Klatskin's Tumor (Klatskin Tumor)

Adenocarcinoma of the common hepatic duct bifurcation. These tumors are generally small, sharply localized, and seldom metastasizing. G. Klatskin's original review of 13 cases was published in 1965. Once thought to be relatively uncommon, tumors of the bifurcation of the bile duct now appear to comprise more than one-half of all bile duct cancers. (From Holland et al., Cancer Medicine, 3d ed, p1457)

Also Known As:

Networked: 47 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Jaundice
3.	Carcinoma (Carcinomatosis)
4.	Pathologic Constriction (Stenosis)
5.	Cholangiocarcinoma

Experts

1.	Paul, Andreas: 2 articles (11/2010 - 09/2004)
2.	Shen, Yan: 2 articles (08/2005 - 02/2005)
3.	Zhang, Min: 2 articles (08/2005 - 02/2005)
4.	Hu, Anbin: 1 article (07/2015)
5.	Lin, Yueming: 1 article (07/2015)
6.	Wang, Guodong: 1 article (07/2015)
7.	Liu, Furong: 1 article (07/2015)
8.	He, Xiaoshun: 1 article (07/2015)
9.	Ma, Yi: 1 article (07/2015)
10.	Zhu, Xiaofeng: 1 article (07/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Klatskin's Tumor:

1.	BismuthIBA 08/07/2007 - "Optimal biliary drainage for inoperable Klatskin's tumor based on Bismuth type." 09/01/2007 - "These findings were compatible with Klatskin's tumor, Bismuth type III. Considering the patient's old age, palliative combined modality therapy was performed. " 08/07/2007 - "ERBD is recommended as the first-line drainage procedure for the palliation of jaundice in patients with inoperable Klatskin's tumor of Bismuth type II or III, but IPTBD is the best option for Bismuth type IV." 01/07/2015 - "A 75-year-old man presented with jaundice and was diagnosed with Bismuth type IV Klatskin tumor. " 07/01/2015 - "Hereby, it is presented a 32-year-old patient with bile duct resection, left hemi-hepatectomy and loco-regional lymph nodes dissection, for a type IIIB Bismuth-Corlette Klatskin tumor, which, furthermore, 6 years later, underwent a pancreaticoduodenectomy for a metachronous carcinoma of the ampulla of Vater. "
2.	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 07/01/2005 - "Detection of Klatskin's tumor in extrahepatic bile duct strictures using delayed 18F-FDG PET/CT: preliminary results for 22 patient studies."
3.	Primary sclerosing cholangitisIBA 06/01/1992 - "The value of cholangiography in determining the prognosis and appearance of primary sclerosing cholangitis and in diagnosing Klatskin tumor was examined. " 12/01/2012 - "A female patient with primary sclerosing cholangitis developed a cholangiocarcinoma (Klatskin tumor) at the age of 42 years. " 12/01/2009 - "Indications for liver transplantation were metastatic neuroendocrine tumor disease (n = 5), primary sclerosing cholangitis (n = 5), hepatitis C virus (n = 2), metastatic gastrointestinal stromal tumor (n = 1), Klatskin tumor (n = 1), alcohol cirrhosis (n = 1), alpha-1 antitrypsin deficiency (n = 1), and chemotherapy-induced cirrhosis (n = 1). "
4.	Intrahepatic cholangiocarcinomaIBA 12/01/2012 - "We retrospectively analyzed the CEUS pattern of 39 patients with HCC, 11 patients with intrahepatic cholangiocarcinoma (ICC), 3 patients with Klatskin tumor, and 4 patients with gallbladder carcinoma. " 03/01/2009 - "The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis."
5.	perfluoro- 2,2,2',2'- tetramethyl- 4,4'- bis(1,3- dioxolane)IBA 01/01/2013 - "PTBD should be seriously considered for biliary decompression when treating patients with Klatskin tumor." 08/07/2007 - "To investigate differences in the effects of biliary drainage procedures in patients with inoperable Klatskin's tumor based on Bismuth type, considering endoscopic retrograde biliary drainage (ERBD), external percutaneous transhepatic biliary drainage (EPTBD) and internal biliary stenting via the PTBD tract (IPTBD). "
6.	tranilast (N 5')IBA 04/01/2007 - "The indications were cholestasis, arising from recurrent tumor growth (n = 5, 62.5%), that included gastric carcinoma after previous gastrectomy (n = 4) and a periampullary carcinoma after previous Whipple procedure (n = 1); arising from Klatskin tumor (n = 2, 25%); and from benign stenosis of a hepaticojejunostomy (n = 1, 12.5%). " 12/01/2009 - "Indications for liver transplantation were metastatic neuroendocrine tumor disease (n = 5), primary sclerosing cholangitis (n = 5), hepatitis C virus (n = 2), metastatic gastrointestinal stromal tumor (n = 1), Klatskin tumor (n = 1), alcohol cirrhosis (n = 1), alpha-1 antitrypsin deficiency (n = 1), and chemotherapy-induced cirrhosis (n = 1). "
7.	Matrix MetalloproteinasesIBA 03/01/2009 - "The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis."
8.	PlasticsIBA 09/01/1990 - "Two patients received two prostheses inserted simultaneously in both the left and right hepatic ducts for Klatskin tumor type III. Immediate results were satisfactory despite an operative mortality of 18%, and neither early nor late clogging was observed even in patients who presented previously with sludge above plastic stents that were removed. "
9.	IridiumIBA 01/01/1986 - "This "Y-shaped" distribution of iridium seeds irradiates a target volume which corresponds very well to the "Y-shaped" volume of a Klatskin's tumor. "
10.	Factor IX (PTC)FDA LinkGeneric 06/24/1990 - "The subsequent performed investigations as ultrasonography and PTC--showed the Klatskin tumor, which was proven by the operation performed and histology. "

