Mucoepidermoid Carcinoma

A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)

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Networked: 443 relevant articles (5 outcomes, 55 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Neoplasm Metastasis (Metastasis)
3.	Adenoid Cystic Carcinoma (Cylindroma)
4.	Carcinoma (Carcinomatosis)
5.	Adenocarcinoma

Experts

1.	Cho, Sung-Dae: 5 articles (09/2015 - 02/2014)
2.	Liu, Bin: 5 articles (12/2014 - 01/2003)
3.	de Almeida, Oslei Paes: 5 articles (01/2013 - 01/2004)
4.	Xuan, Ming: 5 articles (10/2010 - 08/2008)
5.	Yang, Sen: 5 articles (10/2010 - 08/2008)
6.	Shimozato, Kazuo: 4 articles (05/2015 - 07/2006)
7.	Inagaki, Hiroshi: 4 articles (05/2015 - 07/2006)
8.	Wang, Jing: 4 articles (01/2012 - 03/2002)
9.	Li, Yan: 4 articles (08/2011 - 01/2003)
10.	Guo, Li-juan: 4 articles (10/2010 - 08/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mucoepidermoid Carcinoma:

1.	gefitinib (Iressa)FDA Link 04/01/2009 - "Gefitinib as targeted therapy for mucoepidermoid carcinoma of the lung: possible significance of CRTC1-MAML2 oncogene." 05/01/2012 - "Gefitinib resistant human lung adenocarcinoma cell line SPC-A-1 and gefitinib-sensitive human lung mucoepidermoid carcinoma cell line NCI-H292 were used. " 04/01/2009 - "Recent reports of a clinical response to gefitinib in pulmonary mucoepidermoid carcinoma (MEC) in the absence of sensitizing EGFR mutations suggest that tyrosine kinase inhibitors (TKIs) may be effective in this tumor type. " 10/01/2005 - "The present study was designed to clarify whether gefitinib modifies mucin production in lung cancer cell lines apart from its anti-proliferative effects, using A549 adenocarcinoma and NCI-H292 mucoepidermoid carcinoma cells expressing EGFR and MUC5AC mRNA. " 02/01/2008 - "Iressa, Tarceva, Erbitux or radiolabelled antibodies) can be applied for the therapy of mucoepidermoid carcinoma."
2.	squamous cell carcinoma-related antigenIBA 12/01/1990 - "Squamous cell carcinoma-antigen for detection of squamous cell and mucoepidermoid carcinoma after primary treatment: a preliminary report." 12/01/1990 - "This study evaluated the efficacy of using the periodic measurement of the serum level of squamous cell carcinoma antigen (SCC-antigen) for determining the local recurrence and/or metastasis of squamous cell and mucoepidermoid carcinomas after primary treatment. " 12/01/1990 - "Changes in the SCC-antigen level with mucoepidermoid carcinoma seemed to be less sensitive than with squamous cell carcinoma."
3.	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/01/2013 - "Of the 697 NSCLC patients, 235 (33.7%) patients had tyrosine kinase inhibitor (TKIs) sensitive EGFR mutations in 41 (14.5%) of the 282 squamous carcinomas, 155 (52.9%) of the 293 adenocarcinomas, 34 (39.5%) of the 86 adenosquamous carcinomas, one (9.1%) of the 11 large-cell carcinomas, 2 (11.1%) of the 18 sarcomatoid carcinomas, and 2 (28.6%) of the 7 mucoepidermoid carcinomas. " 04/01/2009 - "Recent reports of a clinical response to gefitinib in pulmonary mucoepidermoid carcinoma (MEC) in the absence of sensitizing EGFR mutations suggest that tyrosine kinase inhibitors (TKIs) may be effective in this tumor type. "
4.	MucinsIBA 01/01/2014 - "Based on positive intracellular mucin staining and the lack of extracellular-matrix material, the cytologic diagnosis rendered was 'suspicious for low grade mucoepidermoid carcinoma'. " 03/01/2013 - "Mucoepidermoid carcinoma (MEC), the most common salivary gland malignancy of the upper aerodigestive tract and tracheobronchial tree, is also known for its considerable cellular heterogeneity including epidermoid, intermediate and mucin producing cells. " 02/01/2011 - "In the other two cases (cases 4 and 5) histological examination revealed a mucin-filled glandular and cystic structure resembling mucoepidermoid carcinoma, although the lesions lacked a squamoid cell component. " 01/01/2011 - "Expression of mucin (MUC) genes in mucoepidermoid carcinoma." 10/01/2008 - "Mucin plugs, mucous and intermediate cells of mucoepidermoid carcinomas were positive for LPLUNC1 and SPLUNC2, but areas composed of epidermoid and clear cells were negative for all PLUNCs. "
5.	ParaffinIBA 01/01/2013 - "In the present study, 95 mucoepidermoid carcinomas (paraffin-embedded materials) were analyzed for CRTC1-MAML2 and CRTC3-MAML2 fusions by RT-PCR and for the MAML2 gene split by FISH. " 09/01/1994 - "Prognostic significance of cell proliferation in mucoepidermoid carcinomas of the salivary gland: clinicopathological study using MIB 1 antibody in paraffin sections." 10/01/2012 - "This retrospective study included 46 formalin-fixed, paraffin-embedded blocks of mucoepidermoid carcinoma. " 03/01/2008 - "We screened a total of 67 formalin-fixed, paraffin-embedded mucoepidermoid carcinomas for the presence of chimeric genes. " 07/01/2006 - "RNA was extracted from archival materials: histologic paraffin specimens in all cases and cytologic specimens in 10 mucoepidermoid carcinoma cases. "
