Mucinous Cystadenocarcinoma

A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)

Also Known As:

Networked: 200 relevant articles (4 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Serous Cystadenocarcinoma
3.	Carcinoma (Carcinomatosis)
4.	Endometrioid Carcinoma
5.	Mucinous Cystadenoma

Experts

1.	Al Skaini, Mohammad Saad: 2 articles (01/2015 - 02/2014)
2.	El Hakeem, Ismail: 2 articles (01/2015 - 02/2014)
3.	Rabie, Mohammad Ezzedien: 2 articles (01/2015 - 02/2014)
4.	Saito, Tsuyoshi: 2 articles (08/2012 - 10/2007)
5.	Chao, Tai-Kuang: 2 articles (06/2012 - 03/2009)
6.	Lin, Chih-kung: 2 articles (06/2012 - 01/2008)
7.	Jin, Jong-Shiaw: 2 articles (03/2009 - 01/2008)
8.	Li, Shuang: 2 articles (02/2007 - 01/2006)
9.	Zhu, Changhong: 2 articles (02/2007 - 01/2006)
10.	Burger, H G: 2 articles (06/2001 - 03/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mucinous Cystadenocarcinoma:

1.	Carboplatin (JM8)FDA LinkGeneric 03/01/1987 - "The chemotherapeutic effects of CDDP, CBDCA and CHIP on human ovarian cancers heterotransplanted into nude mice (mucinous cystadenocarcinoma OVA-1, poorly differentiated adenocarcinoma OVA-2, endometrioid adenocarcinoma OVA-3, serous cystadenocarcinoma OVA-4, and three yolk sac tumors YST-1, YST-2, YST-3) were examined. " 01/01/2001 - "Paclitaxel and carboplatin may be effective in treating mucinous cystadenocarcinoma of the ovary." 01/01/2018 - "We herein report the case of 23-year-old woman with an extremely large ovarian papillary mucinous cystadenocarcinoma diagnosed during pregnancy, identified on ultrasound and magnetic resonance imaging, and treated by surgical resection followed by adjuvant chemotherapy with carboplatin and paclitaxel." 10/01/2009 - "Combined chemotherapy with paclitaxel and carboplatin for mucinous cystadenocarcinoma of the ovary during pregnancy." 01/01/2001 - "We report a case of complete response of a stage IV mucinous cystadenocarcinoma of the ovary to systemic chemotherapy employing paclitaxel and carboplatin. "
2.	Paclitaxel (Taxol)FDA LinkGeneric 01/01/2001 - "Paclitaxel and carboplatin may be effective in treating mucinous cystadenocarcinoma of the ovary." 01/01/2018 - "We herein report the case of 23-year-old woman with an extremely large ovarian papillary mucinous cystadenocarcinoma diagnosed during pregnancy, identified on ultrasound and magnetic resonance imaging, and treated by surgical resection followed by adjuvant chemotherapy with carboplatin and paclitaxel." 10/01/2009 - "Combined chemotherapy with paclitaxel and carboplatin for mucinous cystadenocarcinoma of the ovary during pregnancy." 01/01/2001 - "We report a case of complete response of a stage IV mucinous cystadenocarcinoma of the ovary to systemic chemotherapy employing paclitaxel and carboplatin. " 01/01/2001 - "Complete response of a stage IV mucinous cystadenocarcinoma of the ovary to systemic chemotherapy employing paclitaxel and carboplatin."
3.	Tumor Biomarkers (Tumor Markers)IBA 11/01/2005 - "It seems that screening with the tumor markers will be helpful for the diagnosis, because it is very difficult to diagnose a retroperitoneal mucinous cystadenocarcinoma before the operation." 01/01/1994 - "The concentration of the tumor marker CA 15-3 was measured by immunoassay in cyst fluid from six pseudocysts, five serous cystadenomas, three mucinous cystic neoplasms, and six mucinous cystadenocarcinomas. " 03/01/1992 - "When both CA54/61 and CA125 were assessed in sera from 36 patients with mucinous cystadenocarcinoma, the positive rates of CA54/61 and CA125 were 64% (or 56%) and 36% (or 56%), respectively, suggesting that CA54/61 is of clinical value as a new tumor marker for ovarian cancers, including mucinous tumors." 03/01/2003 - "OVS1 monoclonal antibody (MAb) produced against ovarian cancer is currently used to identify mucinous cystadenocarcinoma antigen as a tumor marker secreted in serum. "
