Leiomyomatosis

01/01/2015 - "To determine the efficacy of the medroxyprogesterone for abnormal uterine bleeding associated with leiomyomatosis in perimenopause women. "

06/01/2012 - "Strong family history of uterine leiomyomatosis warrants fumarate hydratase mutation screening."
01/01/2010 - "Evidence for a new fumarate hydratase gene mutation in a unilateral type 2 segmental leiomyomatosis."
01/01/2008 - "Single base mutation in the fumarate hydratase gene leading to segmental cutaneous leiomyomatosis."
09/01/2006 - "Diffuse and segmental variants of cutaneous leiomyomatosis: novel mutations in the fumarate hydratase gene and review of the literature."
04/01/2002 - "Activity of fumarate hydratase is reduced in lymphoblastoid cells from individuals with leiomyomatosis. "

01/01/2014 - "In general, disseminated peritoneal leiomyomatosis is seen in women who are of childbearing age with estrogen hypersecretion. "
06/01/2000 - "Leiomyomatosis peritonealis disseminata has been attributed to estrogen stimulation and is seen only rarely in postmenopausal women. "
05/01/1994 - "Disseminated peritoneal leiomyomatosis (DPL) is a very rare disorder, characterized by the presence of multiple intraabdominal smooth muscle nodules and frequently associated with a high estrogen production. "
01/01/2011 - "We report a case of leiomyomatosis peritoneais disseminata with sarcomatous degeneration in a 37-year-old nulligravid patient with no exposure to exogenous estrogen or progesterone, revealed by increased abdominal perimeter. "
11/01/2002 - "It is possible that a high concentration of serum estradiol and high level of tissue estrogen receptor are related to the intravenous leiomyomatosis."

01/01/2015 - "Leiomyomatosis peritonealis disseminata positive for progesterone receptor."
01/01/1989 - "Immunohistologic detection of estrogen and progesterone receptors in disseminated peritoneal leiomyomatosis."
03/01/2014 - "Histopathological studies confirmed pelvic intravascular leiomyomatosis in the hysterectomy sections and the pulmonary nodules were proved to be benign metastasizing leiomyoma with strong positivity of estrogen as well as progesterone receptors. "
01/01/2004 - "Vessel walls harboring intravascular tumor were investigated immunohistochemically for Factor VIII, CD 34, estrogen and progesterone receptors with the hope of making the histogenesis of intravenous leiomyomatosis clear. "

08/01/2005 - "His mother, who exhibited esophageal leiomyomatosis and is heterozygous for AS, showed a discontinuous staining pattern for collagen alpha5(IV) chain along the epidermal basement membrane in a skin biopsy specimen. "
11/01/1994 - "Studies in humans have revealed a family of genes encoding alpha 1-alpha 6 collagen IV chains and implicated alpha 3-alpha 6 in disease processes (Goodpasture and Alport syndromes and diffuse leiomyomatosis). "
10/01/1995 - "We have shown previously that the 5' ends of the genes for the alpha 5(IV) and alpha 6(IV) collagen chains lie head-to-head on Xq22 and are deleted in patients with Alport syndrome (AS)-associated diffuse leiomyomatosis. "
11/01/1992 - "Alport syndrome and diffuse leiomyomatosis: deletions in the 5' end of the COL4A5 collagen gene."

09/01/2002 - "We present a case of esophageal leiomyomatosis with imaging features on barium swallow and computed tomography (CT)."
01/01/2000 - "Esophageal leiomyomatosis should be considered in a young patient with long-standing dysphagia in whom smooth, tapered esophageal narrowing on barium study and circumferential esophageal wall thickening on CT scan are seen. "
02/01/2008 - "Leiomyomatosis should be considered as a cause of psuedoachalasia in patients with symptoms suggestive of achalasia and atypical barium findings. "

11/01/2013 - "These observations suggest that deletion of the 5' exons of COL4A6 and of the common promoter of the COL4A5 and COL4A6 genes is not essential for the development of leiomyomatosis in patients with ATS, and that COL4A5_COL4A6 deletions extending into COL4A6 exon 3 may not result in ATS-DL."
11/01/2013 - "Rarely, families have a contiguous gene deletion comprising at least exon 1 of COL4A5 and the first exons of COL4A6, associated with the development of diffuse leiomyomatosis (ATS-DL). "
05/01/2011 - "This is the largest deletion reported to date that has been associated with ATS-DL and this case should lead us to reconsider the mechanisms that might be involved in the development of diffuse leiomyomatosis."
01/01/2011 - "This is a study of a patient who manifests all of the features of a diffuse leiomyomatosis-Alport syndrome (DL-ATS), and her two-year-old son who has already been diagnosed with Alport syndrome. "

04/01/1993 - "Immunohistochemically, a second case with leiomyomatosis peritonealis disseminata from the same investigation material shows the transformation of desmin- and actin-positive decidual cells into myofibroblasts and leiomyocytes in the form of a direct metaplasia. "
04/01/2002 - "All mesenteric lymph nodes removed showed leiomyomatosis, which was verified by immunohistochemical study showing positive immunostaining for smooth muscle actin, desmin, and vimentin, but negative staining for HMB-45. "

