Villous Adenoma

An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)

Also Known As:

Networked: 200 relevant articles (4 outcomes, 9 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Adenoma (Adenomas)
2.	Carcinoma (Carcinomatosis)
3.	Adenocarcinoma
4.	Polyps
5.	Neoplasms (Cancer)

Experts

1.	Han, Ying: 2 articles (05/2009 - 12/2008)
2.	Zhou, Zhi-yong: 2 articles (05/2009 - 12/2008)
3.	Wang, Lu-ping: 2 articles (05/2009 - 12/2008)
4.	Epstein, Jonathan I: 2 articles (09/2008 - 02/2002)
5.	Corfield, A P: 2 articles (11/2001 - 02/2000)
6.	Warren, B F: 2 articles (11/2001 - 02/2000)
7.	Thomas, M G: 2 articles (11/2001 - 02/2000)
8.	Sylvester, P A: 2 articles (11/2001 - 02/2000)
9.	Shiba, Hiroaki: 1 article (03/2015)
10.	Tsutsumi, Jun: 1 article (03/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Villous Adenoma:

1.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 02/01/1994 - "PDT holds promise in the non-surgical management of villous adenomas, particularly after initial tumour debulking with the Nd-YAG laser." 01/01/1998 - "Two patients with rectal villous adenomas treated with mTHPc showed 60-80% reduction in size (observed endoscopically) within few days after PDT, with better effects for treatment carried out 4 rather than 2 days after the sensitization. "
2.	MucinsIBA 12/01/1984 - "Villous adenoma was weakly positive in the PAS stain but negative in A1-B1 and HID stains, showing that it did not produce mucin. " 02/01/2015 - "GNAS mutations are associated with mucin production in low-grade appendiceal mucinous neoplasms, villous adenomas, and carcinomas." 11/01/1998 - "Included among these neoplasms are papillary and villous adenomas, lesions with mucinous duct ectasia and mucin-producing carcinomas. " 11/01/2001 - "Here we examined secreted mucins in tubular, tubulovillous and villous adenomas of the rectum using non-VNTR antibodies designed to assess mature mucin. " 01/01/2010 - "A total of 454 polyp specimens comprising 36 hyperplastic polyps, 15 serrated adenomas, 258 tubular adenomas, 114 tubulovillous adenomas, and 31 villous adenomas were included in this study, and were immunostained for MUC1, MUC2, MUC5AC and MUC6 by using mucin specific antibodies. "
3.	AntibodiesIBA 11/01/2001 - "Here we examined secreted mucins in tubular, tubulovillous and villous adenomas of the rectum using non-VNTR antibodies designed to assess mature mucin. " 05/01/2006 - "Immunohistochemistry with the antibodies p16, p53, and p63 was performed in tubular, tubular-villous, and villous adenomas (n = 30) and in well, moderately, and poorly differentiated adenocarcinomas (n = 30). " 01/01/2010 - "A total of 454 polyp specimens comprising 36 hyperplastic polyps, 15 serrated adenomas, 258 tubular adenomas, 114 tubulovillous adenomas, and 31 villous adenomas were included in this study, and were immunostained for MUC1, MUC2, MUC5AC and MUC6 by using mucin specific antibodies. " 06/15/1989 - "We utilized domain-specific probes and polyclonal antibodies against CEA-related antigens to study sodium butyrate-induced expression of the CEA gene family in a villous adenoma-derived cell line, which is nontumorigenic in nude mice (VACO 235), and two colonic carcinoma cell lines known to respond to sodium butyrate exposure by phenotypic differentiation (HT-29 and LS 174T). "
4.	AntigensIBA 10/15/1986 - "The antigens were readily detectable on normal stomach epithelium, in villous adenomas and in inflammatory bowel mucosa. " 01/01/1983 - "Another monosialoganglioside is an antigen expressed by cells of gastrointestinal tract tumours such as of the pancreas, stomach and large bowel and by cells of villous adenomas of the colon, but not by cells of normal colonic mucosa. " 01/01/1983 - "Thus, the percentage of antigen-positive cells increased from 18 and 43% to 70% of cultures from tubular, villotubular and villous adenomas, respectively. " 09/01/2008 - "Immunohistochemical expression of prostatic antigens in adenocarcinoma and villous adenoma of the urinary bladder." 01/01/1992 - "Because gastrointestinal malignancies resemble each other in their expression of many soluble antigens, we compared the cytokeratins of seven colonic, three gastric, six pancreatic, and one duodenal carcinoma cell lines, and one colon villous adenoma cell line. "
