Small Cell Carcinoma

An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)

Also Known As:

Networked: 2317 relevant articles (114 outcomes, 249 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Squamous Cell Carcinoma (Epidermoid Carcinoma)
3.	Lung Neoplasms (Lung Cancer)
4.	Neoplasm Metastasis (Metastasis)
5.	Carcinoma (Carcinomatosis)

Experts

1.	Terada, Tadashi: 7 articles (01/2015 - 04/2009)
2.	Pelosi, Giuseppe: 7 articles (04/2011 - 11/2003)
3.	Cheng, Liang: 6 articles (09/2015 - 11/2004)
4.	Lopez-Beltran, Antonio: 5 articles (09/2015 - 07/2005)
5.	Sato, Yuichi: 5 articles (01/2015 - 02/2004)
6.	Jiang, Shi-Xu: 5 articles (01/2015 - 02/2004)
7.	Viale, Giuseppe: 5 articles (04/2011 - 11/2003)
8.	Epstein, Jonathan I: 4 articles (12/2015 - 01/2008)
9.	Vessella, Robert L: 4 articles (12/2015 - 04/2003)
10.	MacLennan, Gregory T: 4 articles (09/2015 - 07/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Small Cell Carcinoma:

1.	Cisplatin (Platino)FDA LinkGeneric 09/01/1981 - "The antitumor efficacy of high-dose cisplatin in heavily pretreated patients with small cell carcinoma of the lung appears to be marginal." 04/01/1983 - "Evaluation of single-agent cisplatin in the management of non-small cell carcinoma of the lung: a Southwest Oncology Group Study." 09/01/1981 - "Phase II trial of cisplatin in small cell carcinoma of the lung." 03/01/1991 - "Does the substitution of cisplatin in a standard four drug regimen improve survival in small cell carcinoma of the lung? " 07/01/1985 - "[The evaluation of single administration of cisplatin in non-small cell carcinoma of the lung]."
2.	Etoposide (VP 16)FDA LinkGeneric 05/01/1986 - "To evaluate postulated dose-response relationships of etoposide (VP-16) for patients with recurrent small cell carcinoma of the lung, a prospectively randomized study was undertaken. " 11/01/1984 - "Phase II trial of etoposide in previously treated small cell carcinoma of the lung." 01/01/2008 - "We discuss a 47-year-old woman with a newly diagnosed non-small cell carcinoma of the lung on etoposide who was admitted with encephalopathy. " 04/01/1991 - "[A case of small cell carcinoma of the lung responding well to oral etoposide therapy]." 01/01/1987 - "Etoposide combination therapy for small cell carcinoma of the lung."
3.	Methotrexate (Mexate)FDA LinkGeneric 05/01/1982 - "Lack of efficacy of high-dose methotrexate by 30-hour infusion in patients with progressive small cell carcinoma of the lung." 10/01/1980 - "Phase II study of high-dose methotrexate in the treatment of patients with non-small cell carcinoma of the lung: an Eastern Cooperative Oncology Group study." 01/27/1983 - "Unstable methotrexate resistance in human small-cell carcinoma associated with double minute chromosomes." 01/01/1979 - "Little information exists regarding the use of high dose methotrexate in small cell carcinoma of the lung. " 01/01/1984 - "Combination chemotherapy using high or low dose methotrexate for small cell carcinoma of the lung--a randomised trial."
4.	irinotecan (Camptosar)FDA LinkGeneric 05/01/1991 - "The results showed that CPT-11 was highly effective against non-small cell and small cell carcinomas of the lung." 11/01/2014 - "According to the regimen used for lung small cell carcinoma, we administered CDDP/CPT-11. " 05/15/2011 - "Use of irinotecan for treatment of small cell carcinoma of the prostate." 06/01/2008 - "A total of 12 esophageal small-cell carcinoma patients were treated with CPT-11 (70 mg/m(2)) on Days 1 and 15 and CPT-11 plus CDDP (80 mg/m(2)) on Day 1 with each cycle repeated every 4 weeks at our institution. " 11/01/2006 - "Recently, the combined treatment of CPT-11 and CDDP was reported to demonstrate a better influence on a patient's survival for small cell carcinoma of the lung. "
5.	Carboplatin (JM8)FDA LinkGeneric 05/01/1999 - "A remaining patient, alive 6 months after total resection of the thymic small cell carcinoma following irradiation, received preoperatively three cycles of the intra-arterial administration using CBDCA via bilateral internal mammary arteries. " 01/01/2002 - "Effectiveness of preoperative chemotherapy using carboplatin (CBDCA) and surgery against an esophageal small cell carcinoma." 10/01/2004 - "A randomised phase III study of palliative radiation with concomitant carboplatin for brain metastases from non-small cell carcinoma of the lung." 07/15/1993 - "Carboplatin has shown activity in oat cell carcinoma of the lung, another tumor of neuroectodermal origin. " 01/01/2014 - "[Carboplatin plus irinotecan induced partial response in a patient with small cell carcinoma of the prostate; a case report]."
