Giant Cell Carcinoma

An epithelial neoplasm characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (From Stedman, 25th ed & Segen, Dictionary of Modern Medicine, 1992)

Also Known As:

Networked: 78 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma)
2.	Neoplasms (Cancer)
3.	Adenocarcinoma
4.	Neoplasm Metastasis (Metastasis)
5.	Sarcoma (Soft Tissue Sarcoma)

Experts

1.	Zheng, J: 3 articles (01/2001 - 10/2000)
2.	Zhang, Zhi-Qian: 2 articles (10/2011 - 04/2004)
3.	Wang, Enhua: 2 articles (06/2008 - 04/2008)
4.	Wu, B: 2 articles (01/2001 - 10/2000)
5.	Wang, J: 2 articles (01/2001 - 10/2000)
6.	You, J: 2 articles (01/2001 - 10/2000)
7.	Fang, W: 2 articles (01/2001 - 10/2000)
8.	Cui, X: 2 articles (01/2001 - 10/2000)
9.	Wu, X: 2 articles (12/2000 - 10/2000)
10.	Fu, J: 2 articles (12/2000 - 10/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Giant Cell Carcinoma:

1.	Connexin 43 (Connexin43)IBA 04/01/2004 - "Transfection of Cx43 into giant cell carcinoma PG cells increased homologous communication and eliminated the rectifying behavior of heterologous communication. " 10/01/2011 - "We have previously shown that transfection of connexin43 (Cx43) cDNA retarded the growth of a highly metastatic human pulmonary giant cell carcinoma cell line, PG, both in vitro and in vivo. " 06/01/2006 - "In addition, connexin 43 expression vector was transfected into the lung giant cell carcinoma cell line LH(7) followed by analyses of connexin 43 and E-cadherin expressions, the growth rates and cell cycle profiles of the transfected cells. "
2.	alpha-Fetoproteins (AFP)IBA 04/01/1999 - "Positive reactivity with CEA and alcian blue PAS and absence of AFP helped in differentiating one giant cell carcinoma from hepatocellular carcinoma. "
3.	Alcian BlueIBA 04/01/1999 - "Positive reactivity with CEA and alcian blue PAS and absence of AFP helped in differentiating one giant cell carcinoma from hepatocellular carcinoma. "
4.	Complementary DNA (cDNA)IBA 09/01/2003 - "This study was designed to explore the effect of transfection of the full-length cDNA of antisense hTERT on the malignant phenotype of human pulmonary giant cell carcinoma cell line (PLA-801D) and its potential role in the gene therapy for cancers. " 12/01/2000 - "[Regulatory effect of antisense VEGF121 cDNA transfection on angiogenesis and metastasis of human lung giant cell carcinoma]." 10/01/2000 - "[Inhibition of growth and metastasis of human giant cell carcinoma of the lung by transfection of antisense VEGF121 cDNA]." 10/01/2011 - "We have previously shown that transfection of connexin43 (Cx43) cDNA retarded the growth of a highly metastatic human pulmonary giant cell carcinoma cell line, PG, both in vitro and in vivo. " 07/01/1994 - "A recombinant plasmid, which contains a full length cDNA of human tissue inhibitor of metalloproteinases-1 (TIMP-1), was constructed by using gene recombinant technique, and introduced into a highly metastatic human giant cell carcinoma (PG) by lipofectin technique. "
5.	Etoposide (VP 16)FDA LinkGeneric 06/01/1992 - "Each patient was given etoposide at 500 mg/m2/day on day 1 to 3 continuously (total dose 1,500 mg/m2) and cisplatin at 80 mg/m2 on day 1. Fifteen patients (7 adenocarcinoma, 5 small cell lung cancer, 2 squamous cell lung cancer and 1 sarcoma, which latter was difficult to distinguish from giant cell carcinoma) were entered in this study. "
6.	Cisplatin (Platino)FDA LinkGeneric 06/01/1992 - "Each patient was given etoposide at 500 mg/m2/day on day 1 to 3 continuously (total dose 1,500 mg/m2) and cisplatin at 80 mg/m2 on day 1. Fifteen patients (7 adenocarcinoma, 5 small cell lung cancer, 2 squamous cell lung cancer and 1 sarcoma, which latter was difficult to distinguish from giant cell carcinoma) were entered in this study. "
7.	Messenger RNA (mRNA)IBA 06/20/2008 - "There was an elevated expression of RhoC and RhoGDIa protein and mRNA in subclone of lung giant cell carcinoma cell line with a higher metastatic capacity BE1 than in LH7 with a lower metastatic capacity. " 04/20/2008 - "TCF-4 mRNA expression levels were incompatible in different histology types, the expression level of TCF-4 was relatively high in giant cell carcinoma cells, but low in lung adencarcinoma cells. " 06/01/1986 - "High levels of c-myc mRNA were observed in two human tumor cell lines, a giant cell carcinoma of the lung (C-Lu99) and a colon cancer (C1). " 01/01/2001 - "To investigate genes involved in cancer metastasis, mRNA differential display was used to compare the levels of gene expression in two cell sublines derived from human giant cell carcinoma of lung (PG) which had different metastatic potentials. " 07/01/2003 - "The differential expression of IL-18 protein or mRNA level between highly and poorly metastatic sublines of human lung giant cell carcinoma metastatic model was detected by Western blot, semi-quantitative RT-PCR and northern blot analysis. "
8.	VimentinIBA 08/01/1986 - "Four of the eight giant cell carcinomas (50%) demonstrated vimentin expression. " 10/01/1997 - "Mesenchymal type expressed mesenchymal markers, vimentin and CD68 in four osteoclastoid type giant cell carcinomas, the mucinous cystadenocarcinoma, six ductal carcinomas and ten chronic pancreatitises. " 01/01/2000 - "Pleomorphic giant cell carcinoma of the esophagus with coexpression of cytokeratin and vimentin and neuroendocrine differentiation." 03/01/1991 - "Immunohistochemical features of giant cell carcinoma of the lung: patterns of expression of cytokeratins, vimentin, and the mucinous glycoprotein recognized by monoclonal antibody A-80." 07/01/1988 - "Ten examples of giant cell carcinoma of the lung were examined by immunohistochemistry for expression of keratin and vimentin intermediate filaments and for epithelial membrane antigen (EMA). "
9.	ThyroglobulinFDA Link 07/01/1989 - "Discussed is a case of a giant cell carcinoma that presented a high value of serum thyroglobulin. " 05/01/2007 - "Histologic variants of papillary and follicular carcinomas associated with anaplastic spindle and giant cell carcinomas of the thyroid: an analysis of rhabdoid and thyroglobulin inclusions." 01/01/1983 - "The only small-cell variant of follicular carcinoma and ten of 14 spindle and giant cell carcinomas showed the lowest thyroglobulin reactivity. " 05/01/2007 - "We describe the histologic variants of papillary and follicular carcinomas associated with 109 spindle and giant cell carcinomas (SGCC) of the thyroid and determine the incidence of rhabdoid and thyroglobulin inclusions in these tumors. "
10.	Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric 05/01/2003 - "To describe a patient with human chorionic gonadotropin (hCG)-secreting giant cell carcinoma of the lung manifesting as painful gynecomastia, which resolved after surgical treatment. " 05/01/2003 - "Gynecomastia attributable to human chorionic gonadotropin-secreting giant cell carcinoma of lung." 01/01/2001 - "Human chorionic gonadotropin (hCG)-producing large or giant cell carcinoma of the lung is not uncommon, but primary pulmonary choriocarcinoma is an extremely rare entity. " 05/01/1987 - "Such differentiation may occur in visceral carcinomas as a focal change, and rarely as the sole pathway of tumor differentiation in extragonadal organs, where it has been termed primary choriocarcinoma or giant cell carcinoma with ectopic human chorionic gonadotropin production."

Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation) 09/01/1991 - "The morphological features of xenografts were consistent with those of the parental giant cell carcinoma. " 09/01/1991 - "[Orthotopic xenotransplantation of human lung giant cell carcinoma and study on its invasion and metastasis]."
2.	Drug Therapy (Chemotherapy) 06/02/2005 - "This is a first report of a rare case with stage IV pulmonary giant cell carcinoma who has survived long-term after undergoing aggressive surgical treatment and chemotherapy." 06/02/2005 - "Long-term survival after an aggressive surgical resection and chemotherapy for stage IV pulmonary giant cell carcinoma." 12/01/1982 - "Preoperative chemotherapy for giant cell carcinoma of the thyroid." 02/01/1973 - "Combined chemotherapy and radiation therapy in spindle and giant cell carcinoma of the thyroid gland. " 04/27/1990 - "Anaplastic carcinomas with areas of differentiated thyroid carcinoma and small cell carcinomas (after exclusion of malignant lymphoma of the thyroid) showed a higher response rate to chemotherapy than spindle or giant cell carcinoma or thyroid sarcoma."
3.	Catheters 01/01/1992 - "The value of fine catheter aspiration cytology in the diagnosis of metastatic tumours is illustrated by a case of pleomorphic giant cell carcinoma of the pancreas which had metastasized to the peritoneal cavity. " 01/01/1992 - "Diagnosis of metastatic pleomorphic giant cell carcinoma of the pancreas using fine catheter aspiration cytology."
4.	Highly Active Antiretroviral Therapy (HAART) 01/01/2009 - "A 66-year-old man, who was discovered to have human immunodeficiency virus (HIV) infection 22 months previously and was treated with highly active antiretroviral (HAART) therapy, developed giant cell carcinoma of the lung. " 01/01/2009 - "Since giant cell carcinoma of the lung occurs mainly in elderly men who smoke heavily, there may not be a possibility that the HIV or HAART was causative in our patient."
5.	Transplants (Transplant) 04/01/2013 - "This report describes the morphological features of a pleomorphic giant cell carcinoma with focal trophoblastic differentiation of the urinary bladder in a male, 12 years post living related donor renal transplant. "