Therapies and Procedures

1.	Liver Transplantation 02/01/2005 - "This study was to summarize the indication and value of orthotopic liver transplantation for patients with Klatskin tumor. " 07/14/2015 - "Liver transplantation was equivalent to radical resection for klatskin tumor treatment in terms of patient survival, with potential higher long-term patient survival rate and lower recurrence. " 07/14/2015 - "We retrieved Medline for articles on treatment of klatskin tumor published from January 1996 to December 2014, and choose the literatures including liver transplantation and radical resection. " 07/14/2015 - "To compare the survival results of liver transplantation with radical resection for klatskin tumor based on the published literatures. " 07/14/2015 - "[Survival outcome comparative analysis of Liver transplantation and radical resection surgery for Klatskin tumor]."
2.	Adjuvant Radiotherapy 02/01/2000 - "Our data clearly suggest the improved prognosis of patients with locally advanced Klatskin tumor by integrated adjuvant radiotherapy with IORT and PORT to complete gross tumor resection with acceptable treatment mortality and morbidity." 02/01/2000 - "The objective of this study was to determine the benefits of adjuvant radiotherapy after radical resection of locally advanced main hepatic duct carcinoma (Klatskin tumor). "
3.	Stents 01/07/2015 - "Placement of ¹²⁵I seed strands and stents for a type IV Klatskin tumor." 01/01/1999 - "Fifty-two patients who had undergone resection of a Klatskin tumor were divided into 2 groups, comparing patients who had had preoperative ERCP and stent placement (n = 41) and patients without preoperative drainage (n = 11). " 01/01/1997 - "[The penetration of a bile duct metal stent into the duodenal bulb as a late complication of combined stent/radiotherapy in Klatskin's tumor]." 01/01/2013 - "Transhepatic transanastomotic stent, A reliable method for hepatojejunostomy and prevention of anastomotic leakage following radical resection in patients suffering from klatskin tumor." 09/01/1999 - "Multiple stents in treatment of obstructive jaundice associated with Klatskin's tumor."
4.	Laparotomy 09/01/2000 - "Twenty-one consecutive patients with Klatskin tumor who had undergone laparotomy were included in this study. " 09/01/2007 - "A more accurate preoperative staging, perhaps by systematic use of pre-OLT laparotomy, and the use of adjuvant, and most importantly neoadjuvant therapy may improve the results of OLT in Klatskin's tumor."
5.	Brachytherapy 05/01/2001 - "Intraluminal brachytherapy combined with stent implantation is a safe method and appears to prolong survival in inoperable patients with Klatskin's tumor and carcinoma of papilla Vateri compared with nontreated patients in previous studies. " 05/01/2001 - "Thirty-two patients aged 41-80 years with nonresectable biliary malignancies--Klatskin's tumor (n = 17), gallbladder carcinoma (n = 11) and carcinoma of papilla Vateri (n = 4)--were treated with a combination of intraluminal brachytherapy (source Ir192, high-dose radiation regimen, total dose 30 Gy) and metallic stent implantation. "