Fibroadenoma

An adenoma containing fibrous tissue. It should be differentiated from ADENOFIBROMA which is a tumor composed of connective tissue (fibroma) containing glandular (adeno-) structures. (From Dorland, 27th ed)

Also Known As:

Networked: 717 relevant articles (10 outcomes, 65 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cicatrix (Scar)
2.	Pain (Aches)
3.	Carcinoma (Carcinomatosis)
4.	Neoplasms (Cancer)
5.	Mastitis

Experts

1.	Gebrim, L H: 6 articles (01/2004 - 03/2000)
2.	Littrup, Peter J: 5 articles (09/2005 - 11/2002)
3.	Michal, Michal: 4 articles (10/2014 - 10/2007)
4.	Kazakov, Dmitry V: 4 articles (10/2014 - 10/2007)
5.	Baracat, E C: 4 articles (04/2009 - 11/2001)
6.	McDermott, Enda: 4 articles (03/2007 - 02/2003)
7.	O'Higgins, Niall: 4 articles (03/2007 - 02/2003)
8.	Hill, Arnold D K: 4 articles (03/2007 - 02/2003)
9.	Duffy, Michael J: 4 articles (03/2007 - 02/2003)
10.	Francescatti, Darius: 4 articles (09/2005 - 11/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Fibroadenoma:

