Follicular Adenocarcinoma

An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)

Also Known As:

Adenocarcinoma, Follicular; Follicular Thyroid Carcinoma; Thyroid Carcinoma, Follicular; Adenocarcinomas, Follicular; Carcinoma, Follicular Thyroid; Carcinomas, Follicular Thyroid; Follicular Adenocarcinomas; Follicular Thyroid Carcinomas; Thyroid Carcinomas, Follicular

Networked: 922 relevant articles (10 outcomes, 87 trials/studies)

Relationship Network

Disease Context: Research Results

Neoplasms: 1324753
- Neoplasms by Histologic Type: 2
  - Glandular and Epithelial Neoplasms: 439
    - Carcinoma: 141855
      - Adenocarcinoma: 58365
        Follicular Adenocarcinoma: 922
        follicular Thyroid cancer: 406
        Follicular Papillary Carcinoma: 2

Related Diseases

1.	Neoplasms (Cancer)
2.	Thyroid Neoplasms (Thyroid Cancer)
3.	Adenoma (Adenomas)
4.	Papillary Thyroid Cancer
5.	Neoplasm Metastasis (Metastasis)

Experts

1.	Dralle, Henning: 21 articles (01/2021 - 07/2002)
2.	Zedenius, Jan: 20 articles (06/2022 - 04/2003)
3.	Miyauchi, Akira: 15 articles (09/2022 - 11/2005)
4.	Juhlin, C Christofer: 15 articles (06/2022 - 10/2014)
5.	Larsson, Catharina: 13 articles (06/2022 - 04/2003)
6.	Ito, Yasuhiro: 12 articles (09/2022 - 06/2006)
7.	Hirokawa, Mitsuyoshi: 11 articles (09/2022 - 01/2013)
8.	Hoang-Vu, Cuong: 11 articles (09/2012 - 07/2002)
9.	Stenman, Adam: 10 articles (06/2022 - 09/2019)
10.	Lange, Dariusz: 10 articles (06/2019 - 01/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Follicular Adenocarcinoma:

