/2004 - 05/2002)
7.	Kim, Sung-Heun: 1 article (11/2015)
8.	de Lima, Mário Maciel: 1 article (11/2015)
9.	Lee, Jong-Min: 1 article (11/2015)
10.	Ki, Kyung-Do: 1 article (11/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mucinous Cystadenoma:

1.	Protons (Proton)IBA 01/01/2006 - "Proton MRS imaging may be helpful for the investigation of the underlying pathophysiology of ovarian mucinous cystadenomas."
2.	EnzymesIBA 04/01/1995 - "It has been suggested that activity of pancreatic enzymes and concentrations of tumoral markers in cyst fluid may help to distinguish pseudocyst, serous, and mucinous cystadenomas. "
3.	ParaffinIBA 01/01/1999 - "We analyzed 11 samples of pancreatic adenocarcinoma, three samples of pancreatic mucinous cystadenoma, and two samples without tumors in formalin-fixed paraffin embedded tissue sections. " 07/01/2005 - "Histologic sections of formalin-fixed, paraffin-embedded specimens from 11 patients with benign serous or mucinous cystadenomas, 14 patients with serous or mucinous borderline tumors, and 80 patients with epithelial-ovarian adenocarcinomas (29 serous, 17 endometrioid, 14 mucinous, and 20 clear cell adenocarcinomas) were stained for P-LAP and GLUT4 using each polyclonal antibody. " 01/01/1996 - "To establish a basis for the interpretation of DNA flow cytometric results of gynecologic neoplasms, paraffin blocks from 121 patients with a diagnosis of serous cystadenoma (n = 37), mucinous cystadenoma (n = 28), leiomyoma (n = 41), and fibrothecoma (n = 15), and normal tissue samples obtained from some of these patients, including ovary (n = 20), cervix (n = 20), and myometrium (n = 20) were analyzed for nuclear DNA content. " 04/01/2009 - "The study was performed on formalin-fixed, paraffin-embedded tissue samples from 75 epithelial ovarian tumors, 15 serous cystadenomas, 15 mucinous cystadenomas, 5 borderline serous cystadenomas, 5 borderline mucinous cystadenomas, 15 serous cystadenocarcinomas, 15 mucinous cystadenocarcinomas and 5 endometrioid carcinomas. " 01/01/1993 - "Nuclear DNA content in eight surgically resected mucin-producing pancreatic tumors (MPPT) consisting of two mucinous intraductal adenocarcinomas (MIDAC), two mucinous intraductal adenomas (MIDA), one mucinous cyst-adenocarcinoma (MCAC), and three mucinous cystadenomas (MCA) were measured by flow cytometry using paraffin-embedded tissue samples. "
4.	Carcinoembryonic AntigenIBA 01/01/2013 - "We report two patients presenting with mucinous cystadenoma of the appendix with elevation of serum carcinoembryonic antigen (CEA), which has rarely been reported. " 01/01/2013 - "Mucinous cystadenoma of the appendix presenting with an elevated carcinoembryonic antigen (CEA): Report of two cases and review of the literature." 11/01/2004 - "It is often difficult to discriminate GDC from pancreatic cystic tumour, in particular pancreatic mucinous cystadenoma, in which concentrations of carcinoembryonic antigen and CA 19-9 are classically raised. " 07/01/1997 - "Mucinous cystadenoma of the appendix with raised serum carcinoembryonic antigen concentration: clinical and pathological features." 04/01/1998 - "Combined measurement of CA 72-4 and carcinoembryonic antigen may be used to distinguish accurately mucinous cystadenomas and cystadenocarcinomas from serous cystadenomas and pseudocysts."
5.	Formaldehyde (Formol)FDA Link 01/01/1999 - "We analyzed 11 samples of pancreatic adenocarcinoma, three samples of pancreatic mucinous cystadenoma, and two samples without tumors in formalin-fixed paraffin embedded tissue sections. " 07/01/2005 - "Histologic sections of formalin-fixed, paraffin-embedded specimens from 11 patients with benign serous or mucinous cystadenomas, 14 patients with serous or mucinous borderline tumors, and 80 patients with epithelial-ovarian adenocarcinomas (29 serous, 17 endometrioid, 14 mucinous, and 20 clear cell adenocarcinomas) were stained for P-LAP and GLUT4 using each polyclonal antibody. " 04/01/2009 - "The study was performed on formalin-fixed, paraffin-embedded tissue samples from 75 epithelial ovarian tumors, 15 serous cystadenomas, 15 mucinous cystadenomas, 5 borderline serous cystadenomas, 5 borderline mucinous cystadenomas, 15 serous cystadenocarcinomas, 15 mucinous cystadenocarcinomas and 5 endometrioid carcinomas. "
6.	Proliferating Cell Nuclear Antigen (PCNA)IBA 11/01/1995 - "Mucinous cystadenoma of the lung appears to be a benign neoplasm because of its clinical course and immunohistochemical low expression of proliferation markers such as PCNA and MIB1." 11/01/1995 - "This study of two cases was performed to characterize mucinous cystadenoma clinically and immunohistochemically, using proliferation markers (proliferating cell nuclear antigen [PCNA], MIB1) and carcinoembryonic antigen expression. "
7.	LDL Receptors (LDL Receptor)IBA 07/01/2000 - "Immunohistochemical studies of these mucinous cystadenomas showed that LDL receptors were distributed in the benign cystadenoma cells and in the stromal cells of borderline tumors, but not in the cystadenoma cells of borderline tumors. "
8.	stage-specific embryonic antigen-4IBA 08/01/2010 - "In this study, we investigated the expression of SSEA-4 in 479 cases of various degrees of ovarian epithelial lesions by immunohistochemistry, consisting of 45 normal ovarian epithelia, 110 benign serous ovarian cystadenomas, 68 borderline serous ovarian cystadenomas, 104 invasive serous ovarian carcinomas, 64 benign serous mucinous cystadenomas, 48 borderline mucinous ovarian cystadenomas, and 40 invasive mucinous carcinomas. "
9.	fascinIBA 01/01/2006 - "In the study, 94 malign epithelial ovarian neoplasms, 13 borderline epithelial ovarian neoplasms, 25 serous and mucinous cystadenomas and four normal ovarian tissues were examined by means of immunohistochemistry, using monoclonal antihuman fascin antibody, clone IM20. "
10.	MucinsIBA 01/01/2011 - "Histology confirmed the presence of a mucinous cystadenoma with the presence of acellular mucin on the serosal surface of the appendix. " 07/01/2005 - "Neoplastic cells containing epithelial acidic mucin are usually found in mucinous cystadenomas. " 02/01/2000 - "Mucinous cystadenomas contain a single layer of mucin-producing, columnar epithelium lacking significant atypia. " 06/01/1995 - "Mucin histochemistry of ovarian mucinous cystadenomas expressing gastrointestinal characteristics." 02/01/1992 - "Histochemical demonstration of gastrointestinal mucins in ovarian mucinous cystadenoma."

