Small Cell Carcinoma

An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)

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Networked: 3008 relevant articles (158 outcomes, 304 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Lung Neoplasms (Lung Cancer)
3.	Carcinoma (Carcinomatosis)
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma)
5.	Adenocarcinoma

Experts

1.	Cheng, Liang: 10 articles (10/2020 - 03/2005)
2.	Pelosi, Giuseppe: 10 articles (01/2020 - 11/2003)
3.	Lopez-Beltran, Antonio: 8 articles (12/2018 - 03/2005)
4.	Terada, Tadashi: 8 articles (01/2015 - 04/2009)
5.	Epstein, Jonathan I: 6 articles (05/2023 - 01/2008)
6.	Trent, Jeffrey M: 6 articles (01/2020 - 02/2016)
7.	MacLennan, Gregory T: 6 articles (12/2018 - 03/2005)
8.	Foulkes, William D: 5 articles (10/2023 - 04/2015)
9.	Witkowski, Leora: 5 articles (10/2023 - 04/2015)
10.	Li, Jing: 5 articles (04/2023 - 02/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Small Cell Carcinoma:

1.	Cisplatin (Platino)FDA LinkGeneric 09/01/1981 - "The antitumor efficacy of high-dose cisplatin in heavily pretreated patients with small cell carcinoma of the lung appears to be marginal." 04/01/1983 - "Evaluation of single-agent cisplatin in the management of non-small cell carcinoma of the lung: a Southwest Oncology Group Study." 09/01/1981 - "Phase II trial of cisplatin in small cell carcinoma of the lung." 06/01/2019 - "A 54-year-old male patient with a diagnosis of metastatic small cell carcinoma was under cisplatin-based regimen. " 10/19/2017 - "Due to the rarity of this entity, prognosis has still not been well established, and treatment has not been standardized, cisplatin-based treatment has been used in this case similar to small cell carcinoma of the lung."
2.	Etoposide (VP 16)FDA LinkGeneric 05/01/1986 - "To evaluate postulated dose-response relationships of etoposide (VP-16) for patients with recurrent small cell carcinoma of the lung, a prospectively randomized study was undertaken. " 11/01/1984 - "Phase II trial of etoposide in previously treated small cell carcinoma of the lung." 08/31/1986 - "From March 1981 to January 1984, 116 patients with advanced non-small-cell carcinoma of the lung (NSCCL) were randomly assigned to 3 combinations as follows: CDDP + DVA, CDDP + VP16 and DXR + CTX. " 02/01/1985 - "Probable cure of small cell carcinoma of the lung by etoposide." 06/01/1984 - "It is concluded that Etoposide is an effective agent in treating small cell carcinoma of the lung, but of limited values when used as a single agent. "
3.	Methotrexate (Mexate)FDA LinkGeneric 05/01/1982 - "Lack of efficacy of high-dose methotrexate by 30-hour infusion in patients with progressive small cell carcinoma of the lung." 02/01/1975 - "Alkylants and Methotrexate are especially effective in the oat cell carcinomas. " 10/01/1980 - "Phase II study of high-dose methotrexate in the treatment of patients with non-small cell carcinoma of the lung: an Eastern Cooperative Oncology Group study." 01/27/1983 - "Unstable methotrexate resistance in human small-cell carcinoma associated with double minute chromosomes." 01/01/1979 - "Little information exists regarding the use of high dose methotrexate in small cell carcinoma of the lung. "
4.	Carboplatin (JM8)FDA LinkGeneric 05/01/1999 - "A remaining patient, alive 6 months after total resection of the thymic small cell carcinoma following irradiation, received preoperatively three cycles of the intra-arterial administration using CBDCA via bilateral internal mammary arteries. " 01/01/2002 - "Effectiveness of preoperative chemotherapy using carboplatin (CBDCA) and surgery against an esophageal small cell carcinoma." 10/01/2004 - "A randomised phase III study of palliative radiation with concomitant carboplatin for brain metastases from non-small cell carcinoma of the lung." 07/15/1993 - "Carboplatin has shown activity in oat cell carcinoma of the lung, another tumor of neuroectodermal origin. " 12/01/2016 - "[Etoposide and Carboplatin Effective for Treatment of Small Cell Carcinoma of Prostate : A Report of Two Cases]."
5.	Irinotecan (Camptosar)FDA LinkGeneric 05/01/1991 - "The results showed that CPT-11 was highly effective against non-small cell and small cell carcinomas of the lung." 11/01/2014 - "According to the regimen used for lung small cell carcinoma, we administered CDDP/CPT-11. " 05/15/2011 - "Use of irinotecan for treatment of small cell carcinoma of the prostate." 06/01/2008 - "A total of 12 esophageal small-cell carcinoma patients were treated with CPT-11 (70 mg/m(2)) on Days 1 and 15 and CPT-11 plus CDDP (80 mg/m(2)) on Day 1 with each cycle repeated every 4 weeks at our institution. " 11/01/2006 - "Recently, the combined treatment of CPT-11 and CDDP was reported to demonstrate a better influence on a patient's survival for small cell carcinoma of the lung. "
