Osteoblastoma

A benign, painful, tumor of bone characterized by the formation of osteoid tissue, primitive bone and calcified tissue. It occurs frequently in the spine of young persons. (From Dorland, 27th ed; Stedman, 25th ed)

Also Known As:

Networked: 103 relevant articles (3 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Osteoid Osteoma
3.	Scoliosis
4.	Neck Pain (Cervicalgia)
5.	Osteosarcoma (Osteogenic Sarcoma)

Experts

1.	Hogendoorn, Pancras C W: 3 articles (01/2013 - 01/2010)
2.	Cleton-Jansen, Anne-Marie: 3 articles (01/2013 - 01/2010)
3.	Cai, Yongping: 2 articles (12/2012 - 01/2010)
4.	Mohseny, Alexander B: 2 articles (12/2012 - 01/2010)
5.	Povýsil, C: 2 articles (07/2008 - 04/2003)
6.	Kumasaka, Soma: 1 article (11/2015)
7.	Miyazaki, Masaya: 1 article (11/2015)
8.	Tsushima, Yoshito: 1 article (11/2015)
9.	Sciubba, Daniel M: 1 article (06/2015)
10.	Gokaslan, Ziya L: 1 article (06/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Osteoblastoma:

1.	SalicylatesIBA 10/01/1993 - "Their clinical presentations and distribution in the skeleton, however, are distinct: osteoid osteoma is usually accompanied by nocturnal pain promptly relieved by salicylates; osteoblastoma arises predominantly in the axial skeleton, spinal lesions constituting one-third of reported cases. "
2.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 10/01/2012 - "In the case of persistent neck pain, not readily relieved by aspirin and possibly accompanied by stiffness, scoliosis or neurological deficits, especially in young subjects, osteoblastoma of cervical spine may be one of the diagnostic options to be considered, in order to avoid delay in diagnosis. "
3.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 11/01/2011 - "Osteoblastoma is most frequently located in the axial skeleton, and the pain is usually not worse at night and is less likely to be relieved with NSAIDs. "
4.	Alkaline PhosphataseIBA 12/01/1992 - "[An electron microscopic study on osteoblastoma--ultrastructure and fine localization of alkaline phosphatase]." 05/01/1978 - "Studies on the fine structure of osteoblastoma with notes on the localization of nonspecific acid and alkaline phosphatase." 12/01/1992 - "From these findings we conclude that the aggressive osteoblastoma cells are more immature in morphology and show increased synthesis of alkaline phosphatase." 12/01/1992 - "In conventional osteoblastoma, ultrastructural features and location of alkaline phosphatase activity of the osteoblast-like cell were similar to those of normal osteoblast. " 08/01/1991 - "Bone tumors were categorized into alkaline phosphatase (ALPase)-positive (2 ossifying fibromas, 1 benign osteoblastoma and 16 osteosarcomas) and negative (2 chondromas, 2 chondrosarcomas, 3 non-ossifying fibromas, 2 malignant fibrous histiocytomas and 6 giant cell tumors of bone) groups. "
5.	beta CateninIBA 01/01/2013 - "Recurrent chromosome 22 deletions in osteoblastoma affect inhibitors of the Wnt/beta-catenin signaling pathway." 01/01/2010 - "Therefore, in this study, we examined nuclear beta-catenin expression in 52 human osteosarcoma biopsies, 15 osteoblastomas (benign bone tumours), and four human osteosarcoma cell lines by immunohistochemistry. " 01/01/2010 - "Absence of nuclear beta-catenin staining was found in 90% of the biopsies and all osteosarcoma cell lines, whereas strong nuclear beta-catenin staining was observed in all osteoblastomas. " 01/01/2013 - "In line with deletions of the latter two genes, high beta-catenin protein expression has previously been reported in osteoblastoma and aberrations affecting the Wnt/beta-catenin pathway have been found in other bone lesions, including osteoma and osteosarcoma. "