6.	Vinblastine (Vinblastine Sulfate)FDA Link 03/01/1983 - "Phase II study of vinblastine in small cell carcinoma of the lung." 09/01/1983 - "Lack of efficacy of vinblastine and cisplatin in patients with progressive small cell carcinoma of the lung." 03/01/1986 - "Forty-four patients with non-small cell carcinoma of the lung were treated every 3 weeks with vinblastine (4 mg/m2/day iv X 2) and cisplatin (20 mg/m2/day iv X 3). " 03/01/1983 - "It is concluded that vinblastine appears to be inferior to other vinca alkaloids in the treatment of small cell carcinoma of the lung." 03/01/1986 - "Cisplatin and vinblastine chemotherapy for metastatic non-small cell carcinoma followed by irradiation in patients with regional disease."
7.	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 09/01/1981 - "The serial measurement of plasma calcitonin is useful in the management of the patient with small cell carcinoma of the lung." 03/01/1983 - "A study was made of immunoreactive calcitonin (iCT) secretion by continuous cultures of small cell carcinoma of the lung (SCCL). " 03/01/1983 - "Calcitonin secretion by continuous cultures of small cell carcinoma of the lung: incidence and immunoheterogeneity studies." 11/01/1996 - "Serum calcitonin in small cell carcinoma of the prostate." 01/01/1990 - "Calcitonin free oat-cell carcinoma of the thyroid gland."
8.	Doxorubicin (Adriamycin)FDA LinkGeneric 07/01/1978 - "An acceptable rate of complications in combined doxorubicin-irradiation for small cell carcinoma of the lung: A Southwest Oncology Group Study." 12/01/1982 - "Muscular pseudotumor of the breast following doxorubicin and radiation therapy for oat cell carcinoma of the lung." 01/01/1984 - "A 56-year-old male, following pneumonectomy for oat cell carcinoma, was receiving Adriamycin intravenously. " 01/01/1981 - "A patient is described who developed chest pain during adriamycin administration given for the first time for small cell carcinoma of the lung. " 02/01/2004 - "Selenium treatment of the doxorubicin-resistant cell line, U-1285dox, derived from human small cell carcinoma of the lung, resulted in massive apoptosis. "
9.	Lomustine (CCNU)FDA Link 02/01/1979 - "CCNU nephrotoxicity following sustained remission in oat cell carcinoma." 01/01/1980 - "A second trial compared NMU with CCNU in the treatment of small cell carcinoma in a regimen of combined chemo-radiotherapy. " 01/01/1981 - "In 38 evaluable patients with small cell carcinomas, 24-hour infusions of MTX at 200 mg/m2 in combination with cyclophosphamide and CCNU produced a 43% complete remission (CR) rate for a median survival of 62 weeks. " 04/01/1982 - "55 selected patients with inoperable small cell carcinoma of the lung have been induced in a randomized prospective trial in order to compare the efficacy of ifosfamide monotherapy with the combination of ifosfamid + CCNU. " 04/15/1982 - "A comparison of CTX + CCNU and CTX + CCNU + procarbazine as initial systemic treatment was made in 440 evaluable patients with small-cell carcinoma of the lung. "
10.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 07/01/1985 - "High-dose cyclophosphamide in small-cell carcinoma of the lung." 02/01/1983 - "As the tumours were human in origin it raises the question whether high dose cyclophosphamide therapy and priming have a role to play in the treatment of patients with oat cell carcinoma." 01/01/1983 - "Serum cyclophosphamide activity in patients treated for small cell carcinoma of the lung." 03/01/1973 - "A clinical trial of cyclophosphamide (NSC-26271) and radiation therapy for oat cell carcinoma of the lung." 01/01/1989 - "A total of 31 patients with previously untreated small-cell carcinoma of the lung were treated with very-high-dose cyclophosphamide, using autologous bone marrow transplantation (ABMT) to assist haematological recovery. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 08/01/1988 - "Small cell carcinoma of the urinary bladder: a case of remarkable remission with combined chemotherapy." 04/15/1993 - "Bladder preservation and durable complete remission of small cell carcinoma of the bladder with systemic chemotherapy and adjuvant radiation therapy." 07/01/1991 - "Importance of fiberoptic bronchoscopy before and during chemotherapy for small cell carcinoma of the lung in the evaluation of complete remission." 07/01/2002 - "To study the clinicopathologic characteristics, prognostic factors, response to chemotherapy, chemotherapy-caused disease-free interval and overall survival of small cell carcinoma of uterine cervix (SCCUC). " 04/01/1990 - "During this period fibreoptic bronchoscopy became more widely available in the region, and multiple drug chemotherapy became first line treatment for small cell carcinoma. "