6.	Proteins (Proteins, Gene)IBA 09/01/2012 - "This study evaluates the expression of PLUNC proteins in 30 cases of salivary gland mucoepidermoid carcinomas. " 08/01/2000 - "This study showed that Bcl-2 proteins, p53 protein, TUNEL and Ki-67 are potentially useful prognostic markers for survival in patients with mucoepidermoid carcinoma of the oral minor salivary glands." 09/01/2012 - "Expression pattern of PLUNC proteins as an auxiliary tool for the diagnosis of high-grade mucoepidermoid carcinoma of the salivary gland." 02/01/2012 - "Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship." 01/01/2012 - "We measured the expressions of Slit2 and Robo1 proteins in human mucoepidermoid carcinoma Mc3 cells using immunohistochemistry and flow cytometry. "
7.	DNA (Deoxyribonucleic Acid)IBA 08/01/2008 - "To study the expression of inhibitor-1 of DNA binding/differentiation-1 (Id-1) and thrombospondin-1 (TSP-1) genes in mucoepidermoid carcinoma of different malignant degree and analyze the relationship between them. " 10/01/2012 - "Low-risk HPV DNA could not be detected in any of the samples, whereas high-risk HPV DNA was found in two samples of mucoepidermoid carcinoma, which also showed the highest immunoreactivity with p16. " 08/01/2008 - "[The expression of inhibitor-1 of DNA binding/differentiation-1 and thrombospondin-1 in mucoepidermoid carcinoma of different malignant degree]." 05/01/2005 - "The role of DNA ploidy and Ki-67 in the grading of mucoepidermoid carcinomas." 11/01/2000 - "Oncocytic mucoepidermoid carcinoma of the parotid gland: report of a case with DNA ploidy analysis and review of the literature."
8.	Keratins (Keratin)IBA 12/01/2008 - "The immunoprofile of the normal salivary glands was variable according to the component but, in general, cytokeratin profile in mucoepidermoid carcinoma showed similarity to the immunoexpression on the excretory duct unit of normal salivary glands." 12/01/2008 - "Cytokeratin immunoexpression in mucoepidermoid carcinoma was variable according to the cellular type; but regardless of the cellular type studied, cytokeratins 7 and 13 were, respectively, constantly high and low expressed. " 12/01/2008 - "Comparative cytokeratin expression in the different cell types of salivary gland mucoepidermoid carcinoma." 08/01/2006 - "Cytokeratin profile in mucoepidermoid carcinoma is not related to its histological grading of malignancy." 12/01/2008 - "The aim of this study was to assess the expression of cytokeratins in mucoepidermoid carcinoma, comparing to cytokeratin expression in normal salivary glands, in order to establish a possible correlation between tumor cells immunostaining and mucoepidermoid carcinoma histogenesis and differentiation. "
9.	Messenger RNA (mRNA)IBA 09/01/2010 - "to determine the effects of survivin antisense oligonucleotide (ASODN) on the expression levels of survivin mRNA and human mucoepidermoid carcinoma cell line (highly metastatic Mc3) apoptosis and to explore the feasibility of survivin gene as the mucoepidermoid carcinoma therapeutic targets. " 02/01/2009 - "The mean expression level of TPX2 mRNA was higher in mucoepidermoid carcinomas (0.53+/-0.51) than in normal submandibular glands (0.047+/-0.029); a significant association was found (Mann-Whitney U test, P=0.0067). " 03/01/1996 - "The level of mRNA for c-erb was elevated only in mucoepidermoid carcinomas. " 02/01/2009 - "The expression of TPX2 mRNA was investigated in 20 human salivary gland carcinomas (8 mucoepidermoid carcinomas, 7 adenoid cystic carcinomas, 5 acinic cell carcinomas) and 6 normal submandibular glands using real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR). " 04/01/2006 - "We examined the expression of Bub1 mRNA and protein in 21 human salivary gland tumors (7 pleomorphic adenomas, 2 warthin tumors, 5 mucoepidermoid carcinomas, 3 adenoid cystic carcinomas and 4 acinic cell carcinomas) and 3 normal submandibular glands using real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) or western blotting. "
10.	Formaldehyde (Formol)FDA Link 10/01/2012 - "This retrospective study included 46 formalin-fixed, paraffin-embedded blocks of mucoepidermoid carcinoma. " 03/01/2008 - "We screened a total of 67 formalin-fixed, paraffin-embedded mucoepidermoid carcinomas for the presence of chimeric genes. " 02/01/2013 - "Our reverse transcription-polymerase chain reaction using formalin-fixed, paraffin-embedded tumor tissue failed to detect any fusion-gene transcripts which are specifically identified in ordinary mucoepidermoid carcinoma. " 01/01/2013 - "Immunoexpression of p63 protein was studied and quantified in 9 formalin-fixed paraffin-embedded mucous retention cysts, 4 papillary cystadenomas, and 19 low-grade and 9 high-grade mucoepidermoid carcinomas. " 05/01/2009 - "Forty-four formalin-fixed and paraffin-embedded samples of pleomorphic adenoma, adenoid cystic carcinoma, mucoepidermoid carcinoma and polymorphous low-grade adenocarcinoma were included in the study. "