5.	SialomucinsIBA 06/01/1989 - "N-acetylated and C7,C9 O-acetylated sialomucin were mainly obtained in those adenomas with moderate and severe dysplasia (55-64.3%) and the proportion was even higher in cases of villous adenomas, familial polyps, adenomas with focal cancer and advanced carcinoma. " 01/01/1987 - "Acid mucosubstances distribution pattern showed that sialomucin predominated in the colon mucosa harboring a carcinoma and in the tubulo-villous polyps as well as in the mucosa remote from adenocarcinoma and from the two cases of familial polyposis coli histologically considered as tubulo-villous adenomas. " 01/01/1992 - "Histochemical study disclosed a predominant sialomucin secretion by villous adenoma and sulfomucin secretion by epithelial cells lining the accessory or main caudal pancreatic ducts. " 09/01/1990 - "In contrast, malignant lesions (pancreatic adenocarcinoma [12 cases], cystadenocarcinoma [two cases]) or premalignant lesions (mucinous cystadenoma [one case], ductectatic mucinous cystadenoma [four cases], villous adenoma of the main pancreatic duct [two cases]) showed a predominant sialomucin secretion, except for three poorly differentiated pancreatic carcinomas that did not show mucin staining. " 05/01/1993 - "Neutral mucins, acidic sulphomucins, and sialomucins were identified within the villous adenoma and adjacent areas of cystitis glandularis. "
6.	sulfomucinIBA 08/01/1981 - "Mucus with more acid histochemical properties (PAS AM 2.5 blue colouration) with sulphomucin (alcioanophilia at pH 1) was secreted by carcinomas of papillary structure (7 cases), the majority intensely mucus forming similarly as villous adenoma. " 01/01/1992 - "Histochemical study disclosed a predominant sialomucin secretion by villous adenoma and sulfomucin secretion by epithelial cells lining the accessory or main caudal pancreatic ducts. " 05/01/1993 - "Neutral mucins, acidic sulphomucins, and sialomucins were identified within the villous adenoma and adjacent areas of cystitis glandularis. "
7.	Messenger RNA (mRNA)IBA 02/01/2000 - "10 villous adenomas showed mature MUC5AC glycoprotein and all 11 expressed MUC5AC mRNA. " 03/01/1989 - "We used a sensitive RNA:RNA in situ hybridization technique to study steady-state levels of c-myc proto-oncogene mRNA in primary human colon adenocarcinomas, villous adenomas, and normal mucosa samples. "
8.	RNA (Ribonucleic Acid)IBA 01/01/2009 - "Total RNA was extracted, amplified, and biotinylated from colonic biopsies of 15 patients with CRC, 15 with villous adenoma and 8 normal controls. " 03/01/1989 - "c-myc RNA was detectable in all the carcinomas (eight) and villous adenomas (four), but steady-state levels varied from high to low in different tumors with similar histology. " 03/01/1989 - "We used a sensitive RNA:RNA in situ hybridization technique to study steady-state levels of c-myc proto-oncogene mRNA in primary human colon adenocarcinomas, villous adenomas, and normal mucosa samples. "
9.	Proteins (Proteins, Gene)IBA 01/01/2001 - "In this study, p185 and p53 overexpression was analyzed in colorectal adenomas (22 tubular adenomas and 2 tubulo-villous adenomas) and moderately differentiated adenocarcinomas (n = 22) in order to determine whether there was a relationship between these two proteins. " 01/01/1991 - "Using a silver staining technique (AgNOR technique), we have investigated the nucleolar organizer-associated proteins (NORs) in formalin-fixed paraffin embedded specimens of 20 large bowel adenocarcinomas, 10 tubular adenomas with low grade dysplasia and 10 villous adenomas with high grade dysplasia; the mean number of small NOR (SN), large NOR (LN) and total NOR (TN) was determined for each case. "
10.	Bile Acids and Salts (Bile Acids)IBA 09/01/2002 - "The study does not support an association between colorectal cancer and fecal bile acids or pH. However, there is evidence that increases in major bile acids are associated with villous adenomas." 05/01/1986 - "Cholera, villous adenoma and bile salts are among the causes of secretory diarrhea. " 09/01/2002 - "Although there was no overall association between colorectal adenomas and fecal bile acids or pH, villous adenomas were associated with increasing concentrations of major bile acids and decreasing concentration of minor bile acids, and there was a suggestion of an inverse association with an acid pH. High levels of fecal calcium were associated with a reduced risk of both colorectal cancer and adenoma, but this was not statistically significant. "