4.	olaparibIBA 12/15/2020 - "Pancreatic mucinous cystadenocarcinoma in a patient harbouring BRCA1 germline mutation effectively treated with olaparib: A case report."
5.	AntigensIBA 04/01/1985 - "One hundred percent of ovarian mucinous cystadenocarcinomas expressed high levels of the antigen with intense staining of 80 to 100% of the tumoral area, thus confirming our previous finding with radioimmunoassay and absorption analyses. " 09/01/1975 - "Antigens of mucinous cystadenocarcinoma have not yet been examined for their possible fetal or placental origins. " 03/01/1995 - "The results showed that 75% of mucinous cystadenocarcinomas were negative for all 3 antigens as were 2 of the 5 (40%) clear cell carcinomas. " 04/01/1985 - "The antigen thus appears to be a colorectal tissue-specific antigen showing increased levels in ovarian mucinous cystadenocarcinomas and in some gastrointestinal tumors. " 10/01/1975 - "An ovarian cystadenocarcinoma-associated antigen (OCAA) was found to be common to all serous and mucinous cystadenocarcinomas of the ovary. "
6.	Proteins (Proteins, Gene)FDA Link 02/01/2006 - "In the immunohistochemical study, 3 cases (3/6, 50%) of borderline mucinous cystic tumor and two cases (2/8, 25%) of mucinous cystadenocarcinoma show positive staining for KIT protein. " 09/09/2015 - "Expression of c-myc protein and mutations in the KRAS gene in 24 cases of ovarian mucinous cystadenoma, 46 cases of ovarian borderline mucinous cystadenoma, and 46 cases of ovarian mucinous cystadenocarcinoma were detected using the immunohistochemistry PV-9000 2-step method and polymerase chain reaction-restriction fragment length polymorphism. " 08/01/1996 - "Our results show that p53 protein accumulation is associated to a similar degree with both malignant mucinous cystadenocarcinomas and mucinous cystademonas of borderline malignancy. " 08/30/2013 - "Immunohistochemical staining and Western blot were used to examine the expressions of DLC1 and PAI-1 protein in 25 specimens normal ovarian tissues, 52 specimens of serous cystadenocarcinoma tissues and 23 specimens of mucinous cystadenocarcinoma tissues. " 09/01/1993 - "Gonadotropin-releasing hormone was shown to be present in extracts of ovarian mucinous cystadenocarcinoma sample (0.8 +/- 0.12 pg/mg of protein) and ovarian adenocarcinoma cell line SK-OV3 (0.92 +/- 0.17 pg/mg of protein) but not in the normal ovary and placenta. "
7.	Monoclonal AntibodiesIBA 06/01/1995 - "Two newly established murine monoclonal antibodies (MAbs), OVS1 and OVS2, to human ovarian mucinous cystadenocarcinoma were further characterized for diagnostic efficacy. " 06/01/1995 - "Establishment of OVS1 and OVS2 monoclonal antibodies recognizing human ovarian mucinous cystadenocarcinoma." 12/01/1992 - "OVS1 and OVS2 monoclonal antibodies (MAbs) were established by fusing murine myeloma cell line NS1/1-Ag4-1 with mouse spleen cells immunized with fresh human ovarian mucinous-cystadenocarcinoma tissue. " 12/01/1992 - "Immuno-histological characterization of OVS1 and OVS2 monoclonal antibodies recognizing human ovarian mucinous cystadenocarcinoma." 03/01/1995 - "An immunocytochemistry study was performed to compare the immunoreactivity of the monoclonal antibodies OC 125, EGFR and OV 632 with smear imprints from 60 ovarian tumours (21 serous cystadenocarcinomas, 12 mucinous cystadenocarcinomas, 9 endometrioid carcinomas, 5 clear cell carcinomas and 5 mixed tumours). "