04/01/2002 - "All mesenteric lymph nodes removed showed leiomyomatosis, which was verified by immunohistochemical study showing positive immunostaining for smooth muscle actin, desmin, and vimentin, but negative staining for HMB-45. "

11/01/2003 - "Although partial deletions of the type IV collagen genes COL4A5 and COL4A6, paired head-to-head on chromosome Xq22, are known to cause diffuse leiomyomatosis, loss of function for type IV collagen does not explain smooth muscle overgrowth. "
11/01/1993 - "Alport-leiomyomatosis syndrome is a polygenic syndrome with a dominant X-linked inheritance pattern resulting from a large deletion in the 5' end of the COL4A5 gene coding for the type IV collagen alpha 5 chains. "
01/01/2009 - "Alport syndrome and leiomyomatosis are caused by mutation of the genes encoding for the alpha chain of type IV collagen. "
08/01/2005 - "A Japanese family with Alport syndrome associated with esophageal leiomyomatosis: genetic analysis of COL4A5 to COL4A6 and immunostaining for type IV collagen subtypes."
06/01/1999 - "Absence of the alpha6(IV) chain of collagen type IV in Alport syndrome is related to a failure at the protein assembly level and does not result in diffuse leiomyomatosis."

10/01/2012 - "UAE was a highly effective treatment for diffuse uterine leiomyomatosis with mid-term durability and may be a valuable alternative to hysterectomy."
06/01/2015 - "Here we report a rare case of GIST and multiple uterine leiomyomatosis in a middle aged patient with longstanding cutaneous leiomyomatosis who underwent GIST excision and hysterectomy. "
06/01/2014 - "This procedure should be considered as a therapeutic option in women suffering from symptoms of diffuse uterine leiomyomatosis who wish to avoid hysterectomy."
03/01/2013 - "The reported case is that of a 72 year-old patient who had undergone a total hysterectomy with bilateral annessiectomy surgery 20 years earlier subsequently to a diagnosis for uterine leiomyomatosis. "
01/01/2013 - "Use of morcellation during laparoscopic hysterectomy may result in seeding of uterine tissue throughout the abdominal cavity and development of 'iatrogenic' leiomyomatosis peritonealis disseminata. "

10/01/2012 - "The aim of the current study was to evaluate the efficacy of uterine artery embolization (UAE) in the management of diffuse uterine leiomyomatosis with mid-term follow-up. "
10/01/2012 - "Uterine artery embolization (UAE) for diffuse leiomyomatosis of the uterus: clinical and imaging results."
02/01/2008 - "Six patients with symptomatic diffuse uterine leiomyomatosis underwent technically successful uterine artery embolization. "
02/01/2008 - "Uterine artery embolization in patients with symptomatic diffuse leiomyomatosis of the uterus."

09/01/1990 - "A case of intravenous leiomyomatosis with cardiac extension was treated successfully with a two-stage operation: resection of the intracardiac and intracaval mass for the first stage and total hysterectomy with bilateral salpingo-oophorectomy for the second. "
03/01/2011 - "The present report describes a 29-year-old patient underwent transabdominal hysterectomy and Bilateral Salpingo oophorectomy six years ago because of leiomyomatosis peritonealis disseminata. "
11/01/2005 - "We describe a 41-year-old woman with disseminated leiomyomatosis peritonei who underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy. "
12/10/2003 - "Recurrent leiomyomatosis peritonealis disseminata after hysterectomy and bilateral salpingo-oophorectomy during combined hormone replacement therapy."
12/10/2003 - "To our knowledge, this is the first case reporting the recurrence of leiomyomatosis peritonealis disseminata during combined hormone replacement therapy after hysterectomy and bilateral salpingo-oophorectomy and six laparotomies because of recurrence of the disease."

01/01/2004 - "Successful therapy for intravenous leiomyomatosis is dependent on total surgical excision of the tumor, cessation of ovarian function and avoidance of postoperative estrogen replacement therapy."

04/01/2003 - "The case was a 46-year-old woman, with intravenous leiomyomatosis originating from the uterus and extending to the inferior vena cava and right atrium, with extensive intracaval attachment, diagnosed from the various preoperative studies and operated successfully through the single-stage approach using cardiopulmonary bypass. "
06/01/2000 - "Intravenous leiomyomatosis extending into the right ventricular cavity: one-stage radical operation using cardiopulmonary bypass--a case report."
09/01/1999 - "We report the cases of two patients, the first with leiomyosarcoma of the inferior vena cava and the other with intravenous leiomyomatosis of the uterus that showed intravascular growth up to right atrium and ventricle, who underwent successful radical resection in a one-stage procedure with the use of cardiopulmonary bypass. "
12/01/1986 - "The case of a young female patient with pelvic intravenous leiomyomatosis extending into the right side of the heart successfully managed with tumor excision under cardiopulmonary bypass in staged procedure is presented."
10/01/1994 - "On the basis of a diagnosis of intravenous leiomyomatosis the neoplasm was extirpated by a one-stage cardiotomy and laparotomy with the aid of cardiopulmonary bypass. "