Therapies and Procedures

1.	Solid-State Lasers 04/01/1999 - "Endoscopic Nd:YAG laser therapy for villous adenomas of the right colon." 07/01/1996 - "Endoscopic Nd:YAG laser therapy for villous adenomas of the colon and rectum." 02/01/1994 - "Endoscopic Nd-YAG laser surgery in the treatment of villous adenomas of the rectum." 03/01/1986 - "Between November, 1978 and July, 1985 36 recurrent broad-based villous adenomas in the gastrointestinal tract were treated with the Nd:YAG laser. " 12/05/1992 - "It would appear that endoscopic resection prior to Nd:YAG laser photocoagulation is a safe and effective method for the destruction of colorectal villous adenomas."
2.	Light Coagulation 07/01/1988 - "We report the results of endoscopic photocoagulation in the treatment of villous adenomas of the rectum in 49 consecutive patients (26 males, and 23 females, mean age: 74 years). " 12/05/1992 - "It would appear that endoscopic resection prior to Nd:YAG laser photocoagulation is a safe and effective method for the destruction of colorectal villous adenomas." 05/01/1991 - "It would appear that the treatment with endoscopic resection prior to Nd:YAG laser photocoagulation is a safe and effective method in the destruction of colorectal villous adenomas." 12/05/1992 - "Endoscopic snare resection prior to Nd:YAG laser photocoagulation was used to treat benign colorectal villous adenoma. " 05/01/1991 - "The association of endoscopic resection with Nd:YAG laser photocoagulation was used to treat benign colorectal villous adenomas. "
3.	Laser Therapy (Surgery, Laser) 07/01/1988 - "In conclusion, these results confirm the efficacy of laser therapy in small- and intermediate-sized villous adenomas of the rectum. " 03/01/1994 - "Endoscopic laser therapy for small villous adenomas of the duodenum." 05/01/1990 - "The importance of polypectomy prior to laser therapy in broad-based villous adenomas." 05/01/1990 - "A villous adenoma of the distal duodenum treated by laser therapy." 09/01/1989 - "The laser therapy should be therefore considered in treating large sessile duodenal villous adenoma occurring in inoperable patients. "
4.	Heterologous Transplantation (Xenotransplantation) 11/01/1994 - "We conclude that the human-scid xenograft described here represents a viable animal model with which to study the potential malignant dedifferentiation of villous adenomas over a prolonged period of time and to evaluate the possible contribution of selected oncogenic vectors on the malignant transformation of these adenomas."
5.	Enema (Enemas) 01/01/2010 - "We present a case of giant villous adenoma to evaluate the contribution of its radiological features including double contrast barium enema, computed tomography and magnetic resonance imaging examinations for the differential diagnosis." 09/01/1986 - "Villous adenoma may have a specific appearance on barium enema examination but specific CT findings of villous adenoma have not been previously described. " 10/01/1975 - "The radiological appearances on double contrast barium enema examination of 14 cases of villous adenoma are described and illustrated. " 01/01/1993 - "Subsequent barium enema and fiberoptic proctocolonoscopic examinations, which were available on 32 of 59 cases, revealed 6 adenomatous polyps, one villous adenoma with focal severe atypia, and 4 cases of diverticular disease. " 11/01/1990 - "We have reported the case of a 58-year-old woman with nonspecific abdominal complaints in whom barium enema and subsequent colonoscopy showed a 3 cm lobulated adenocarcinoma within a villous adenoma arising from the appendiceal stump. "