6.	Vinblastine (Vinblastine Sulfate)FDA Link 03/01/1983 - "Phase II study of vinblastine in small cell carcinoma of the lung." 09/01/1983 - "Lack of efficacy of vinblastine and cisplatin in patients with progressive small cell carcinoma of the lung." 03/01/1986 - "Forty-four patients with non-small cell carcinoma of the lung were treated every 3 weeks with vinblastine (4 mg/m2/day iv X 2) and cisplatin (20 mg/m2/day iv X 3). " 03/01/1983 - "It is concluded that vinblastine appears to be inferior to other vinca alkaloids in the treatment of small cell carcinoma of the lung." 03/01/1986 - "Cisplatin and vinblastine chemotherapy for metastatic non-small cell carcinoma followed by irradiation in patients with regional disease."
7.	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 09/01/1981 - "The serial measurement of plasma calcitonin is useful in the management of the patient with small cell carcinoma of the lung." 03/01/1983 - "A study was made of immunoreactive calcitonin (iCT) secretion by continuous cultures of small cell carcinoma of the lung (SCCL). " 03/01/1983 - "Calcitonin secretion by continuous cultures of small cell carcinoma of the lung: incidence and immunoheterogeneity studies." 11/01/1996 - "Serum calcitonin in small cell carcinoma of the prostate." 01/01/1990 - "Calcitonin free oat-cell carcinoma of the thyroid gland."
8.	Doxorubicin (Adriamycin)FDA LinkGeneric 07/01/1978 - "An acceptable rate of complications in combined doxorubicin-irradiation for small cell carcinoma of the lung: A Southwest Oncology Group Study." 01/01/1984 - "A 56-year-old male, following pneumonectomy for oat cell carcinoma, was receiving Adriamycin intravenously. " 12/01/1982 - "Muscular pseudotumor of the breast following doxorubicin and radiation therapy for oat cell carcinoma of the lung." 01/01/1981 - "A patient is described who developed chest pain during adriamycin administration given for the first time for small cell carcinoma of the lung. " 02/01/2004 - "Selenium treatment of the doxorubicin-resistant cell line, U-1285dox, derived from human small cell carcinoma of the lung, resulted in massive apoptosis. "
9.	Lomustine (CCNU)FDA Link 02/01/1979 - "CCNU nephrotoxicity following sustained remission in oat cell carcinoma." 01/01/1980 - "A second trial compared NMU with CCNU in the treatment of small cell carcinoma in a regimen of combined chemo-radiotherapy. " 01/01/1981 - "In 38 evaluable patients with small cell carcinomas, 24-hour infusions of MTX at 200 mg/m2 in combination with cyclophosphamide and CCNU produced a 43% complete remission (CR) rate for a median survival of 62 weeks. " 04/01/1982 - "55 selected patients with inoperable small cell carcinoma of the lung have been induced in a randomized prospective trial in order to compare the efficacy of ifosfamide monotherapy with the combination of ifosfamid + CCNU. " 04/15/1982 - "A comparison of CTX + CCNU and CTX + CCNU + procarbazine as initial systemic treatment was made in 440 evaluable patients with small-cell carcinoma of the lung. "
10.	GemcitabineFDA Link 09/01/2004 - "We have found that single-agent gemcitabine represent a sufficiently safe therapeutic option in unfit patients with inoperable non-small cell carcinoma (NSCLC)." 10/01/2001 - "We describe a 69-year-old man with a non-small cell carcinoma of the lung, stage III B, who developed bilateral multiple erythematous lesions in the abdominal-inguinal area following treatment with gemcitabine. " 01/01/2001 - "A new cell line (SKS) established from ascites of a patient with neuroendocrine small cell carcinoma of the uterine cervix had a good tumorigenicity and caused marked peritoneal dissemination, and was also highly sensitive to gemcitabine in an in vitro chemosensitivity test. " 01/01/2001 - "A 55 year old female receiving gemcitabine for stage IV non-small cell carcinoma of the lung developed the clinical-radiologic syndrome of posterior reversible encephalopathy syndrome (PRES). " 01/01/2001 - "SKS was highly sensitive to gemcitabine, and the 50% growth inhibitory concentration was 30 nM. SKS cells are useful as a model of neuroendocrine small cell carcinoma of the cervix, and chemotherapy using gemcitabine may possibly be effective in this malignancy."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 08/01/1988 - "Small cell carcinoma of the urinary bladder: a case of remarkable remission with combined chemotherapy." 