1.	Estriol (Epiestriol)IBA 11/01/2007 - "Efficacy of estriol in inhibiting epithelial proliferation in mammary fibroadenoma: randomized clinical trial." 09/06/2007 - "Effect of oral contraceptive with and without associated estriol on ultrasound measurements of breast fibroadenoma: randomized clinical trial." 11/01/2007 - "The aim of this study was to evaluate the proliferative activity of mammary fibroadenoma through expression of Ki-67 and c-myc antigens, following administration of oral contraceptive with or without estriol. " 09/06/2007 - "The aim of this study was to evaluate the proliferative activity of breast fibroadenoma as shown by ultrasound measurements, following administration of oral contraceptives with and without associated estriol. " 09/06/2007 - "The results confirm that estriol may block the protective effect of oral contraceptives on fibroadenomas, since we observed decreased fibroadenoma width among the group 1 patients but not the group 2 patients."
2.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 09/01/2004 - "We found 3 vessel types: feeding vessels, which are prominent vessels leading from the surrounding breast tissue into the fibroadenoma; capsular vessels, which are located within the tissue capsule; and segmental vessels, which are located within the fibrous septa of the fibroadenoma. " 09/01/2004 - "We categorized the detected vessels according to their location in or on the fibroadenoma, counted the different types of vessels, and tested for correlations between vessel distributions or numbers and histopathologic findings. " 08/01/1998 - "(A Student t test could not be performed in one case of fibroadenoma; size permitted only one countable field according to the authors' criteria.) The 18 cases with normal tissue had 21-229 vessels (mean, 80.5 vessels) per field; in 16 (89%) of the 18 cases, these vessel counts were significantly higher (P < .01) than those in the fibroadenoma cases. " 01/01/1994 - "The 3 false positive results occurred in patients with mastitis, fibroadenoma and an ectatic vessel, respectively. " 06/01/2004 - "Using computer-assisted techniques on immunostained breast tissue (normal [n = 28], fibrocystic [n = 37], fibroadenomas [n = 19], invasive carcinomas [n = 19]), values were obtained for microvessel density (MVD), mean vessel area (MVA), vessel orientation (shape) and epithelial:stromal ratio (E:S). "
3.	Ethyl Ether (Ether)IBA 06/01/1983 - "Unique to the action of the methyl ether of 4-nitroestrone on mammary tumors was the destruction of adenocarcinomas while permitting the appearance of fibroadenomas. " 12/01/1962 - "[An unusual case of bilateral mammary pericanalicular fibroadenoma in a male, cured after treatment with methyltestosterone hexvlenol ether]."
4.	Methyltestosterone (Android)FDA Link 12/01/1962 - "[An unusual case of bilateral mammary pericanalicular fibroadenoma in a male, cured after treatment with methyltestosterone hexvlenol ether]."
5.	FANFTIBA 01/01/1984 - "The incidences of mammary fibroadenoma in the NF group and of lower urinary tract tumors in the FANFT group were significantly greater (P less than 0.01) than those of these tumors in the control group."
6.	gadomer 17IBA 11/01/2000 - "With Gadomer-17, the mean values for K(PS) and fPV were significantly greater in carcinomas than in fibroadenomas (P < .004 and .04, respectively). "
7.	DNA (Deoxyribonucleic Acid)IBA 09/01/2004 - "Lack of DNA copy number alterations revealed with comparative genomic hybridization in fibroadenomas of the breast." 05/01/1999 - "There was no LOH detected in epithelial DNA from a fibroadenoma. " 11/01/1989 - "DNA ploidy in fibroadenomas (abstract)." 04/01/2013 - "The objective of the present work was to study the expression of γH2AX in infiltrating ductal carcinoma (IDC) and fibroadenoma (FA) cases and to associate the expression in IDC with cytomorphological features and DNA ploidy. " 07/01/2014 - "Methods : We detected the expression of HPV 16/18 DNA and p53 protein in invasive ductal carcinoma in 45 cases, breast fibroadenoma in 20 cases and normal breast tissues in 20 cases. "
8.	ParaffinIBA 01/01/2012 - "We used paraffin-embedded blocks from 10 breast tissues diagnosed with fibroadenoma and as control 10 healthy tissue samples. " 11/01/2009 - "Paraffin-embedded tissue samples from 63 untreated female patients with IDC and 32 female patients with fibroadenoma were used. " 01/01/2014 - "One hundred patients with histopathologic diagnosis of invasive ductal carcinoma and 50 patients with fibroadenoma of breast (as the control group) have selected, then 150 paraffin blocks have obtained. " 01/01/2012 - "Paraffin-embedded tissue samples from 63 untreated female patients with invasive ductal carcinoma (IDC) and 32 female patients with fibroadenoma were studied. " 09/01/2004 - "Using comparative genomic hybridization, we analyzed 20 paraffin-embedded samples of fibroadenomas of the breast from patients with no familial or previous history of breast cancer. "
9.	Messenger RNA (mRNA)IBA 01/01/2013 - "The CCR5 mRNA relative expression level between adjacent normal tissues and fibroadenoma tissues was not significantly different (P > 0.05). " 06/01/2009 - "Protein levels of PRA and PRB were higher in fibroadenomas compared to normal breast tissue (P = 0.038 and P = 0.031), while the PRs mRNA levels were similar in both tissues (P = 0.721 and P = 0.139). " 03/15/2004 - "In 1 case of fibroadenoma, NY-ESO-1 mRNA was 8% of the testicular level, and protein was detected by Western blot analysis. " 03/01/2013 - "JMJD2A mRNA level in infiltrating duct carcinoma was higher than fibroadenoma by quantitative real-time PCR. " 09/28/2010 - "the expression level of SM22α mRNA in breast cancer was significantly lower than that in breast fibroadenoma or adjacent normal breast tissue (5.1% ± 2.4% vs 15.1% ± 5.3% vs 30.1% ± 5.1%, P < 0.01). "
10.	AntigensIBA 01/01/1980 - "However, 3 out of 5 human breast fibroadenomas, already positive for D-type virus interspecies-specific antigen before cultivation, are able to induce a transient D-type retrovirus interspecies-specific antigen production after 3 to 4 months of cocultivation with bat lung cells. " 01/01/1980 - "Nine human breast fibroadenomas, initially negative for D-type retrovirus interspecies-specific antigen, do not produce that antigen during 6 months of cocultivation with bat lung cells. " 01/01/1980 - "Production of primate D-type virus interspecies-specific antigen during cocultivation of human breast fibroadenoma cells with bat lung cells." 09/01/1981 - "The study showed the new antigen induced by herpes simplex virus type 2 (HSV-2) to be present not only in cancer tumors of the cervix and corpus uteri, and ovaries but also in malignant tumors of the mammary glands, kidneys, urinary bladder, as well as in tissues of fibrous-cystic mastopathy and fibroadenoma of the mammary glands. " 01/01/2010 - "The aim was to compare the expression of MUC1 and carbohydrate antigens in 124 tissue samples; 42 fibroadenoma (FA), 23 nonproliferative benign diseases (NPF), 25 usual epithelial hyperplasia (UEH), 7 atypical ductal hyperplasia (ADH), and 27 breast normal tissues. "

