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Benign Fibrous Histiocytoma (Dermatofibroma)

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A benign tumor composed, wholly or in part, of cells with the morphologic characteristics of HISTIOCYTES and with various fibroblastic components. Fibrous histiocytomas can occur anywhere in the body. When they occur in the skin, they are called dermatofibromas or sclerosing hemangiomas. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 5th ed, p1747)

Also Known As:

Dermatofibroma; Dermatofibromas; Histiocytoma, Benign Fibrous; Angioma, Sclerosing; Angiomas, Sclerosing; Benign Fibrous Histiocytomas; Cutaneous Histiocytoma; Cutaneous Histiocytomas; Fibrous Histiocytoma; Fibrous Histiocytoma, Benign; Fibrous Histiocytomas; Fibrous Histiocytomas, Benign; Hemangiomas, Sclerosing; Histiocytomas, Benign Fibrous; Histiocytomas, Cutaneous; Histiocytomas, Fibrous; Sclerosing Angioma; Sclerosing Angiomas; Sclerosing Hemangioma; Sclerosing Hemangiomas; Hemangioma, Sclerosing; Histiocytoma, Cutaneous; Histiocytoma, Fibrous

Networked: 355 relevant articles (7 outcomes, 29 trials/studies)

Relationship Network

Disease Context: Research Results

Neoplasms: 649836
- Neoplasms by Histologic Type: 1
  - Connective and Soft Tissue Neoplasms
    - Connective Tissue Neoplasms: 6
      - Fibrous Tissue Neoplasms
        Histiocytoma: 90
        Benign Fibrous Histiocytoma: 355
        Bazex-Dupre-Christol syndrome: 60
        Diaphyseal medullary stenosis with malignant fibrous histiocytoma: 4

Related Diseases

1.	Keloid
2.	Molluscum Contagiosum
3.	Malignant Fibrous Histiocytoma
4.	Sarcoma (Soft Tissue Sarcoma)
5.	Nevus (Nevi)

Experts

1.	Folpe, Andrew L: 4 articles (09/2015 - 04/2004)
2.	Fletcher, Christopher D M: 3 articles (09/2015 - 01/2002)
3.	Ihn, Hironobu: 3 articles (05/2014 - 01/2003)
4.	Glusac, Earl J: 3 articles (07/2005 - 08/2002)
5.	Mertens, Fredrik: 2 articles (09/2015 - 08/2014)
6.	Nilsson, Jenny: 2 articles (09/2015 - 08/2014)
7.	Domanski, Henryk A: 2 articles (09/2015 - 08/2014)
8.	Tayebwa, Johnbosco: 2 articles (09/2015 - 08/2014)
9.	Magnusson, Linda: 2 articles (09/2015 - 08/2014)
10.	Won, Chong Hyun: 2 articles (05/2015 - 02/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Benign Fibrous Histiocytoma:

1.	Factor XIIIaIBA 08/01/2005 - "In this study, we examined the fine structures and potential heterogeneity among the subgroup of factor XIIIa (FXIIIa) positive dendritic cells consisted of eleven cases of dermatofibroma (DF). " 07/01/2005 - "The digital AFs, fibrokeratomas, and dermatofibromas stained predominately for Factor XIIIa, with no or minimal staining for CD34. " 11/01/2002 - "Aneurysmal fibrous histiocytoma showing transition from factor XIIIa-positive to -negative." 04/01/2002 - "Benign fibrous histiocytoma: an additional case richly endowed with factor XIIIa(+) cells." 09/01/1997 - "In contrast to classic Schwannian/neurogenic granular cell tumours, granular cell dermatofibromas were S100 protein negative, but showed variable reactivity for factor XIIIa (10-50%) in 4/5, for smooth muscle specific actin (10-50%) in 2/5 and with E9 (10-30%) in 3/5 lesions. "
2.	Dermatofibrosarcoma protuberansIBA 01/01/2013 - "In this study, a giant dermatofibroma case, which is histopathologically, ulcerative dermatofibroma, the biggest lesion of the head and neck region and seen rarely in the literature that has characteristics similar to dermatofibrosarcoma protuberans, has been presented. " 03/01/2010 - "In this study, we investigated the utility of D2-40 in separating dermatofibroma from dermatofibrosarcoma protuberans and compared the results with other commonly used immunostains. " 11/01/2007 - "A study of CD117 expression in dermatofibrosarcoma protuberans and cellular dermatofibroma." 07/01/2006 - "Dermatofibroma and dermatofibrosarcoma protuberans: a comparative ultrastructural study." 01/15/2002 - "Overrepresentation of 17q22-qter and 22q13 in dermatofibrosarcoma protuberans but not in dermatofibroma: a comparative genomic hybridization study."
3.	Estrogens (Estrogen)FDA Link 10/01/2012 - "Supernumerary breast tissue with Toker cells clinically and dermoscopically mimicking atrophic dermatofibroma: the efficacy of estrogen receptor immunoreactivity." 09/01/1993 - "Eight cases of sclerosing hemangioma obtained freshly at surgery had a quantitative analysis of estrogen and progesterone receptors performed by enzyme immunoassay. " 10/01/2010 - "To test this hypothesis, monoclonal anti-estrogen receptor (ER) a, anti-progesterone receptor (PR), anti-Factor XIIIa, and polyclonal anti-vascular endothelial growth factor (VEGF) antibodies were applied by immunohistochemistry on a series of 21 MCAHs and, compared to 10 cases of dermatofibroma (DF) and 5 cases of chronic dermatitis presenting multinucleate cells. " 07/01/2005 - "We immunostained specimens from 15 cases of sclerosing hemangioma and 15 samples of fetal lung tissue using antibodies against thyroid transcription factor 1, MUC1, Thomsen-Friedenreich antigen, and CD44v6, known as markers for type II pneumocytes, and a panel of antibodies against cytokeratin, epithelial membrane antigen, synaptophysin, CD56, estrogen receptor, and progesterone receptor. "
4.	dasatinib (BMS 354825)FDA Link 03/01/2007 - "Dasatinib is likely to be effective against dermatofibroma sarcoma protuberans and cutaneous acute lymphoblastic leukemia, and has caused panniculitis. "
5.	Muramidase (Lysozyme)IBA 11/01/1985 - "In this study the immunohistochemical analysis of distinct morphologic variants of benign fibrous histiocytoma (BFH) of the skin was performed with immunoperoxidase technique for both lysozyme and alpha-1-antitrypsin (A1AT). " 11/01/1986 - "The marked heterogeneity in lysozyme expression in cutaneous histiocytoma may indicate that a proportion of these tumors show relatively primitive histiocytic differentiation and do not express lysozyme. " 11/01/1986 - "Lysozyme was less reliable as a histiocytic marker in cutaneous histiocytoma; forty percent of these tumors were negative for lysozyme expression. " 11/01/1982 - "Cells positive for lysozyme were found only in 13 out of 100 cases of dermatofibroma, one out of 4 cases of xanthogranuloma and 8 out of 33 cases of malignant fibrous histiocytoma. " 11/01/1986 - "Lysozyme was not detectable in the tumor cells in lymphomatoid granulomatosis, atypical cutaneous histiocytoma, and histiocytic lymphosarcoma. "
6.	ParaffinIBA 03/01/2004 - "HSP47 staining on paraffin sections from diseased skin specimens revealed that skin ulcer, keloid, nodular fascitis, spindle cell lipoma, and dermatofibroma had strong signals for HSP47 compared with the signals obtained from normal skin. " 05/01/2006 - "The expressions of p-STAT3 and p-ERK were analyzed by immunohistochemical staining in formalin-fixed, paraffin-embedded tissue sections of human DFSP and dermatofibroma. " 12/01/1995 - "In addition DNA from six other patients with sclerosing hemangioma was analyzed with paraffin-embedded sections. " 08/01/1997 - "In this study, we investigated this role by immunohistochemically staining PDGF and PDGF beta-receptors in paraffin-embedded dermatofibroma (DF), dermatofibrosarcoma protuberans (DFSP) and malignant fibrous histiocytoma (MFH) tissue. " 01/01/1987 - "Using the PAP technique and the indirect immunofluorescence method, paraffin sections of formaldehyde fixed tissue specimens of 25 tumours (12 benign fibrous histiocytomas, 12 malignant fibrous histiocytomas, and 1 atypical fibroxanthoma) were studied. "
