Hidrocystoma

A cystic form of sweat gland adenoma (ADENOMA, SWEAT GLAND). It is produced by the cystic proliferation of apocrine secretory glands. It is not uncommon, occurring in adult life in no particular age group, with males and females equally affected. The commonest site is around the eye, particularly lateral to the outer canthus. It is cured by surgical removal. (Stedman, 25th ed; Rook et al., Textbook of Dermatology, 4th ed, p2410)

Also Known As:

Networked: 82 relevant articles (12 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hyperhidrosis
2.	Hidradenitis Suppurativa
3.	Pachyonychia Congenita (Jadassohn-Lewandowsky Syndrome)
4.	Benign Familial Pemphigus (Hailey Hailey Disease)
5.	Gustatory Sweating (Frey's Syndrome)

Experts

1.	Daudén, E: 2 articles (02/2017 - 05/2001)
2.	Sanz-Sánchez, T: 2 articles (02/2017 - 05/2001)
3.	Novitskaya, E: 2 articles (11/2013 - 06/2013)
4.	Rene, C: 2 articles (11/2013 - 06/2013)
5.	Azevedo, Mariane G: 1 article (01/2022)
6.	Bennardo, Luigi: 1 article (01/2022)
7.	Cannarozzo, G: 1 article (01/2022)
8.	Fazia, G: 1 article (01/2022)
9.	Nisticò, S P: 1 article (01/2022)
10.	Pigatto, João A T: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hidrocystoma:

1.	Trichloroacetic AcidIBA 04/15/2007 - "Findings suggested that chemical ablation with trichloroacetic acid may be a useful treatment for apocrine hidrocystomas in cats." 01/01/2022 - "There are several reports of application of trichloroacetic acid (TCA) for treatment of eyelid apocrine hidrocystomas with high success rates in humans. " 01/01/2022 - "Trichloroacetic Acid Injection for Treatment of Eyelid Apocrine Hidrocystomas in a Cat." 07/01/2009 - "Multiple apocrine hidrocystomas of the eyelids treated with trichloroacetic acid." 04/15/2007 - "Use of chemical ablation with trichloroacetic acid to treat eyelid apocrine hidrocystomas in a cat."
2.	Type A Botulinum Toxins (Botox)FDA Link 10/01/2018 - "Intralesional botulinum toxin-A for treatment of multiple hidrocystomas is a simple and well-tolerated procedure. " 10/01/2018 - "Intralesional botulinum toxin-A injection for the treatment of multiple eccrine hidrocystomas." 02/01/2017 - "Herein we describe the effective use of botulinum toxin A in a 29-year-old man with multiple facial apocrine hidrocystomas, which, to our knowledge, has not yet been reported in the English-language literature." 02/01/2017 - "Recent reports illustrate that multiple eccrine hidrocystomas have been successfully treated with botulinum toxin A. " 02/01/2017 - "Multiple apocrine hidrocystomas successfully treated with botulinum toxin A."
3.	Botulinum Toxins (Botulinum Toxin)IBA 01/01/2009 - "Multiple eccrine hidrocystomas--from diagnosis to treatment: the role of dermatoscopy and botulinum toxin." 05/01/2003 - "Multiple eccrine hidrocystomas: a new therapeutic option with botulinum toxin." 05/01/2009 - "Besides palmar and plantar hyperhidrosis, botulinum toxin has demonstrated efficacy in different conditions associated with hyperhidrosis, such as dyshidrosis, multiple eccrine hidrocystomas, hidradenitis suppurativa, Frey syndrome, but also in different conditions worsened by hyperhidrosis such as Hailey-Hailey disease, Darier disease, inversed psoriasis, aquagenic palmoplantar keratoderma, pachyonychia congenital. " 11/15/2010 - "Multiple modalities have been used to treat hidrocystomas, including excision, pulsed-dye laser, electrodesiccation, curettage, tricholoracetic acid, botulinum toxin, and anticholinergics." 09/01/2020 - "A number of therapies have shown efficacy for multiple hidrocystomas, including lasers, intracystic trichloroacetic acid, intracystic hypertonic glucose, topical and oral anticholinergics, and botulinum toxin. "
4.	AtropineFDA LinkGeneric 04/01/2018 - "Multiple eccrine hidrocystoma (EH) has been treated with topical atropine with variable results. " 04/01/2018 - "A rare complication of topical atropine for treatment of eccrine hidrocystoma: Pharmacological fixed dilated pupils." 05/01/2001 - "Efficacy and safety of topical atropine in treatment of multiple eccrine hidrocystomas." 04/01/1997 - "We describe clinically and histologically typical eccrine hidrocystomas on the eyelids and forehead of a 60-year-old woman which were successfully treated with topical atropine. " 05/01/2020 - "The treatment of such lesions is based on surgical excision if they are isolated, daily application of topical atropine 1%, or CO2 laser for multiple apocrine hidrocystomas."
5.	Cholinergic Antagonists (Anticholinergics)IBA 02/01/2017 - "Topical anticholinergic drugs in the treatment of multiple hidrocystomas: a cross-over, randomized, double-blind, placebo-controlled study." 01/01/2021 - "Local anticholinergic treatment for multiple eccrine hidrocystomas: report of two cases and literature review." 11/15/2010 - "Multiple modalities have been used to treat hidrocystomas, including excision, pulsed-dye laser, electrodesiccation, curettage, tricholoracetic acid, botulinum toxin, and anticholinergics." 09/01/2020 - "A number of therapies have shown efficacy for multiple hidrocystomas, including lasers, intracystic trichloroacetic acid, intracystic hypertonic glucose, topical and oral anticholinergics, and botulinum toxin. "
6.	SolutionsIBA 04/01/2020 - "Therapeutic treatment of multiple eccrine hidrocystomas with topical glycopyrronium tosylate 2.4% solution." 12/01/2006 - "Eccrine hidrocystomas have been successfully treated with topical atropine solution. " 01/01/2010 - "This report describes the successful treatment of multiple center facial eccrine hidrocystomas associated with craniofacial hyperhidrosis with 0.5% glycopyrrolate aqueous solution applied locally for 1 week. "
7.	Glycopyrrolate (Glycopyrronium Bromide)FDA LinkGeneric 11/01/2008 - "Multiple eccrine hidrocystomas treated with glycopyrrolate." 12/01/2021 - "Topical glycopyrrolate followed by microneedling: a novel treatment option for eccrine hidrocystomas." 01/01/2010 - "Therapeutic Hotline: Topical glycopyrrolate: a successful treatment for craniofacial hyperhidrosis and eccrine hidrocystomas." 01/01/2010 - "This report describes the successful treatment of multiple center facial eccrine hidrocystomas associated with craniofacial hyperhidrosis with 0.5% glycopyrrolate aqueous solution applied locally for 1 week. "
8.	Ophthalmic Solutions (Eye Drops)IBA 03/01/2022 - "Multiple eccrine hidrocystomas of the face treated successfully with 1% atropine eye drops."
9.	S100 Proteins (S 100 Protein)IBA 04/01/1986 - "The detection of S-100 protein was considered to be more helpful in classifying hidrocystomas than that of CEA." 04/01/1986 - "S-100 protein was detected in the cells of one solitary eccrine hidrocystoma, but not in those of 2 cases of "classic", multiple-lesion type of eccrine hidrocystoma. " 04/01/1986 - "On the bases of this immunostaining pattern in normal sweat glands, we attempted to correlate the origin of 8 cases of hidrocystoma to the presence of S-100 protein-positive cells. " 04/01/1986 - "The histogenesis of hidrocystomas was examined by the use of immunostaining for S-100 protein. " 04/01/1986 - "S-100 protein-positive cells in hidrocystomas."
10.	Glucose (Dextrose)FDA LinkGeneric 09/01/2020 - "A number of therapies have shown efficacy for multiple hidrocystomas, including lasers, intracystic trichloroacetic acid, intracystic hypertonic glucose, topical and oral anticholinergics, and botulinum toxin. "