Therapies and Procedures

1.	Cryosurgery 04/01/2005 - "Recent studies have demonstrated that, as a primary therapy for breast fibroadenoma, cryoablation is safe and effective with durable results that can be reproduced in community practices. " 09/01/2005 - "Cryoablation for breast fibroadenomas has previously been reported as safe and effective both acutely and at the 1-year follow-up mark, and thus has been implemented as a treatment option. " 06/01/2004 - "Cryoablation is safe and effective in treating breast fibroadenomas. " 06/01/2015 - "Ultrasound-guided cryoablation of breast fibroadenoma: a pilot trial." 02/01/2013 - "Ultrasound guided cryoablation of fibroadenomas."
2.	Aftercare (After-Treatment) 12/01/1962 - "[An unusual case of bilateral mammary pericanalicular fibroadenoma in a male, cured after treatment with methyltestosterone hexvlenol ether]."
3.	Mastectomy (Mammectomy) 01/01/2014 - "Fibroadenomas and mastectomy samples were not infiltrated with Tregs. " 01/01/2010 - "This unique case report presents a 22-year-old female who presented with an enlarging breast mass measuring 23 × 28 cm. After core needle biopsy, the mass was diagnosed as a giant fibroadenoma and treated surgically with mastectomy. " 03/01/1988 - "This case report describes the history and management of a teenager who had multiple giant fibroadenomas in one breast, eventually requiring mastectomy and reconstruction. " 02/01/2004 - "We report the case of a young patient given CsA who developed multiple bilateral fibroadenomas of the breasts 3 years after renal transplantation, leading to bilateral mastectomy. " 02/01/2004 - "Multiple bilateral fibroadenomas of the breasts requiring mastectomy in a renal transplant patient."
4.	Lasers (Laser) 08/01/2014 - "Using laser capture microdissection, we show that MED12 fibroadenoma mutations are present in stromal but not epithelial mammary cells. " 01/01/2010 - "In this paper the laser treatment in two patients, one with bilateral fibroadenomas, with 6 and 8 year follow-up is presented." 04/01/2005 - "Results are presented of a study to monitor the changes in the optical properties of breast tissue over a 12-month period after interstitial laser photocoagulation treatment of a fibroadenoma. " 12/01/2012 - "Laser interstitial thermotherapy (LITT) is potentially a novel method to treat small breast fibroadenoma, without the need for surgical removal. " 12/01/2012 - "Laser interstitial thermotherapy of small breast fibroadenomas: numerical simulations."
5.	Mammaplasty (Breast Reconstruction) 08/01/1988 - "The aim of this study was to determine the proliferative activity within the epithelial cells of the normal human breast in 122 patients (6 reduction mammoplasties and 116 fibroadenoma excisions) in relation to age and the phase of the menstrual cycle. " 01/01/2015 - "Inframammarial Giant Fibroadenoma Removing and a Nipple-sparing Breast Reconstruction in an Adolescent: A Case Report." 10/01/2012 - "Giant fibroadenoma (GFA) may present with breast asymmetry and can be excised with an inframammary incision (IFI) or reduction mammoplasty incision (RMI). " 10/01/2012 - "Differential diagnosis and management of giant fibroadenoma: comparing excision with reduction mammoplasty incision and excision with inframammary incision." 07/01/2004 - "One patient developed symptomatic giant fibroadenomas and underwent bilateral mammoplasty. "