Small Cell Sarcoma

A sarcoma characterized by the presence of small cells, cells measuring 9-14 micrometers with a faint or indistinct rim of cytoplasm and an oval-to-elongated nucleus with relatively dense chromatin. (From Segen, Dictionary of Modern Medicine, 1992)

Also Known As:

Networked: 11 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Osteosarcoma (Osteogenic Sarcoma)
2.	Sarcoma (Soft Tissue Sarcoma)
3.	Neoplasms (Cancer)
4.	Mesenchymal Chondrosarcoma
5.	Synovial Sarcoma (Synovioma)

Experts

1.	Trent, J C: 1 article (12/2014)
2.	Dumont, S N: 1 article (12/2014)
3.	Dumont, A G: 1 article (12/2014)
4.	Yang, D: 1 article (12/2014)
5.	Blay, J-Y: 1 article (12/2014)
6.	Reynoso, D: 1 article (12/2014)
7.	Krzakowski, Maciej: 1 article (10/2005)
8.	Söder, Stephan: 1 article (08/2005)
9.	Oliveira, André M: 1 article (08/2005)
10.	Inwards, Carrie Y: 1 article (08/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Small Cell Sarcoma:

1.	Doxorubicin (Adriamycin)FDA LinkGeneric 12/01/2014 - "This work identifies a combination of targeted agents and doxorubicin that are effective against small cell sarcoma cell lines. " 12/01/2014 - "Targeted polytherapy in small cell sarcoma and its association with doxorubicin."
2.	Collagen Type II (Type II Collagen)IBA 08/01/2005 - "Type II collagen as specific marker for mesenchymal chondrosarcomas compared to other small cell sarcomas of the skeleton." 08/01/2005 - "In our study on a large series of mesenchymal chondrosarcomas (n=30) and other small cell sarcomas (Ewing's sarcomas (n=12), synovial sarcomas (n=6), hemangiopericytomas (n=5), small cell osteosarcomas (n=3), and desmoplastic small round cell tumors (n=1)), we could establish the presence of type II collagen in the extracellular tumor matrix of the small cell areas of mesenchymal chondrosarcomas as a specific and sensitive marker to identify mesenchymal chondrosarcomas and to exclude other small cell neoplasms (except chondroblastic areas in small cell osteosarcomas). "
3.	N 30IBA 08/01/2005 - "In our study on a large series of mesenchymal chondrosarcomas (n=30) and other small cell sarcomas (Ewing's sarcomas (n=12), synovial sarcomas (n=6), hemangiopericytomas (n=5), small cell osteosarcomas (n=3), and desmoplastic small round cell tumors (n=1)), we could establish the presence of type II collagen in the extracellular tumor matrix of the small cell areas of mesenchymal chondrosarcomas as a specific and sensitive marker to identify mesenchymal chondrosarcomas and to exclude other small cell neoplasms (except chondroblastic areas in small cell osteosarcomas). "
4.	tranilast (N 5')IBA 08/01/2005 - "In our study on a large series of mesenchymal chondrosarcomas (n=30) and other small cell sarcomas (Ewing's sarcomas (n=12), synovial sarcomas (n=6), hemangiopericytomas (n=5), small cell osteosarcomas (n=3), and desmoplastic small round cell tumors (n=1)), we could establish the presence of type II collagen in the extracellular tumor matrix of the small cell areas of mesenchymal chondrosarcomas as a specific and sensitive marker to identify mesenchymal chondrosarcomas and to exclude other small cell neoplasms (except chondroblastic areas in small cell osteosarcomas). "
5.	Progesterone Receptors (Progesterone Receptor)IBA 10/01/1989 - "Of the 26 samples assayed for progesterone receptors, measurable bindings were found in 14 of 17 meningiomas, 1 of 2 astrocytomas, 1 malignant lymphoma, 1 hemangioblastoma, 1 ganglioglioma, 1 glioblastoma multiforme, 1 anaplastic ependymoma, 1 small cell sarcoma, and 1 neurilemoma. "
6.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 07/01/1976 - "B., who was receiving cyclophosphamide (CY) for chemotherapy of a localized undifferentiated small cell sarcoma of the chest wall, developed generalized urticaria on three separate occasions immediately after CY administration. "
7.	AntibodiesIBA 01/01/2003 - "The use of a wide panel of antibodies confirmed (in 74% of the cases) and corrected (in 26%) the diagnosis of a diversity of small cell sarcomas established by routine methods. "
8.	sorafenib (BAY 43-9006)FDA Link 12/01/2014 - "This work provides evidence of synergy of combinations of vorinostat, 17-DMAG and sorafenib in small cell sarcoma. "
9.	17- (dimethylaminoethylamino)- 17- demethoxygeldanamycinIBA 12/01/2014 - "This work provides evidence of synergy of combinations of vorinostat, 17-DMAG and sorafenib in small cell sarcoma. "
10.	vorinostat (suberoylanilide hydroxamic acid)FDA Link 12/01/2014 - "This work provides evidence of synergy of combinations of vorinostat, 17-DMAG and sorafenib in small cell sarcoma. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 10/30/2005 - "Chemotherapy may also be used following local treatment, although the role of adjuvant chemotherapy is better defined in small-cell sarcomas. " 10/30/2005 - "The principles of chemotherapy used for primary bone neoplasms are essentially similar in spindle-cell and small-cell sarcomas. " 01/01/1999 - "The use of chemotherapy is justified only in small-cell sarcomas in which metastasis occurs frequently and chemotherapy is known to be effective. " 04/01/1989 - "The chemotherapy protocol described by Rosen was selected according to histological classification of sarcomas (small cell sarcoma, spindle cell sarcoma, pleomorphic sarcoma). " 10/01/1989 - "Osteosarcoma, rhabdomyosarcoma, Ewing's sarcoma, and other small-cell sarcomas are sensitive to chemotherapy, which should be given preoperatively, continued postoperatively, and modified according to the tumor response. "
2.	Adjuvant Chemotherapy 10/30/2005 - "Chemotherapy may also be used following local treatment, although the role of adjuvant chemotherapy is better defined in small-cell sarcomas. "
3.	Heterologous Transplantation (Xenotransplantation) 06/01/1994 - "In two cases the primary xenografts (teratocarcinoma and small-cell sarcoma) were retransplanted into 11 CsA-immunosuppressed rats. "
4.	Combination Drug Therapy (Combination Chemotherapy) 04/01/1983 - "According to this subclassification, patients with the small cell type of lesions responded to combination chemotherapy and irradiation, as usually do other small cell sarcomas. "