Therapies and Procedures

1.	Therapeutics 07/01/2020 - "Marginal resection and local adjuvant therapy was undertaken, and pathology confirmed the mass to be an apocrine hidrocystoma. " 04/01/2001 - "Both electrodessiation and excision are effective therapies for multiple apocrine hidrocystomas. " 09/01/2020 - "Multiple hidrocystomas were successfully treated with a variety of therapies, including destructive surgical procedures and skin-directed therapies requiring ongoing or repeated therapy. " 01/01/2009 - "Intralesional botulinum toxin A offers a novel treatment for patients with multiple hidrocystomas that have failed other therapies." 09/01/1998 - "Multiple facial eccrine hidrocystomas: effective topical therapy with atropine."
2.	Electrosurgery 04/01/2001 - "The efficacy of electrosurgery and excision in treating patients with multiple apocrine hidrocystomas." 04/01/2001 - "To compare the results of electrosurgery and excision in treating multiple apocrine hidrocystomas. " 03/01/2005 - "Although these lesions have been treated successfully with meticulous surgical extirpation and electrosurgery, this report describes the successful treatment of two patients, each with multiple large (>7 mm) periocular apocrine hidrocystomas by either chemical ablation of the cystic epithelium with trichloroacetic acid (TCA) or surgical excision. "
3.	Gas Lasers 06/01/1989 - "Although solitary apocrine hidrocystomas are easily treated with excision, we had good results employing carbon dioxide laser vaporization in the treatment of numerous hidrocystomas." 01/01/2022 - "CO2 laser in the management of eccrine hidrocystomas: a retrospective study." 01/01/2009 - "While numerous treatment modalities exist for solitary hidrocystomas including simple excision, electrodesiccation, and CO2 laser, treatment of multiple hidrocystomas can be challenging. " 06/01/2001 - "Carbon dioxide laser is an efficient method of the treatment for multiple apocrine hidrocystomas." 06/01/2001 - "To determine the efficacy and cosmetic outcome of carbon dioxide laser vaporization in the treatment of multiple apocrine hidrocystomas. "
4.	Lasers (Laser) 07/17/2020 - "We present a case of multiple apocrine hidrocystomas on the nasal dorsum which became apparent after ablative laser treatment. " 01/01/2023 - "These case findings underscore the effectiveness of ablative carbon dioxide fractional lasers in treating apocrine hidrocystomas." 01/01/2019 - "If in the majority of cases a treatment based on argon laser is sufficient, more voluminous hidrocystomas require surgical resection. " 10/01/1996 - "Argon laser proved to be successful to treat multiple eccrine hidrocystomas." 01/01/2019 - "Treatment of multiple eccrine hidrocystoma with oral isotretinoin following erbium-yttrium aluminum garnet laser."
5.	Percutaneous Collagen Induction 12/01/2021 - "Topical glycopyrrolate followed by microneedling: a novel treatment option for eccrine hidrocystomas."