1.	RacivirIBA 11/25/2023 - "The present study investigated the prognostic factors for follicular thyroid carcinoma (FTC) with the incorporation of the histologic subtype and degree of vascular invasion (VI). " 11/01/2023 - "This study aimed to investigate the association between the extent of vascular invasion (VI) and the outcome of widely invasive follicular thyroid carcinoma (WI-FTC). " 09/27/2021 - "In the present study, we analyzed the TCGA cohort of papillary and follicular thyroid carcinoma (PTC and FTC) for their DNAm age and association with clinic-pathological features. " 02/01/2021 - "Of these patients, 73 that were diagnosed with follicular thyroid carcinoma (FTC) were included in the present study. " 01/01/2020 - "The study aimed to compare the prognostic value of the 4th edition of World Health Organization classification (WHO-2017) with the previous WHO classification (WHO-2004) for follicular thyroid carcinoma (FTC). "
2.	Messenger RNA (mRNA)IBA 01/01/2016 - "In contrast, follicular thyroid carcinomas showed significant upregulation of FOXO4 mRNA.In" 05/01/2008 - "Quantitative RT-PCR showed that almost all the papillary thyroid carcinomas and 13 out of 16 follicular thyroid carcinomas express much higher HMGA2 specific mRNA levels in comparison to normal thyroids and adenomas. " 03/01/2019 - "mRNA levels of ID1, ID2, ID3, and ID4 genes were quantified and their expression was observed by immunohistochemistry in 194 thyroid samples including 68 goiters, 16 follicular adenomas, 75 classic papillary thyroid carcinomas, 18 follicular variants of papillary thyroid carcinoma, 5 follicular thyroid carcinomas, and 1 anaplastic thyroid cancer, besides 11 normal thyroid tissues. " 03/01/2003 - "A significant difference in expression levels was observed between papillary and follicular thyroid carcinomas with the latter having elevated mRNA levels of beta-catenin. " 01/01/2001 - "Especially, they stimulate NIS mRNA expression and iodide uptake in human follicular thyroid carcinoma cells. "
3.	SymportersIBA 01/01/2001 - "In contrast, papillary and follicular thyroid carcinomas demonstrated lower symporter protein expression (20%). " 05/01/2000 - "Positive staining of the symporter protein was performed in the follicular thyroid carcinomas, otherwise, the metastatic tissues could not have demonstrated the protein in the staining. " 11/10/2000 - "A higher percentage of positive results of the symporter mRNA were found in normal benign thyroid tissues and the thyroid tissues of hyperthyroidism, and nodular hyperplasia (84.6%); however follicular adenoma, papillary and follicular thyroid carcinomas demonstrated a lower percentage of expression in the RT-PCR studies (46.7%). " 04/01/2004 - "Differential effects of natural flavonoids on growth and iodide content in a human Na*/I- symporter-transfected follicular thyroid carcinoma cell line."
4.	Iodide Peroxidase (Deiodinase)IBA 03/01/2006 - "The efficacy of the thyroid peroxidase marker for distinguishing follicular thyroid carcinoma from follicular adenoma." 05/01/2012 - "Minimally invasive follicular thyroid carcinoma developed in dyshormonogenetic multinodular goiter due to thyroid peroxidase gene mutation." 01/19/2012 - "Minimal Invasive Follicular Thyroid Carcinoma Developed in Dyshormonogenetic Multinodular Goiter Due to Thyroid Peroxidase Gene Mutation." 09/01/1994 - "Retinoids stimulate type I iodothyronine 5'-deiodinase activity in human follicular thyroid carcinoma cell lines." 01/01/1996 - "Nevertheless, first data indicate that reduced 5'-deiodinase type I expression in tumor tissues can be re-induced by treatment with retinoids at least in follicular thyroid carcinoma. "
5.	Tyrosine Kinase InhibitorsIBA 11/03/2023 - "Tracheoesophageal fistula development following radiotherapy and tyrosine kinase inhibitors in a patient with advanced follicular thyroid carcinoma: a case-based review." 