2.	Radiotherapy 01/01/2013 - "The patient remains alive without any disease 1 year and 8 months after the treatment, suggesting the efficacy of radiotherapy in small cell carcinoma of the vagina. " 05/01/1981 - "The place of preoperative radiotherapy in the treatment of oat-cell carcinoma is considered and it is concluded that improved results are obtained by this combined treatment. " 07/01/2010 - "Phase I dose escalation trial of hypofractionated limited-field external beam thoracic radiotherapy for limited-stage small cell carcinoma of the lung." 06/01/1986 - "From July 1979 through March 1984 the Radiation Therapy Oncology Group conducted a randomized study comparing fast neutron radiotherapy versus mixed beam (neutron/photon) radiotherapy versus conventional radiotherapy for patients with non-small cell carcinoma of the lung. " 05/01/1969 - "Comparative trial of surgery and radiotherapy for oat-cell carcinoma of the bronchus: five-year results."
3.	Combination Drug Therapy (Combination Chemotherapy) 01/01/1986 - "The treatment of patients with small cell carcinoma of the lung (SCCL) with combination chemotherapy and radiation has dramatically improved survival in the past decade. " 05/01/1999 - "After complete or partial remission is achieved by the combination chemotherapy, surgical resection may be recommended as the second therapy that occasionally produces long-term remission and possibly long-term survival for patients with small cell carcinoma of the esophagus, such as the present case." 01/01/1989 - "This ongoing trial shows that a weekly combination chemotherapy regimen is effective in producing high response rates in small cell carcinoma." 10/01/1986 - "This study demonstrates that the prognosis for the majority of patients with small cell carcinoma of the bronchus has improved significantly with the introduction of combination chemotherapy." 11/21/1980 - "In small cell carcinoma combination chemotherapy may result not only in palliation, but in an improved survival in a high percentage of patients. "
4.	Adjuvant Chemotherapy 10/01/2010 - "We conclude that adjuvant chemotherapy was effective for small cell carcinoma of the stomach, which was to be considered to have a poor prognosis." 01/01/2015 - "The patient was treated with the same adjuvant chemotherapy as that used for small cell carcinoma of the lung. " 12/01/2014 - "We report the fourteenth case of a 52-year-old woman with neuroendocrine small cell carcinoma of the vulva, treated by surgery and combined chemoradiotherapy 46 Gy and cisplatinum-étoposide and adjuvant chemotherapy. " 10/01/2011 - "Because of its low incidence (2%-3% of non-small cell carcinomas) and the difficulties in diagnosis, data regarding treatment outcomes are based on series in which the diagnosis is frequently made retrospectively in reclassification, the numbers of patients are small, and the determinants of therapy choice (e.g., treatment with or without adjuvant chemotherapy postresection) cannot be known. " 03/01/2010 - "Small cell carcinoma of the gall bladder: role of adjuvant chemotherapy."
5.	Immunotherapy 01/01/1985 - "[Significance of immunotherapy as an adjunct to surgical treatment in non-small cell carcinoma of the lung]." 09/01/1978 - "Since small cell carcinoma is a treatable disease, with surgery being beneficial in a few cases and with chemotherapy, radiotherapy, and immunotherapy contributing to prolonged survival in patients with inoperable disease, it is essential that the clinical and pathologic features of small cell carcinoma be quickly recognized in a newly presenting patient so that appropriate therapy may be offered." 06/01/1982 - "Combination chemotherapy, radiotherapy, and BCG immunotherapy in limited small-cell carcinoma of the lung: a Southwest Oncology Group Study." 06/01/1982 - "It appears that BCG immunotherapy has no beneficial effect on response rate, duration of response, or survival in programs using chemotherapy and radiotherapy for control of limited small-cell carcinoma of the lung except in this small group of long-term survivors." 06/01/1982 - "From November 1976 to March 1979 the Southwest Oncology Group treated 298 patients with limited (disease confined to the chest and encompassed by one radiotherapy port) small-cell carcinoma of the lung with combination chemotherapy and radiotherapy with or without BCG immunotherapy. "