Hidrocystoma

A cystic form of sweat gland adenoma (ADENOMA, SWEAT GLAND). It is produced by the cystic proliferation of apocrine secretory glands. It is not uncommon, occurring in adult life in no particular age group, with males and females equally affected. The commonest site is around the eye, particularly lateral to the outer canthus. It is cured by surgical removal. (Stedman, 25th ed; Rook et al., Textbook of Dermatology, 4th ed, p2410)

Also Known As:

Networked: 57 relevant articles (8 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hyperhidrosis
2.	Hidradenitis Suppurativa
3.	Benign Familial Pemphigus (Hailey Hailey Disease)
4.	Gustatory Sweating (Frey's Syndrome)
5.	Psoriasis (Pustulosis Palmaris et Plantaris)

Experts

1.	Novitskaya, E: 2 articles (11/2013 - 06/2013)
2.	Rene, C: 2 articles (11/2013 - 06/2013)
3.	de Peralta-Venturina, Mariza N: 1 article (12/2015)
4.	Balzer, Bonnie L: 1 article (12/2015)
5.	Frishberg, David P: 1 article (12/2015)
6.	Mertens, Richard B: 1 article (12/2015)
7.	Ayhan, Erhan: 1 article (05/2015)
8.	Ataseven, A: 1 article (12/2014)
9.	Tunçez Akyürek, F: 1 article (12/2014)
10.	Kurtipek, E: 1 article (12/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hidrocystoma:

1.	Botulinum Toxins (Botulinum Toxin)IBA 01/01/2009 - "Intralesional botulinum toxin A offers a novel treatment for patients with multiple hidrocystomas that have failed other therapies." 01/01/2011 - "Multiple eccrine hidrocystomas treated with botulinum toxin A." 01/01/2009 - "We report 2 patients, a 45- and a 56-year-old woman, with multiple facial eccrine hidrocystomas suggested by dermatoscopy, confirmed by histology and treated with botulinum toxin A with excellent results. " 01/01/2009 - "Multiple eccrine hidrocystomas--from diagnosis to treatment: the role of dermatoscopy and botulinum toxin." 01/01/2009 - "Treatment for multiple periorbital eccrine hidrocystomas: botulinum toxin A."
2.	Trichloroacetic AcidIBA 04/15/2007 - "Findings suggested that chemical ablation with trichloroacetic acid may be a useful treatment for apocrine hidrocystomas in cats." 07/01/2009 - "Multiple apocrine hidrocystomas of the eyelids treated with trichloroacetic acid." 04/15/2007 - "Use of chemical ablation with trichloroacetic acid to treat eyelid apocrine hidrocystomas in a cat." 03/01/2005 - "Treatment of multiple apocrine hidrocystomas with trichloroacetic acid." 03/01/2005 - "Although these lesions have been treated successfully with meticulous surgical extirpation and electrosurgery, this report describes the successful treatment of two patients, each with multiple large (>7 mm) periocular apocrine hidrocystomas by either chemical ablation of the cystic epithelium with trichloroacetic acid (TCA) or surgical excision. "
3.	S100 Proteins (S 100 Protein)IBA 04/01/1986 - "The detection of S-100 protein was considered to be more helpful in classifying hidrocystomas than that of CEA." 04/01/1986 - "S-100 protein was detected in the cells of one solitary eccrine hidrocystoma, but not in those of 2 cases of "classic", multiple-lesion type of eccrine hidrocystoma. " 04/01/1986 - "On the bases of this immunostaining pattern in normal sweat glands, we attempted to correlate the origin of 8 cases of hidrocystoma to the presence of S-100 protein-positive cells. " 04/01/1986 - "The histogenesis of hidrocystomas was examined by the use of immunostaining for S-100 protein. " 04/01/1986 - "S-100 protein-positive cells in hidrocystomas."
4.	Atropine (Hyoscyamine)FDA LinkGeneric 02/01/2009 - "Successful treatment of multiple eccrine hidrocystoma with topical atropine sulfate ointment." 12/01/2006 - "Eccrine hidrocystomas have been successfully treated with topical atropine solution. " 11/01/2004 - "Two cases of multiple eccrine hidrocystomas are reported who showed no response to 1% atropine ointment." 11/01/2004 - "Multiple eccrine hidrocystomas: report of two cases treated unsuccessfully with atropine ointment." 05/01/2001 - "Efficacy and safety of topical atropine in treatment of multiple eccrine hidrocystomas."
5.	aluminum chlorideIBA 01/01/2010 - "Topical 0.03% Atropine vs. 15% aluminum chloride in treating multiple eccrine hidrocystomas: a randomized single blind controlled study."
6.	Melanins (Melanin)IBA 03/01/1999 - "These findings suggest that the present case was a hidrocystoma of eccrine secretory coil with abnormal melanin accumulation." 04/01/1985 - "A case of pigmented apocrine hidrocystoma is presented with evidence of melanin as the underlying mechanism of the pigmentation. " 04/01/2014 - "No hidrocystomas had melanin deposits, and one case had hemosiderin deposits in a scarred cyst wall in addition to cyst lipofuscin pigments. "
7.	Keratins (Keratin)IBA 02/01/1999 - "Cytokeratin expression in 8 cases of multiple type of unequivocal eccrine hidrocystoma was analyzed immunohistochemically. " 02/01/1999 - "Immunohistochemical analysis of cytokeratin expression in multiple eccrine hidrocystoma." 07/01/1999 - "Immunohistochemical analysis of cytokeratin expression in apocrine cystadenoma or hidrocystoma." 04/01/1997 - "In addition, they expressed human milk fat globulin 1. Tumors diagnosed as eccrine hidrocystomas expressed a keratin pattern of excretory type. " 04/01/1997 - "Apocrine cystadenoma, apocrine hidrocystoma, and eccrine hidrocystoma: three distinct tumors defined by expression of keratins and human milk fat globulin 1."
8.	clopidogrel (Plavix)FDA Link 11/01/2013 - "Comment on 'Spontaneous haemorrhage in an eyelid hidrocystoma in a patient treated with clopidogrel'." 11/01/2013 - "'Spontaneous haemorrhage in an eyelid hidrocystoma in a patient treated with clopidogrel' by Tehrani et al." 06/01/2013 - "Spontaneous haemorrhage in an eyelid hidrocystoma in a patient treated with clopidogrel."
9.	Phenobarbital (Luminal)FDA Link 10/01/1996 - "Apocrine tumors such as apocrine hidrocystoma, syringocystadenoma papilliferum, or hidradenoma papilliferum showed intense CD44 positivity in the portion of cells in contact with the neighboring stroma and focally on the luminal side of cells with apocrine secretion. " 07/01/1995 - "In our opinion, multiple hidrocystomas of the face are apocrine hidrocystomas in which characteristic 'decapitation' secretion has been effaced by the pressure of cyst contents against the lining epithelium; only after serial sections is it possible to identify some areas of the cyst lining showing apocrine secretion in the luminal border of columnar cells."
10.	ParaffinIBA 06/01/2009 - "Nine paraffin embedded biopsies of eyelid hidrocystoma were retrieved from our archives. " 04/01/2000 - "Enzymatic cell separation specimens were prepared from paraffin-embedded tissues of 18 sweat gland carcinomas (14 porocarcinomas, one classic eccrine adenocarcinoma, two microcystic adnexal carcinomas and one mostly ductal apocrine carcinoma) and 47 benign sweat gland tumours (three syringocystadenomas, five spiradenomas, 14 cylindromas, three syringomas, seven nodular hidradenomas, 10 cutaneous mixed tumours, four poromas and one apocrine hidrocystoma). "

