Klatskin Tumor

Cholangiocarcinoma arising near or at the confluence of the right and left hepatic ducts (COMMON HEPATIC DUCT). These tumors are generally small, sharply localized, and seldom metastasizing.

Also Known As:

Hilar Cholangiocarcinoma; Perihilar Cholangiocarcinoma; Cholangiocarcinoma, Hilar; Cholangiocarcinoma, Perihilar; Cholangiocarcinomas, Hilar; Cholangiocarcinomas, Perihilar; Hilar Cholangiocarcinomas; Klatskins Tumor; Perihilar Cholangiocarcinomas; Tumor, Klatskin; Tumor, Klatskin's; Klatskin's Tumor

Networked: 1116 relevant articles (82 outcomes, 151 trials/studies)

Relationship Network

Disease Context: Research Results

Neoplasms: 1324753
- Neoplasms by Histologic Type: 2
  - Glandular and Epithelial Neoplasms: 439
    - Carcinoma: 141855
      - Adenocarcinoma: 58365
        Cholangiocarcinoma: 7335
        Klatskin Tumor: 1116

Related Diseases

1.	Neoplasms (Cancer)
2.	Sclerosing Cholangitis
3.	Neoplasm Metastasis (Metastasis)
4.	Jaundice (Icterus)
5.	Cholangiocarcinoma

Experts

1.	Nagino, Masato: 36 articles (12/2022 - 02/2003)
2.	Ebata, Tomoki: 33 articles (03/2022 - 02/2003)
3.	Rosen, Charles B: 27 articles (01/2021 - 10/2002)
4.	Gores, Gregory J: 26 articles (08/2021 - 10/2002)
5.	Heimbach, Julie K: 25 articles (01/2021 - 05/2004)
6.	Igami, Tsuyoshi: 23 articles (01/2022 - 01/2007)
7.	van Gulik, Thomas M: 23 articles (12/2021 - 02/2003)
8.	Yokoyama, Yukihiro: 22 articles (01/2022 - 01/2007)
9.	Pawlik, Timothy M: 20 articles (04/2022 - 08/2012)
10.	Mizuno, Takashi: 18 articles (01/2022 - 08/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Klatskin Tumor:

1.	6-propylchromone-2-carboxylic acid (PCCA)IBA 01/01/2021 - "This study aimed to compare the predictive efficacy of four different lymph node (LN) staging systems on the overall survival (OS) of patients with surgically resected perihilar cholangiocarcinoma (pCCA), and construct a novel prognostic nomogram to predict OS in pCCA patients. " 01/01/2021 - "Major liver resection has evolved as the mainstay of treatment for patients with perihilar cholangiocarcinoma (pCCA). " 08/01/2018 - "The refinement in surgical techniques combined with the preoperative management has improved the resectability rate of perihilar cholangiocarcinoma (pCCA). " 06/01/2023 - "This study aimed to assess whether postoperative adjuvant chemoimmunotherapy could lead to better clinical outcomes for high-risk patients with perihilar cholangiocarcinoma (pCCA). " 02/01/2023 - "Background and study aims Accurate assessment of the lymph node (LN) status is crucial in resectable perihilar cholangiocarcinoma (pCCA) to prevent major surgery in patients with extraregional metastatic LNs (MLNs). "
2.	BismuthIBA 08/01/2009 - "The radical resection is still the best treatment for Bismuth-Corlette type I and II hilar cholangiocarcinoma. " 02/26/2008 - "Curative resection with hemihepatectomy is a safe and effective option for hilar cholangiocarcinoma, especially for Bismuth III or IV type. " 05/01/2021 - "The transhepatic hilar approach might be the better choice for surgical resection of Bismuth types III and IV perihilar cholangiocarcinoma because it is associated with lower mortality and improved survival." 10/01/2023 - "With the continuous accumulation of laparoscopic radical resection for perihilar cholangiocarcinoma(PHC), the safety and feasibility have been confirmed, and some studies have shown that considering the comparable long-term prognosis and short-term outcomes of laparoscopic surgery and open surgery, laparoscopic surgery could be a technically feasible surgical method for PHC patients of all Bismuth-Corlette types. " 11/01/2018 - "In this study, we compared outcomes of left-side and right-side resections for Bismuth type III hilar cholangiocarcinoma and analyzed factors affecting survival. "
3.	PlasticsIBA 04/01/2018 - "This study aimed to determine whether the back-propagation artificial neural network (BP-ANN) model could be constructed to accurately in predicting early occlusion of bilateral plastic stent placement for inoperable hilar cholangiocarcinoma (HCA). " 01/01/2023 - "Two 2 (8%) patients with Klatskin tumor type IV underwent bilateral bilioduodenal stenting with plastic and bifurcation self-expanding stents. " 01/01/2023 - "In Klatskin tumor type I, 11 patients (44%) underwent bilioduodenal stenting of common hepatic duct with plastic stent; 5 (20%) patients with Klatskin tumor type II received self-expanding stents. " 04/01/2018 - "Artificial Neural Networking Model for the Prediction of Early Occlusion of Bilateral Plastic Stent Placement for Inoperable Hilar Cholangiocarcinoma." 06/01/2003 - "The combination of photodynamic therapy and biliary drainage by plastic endoprosthesis insertion has produced promising results in the treatment of nonresectable hilar cholangiocarcinoma. "
4.	MetalsIBA 11/15/2021 - "Therefore, if possible, bilateral metal stenting is recommended for HMBO caused by hilar cholangiocarcinoma." 01/01/2021 - "In multivariate Cox analysis of the overall survival, metal stenting (HR 0.589, P = 0.002), hilar cholangiocarcinoma (HR 0.419, P = 0.009), and adjuvant treatment (HR 0.596, P = 0.006) were independent predictors of death. " 01/01/2021 - "This meta-analysis was conducted to evaluate the relative clinical efficacy of unilateral and bilateral metal stent insertion for hilar cholangiocarcinoma (HCCA). " 01/01/2020 - "Combined stent-in-stent and side-by-side stenting for hilar cholangiocarcinoma using a novel braided and weaving metal stent." 01/01/2020 - "The medical records of 73 patients with hilar cholangiocarcinoma who underwent endoscopic metal stent insertion between January 2005 and December 2015 were retrospectively reviewed. "
5.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 03/01/2022 - "PDT might be beneficial for the palliation of hilar cholangiocarcinoma. " 05/01/2005 - "PDT using percutaneous cholangioscopy is safe and effective for advanced hilar cholangiocarcinoma, and seems to prolong survival. " 05/01/2005 - "Therefore, the aim of the present study was to investigate the feasibility of (18)F-FDG-PET as a follow-up screening method in patients with hilar cholangiocarcinoma who underwent PDT. " 03/01/2022 - "PDT in patients with hilar cholangiocarcinoma could improve survival without additional AEs. " 03/01/2022 - "To evaluate the efficacy and safety of PDT for treating hilar cholangiocarcinoma. "
