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Primitive Neuroectodermal Tumors (PNET)

A group of malignant tumors of the nervous system that feature primitive cells with elements of neuronal and/or glial differentiation. Use of this term is limited by some authors to central nervous system tumors and others include neoplasms of similar origin which arise extracranially (i.e., NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL). This term is also occasionally used as a synonym for MEDULLOBLASTOMA. In general, these tumors arise in the first decade of life and tend to be highly malignant. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2059)
Also Known As:
PNET; Primitive Neuroectodermal Tumor; Ependymoblastoma; Tumor, Primitive Neuroectodermal; Spongioblastoma; Neuroectodermal Tumors, Primitive; Cerebral Primitive Neuroectodermal Tumor; Neoplasms, Primitive Neuroepithelial; Neuroectodermal Tumor, Primitive; Neuroepithelial Neoplasms, Primitive; Primitive Neuroepithelial Neoplasms; Ependymoblastomas; Medulloepitheliomas; Neoplasm, Primitive Neuroepithelial; Neuroepithelial Neoplasm, Primitive; Neuroepithelial Tumor, Primitive; PNETs; Primitive Neuroepithelial Neoplasm; Primitive Neuroepithelial Tumor; Primitive Neuroepithelial Tumors; Spongioblastomas; Tumor, Primitive Neuroepithelial; Tumors, Primitive Neuroectodermal; Tumors, Primitive Neuroepithelial; Medulloepithelioma; Neuroepithelial Tumors, Primitive
Networked: 1966 relevant articles (124 outcomes, 322 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Neuroendocrine Tumors (Neuroendocrine Tumor)
3. Medulloblastoma
4. Primitive Neuroectodermal Tumors (PNET)
5. Ewing Sarcoma (Sarcoma, Ewing)

Experts

1. Rutkowski, Stefan: 19 articles (11/2020 - 04/2006)
2. Pietsch, Torsten: 18 articles (11/2020 - 02/2002)
3. Phillips, P C: 15 articles (01/2002 - 03/2000)
4. Howe, James R: 14 articles (10/2021 - 03/2012)
5. Pawlik, Timothy M: 13 articles (01/2022 - 08/2019)
6. Gajjar, Amar: 12 articles (01/2021 - 08/2004)
7. Ito, Tetsuhide: 12 articles (01/2019 - 06/2012)
8. Saif, Muhammad Wasif: 12 articles (03/2014 - 03/2010)
9. Grotzer, M A: 12 articles (01/2002 - 03/2000)
10. Korshunov, Andrey: 11 articles (11/2021 - 09/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Primitive Neuroectodermal Tumors:
1. EverolimusFDA Link
2. Sunitinib (Sutent)FDA Link
3. Etoposide (VP 16)FDA LinkGeneric
4. Temozolomide (Temodar)FDA LinkGeneric
5. Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
6. Streptozocin (Streptozotocin)FDA Link
7. Octreotide (Sandostatin)FDA LinkGeneric
8. Cyclophosphamide (Cytoxan)FDA LinkGeneric
9. Carboplatin (JM8)FDA LinkGeneric
10. Vincristine (Oncovin)FDA LinkGeneric

Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Radiotherapy
4. Radiofrequency Ablation
5. Combination Drug Therapy (Combination Chemotherapy)