7.	AntigensIBA 12/01/1994 - "RM 3/1 antigen shows a similar, but broader expression pattern including non-Langerhans cell histiocytoses, xanthelasmata palpebrarum, foreign body granulomas, granuloma annulare, and cellular type dermatofibroma. " 11/01/1987 - "Characteristic round stromal cells, which were considered to be the main component of the sclerosing hemangioma, consisted of immunohistochemically heterogenous cells, that is, positive findings were attained with all three antigens, surfactant apoprotein- and EMA-positive ones, SC- and EMA-positive ones, only EMA-positive ones, and all three negative. " 10/01/1993 - "The consistent presence of CD-34 within all 13 cases of dermatofibrosarcoma protuberans can be used as evidence in support of the view that these lesions are variants of nerve sheath tumors, and distinct from benign fibrous histiocytomas which consistently lack the antigen. " 01/01/1988 - "An immunohistochemical study of six giant cell tumors of bone and eight related lesions (aneurysmal bone cyst, fibrous histiocytoma, and giant cell tumor of tendon sheath) was performed using a panel of monoclonal antibodies directed to the Ia and monocyte-macrophage lineage antigens. " 02/01/2005 - "We evaluated staining for antibodies directed against these two antigens in 202 spindle cell tumors, including cases of follicular dendritic cell tumor (n=14), interdigitating dendritic cell tumor (n=7), leiomyosarcoma (n=17), inflammatory myofibroblastic tumor (n=13), inflammatory pseudotumor (n=2), spindle cell thymoma (n=17), synovial sarcoma (n=11), fibrosarcoma (n=14), liposarcoma (n=27), gastrointestinal stromal tumor (n=13), malignant fibrous histiocytoma (n=18), angiomatoid fibrous histiocytoma (n=4), angiosarcoma (n=10), malignant peripheral nerve sheath tumor (n=8), malignant melanoma (n=16), and spindle cell carcinoma (n=11). "
8.	ApoproteinsIBA 09/01/1993 - "In this study, thirteen cases of sclerosing hemangiomas were analyzed by immunohistochemistry for various histochemical markers including surfactant apoprotein. " 01/01/1984 - "In the two cases of sclerosing hemangiomas, the type II pneumocytes were exuberant and numerous, and in one case contained intranuclear inclusions of surfactant apoprotein. " 09/15/1989 - "The cytoplasm of some of the sclerosing hemangioma tumor cells was positive for the anti-lung surfactant apoprotein monoclonal antibody (PE-10). " 01/01/1984 - "Bronchioloalveolar carcinomas (n = 45), intravascular bronchiolo-alveolar tumors (n = 8), and sclerosing hemangiomas of the lung (n = 2) were stained for surfactant apoprotein by the immunoperoxidase method. " 11/01/1987 - "Characteristic round stromal cells, which were considered to be the main component of the sclerosing hemangioma, consisted of immunohistochemically heterogenous cells, that is, positive findings were attained with all three antigens, surfactant apoprotein- and EMA-positive ones, SC- and EMA-positive ones, only EMA-positive ones, and all three negative. "
9.	Adenocarcinoma of lungIBA 11/01/2015 - "Therefore, the lung tumors were resected and diagnosed as a primary lung adenocarcinoma and a sclerosing angioma. " 06/30/1985 - "Also, benign dermal fibrous histiocytoma and the case of lymph nodal malignant histiocytosis showed an intense reactivity, whereas the immunostaining positivity of the squamous cell carcinoma of the skin, the lung adenocarcinoma, the squamous cutaneous and mucosal epithelium, and the sweat and sebaceous glands was slight. " 09/01/2015 - "The most significant changes in this edition involve (1) use of immunohistochemistry throughout the classification, (2) a new emphasis on genetic studies, in particular, integration of molecular testing to help personalize treatment strategies for advanced lung cancer patients, (3) a new classification for small biopsies and cytology similar to that proposed in the 2011 Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification, (4) a completely different approach to lung adenocarcinoma as proposed by the 2011 Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification, (5) restricting the diagnosis of large cell carcinoma only to resected tumors that lack any clear morphologic or immunohistochemical differentiation with reclassification of the remaining former large cell carcinoma subtypes into different categories, (6) reclassifying squamous cell carcinomas into keratinizing, nonkeratinizing, and basaloid subtypes with the nonkeratinizing tumors requiring immunohistochemistry proof of squamous differentiation, (7) grouping of neuroendocrine tumors together in one category, (8) adding NUT carcinoma, (9) changing the term sclerosing hemangioma to sclerosing pneumocytoma, (10) changing the name hamartoma to "pulmonary hamartoma," (11) creating a group of PEComatous tumors that include (a) lymphangioleiomyomatosis, (b) PEComa, benign (with clear cell tumor as a variant) and " 01/01/1986 - "We communicate a case of dermatofibroma recurrent of Darier and Ferrand localized in the left supra spinal region, that ulcerated when patient was irradiated with cobalt because she had a lung adenocarcinoma. "
10.	malignant SchwannomaIBA 03/01/2003 - "In particular, two cases of myeloid leukemia, one of angiomatous fibrous histiocytoma, one of malignant schwannoma, and one case of rhabdomyosarcoma were detected. " 11/01/1997 - "sarcomatoid carcinoma, GIST, secondaries of a sarcomatoid variant of melanoma, malignant schwannoma, malignant fibrous histiocytoma, peritoneal leiomyomatosis. " 03/01/2010 - "Of interest, in 7 of our 13 cases, a variety of diagnoses, such as cellular dermatofibroma, cellular leiomyoma, neurofibroma, low-grade leiomyosarcoma, fibrosarcoma, low-grade malignant schwannoma, desmoplastic melanoma, cellular neurofibroma, and low-grade malignant peripheral nerve sheet tumor were initially considered. " 09/01/1992 - "In this study we analysed by immunohistochemistry the expression of p53 protein in 14 malignant fibrous histocytomas (MFHs), 22 other types of sarcoma (eight leiomyosarcomas, four rhabdomyosarcomas, four liposarcomas, two fibrosarcomas, two chondrosarcomas, one malignant schwannoma, and one dermatofibrosarcoma protuberans), and 25 non-malignant mesenchymal lesions (eight dermatofibromas, four cases of nodular fasciitis, three leiomyomas, three fibromatoses, two epithelioid.leiomyomas, two neurofibromas, one schwannoma, one myositis ossificans, and one giant cell tumour of tendon sheath). "

