Fibroepithelial Neoplasms

Neoplasms composed of fibrous and epithelial tissue. The concept does not refer to neoplasms located in fibrous tissue or epithelium.

Also Known As:

Neoplasms, Fibroepithelial; Fibroepithelial Neoplasm; Neoplasm, Fibroepithelial

Networked: 8 relevant articles (0 outcomes, 3 trials/studies)

Disease Context: Research Results

Neoplasms: 1324753
- Neoplasms by Histologic Type: 2
  - Glandular and Epithelial Neoplasms: 439
    - Fibroepithelial Neoplasms: 8
  - Connective and Soft Tissue Neoplasms: 1
    - Connective Tissue Neoplasms: 9
      - Fibrous Tissue Neoplasms
        Fibroepithelial Neoplasms: 8
        Fibroadenoma: 957
        Adenofibroma: 62
        Brenner Tumor: 58

Related Diseases

1.	Ductal Carcinoma
2.	Phyllodes Tumor (Cystosarcoma Phylloides)
3.	Carcinoma (Carcinomatosis)

Experts

1.	Tan, Puay Hoon: 3 articles (04/2022 - 08/2010)
2.	Thike, Aye Aye: 3 articles (04/2022 - 08/2010)
3.	Nasir, Nur Diyana Md: 2 articles (04/2022 - 09/2015)
4.	Teh, Bin Tean: 2 articles (04/2022 - 09/2015)
5.	Chan, Jason Yongsheng: 1 article (04/2022)
6.	Guan, Peiyong: 1 article (04/2022)
7.	Hong, Jing Han: 1 article (04/2022)
8.	Huang, Xi Xiao: 1 article (04/2022)
9.	Koh, Joanna: 1 article (04/2022)
10.	Kok, Jessica Sook Ting: 1 article (04/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Fibroepithelial Neoplasms:

1.	Biomarkers (Surrogate Marker)IBA 01/01/2019 - "After further validation of multi-institutional large datasets, MRI-based texture features may become a potential biomarker and be a useful medical decision tool in clinical trials having patients with breast fibroepithelial neoplasms." 07/01/2014 - "Biomarkers distinguishing mammary fibroepithelial neoplasms: a tissue microarray study."
2.	beta CateninIBA 08/01/2003 - "These results support the hypothesis that IGF-I and IGF-II overexpression may be important in the pathogenesis of fibroepithelial neoplasms of the breast and that IGF-I overexpression is likely to be contributing to the nuclear beta-catenin localization observed in the tumours."
3.	Phenobarbital (Luminal)FDA Link 07/01/2013 - "Here, we evaluate GATA3 expression in 86 invasive ductal carcinomas including triple-negative, Her-2, and luminal subtypes, in addition to 13 metaplastic carcinomas and in 34 fibroepithelial neoplasms. "
4.	Keratins (Keratin)IBA 02/01/2022 - "The histology was that of a fibroepithelial neoplasm with the typical leaf-like projections and cystic spaces lined by squamous epithelium containing keratin debris. "
5.	Insulin-Like Growth Factor II (Somatomedin A)IBA 08/01/2003 - "These results support the hypothesis that IGF-I and IGF-II overexpression may be important in the pathogenesis of fibroepithelial neoplasms of the breast and that IGF-I overexpression is likely to be contributing to the nuclear beta-catenin localization observed in the tumours."
6.	Insulin-Like Growth Factor I (IGF-1)IBA 08/01/2003 - "These results support the hypothesis that IGF-I and IGF-II overexpression may be important in the pathogenesis of fibroepithelial neoplasms of the breast and that IGF-I overexpression is likely to be contributing to the nuclear beta-catenin localization observed in the tumours."

Therapies and Procedures

1.	Therapeutics 01/01/2023 - "This study revealed the molecular profiles of MPT that can lead to molecular classification and potential targeted therapy, and suggested that the MPT PDX model can be a useful tool for studying the pathogenesis of fibroepithelial neoplasms and for preclinical drug screening to find new therapeutic strategies for MPT." 04/01/2022 - "Malignant phyllodes tumors (PT) are rare aggressive fibroepithelial neoplasms with high metastatic potential and lack effective therapy. "
2.	Mastectomy (Mammectomy) 09/01/2009 - "Mastectomy showed a 14.5-cm fibroepithelial neoplasm, the majority of which was composed of a cellular spindle/epithelioid-cell proliferation with the focal presence of elongated epithelial clefts consistent with a PT. "