Therapies and Procedures

1.	Radiotherapy 01/01/2011 - "We reported an intermediate-grade mucoepidermoid carcinoma that was managed with wide local excision, medial maxillectomy, and external beam radiotherapy, and the patient has remained disease-free for 7 years. " 07/01/2007 - "One patient is alive, without evidence of recurrent mucoepidermoid carcinoma after 4 years; the other recently completed radiotherapy and is disease-free after 12 months. " 01/01/2014 - "High grade mucoepidermoid carcinoma of nasopharynx is treated with surgical excision combined with radiotherapy and is associated with poor survival. " 09/01/2012 - "One patient with a Stage I mucoepidermoid carcinoma of the parotid gland received postoperative radiotherapy. " 01/01/1999 - "This report analyzes 61 patients with mucoepidermoid carcinomas of the salivary gland treated by surgery alone or by surgery plus radiotherapy. "
2.	Heterologous Transplantation (Xenotransplantation) 11/01/2013 - "To generate and characterize human mucoepidermoid carcinoma cell lines and xenograft models suitable for mechanistic and translational studies. " 03/01/2014 - "In this study, we investigated the apoptotic effects of DBA and its molecular mechanism in human mucoepidermoid carcinoma (MEC) cell lines and tumor xenografts. " 11/01/1992 - "To gain a better understanding of the heterogeneity of these tumors, we conducted in-depth studies of the different cellular subpopulations obtained from primary human mucoepidermoid carcinomas from various sites, and a derived cell line grown in monolayer culture and as a nude mouse xenograft. " 11/01/1983 - "Xenografts included 20 squamous cell carcinomas (SCCs), one mucoepidermoid carcinoma, one adenoid cystic carcinoma, and two melanomas. " 03/01/2014 - "Inhibition of specificity protein 1 by dibenzylideneacetone, a curcumin analogue, induces apoptosis in mucoepidermoid carcinomas and tumor xenografts through Bim and truncated Bid."
3.	Neck Dissection (Radical Neck Dissection) 11/01/2012 - "Twelve years before presentation she received radiation therapy after total parotidectomy and radical neck dissection in treatment of mucoepidermoid carcinoma of the parotid gland. " 09/01/2011 - "Here we would like to present the case of a 71 year old male with mucoepidermoid carcinoma of the base of the tongue successfully treated with surgical excision and neck dissection. " 11/01/2007 - "The first patient was a 75-year-old man with mucoepidermoid carcinoma in the left-side floor of the mouth; requiring resection of the floor of the mouth, partial mandibulectomy, and left supraomohyoid neck dissection. " 07/01/2004 - "With adequate parotidectomy and appropriate neck dissection, patients with mucoepidermoid carcinoma of the parotid gland appear to do well, with few recurrences." 11/01/2006 - "This case report describes the development of a post-treatment enlargement of the sternoclavicular joint, diagnosed as a pseudo-tumour, in a patient who had previously undergone radical neck dissection and post-operative radiotherapy for metastatic mucoepidermoid carcinoma. "
4.	Oral Medicine 06/01/2010 - "The aim of this study was to review the cases of mucoepidermoid carcinoma diagnosed at the Stomatology Service of São Lucas Hospital (PUCRS). " 04/01/2014 - "Oral medicine case book 58: mucoepidermoid carcinoma of the retromolar area."
5.	Immunotherapy 08/01/1997 - "These results should be considered in the cytologic diagnosis of the mucoepidermoid carcinoma using the Mab B72.3 as a diagnostic aid, as well as in future studies for the radiation immunolocalization and immunotherapy of submandibular gland tumors."