Gelsolin

A 90-kDa protein produced by macrophages that severs ACTIN filaments and forms a cap on the newly exposed filament end. Gelsolin is activated by CALCIUM ions and participates in the assembly and disassembly of actin, thereby increasing the motility of some CELLS.

Also Known As:

Networked: 446 relevant articles (11 outcomes, 49 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kiuru-Enari, Sari: 15 articles (01/2015 - 06/2002)
2.	Stossel, Thomas P: 9 articles (10/2015 - 01/2002)
3.	Kelly, Jeffery W: 9 articles (10/2013 - 11/2003)
4.	Chauhan, Abha: 8 articles (03/2014 - 03/2008)
5.	Chauhan, Ved: 8 articles (03/2014 - 03/2008)
6.	Balch, William E: 8 articles (10/2013 - 11/2003)
7.	Lee, Po-Shun: 7 articles (10/2015 - 03/2006)
8.	Ji, Lina: 7 articles (01/2015 - 03/2008)
9.	Page, Lesley J: 5 articles (10/2013 - 11/2003)
10.	Dogan, Ahmet: 5 articles (09/2013 - 02/2011)

Related Diseases

1.	Stroke (Strokes) 01/01/2011 - "Gelsolin could be a promising drug for protection against neurodegeneration following ischemic stroke." 01/01/2011 - "The protective effects of plasma gelsolin on stroke outcome in rats." 01/16/2013 - "Gelsolin improved the prognostic value of National Institutes of Health Stroke Scale score for 6-month unfavorable outcome, but not for 6-month mortality. " 01/16/2013 - "The prognostic value of gelsolin was similar to that of National Institutes of Health Stroke Scale score for 6-month clinical outcomes. " 01/16/2013 - "Plasma gelsolin level was highly correlated with National Institutes of Health Stroke Scale score. "
2.	Neoplasms (Cancer) 01/01/2011 - "The expression of gelsolin was significantly upregulated in 78% of patients with cervical cancer, and gelsolin was selected for further study. " 11/01/2007 - "The aim of this study was to gain more evidence to support the role of Egr-1 in the suppression of cancer cell growth and to examine the potential correlation between Egr-1 and gelsolin. " 10/01/2004 - "High level gelsolin expression and variable gelsolin expression are adverse prognostic factors for NSCLC in this study, which might manifest the high motility and heterogeneity of tumor cells, two distinguishing characteristics for tumors with potentially enhanced invasive and dissemination capabilities." 10/07/2014 - "Here, we report higher gelsolin (GSN) levels in chemoresistant gynecological cancer cells compared with their sensitive counterparts. " 10/07/2014 - "Cell fate regulation by gelsolin in human gynecologic cancers."
3.	Amyloidosis 05/01/2015 - "Insertion of the therapeutic nanobody gene into the gelsolin amyloidosis mouse genome resulted in improved muscle contractility. " 05/01/2015 - "We report a transgenic, GSN nanobody 11 secreting mouse that was used for crossbreeding with gelsolin amyloidosis mice. " 03/01/2015 - "Hereditary gelsolin amyloidosis (AGel amyloidosis) is a rare, dominantly inherited systemic disease with worldwide distribution, caused by a gelsolin gene mutation. " 03/01/2015 - "Relation of gelsolin amyloidosis and periodontal health." 01/01/2015 - "Finnish type of hereditary gelsolin amyloidosis (FGA) is one of the most common diseases of Finnish disease heritage. "
4.	Inflammation 02/01/2015 - "Circulating gelsolin can modulate inflammation and is correlated with HD mortality. " 11/01/2012 - "Intracellular Flightless I (Flii), a gelsolin family member, has been found to have roles modulating actin regulation, transcriptional regulation and inflammation. " 06/01/2012 - "Gelsolin seems essential in many processes, including inflammation, cell motility, neural recovery, apoptosis and even carcinogenesis. " 05/01/2009 - "Plasma gelsolin (pGSN) binds actin and bioactive mediators to localize inflammation. " 01/01/2008 - "Plasma gelsolin as a biomarker of inflammation."
5.	Breast Neoplasms (Breast Cancer) 01/01/2013 - "Low level of Gelsolin was found in metastatic patients (p=0.002) and patients who died from breast cancer (P=0.03) compared to disease free patients at final follow up. " 01/01/2013 - "This study aimed to investigate the germline mutations and expressional profile of Gelsolin in human breast cancer tissues. " 10/01/2015 - "To determine its effect on migration, gelsolin expression was down-regulated as well as overexpressed in breast cancer cell lines. " 01/01/2015 - "Further analyses, performed using a panel of breast cancer cell lines, allowed us to further elucidate the signaling network that might modulate the expression of gelsolin in breast cancer." 10/01/2013 - "By this approach, we identified the actin-severing protein Gelsolin as binding partner for Nm23-H1, verifying their interaction by coimmunoprecipitation in 4T1 cells as well as in human MCF7, MDA-MB-231T, and MDA-MB-435 breast cancer cells. "

Related Drugs and Biologics

1.	Complementary DNA (cDNA)
2.	DNA (Deoxyribonucleic Acid)
3.	Blood Proteins (Serum Proteins)
4.	Vitamin D-Binding Protein
5.	Diclofenac (SR 38)
6.	Carrageenan
7.	Amyloid (Amyloid Fibrils)
8.	Prealbumin (Transthyretin)
9.	Peptides
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Aftercare (After-Treatment)
3.	Transplants (Transplant)
4.	Intensive Care (Surgical Intensive Care)
5.	Kidney Transplantation