8.	Messenger RNA (mRNA)IBA 07/01/2013 - "LRH-1 mRNA was present at low level in normal ovary and serous cystadenocarcinoma, but was elevated approximately 30-fold in GCT, and 8-fold in mucinous cystadenocarcinoma, compared to normal ovary. " 08/01/2005 - "The expression of EDG-7 mRNA was limited in clear cell adenocarcinoma and undetectable in mucinous cystadenocarcinoma. " 11/01/1994 - "Gn-RHR mRNA was detected in four mucinous cystadenocarcinoma specimens, one serous cystadenocarcinoma, and SK-OV-3 cells, but not in white blood cells. " 09/01/1995 - "Relative overexpression of SHBG mRNA was observed in six out of 22 cases (27%) of ovarian cancer (three cases of endometrioid adenocarcinoma, two cases of serous cystadenocarcinoma and one case of mucinous cystadenocarcinoma) in comparison with normal ovaries and benign ovarian tumors. " 07/01/2013 - "Aromatase mRNA was present at low level in normal ovary and serous and mucinous cystadenocarcinoma, and significantly elevated (18-fold) in GCT compared to normal ovary. "
9.	Hormones (Hormone)IBA 10/08/2023 - "[Primary mucinous cystadenocarcinoma of the breast with hormone receptor expression: report of a case]." 01/01/2021 - "Mucinous cystadenocarcinoma of breast is typically triple negative for hormone receptors. " 01/01/2021 - "Mucinous cystadenocarcinoma of breast in a 69-year-old woman with positive hormone receptors, the first case reported." 03/01/2002 - "We report a rare case of mucinous cystadenocarcinoma with virilization, review the literature, and discuss the mechanisms of hormone production by these tumors." 09/01/1993 - "In view of advances in treatment of certain hormone-dependent cancers with analogues of gonadotropin-releasing hormone (Gn-RH), this study was undertaken to establish the signal transduction events interacting with Gn-RH receptor in a cell-free system prepared from human ovarian mucinous cystadenocarcinoma samples. "
10.	Gonadotropin-Releasing Hormone (GnRH)FDA Link 11/01/1994 - "Specific Gn-RH binding sites were shown to be present in plasma membrane isolated from five ovarian mucinous cystadenocarcinoma samples and one serous cystadenocarcinoma (Kd = 15.3 +/- 8.08 nmol/L). " 09/01/1993 - "In view of advances in treatment of certain hormone-dependent cancers with analogues of gonadotropin-releasing hormone (Gn-RH), this study was undertaken to establish the signal transduction events interacting with Gn-RH receptor in a cell-free system prepared from human ovarian mucinous cystadenocarcinoma samples. " 09/01/1993 - "Gonadotropin-releasing hormone was shown to be present in extracts of ovarian mucinous cystadenocarcinoma sample (0.8 +/- 0.12 pg/mg of protein) and ovarian adenocarcinoma cell line SK-OV3 (0.92 +/- 0.17 pg/mg of protein) but not in the normal ovary and placenta. " 09/01/1993 - "Gonadotropin-releasing hormone messenger ribonucleic acid was detected in two of two mucinous cystadenocarcinoma specimens, one of one serous cystadenocarcinoma, and SK-OV3 cells but not in the dysgerminoma, mucinous cystadenoma, and normal ovary and placenta. "