6.	Gemcitabine FDA Link 02/01/2017 - "The aim of this study was to evaluate the efficacy of adjuvant gemcitabine monotherapy following resection for perihilar cholangiocarcinoma with lymph node involvement. " 01/01/2022 - "In this study we investigated the effect of PCI with gemcitabine in patients with inoperable perihilar cholangiocarcinoma (CCA). " 01/01/2022 - "Comment on "Adjuvant S-1 vs gemcitabine for node-positive perihilar cholangiocarcinoma"." 01/01/2022 - "Reply to comment on "Adjuvant S-1 vs gemcitabine for node-positive perihilar cholangiocarcinoma"." 09/01/2021 - "Adjuvant S-1 vs gemcitabine for node-positive perihilar cholangiocarcinoma: A propensity score-adjusted analysis."
7.	perfluoro- 2,2,2',2'- tetramethyl- 4,4'- bis(1,3- dioxolane)IBA 08/01/2014 - "In conclusion, EBD might confer an improved prognosis over PTBD due to prevention of peritoneal seeding, and is recommended as the initial procedure for preoperative biliary drainage in patients with hilar cholangiocarcinoma. " 05/01/2018 - "The objective of the current study was to define long-term survival of patients with resectable hilar cholangiocarcinoma (HCCA) after preoperative percutaneous transhepatic biliary drainage (PTBD) versus endoscopic biliary drainage (EBD). " 08/01/2014 - "This study sought to clarify the benefit of EBD in comparison to PTBD in patients who underwent radical resections of hilar cholangiocarcinoma. " 11/01/2006 - "From January 1, 2000 to December 31, 2002, all unresectable hilar cholangiocarcinoma patients who received only one type of palliative surgical bypass or PTBD in Srinagarind Hospital, Khon Kaen University were included in the present study. " 12/01/2022 - "Comparing the efficacy and complications of Endoscopic Biliary Drainage (EBD) and Percutaneous Transhepatic Biliary Drainage (PTBD) in patients with perihilar cholangiocarcinoma."
8.	Proteins (Proteins, Gene)FDA Link 03/01/2016 - "In the present study, tissue microarrays containing resected hilar cholangiocarcinoma specimens from 92 patients were used to evaluate the expression of SPARCL1 protein by immunohistochemistry (IHC). " 02/01/2005 - "The aim of this study was to assess the effect of HCV core protein on proliferation and apoptosis of hilar cholangiocarcinoma. " 06/14/2023 - "We present the case of a 69-year-old male diagnosed with stage IV perihilar cholangiocarcinoma with loss of expression of MSH2 and MSH6 proteins, but somatic wild type MSH2 and MSH6 genes with Oncomine Comprehensive Assay (OCA) genomic sequencing panel. " 09/01/2015 - "Inhibition of the expression of HDGF downregulated the malignant biological behaviors, suggesting that downregulation of the protein expression of HDGF by RNAi may be a novel therapeutic approach to inhibit the progression of hilar cholangiocarcinoma. " 09/01/2015 - "This was performed by downregulating the protein expression of HDGF in the FRH0201 hilar cholangiocarcinoma cell line by RNA interference (RNAi) in vitro, and revealed that downregulation of the HDGF protein significantly inhibited the malignant biological behavior of the FRH0201 cells. "
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/01/2011 - "This study investigates the expression of HDGF combined with VEGF, their correlation with clinicopathologic features, and their prognosis in human hilar cholangiocarcinoma. " 01/01/2022 - "We investigated the role of Grb2-associated binder 1 (Gab1) in invadopodia and autocrine VEGF in hilar cholangiocarcinoma cells. " 01/01/2022 - "Gab1 regulates invadopodia and autocrine VEGF through SHP2/ERK1/2 in hilar cholangiocarcinoma cells." 08/01/2018 - "These observations suggested that targeting VEGF with RNAi may be an effective therapeutic strategy for treating hilar cholangiocarcinoma." 01/19/2016 - "Increased expression of VEGF, CD105, CD31/Ki-67, and GLUT-1 was confirmed in human perihilar cholangiocarcinomas. "
10.	Messenger RNA (mRNA)IBA 05/18/2018 - "mRNA expression of ADAM-9, - 10, - 11, - 12, - 15, - 17, - 28, and - 33 was analyzed in human hilar cholangiocarcinoma (HC) samples. " 01/01/2021 - "MRPL27 mRNA was significantly upregulated in tumor tissues in cholangiocarcinoma patients including intrahepatic, distal and hilar/perihilar cholangiocarcinoma cases (all p < 0.01). " 01/01/2022 - "The ratio of FXR/GAPDH mRNA was significantly different among the hilar cholangiocarcinoma, control and sham operation groups. " 01/01/2021 - "The Bsep/Gapdh mRNA ratio in hilar cholangiocarcinoma, control group and sham operation group differed markedly. " 06/01/2011 - "miR-373 decreased and closely associated with poor cell differentiation, advanced clinical stage, and shorter survival in hilar cholangiocarcinoma; MBD2 exclusively over-expressed and reciprocally related to miR-373; precursor miR-373 inhibited the luciferase activity of MBD2-3'UTR construct; exogenous miR-373 suppressed the expression of MBD2 and enhanced RASSF1A mRNA in QBC(939) cells; anti-miR-373 inhibitor up-regulated the expression of MBD2 and reduced RASSF1A mRNA in HIBEpic cells. "