Therapies and Procedures

1.	Cryosurgery 12/15/2012 - "Cryosurgery is as effective as alternative therapies for most cases of molluscum contagiosum, dermatofibromas, keloids, and plantar or genital warts. " 04/01/1999 - "Evidence from case report and series suggests that cryosurgery is effective for actinic keratoses, seborrheic keratoses, dermatofibroma, keloids, molluscum contagiosum, and benign nevi. "
2.	Radiotherapy 10/01/1998 - "[Radiotherapy is effective in the adjuvant treatment of dermatofibroma protuberans]." 05/01/1997 - "The authors present a case of a patient with an angiomatoid fibrous histiocytoma of the arm, treated with radiotherapy after three postsurgical recurrences." 05/01/1997 - "Angiomatoid fibrous histiocytoma of the arm treated by radiotherapy for local recurrence--case report." 01/01/1993 - "A case of fibrous histiocytoma of the larynx, treated successfully by radiotherapy, is presented. " 01/15/2000 - "Several of the patients developed treatment-related sequelae, including veno-occlusive disease of the lung and hemorrhagic cystitis (1), myelodysplastic syndrome (1), chemotherapy-induced ovarian failure (1), moist desquamation (1), and dermatofibroma within the radiotherapy volumes (1). "
3.	Complementary Therapies (Alternative Medicine) 12/15/2012 - "Cryosurgery is as effective as alternative therapies for most cases of molluscum contagiosum, dermatofibromas, keloids, and plantar or genital warts. "
4.	Drug Therapy (Chemotherapy) 01/01/2006 - "In the subset of fibrous histiocytomas that invade bone, however adjunctive treatment with radiation and or chemotherapy may be appropriate." 12/01/1982 - "Inflammatory fibrous histiocytoma: an important variant of malignant fibrous histiocytoma highly responsive to chemotherapy." 12/01/1980 - "A metastasizing fibrous histiocytoma arising in the lung of a patient who received radiation therapy and long-term chemotherapy for malignant lymphoma is presented. " 01/15/2000 - "Several of the patients developed treatment-related sequelae, including veno-occlusive disease of the lung and hemorrhagic cystitis (1), myelodysplastic syndrome (1), chemotherapy-induced ovarian failure (1), moist desquamation (1), and dermatofibroma within the radiotherapy volumes (1). " 07/20/2001 - "This study sought to use a microdialysis technique to relate clinical and biochemical responses to the time course of melphalan concentrations in the subcutaneous interstitial space and in tumour tissue (melanoma, malignant fibrous histiocytoma, Merkel cell tumour and osteosarcoma) in patients undergoing regional chemotherapy by Isolated Limb Infusion (ILI). "
5.	Mohs Surgery (Mohs' Micrographic Surgery) 01/01/2015 - "Aneurysmal dermatofibroma successfully treated with Mohs micrographic surgery." 02/01/2004 - "[Treatment of dermatofibroma protuberans with fixed Mohs' micrographic surgery]." 06/01/2008 - "The purpose of this study was to evaluate the use of modified Mohs micrographic surgery (MMS) for dermatofibroma sarcoma protuberans (DFSP) in a single institution by a single surgeon. " 06/01/2008 - "Treatment of dermatofibroma sarcoma protuberans using modified Mohs micrographic surgery: no recurrences and smaller defects."