03/01/2005 - "Furthermore, systemic administration of the FGFR tyrosine kinase inhibitor PD173074 resulted in significant inhibition of follicular thyroid carcinoma-derived cell growth in xenografted severe combined immunodeficient mice. " 12/01/2022 - "Approximately 5-10% of patients will have recurrence or metastases that have the potential to become resistant to RAI treatment.1 10-year overall survival rates are reported to be 10% in these patients versus 56% in patients with RAI avid disease.2 Lenvatinib, a multi-tyrosine-kinase inhibitor (TKI), was shown to have a 65% overall response rate in addition to a significant improvement in progression-free survival (PFS), approved to treat RAI-resistant DTTs.3, 4. We are reporting a very rare case of late renal toxicity in a 68-year-old woman with a history of type 2 diabetes and metastatic RAI-resistant follicular thyroid carcinoma (Hurthle cell variant) who developed thrombotic microangiopathy 21 months after initiation of treatment. " 11/03/2023 - "Tracheoesophageal fistulas (TEF) are a rare complication that can occur in patients with radioactive iodine refractory metastatic follicular thyroid carcinoma (FTC) following treatment with radiotherapy (RT) and tyrosine kinase inhibitors (TKI). "
6.	Gemcitabine FDA Link 08/01/2014 - "Furthermore, TSH-nanoliposomes encapsulated with gemcitabine showed improved anticancer efficacy in vitro and in a tumor model of follicular thyroid carcinoma. " 01/01/2010 - "Paclitaxel and gemcitabine are not a valid chemotherapy option, in particular in patients with progressive, nonradioiodine-accumulating follicular thyroid carcinoma, who were already treated by other chemotherapeutic agents."
7.	lenvatinibIBA 06/01/2021 - "A 61-year-old female patient with a follicular thyroid carcinoma (stage IV) and taking lenvatinib presented to our Oral Medicine Unit with a painful non-healing ulcer with bone exposure, in the posterior right maxilla, after an extraction of a molar tooth which occurred 4 months previously. " 12/01/2022 - "Approximately 5-10% of patients will have recurrence or metastases that have the potential to become resistant to RAI treatment.1 10-year overall survival rates are reported to be 10% in these patients versus 56% in patients with RAI avid disease.2 Lenvatinib, a multi-tyrosine-kinase inhibitor (TKI), was shown to have a 65% overall response rate in addition to a significant improvement in progression-free survival (PFS), approved to treat RAI-resistant DTTs.3, 4. We are reporting a very rare case of late renal toxicity in a 68-year-old woman with a history of type 2 diabetes and metastatic RAI-resistant follicular thyroid carcinoma (Hurthle cell variant) who developed thrombotic microangiopathy 21 months after initiation of treatment. "
8.	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA 05/01/2011 - "Decrease in dipeptidyl peptidase IV activity is linked to the efficacy of differentiating compounds in follicular thyroid carcinoma cell lines."
9.	Proteins (Proteins, Gene)FDA Link 12/03/2015 - "Analysis of the DHS sequences uncovers one mutation (chr18: 52417839G>C) in the tumour cells of a patient with follicular thyroid carcinoma, which affects the binding of the tumour suppressor protein p53 and correlates with decreased expression of its target gene TXNL1. " 01/01/2013 - "As in follicular thyroid carcinoma cells, TSH also induced MT1 protein in primary human thyrocytes, which was PKC dependent as well. " 01/24/2017 - "PAX8-PPARG fusion protein (PPFP) results from a t(2;3)(q13;p25) chromosomal translocation, is found in 30% of follicular thyroid carcinomas, and demonstrates oncogenic capacity in transgenic mice. " 01/01/2016 - "Furthermore, by evaluation of AUF1 or HuR expression, or combination of both proteins on total tissue lysates, we were able to demonstrate a significant difference between follicular adenoma and follicular thyroid carcinoma. " 10/01/2014 - "The PAX8-PPARG gene fusion results in the production of a Pax-8-PPAR-γ fusion protein (PPFP), which is found in approximately one-third of follicular thyroid carcinomas, as well as some follicular-variant papillary thyroid carcinomas. "
10.	MicroRNAs (MicroRNA)IBA 07/10/2015 - "Based on recent studies about miRNA expression in papillary or follicular thyroid carcinomas, the expression profiles of several thyroid relative miRNAs were investigated in one DTC cell line, derived from normal DTC cells by radioiodine treatment. " 01/01/2013 - "In this study we demonstrate that different histopathological types of follicular thyroid carcinomas have distinct miRNA expression profiles. " 10/21/2021 - "Whole-genome Sequencing of Follicular Thyroid Carcinomas Reveal Recurrent Mutations in MicroRNA Processing Subunit DGCR8." 01/01/2019 - "In Silico Integration Approach Reveals Key MicroRNAs and Their Target Genes in Follicular Thyroid Carcinoma." 04/11/2016 - "MATERIAL AND METHODS We conducted qRT-PCR analysis to detect the expressions of several microRNAs in 42 follicular thyroid carcinoma patients and 42 controls. "