Therapies and Procedures

1.	Electrosurgery 04/01/2001 - "The efficacy of electrosurgery and excision in treating patients with multiple apocrine hidrocystomas." 04/01/2001 - "To compare the results of electrosurgery and excision in treating multiple apocrine hidrocystomas. " 03/01/2005 - "Although these lesions have been treated successfully with meticulous surgical extirpation and electrosurgery, this report describes the successful treatment of two patients, each with multiple large (>7 mm) periocular apocrine hidrocystomas by either chemical ablation of the cystic epithelium with trichloroacetic acid (TCA) or surgical excision. "
2.	Gas Lasers 06/01/1989 - "Although solitary apocrine hidrocystomas are easily treated with excision, we had good results employing carbon dioxide laser vaporization in the treatment of numerous hidrocystomas." 01/01/2009 - "While numerous treatment modalities exist for solitary hidrocystomas including simple excision, electrodesiccation, and CO2 laser, treatment of multiple hidrocystomas can be challenging. " 06/01/2001 - "Carbon dioxide laser is an efficient method of the treatment for multiple apocrine hidrocystomas." 06/01/2001 - "Multiple apocrine hidrocystomas: treatment with carbon dioxide laser vaporization." 05/01/2013 - "Treatment of multiple eccrine hidrocystomas with isotretinoin followed by carbon dioxide laser."
3.	Dye Lasers 12/01/2007 - "Lack of effect of the pulsed-dye laser in the treatment of multiple eccrine hidrocystomas: a report of two cases." 02/01/2006 - "Multiple eccrine hidrocystomas: successful treatment with the 595 nm long-pulsed dye laser." 10/01/2001 - "The 585nm pulsed dye laser can effectively treat eccrine hidrocystomas. " 10/01/2001 - "Pulsed dye laser treatment of multiple eccrine hidrocystomas: a novel approach." 06/01/2009 - "Multiple eccrine hidrocystomas--response to treatment with carbon dioxide and pulsed dye lasers."
4.	Semiconductor Lasers 11/01/2005 - "Multiple apocrine hidrocystoma of the face treated with a 1450-nm diode laser."
5.	Laser Therapy (Surgery, Laser) 10/01/1996 - "[Argon laser therapy of multiple eccrine cysts of sweat gland efferent ducts (eccrine hidrocystomas)]."