Therapies and Procedures

1.	Liver Transplantation 04/01/2009 - "Based on good results using neoadjuvant and palliative radiation, a protocol for liver transplantation in selected patients with unresectable hilar cholangiocarcinoma was developed in 1993. " 07/01/2018 - "Efficacy of liver transplantation for hilar cholangiocarcinoma: A protocol for a systematic review and meta-analysis." 01/01/2016 - "Strict Selection Alone of Patients Undergoing Liver Transplantation for Hilar Cholangiocarcinoma Is Associated with Improved Survival." 03/01/2012 - "Local non-resectable, hilar cholangiocarcinoma can be cured by performing a liver transplantation. " 07/01/2018 - "This study will provide a comprehensive evidence summary of the comparison between liver transplantation or surgical resection in the treatment of hilar cholangiocarcinoma."
2.	Neoadjuvant Therapy 07/01/2023 - "Safety and efficacy of neoadjuvant chemotherapy based on our resectability criteria for locally advanced perihilar cholangiocarcinoma." 03/12/2020 - "Seventy-eight patients who underwent surgical resection at our institution for perihilar cholangiocarcinoma from 2004 to 2017, (36 with neoadjuvant therapy), were enrolled in this study. " 01/01/2005 - "If the encouraging data achieved with neoadjuvant therapy prior to LTx are confirmed by further studies, we foresee that renewed interest in LTx for hilar cholangiocarcinoma could arise." 07/01/2023 - "Neoadjuvant chemotherapy (NAC) is not commonly used for perihilar cholangiocarcinoma (PHC). " 08/01/2020 - "[A Case of Unresectable Hilar Cholangiocarcinoma Resected Curatively Through Effective Response to Neoadjuvant Chemotherapy]."
3.	Hepatectomy 01/01/2008 - "Thus, preoperative bile replacement in patients with external biliary drainage is very likely to be effective when highly invasive surgery (e.g., extended hepatectomy for hilar cholangiocarcinoma) is planned." 06/01/2014 - "Laparoscopic-assisted right extended hepatectomy for hilar cholangiocarcinoma with laparoscopically hand-sewn hepaticojejunostomy in select patients can be achieved with good outcomes." 07/01/2010 - "From our recent experienced results, it can be concluded that the surgical strategy for hilar cholangiocarcinoma has been improved remarkably, and major surgical hepatectomy can be done with relative safety, and these aggressive surgical approaches, including combined vascular resection, may be warranted for the surgical treatment of hilar cholangiocarcinoma. " 08/01/2016 - "To investigate the efficacy of our technique and policy on left hepatectomy (LH) with hepatic artery resection but without arterial reconstruction (HAR) in selected patients with hilar cholangiocarcinoma. " 01/01/2009 - "A left hepatectomy and caudate lobectomy combined resection of the ventral segment of the right anterior sector for hilar cholangiocarcinoma--the efficacy of PVE (portal vein embolization) in identifying the hepatic subsegment: report of a case."
4.	Stents 12/01/2019 - "Purpose: This study aims to ascertain the relative outcomes in patients with hilar cholangiocarcinoma (HCCA) undergoing either unilateral or bilateral self-expanded metallic stent (SEMS) insertion. " 04/01/2016 - "This study evaluated the technical and clinical efficacy of percutaneous bilateral biliary stent-in-stent (SIS) deployment technique with a "Y" configuration using open-cell-design stents in type 4 Klatskin tumor patients. " 12/01/2023 - "Additional stenting for hilar cholangiocarcinoma using a novel delivery device after uncovered metallic stent placements." 06/01/2023 - "Radioactive stent insertion for inoperable hilar cholangiocarcinoma: a prospective randomized controlled trial." 01/01/2023 - "A single-center retrospective study of 54 patients with inoperable perihilar cholangiocarcinoma who underwent percutaneous transhepatic biliary stent placement between January 1, 2019, and August 31, 2021, was conducted. "
5.	Radiotherapy 11/01/1995 - "Internal biliary drainage, in conjunction with radiotherapy, appears to be safe and effective palliation of irresectable or recurrent hilar cholangiocarcinoma. " 01/01/2023 - "Inter- and intrafraction dose variations in robotic stereotactic body radiation therapy (SBRT) for perihilar cholangiocarcinoma in the prospective phase I STRONG trial." 01/01/2005 - "Some studies suggest that giving radiation therapy after surgery for hilar cholangiocarcinoma improves the survival rate; however, many of these studies did not specify numbers of subjects or provide an impartial analysis. " 01/01/2021 - "Integration of radiotherapy with anti-PD-1 antibody for the treatment of intrahepatic or hilar cholangiocarcinoma: reflection from four cases." 02/01/2017 - "High dose chemoradiation for unresectable hilar cholangiocarcinomas using intensity modulated external beam radiotherapy: a single tertiary care centre experience."