Therapies and Procedures

1.	Therapeutics 09/01/1996 - "Mean post-diagnostical follow-up was 73 mo, mean follow-up after diagnosis of metastatic spread was 48 mo. Follicular thyroid carcinoma remained as stable disease in 7 of 11 patients, 6 of whom showed metastatic disease after a mean of 20 mo, and only 1 complete remission was achieved using high-dose therapies, with progressive disease in the remaining patients. " 03/01/2023 - "Excellent Response to Multimodal Therapy Approach in Hyperfunctioning Metastatic Follicular Thyroid Carcinoma Diagnosed on 123 I-SPECT/Ultrasound Fusion Imaging." 07/07/2022 - "Papillary and follicular thyroid carcinomas can be treated surgically and with radioiodine therapy, whereas therapeutic options for advanced stage IV medullary and for anaplastic tumours are limited. " 12/01/2015 - "The use of SPECT-CT improves accuracy of post-radioiodine therapy imaging and changes the management strategy in a case of advanced follicular thyroid carcinoma." 01/01/2014 - "In fact, radioiodine can be termed as targeted therapy of papillary and follicular thyroid carcinoma. "
2.	Thyroidectomy 11/01/1993 - "This study was designed to assess the efficacy of thyroid ablation by 1110 MBq of 131I (30 mCi) in patients who had near-total thyroidectomy for papillary, mixed or follicular thyroid carcinoma. " 08/01/2017 - "The present study reports the case of a 65-year-old male who underwent total thyroidectomy for a follicular thyroid carcinoma, Hürthle cell variant, in February 2005. " 09/01/2008 - "This study consisted of 100 consecutive patients (ages 15-81 years; 84 women), who underwent thyroidectomy for papillary or follicular thyroid carcinoma between 2005 and 2006. " 01/01/2023 - "We highlight that if local recurrence occurs in discrete anatomical tissue planes, or in the thyroid bed following open total thyroidectomy for 'benign multinodular goitre', the possibility of this rare presentation of follicular thyroid carcinoma should be considered." 04/28/2022 - "A 59-year-old woman with follicular thyroid carcinoma underwent total thyroidectomy followed by radioiodine treatment. "
3.	Radiotherapy 01/01/2022 - "High Prevalence of Gene Fusions and Copy Number Alterations in Pediatric Radiation Therapy-Induced Papillary and Follicular Thyroid Carcinomas." 01/01/1994 - "Between 1969 and 1991, 113 patients with differentiated thyroid carcinoma (follicular and papillary) received radical dose megavoltage external beam radiotherapy. " 09/01/1984 - "Female residents of 13 counties of Western Washington, in whom papillary, follicular, or mixed papillary-follicular thyroid carcinomas had been diagnosed between 1974 and 1979 were interviewed regarding their medical and reproductive histories and past exposure to radiation treatments. " 10/15/1998 - "To determine the relations among extent of surgery, radioiodine therapy, and external radiation therapy in the treatment of high-risk papillary and non-Hürthle-cell follicular thyroid carcinoma. " 07/01/2017 - "Follicular Thyroid Carcinoma Presenting as Large Solitary Vertebral Metastasis: Report of Two Unusual Cases Treated with Radiotherapy."
4.	Lymph Node Excision (Lymph Node Dissection) 08/01/2011 - "A literature search was carried out in Medline and EMBase using the keywords differentiated/papillary/follicular thyroid carcinoma, lymphadenectomy, lymph node dissection. " 05/01/2011 - "Lymph node dissection must be planned only in the case of large follicular thyroid carcinomas. " 12/01/2008 - "We do not recommend lymph node dissection in follicular thyroid carcinomas <4 cm." 07/01/2004 - "Lymph node dissection in papillary or follicular thyroid carcinoma." 07/01/2010 - "Total thyroidectomy and lymph node dissection was performed with a final histopathological diagnosis of follicular thyroid carcinoma. "
5.	Neck Dissection (Radical Neck Dissection) 06/01/2020 - "There is no indication for prophylactic central neck dissection in follicular thyroid carcinomas, which primarily metastasize hematogenously. " 12/01/1994 - "She underwent subtotal thyroidectomy with modified neck dissection for a follicular thyroid carcinoma, suspected on preoperative diagnosis. " 01/01/2022 - "Twenty-five patients met the following inclusion criteria: classic histology of papillary or follicular thyroid carcinoma treated with total thyroidectomy and neck dissection followed by adjuvant I-131 treatment in our department between January 1, 2003, and December 31, 2013; adult age of > 21 years; and American Joint Committee on Cancer (AJCC ) stage (8th edition) of T0-3, N1b with ≥ 5 positive nodes, and M0. " 01/01/1990 - "Because of the prognostic influence of multiple tumor growth and the slight prognostic influence of lymph node metastases we recommend a total thyroidectomy with neck dissection for follicular thyroid carcinoma." 07/01/2020 - "ATA = American Thyroid Association; CND = central neck dissection; DTC = differentiated thyroid cancer; ETE = extrathyroidal extension; FNA = fine needle aspiration; FTC/HCC = follicular thyroid carcinoma/Hurthle cell carcinoma; NIFTP = noninvasive follicular thyroid neoplasm with papillary-like nuclear features; OR = odds ratio; PTC = papillary thyroid cancer; US = ultrasound."