Therapies and Procedures

1.	Salpingo-oophorectomy 04/01/2021 - "She was disease free for 9 years after she underwent right salpingo-oophorectomy for her mucinous cystadenocarcinoma of right ovary. " 07/01/2002 - "Treatment of a case of primary retroperitoneal mucinous cystadenocarcinoma: is adjuvant hysterectomy and bilateral salpingo-oophorectomy justified?" 08/01/2013 - "We report a case of a 55-year-old woman with a history of total abdominal hysterectomy with bilateral salpingo-oophorectomy for ovarian mucinous cystadenocarcinoma five years back, who presented with complaints of chest pain, abdominal distention, and breathlessness for one week. "
2.	Laparotomy 10/01/2009 - "We present the case of a 36-year-old woman with ovarian mucinous cystadenocarcinoma who underwent exploratory laparotomy during pregnancy, revealing Stage 1c at gestational week 15. " 01/01/2004 - "We present the case of a 36-year-old women with ovarian mucinous cystadenocarcinoma during pregnancy, on whom exploratory laparotomy was performed at the gestational age of 16 weeks. " 03/01/1986 - "Histologic examination of the laparotomy specimen confirmed the presence of a well-differentiated mucinous cystadenocarcinoma, with an apparent appendiceal origin. " 04/01/1977 - "A case of a primary retroperitoneal mucinous cystadenocarcinoma of ovarian type found at laparotomy in the presence of two normal ovaries is described. " 04/01/2001 - "However, following laparotomy, pathologic examination of the frozen sections revealed a mucinous cystadenocarcinoma originating in the appendix and a right hemicolectomy and en bloc partial cystectomy were performed. "
3.	Colectomy 07/01/2009 - "We report the case of appendicular mucinous cystadenocarcinoma in a 55-year-old lady with penetration of the sigmoid colon treated with laparoscopic-assisted sigmoid and en block right hemicolectomy. " 03/01/2003 - "The appropriate treatment for a patient with mucinous cystadenocarcinoma should be a right hemicolectomy. " 01/01/1997 - "In mucinous cystadenocarcinoma right hemicolectomy is the operation of choice. " 10/01/2019 - "Laparoscopic right colectomy associated with hyperthermic intraperitoneal chemotherapy as treatment for mucinous cystadenocarcinoma of the appendix - a video vignette." 05/01/2014 - "[Retroperitoneal mucinous cystadenocarcinoma presenting seven years after appendectomy and right hemicolectomy]."
4.	Drug Therapy (Chemotherapy) 01/01/2004 - "Chemotherapy for ovarian mucinous cystadenocarcinoma during pregnancy: a case report." 11/01/2011 - "[A long-term survival case in advanced mucinous cystadenocarcinoma of the appendix using cytoreductive surgery and S-1/CDDP chemotherapy]." 10/01/2012 - "In this case report, the case of progressive paraparesis, developed in a 52-year-old female patient operated with pulmonary mucinous cystadenocarcinoma diagnosis and who received chemotherapy and RT following surgery, has been reported." 11/01/2011 - "[A case of mucinous cystadenocarcinoma of the appendix with abdominal wall abscess successfully treated by percutaneous drainage and systemic chemotherapy-a case report]." 10/01/2007 - "The pathological diagnosis of the tumor was mucinous cystadenocarcinoma grade 2. Although chemotherapy was not effective for her and she died of the disease 4 months after the surgery, her baby grew well and weighed 3750 g 3 months after delivery. "
5.	Pancreatectomy 01/01/2020 - "Mucinous cystadenocarcinoma (MCC) was diagnosed pathologically based on distal pancreatectomy. " 11/01/2013 - "We report a case of a patient in whom a giant mucinous cystadenocarcinoma was treated with distal pancreatectomy. " 10/01/2009 - "A distal pancreatectomy was performed under the diagnosis of mucinous cystadenocarcinoma. " 06/01/2009 - "A distal pancreatectomy and a splenectomy were performed, and the resected specimen histologically revealed an invasive mucinous cystadenocarcinoma of the pancreas. " 03/10/2005 - "Pancreatic mucinous cystadenocarcinoma was diagnosed and a sub-total pancreatectomy was performed with clear resection margins. "