Therapies and Procedures

1.	Pancreatectomy 06/01/2012 - "We report the case of a 72-year-old female patient with a mucinous cystadenoma, who was found to have a concomitant AP during laparoscopic distal pancreatectomy. " 01/01/2004 - "In January 2002, the patient underwent a spleen-preserving distal pancreatectomy, and histopathological and immunohistochemical examinations led to the diagnosis of pancreatic mucinous cystadenoma with ovarian-like stroma. " 11/01/1998 - "After distal pancreatectomy the diagnosis of mucinous cystadenoma was confirmed; in one case a large pseudocyst was associated with this diagnosis. " 01/01/1988 - "Surgical resection is the method to be chosen, either enucleation (1 case) or pancreatectomy (3 cases), being more important in mucinous cystadenoma because they may become malignant. " 01/01/2014 - "A rare case of mixed mucinous cystadenoma with serous cystadenoma of the pancreas treated by laparoscopic central pancreatectomy."
2.	Laparotomy 02/01/2012 - "The diagnosis of mucinous cystadenomas of the mesocolon is challenging due to the absence of specific clinical, biological and radiological features, and is often made during or after laparotomy. " 01/01/2012 - "A preoperative diagnosis of mucinous cystadenoma of the pancreas was suggested and the patient underwent laparotomy. " 08/30/2008 - "A mucinous cystadenoma of the ovary weighing more than 20 kg was removed with laparotomy. " 01/01/1996 - "Ovarian biopsies had only shown surface mucinous deposits at the time of the first laparotomy but two years later ovarian mucinous cystadenomas of borderline malignancy appeared. " 06/01/1988 - "At laparotomy, a large mucinous cystadenoma was found attached to the root of the ileal mesentery; the ovaries were normal. "
3.	Appendectomy 02/01/2015 - "Appendectomy was carried out and final histopathology revealed mucinous cystadenoma with no evidence of malignancy. " 01/01/2015 - "Open appendectomy was done in two cases of mucinous cystadenoma with no further surgery performed, despite the positive margin in one. " 11/01/2014 - "Mucinous cystadenoma is rare, but it is the commonest of benign appendiceal tumours accounting for 0.6% of appendectomy specimens. " 10/01/2008 - "Appendectomy is the standard of care for mucinous cystadenoma. " 10/01/2008 - "The incidence of appendiceal mucinous cystadenoma was 0.95% of all appendectomy specimens reviewed. "
4.	Cystectomy 05/01/2015 - "We conducted a retrospective analysis of all cases of patients who underwent removal of benign mucinous cystadenomas by either cystectomy or adnexectomy in our institution between December 2006 and June 2013. " 04/01/2008 - "We report a 25-year-old nulliparous lady with a huge benign mucinous cystadenoma managed by laparoscopic cystectomy, followed by an early recurrence within 2 months. " 12/01/2006 - "Follow-up of these patients is very important and transvaginal ultrasound seems to be currently the most effective diagnostic tool for the follow-up of young patients treated with cystectomy for benign mucinous cystadenomas." 02/01/2004 - "Laparoscopic cystectomy of an ovarian mucinous cystadenoma in a 12-year-old girl: a possible role of operative laparoscopy for a huge benign adnexal mass." 01/01/2012 - "Histopathological evaluation after cystectomy showed a mature teratoma and a mucinous cystadenoma."
5.	Transplants (Transplant) 02/01/1989 - "Mucinous cystadenoma simulating renal transplant lymphocele." 07/01/1983 - "It is demonstrated that the development of a generalized pseudomyxoma depends upon the rupture of mucocele or of mucinous cystadenoma or cystadenocarcinoma of the ovary with graft of the muciparous cells floating in the "jelly" on the peritoneum of neighbouring organs. "