Benign Fibrous Histiocytoma (Dermatofibroma)

A benign tumor composed, wholly or in part, of cells with the morphologic characteristics of HISTIOCYTES and with various fibroblastic components. Fibrous histiocytomas can occur anywhere in the body. When they occur in the skin, they are called dermatofibromas or sclerosing hemangiomas. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 5th ed, p1747)
Also Known As:
Dermatofibroma; Dermatofibromas; Histiocytoma, Benign Fibrous; Angioma, Sclerosing; Angiomas, Sclerosing; Benign Fibrous Histiocytomas; Cutaneous Histiocytoma; Cutaneous Histiocytomas; Fibrous Histiocytoma; Fibrous Histiocytoma, Benign; Fibrous Histiocytomas; Fibrous Histiocytomas, Benign; Hemangiomas, Sclerosing; Histiocytomas, Benign Fibrous; Histiocytomas, Cutaneous; Histiocytomas, Fibrous; Sclerosing Angioma; Sclerosing Angiomas; Sclerosing Hemangioma; Sclerosing Hemangiomas; Hemangioma, Sclerosing; Histiocytoma, Cutaneous; Histiocytoma, Fibrous
Networked: 355 relevant articles (7 outcomes, 29 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Keloid
2. Molluscum Contagiosum
3. Malignant Fibrous Histiocytoma
4. Sarcoma (Soft Tissue Sarcoma)
5. Nevus (Nevi)


1. Folpe, Andrew L: 4 articles (09/2015 - 04/2004)
2. Fletcher, Christopher D M: 3 articles (09/2015 - 01/2002)
3. Ihn, Hironobu: 3 articles (05/2014 - 01/2003)
4. Glusac, Earl J: 3 articles (07/2005 - 08/2002)
5. Mertens, Fredrik: 2 articles (09/2015 - 08/2014)
6. Nilsson, Jenny: 2 articles (09/2015 - 08/2014)
7. Domanski, Henryk A: 2 articles (09/2015 - 08/2014)
8. Tayebwa, Johnbosco: 2 articles (09/2015 - 08/2014)
9. Magnusson, Linda: 2 articles (09/2015 - 08/2014)
10. Won, Chong Hyun: 2 articles (05/2015 - 02/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Benign Fibrous Histiocytoma:
1. Factor XIIIaIBA
2. Dermatofibrosarcoma protuberansIBA
3. Estrogens (Estrogen)FDA Link
4. dasatinib (BMS 354825)FDA Link
5. Muramidase (Lysozyme)IBA
6. ParaffinIBA
7. AntigensIBA
12/01/1994 - "RM 3/1 antigen shows a similar, but broader expression pattern including non-Langerhans cell histiocytoses, xanthelasmata palpebrarum, foreign body granulomas, granuloma annulare, and cellular type dermatofibroma. "
11/01/1987 - "Characteristic round stromal cells, which were considered to be the main component of the sclerosing hemangioma, consisted of immunohistochemically heterogenous cells, that is, positive findings were attained with all three antigens, surfactant apoprotein- and EMA-positive ones, SC- and EMA-positive ones, only EMA-positive ones, and all three negative. "
10/01/1993 - "The consistent presence of CD-34 within all 13 cases of dermatofibrosarcoma protuberans can be used as evidence in support of the view that these lesions are variants of nerve sheath tumors, and distinct from benign fibrous histiocytomas which consistently lack the antigen. "
01/01/1988 - "An immunohistochemical study of six giant cell tumors of bone and eight related lesions (aneurysmal bone cyst, fibrous histiocytoma, and giant cell tumor of tendon sheath) was performed using a panel of monoclonal antibodies directed to the Ia and monocyte-macrophage lineage antigens. "
02/01/2005 - "We evaluated staining for antibodies directed against these two antigens in 202 spindle cell tumors, including cases of follicular dendritic cell tumor (n=14), interdigitating dendritic cell tumor (n=7), leiomyosarcoma (n=17), inflammatory myofibroblastic tumor (n=13), inflammatory pseudotumor (n=2), spindle cell thymoma (n=17), synovial sarcoma (n=11), fibrosarcoma (n=14), liposarcoma (n=27), gastrointestinal stromal tumor (n=13), malignant fibrous histiocytoma (n=18), angiomatoid fibrous histiocytoma (n=4), angiosarcoma (n=10), malignant peripheral nerve sheath tumor (n=8), malignant melanoma (n=16), and spindle cell carcinoma (n=11). "
8. ApoproteinsIBA
9. Adenocarcinoma of lungIBA
11/01/2015 - "Therefore, the lung tumors were resected and diagnosed as a primary lung adenocarcinoma and a sclerosing angioma. "
06/30/1985 - "Also, benign dermal fibrous histiocytoma and the case of lymph nodal malignant histiocytosis showed an intense reactivity, whereas the immunostaining positivity of the squamous cell carcinoma of the skin, the lung adenocarcinoma, the squamous cutaneous and mucosal epithelium, and the sweat and sebaceous glands was slight. "
09/01/2015 - "The most significant changes in this edition involve (1) use of immunohistochemistry throughout the classification, (2) a new emphasis on genetic studies, in particular, integration of molecular testing to help personalize treatment strategies for advanced lung cancer patients, (3) a new classification for small biopsies and cytology similar to that proposed in the 2011 Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification, (4) a completely different approach to lung adenocarcinoma as proposed by the 2011 Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification, (5) restricting the diagnosis of large cell carcinoma only to resected tumors that lack any clear morphologic or immunohistochemical differentiation with reclassification of the remaining former large cell carcinoma subtypes into different categories, (6) reclassifying squamous cell carcinomas into keratinizing, nonkeratinizing, and basaloid subtypes with the nonkeratinizing tumors requiring immunohistochemistry proof of squamous differentiation, (7) grouping of neuroendocrine tumors together in one category, (8) adding NUT carcinoma, (9) changing the term sclerosing hemangioma to sclerosing pneumocytoma, (10) changing the name hamartoma to "pulmonary hamartoma," (11) creating a group of PEComatous tumors that include (a) lymphangioleiomyomatosis, (b) PEComa, benign (with clear cell tumor as a variant) and "
01/01/1986 - "We communicate a case of dermatofibroma recurrent of Darier and Ferrand localized in the left supra spinal region, that ulcerated when patient was irradiated with cobalt because she had a lung adenocarcinoma. "
10. malignant SchwannomaIBA

Therapies and Procedures

1. Cryosurgery
2. Radiotherapy
3. Complementary Therapies (Alternative Medicine)
4. Drug Therapy (Chemotherapy)
5. Mohs Surgery (Mohs' Micrographic Surgery)