07/01/1991 - "Importance of fiberoptic bronchoscopy before and during chemotherapy for small cell carcinoma of the lung in the evaluation of complete remission." 07/01/2002 - "To study the clinicopathologic characteristics, prognostic factors, response to chemotherapy, chemotherapy-caused disease-free interval and overall survival of small cell carcinoma of uterine cervix (SCCUC). " 04/01/1990 - "During this period fibreoptic bronchoscopy became more widely available in the region, and multiple drug chemotherapy became first line treatment for small cell carcinoma. " 11/01/2014 - "We conclude that the combination of chemotherapy used was effective for treating the patient's small cell carcinoma of the stomach, which is considered to have a poor prognosis."
2.	Radiotherapy 01/01/2013 - "The patient remains alive without any disease 1 year and 8 months after the treatment, suggesting the efficacy of radiotherapy in small cell carcinoma of the vagina. " 05/01/1981 - "The place of preoperative radiotherapy in the treatment of oat-cell carcinoma is considered and it is concluded that improved results are obtained by this combined treatment. " 01/01/2023 - "The findings of this study suggest that radiotherapy improves survival benefits for patients with small cell carcinoma of the bladder who undergo bladder-sparing surgery. " 07/01/2019 - "A questionnaire-based survey of patients with pathologically proven small cell carcinoma of the bladder treated with definitive radiation therapy between 1990 and 2010 was conducted by the Japanese Radiation Oncology Study Group. " 07/01/2019 - "This study aimed to retrospectively analyse the clinical outcomes associated with definitive radiotherapy for small cell carcinoma of the bladder. "
3.	Therapeutics 01/01/1978 - "Intensive combination chemo-irradiation therapy is safe and highly effective in patients with limited oat-cell carcinoma of the lung, and leads to prolonged disease-free survival." 03/01/1978 - "This study demonstrates that high-dose CY is a safe and effective induction therapy for small cell carcinoma of the lung although the low CR rate obtained is disappointing." 12/28/2012 - "We believe this to be the first case of small cell carcinoma with involvement of the salivary glands reported in the literature with a good outcome after surgery alone without any adjunctive therapy." 05/01/1987 - "Our findings suggest that CT of the abdomen is beneficial in the initial staging of patients with small-cell carcinoma of the lung and provides prognostic information concerning response to therapy and length of survival." 07/01/2004 - "Therefore, surgical resection may be recommended as the second therapy that occasionally produces long-term remission and possibly long-term survival for patients with small cell carcinoma of the esophagus."
4.	Combination Drug Therapy (Combination Chemotherapy) 01/01/1986 - "The treatment of patients with small cell carcinoma of the lung (SCCL) with combination chemotherapy and radiation has dramatically improved survival in the past decade. " 01/01/1989 - "This ongoing trial shows that a weekly combination chemotherapy regimen is effective in producing high response rates in small cell carcinoma." 10/01/1986 - "This study demonstrates that the prognosis for the majority of patients with small cell carcinoma of the bronchus has improved significantly with the introduction of combination chemotherapy." 11/21/1980 - "In small cell carcinoma combination chemotherapy may result not only in palliation, but in an improved survival in a high percentage of patients. " 12/01/1979 - "Although combination chemotherapy and radiation will prlong the disease-free interval in patients with small cell carcinoma of the lung, more than 90% will develop evidence of progressive disease within two years."
5.	Immunotherapy 06/06/2023 - " is the first documented case to show serial and sustained improvement of BDUMP following immunotherapy in the setting of primary non-small cell carcinoma of the lung. " 12/22/2017 - "Affected patients may survive small-cell carcinoma or have immunotherapy-responsive neurological symptoms. " 01/01/1985 - "[Significance of immunotherapy as an adjunct to surgical treatment in non-small cell carcinoma of the lung]." 10/19/2023 - "We present a study to assess the efficacy of chemotherapy alone or combined with immunotherapy for locally advanced or metastatic genitourinary small cell carcinoma (GSCC). " 06/01/2024 - "Immunotherapy combined with targeted therapy in advanced small cell carcinoma of the ovary of hypercalcemic type: A case of overall survival lasting for over 5 years."