6.	Dinoprostone (PGE2)FDA Link 03/01/1988 - "The increased concentrations of prostaglandin E2 found in cases of osteoid osteoma and osteoblastoma confirm studies of explants of these tumors previously recorded in the literature."
7.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 04/01/2007 - "To study the immunoexpression of cyclo-oxygenase (COX) 2 in osteoblastomas (OBs) and osteosarcomas (OSs), and to assess the utility of immunohistochemical analysis for COX 2 in the differential diagnosis of the two tumour forms. " 04/01/2007 - "Utility of immunohistochemical analysis for cyclo-oxygenase 2 in the differential diagnosis of osteoblastoma and osteosarcoma."
8.	bufotalinIBA 08/15/2014 - "In this study, we examined the potential anti-osteoblastoma function of bufotalin, and studied the underlying mechanisms. " 08/15/2014 - "Bufotalin might be investigated as a novel anti-osteoblastoma agent. " 08/15/2014 - "In summary, our results suggest that ER stress contributes to bufotalin-induced apoptosis in osteoblastoma cells. " 08/15/2014 - "Our results showed that bufotalin induced osteoblastoma cell death and apoptosis in dose- and time-dependent manners. " 08/15/2014 - "Bufotalin-induced apoptosis in osteoblastoma cells is associated with endoplasmic reticulum stress activation."
9.	DNA (Deoxyribonucleic Acid)IBA 11/01/1993 - "The DNA profile of the initial biopsy specimen, which was histologically diagnosed as osteoblastoma, was euploid with a near diploid (2c) modal DNA. " 11/01/1993 - "To determine if the malignant transformation, as perceived histologically, in a case of osteoblastoma from the right femur, was also expressed as a quantitative change in nuclear DNA during tumour progression over five months. " 11/01/1993 - "The second biopsy specimen taken one month later also resembled osteoblastoma but showed an aneuploid DNA profile with a diploid modal DNA and some nuclei with ploidy greater than 5c. " 01/01/1989 - "On account of the particularly marked regressive changes, the resolution of DNA histograms was most strongly impaired in chondromatous tumors, whereas it was mostly excellent in highly cellular viable tumor tissue, such as that from Ewing's sarcoma or osteoblastoma. " 04/01/2007 - "DNA mutation performed in p53-positive cases was confirmed in exon 10 in 2 atypical osteoblastomas (2/3), 1 classical osteoblastoma (1/1), and 1 osteosarcoma (1/4). "
10.	tebufenozide (Mimic)IBA 08/01/2007 - "Epithelioid osteoblastomas mimic osteosarcoma because of similar cellularity and cytologic features. " 10/01/2010 - "It can mimic a variety of other benign bone tumors, but more importantly, distinguishing it from osteoblastoma-like osteosarcoma can be difficult. " 12/01/1996 - "Radiological appearances of this disease can mimic several bone conditions, including bone cyst, osteoblastoma and even osteosarcoma. " 05/01/2010 - "In addition, stress fracture, intracortical abscess, intracortical hemangioma, chondroblastoma, osteoblastoma, and compensatory hypertrophy of the pedicle may mimic osteoid osteoma. "

Therapies and Procedures

1.	Curettage 01/01/2014 - "Although curettage and grafting seems to be disadvantageous, it offers advantages in the functional protection in the treatment of carpal bone-located osteoblastoma. " 02/01/2013 - "We herein report two cases of osteoblastoma in the hip region in which diagnosis was delayed that were successfully treated with curettage and followed by high-speed burring." 01/01/2013 - "We present a case of recurrent trapezoid osteoblastoma previously treated with curettage of the trapezoid bone and a case of primary triquetral osteoblastoma. " 01/01/2013 - "Long-term follow-up of a hip joint osteoblastoma after intralesional curettage and cement packing: a case report." 10/01/2010 - "We report the case of an osteoblastoma of the hamate bone that was successfully treated by curettage. "
2.	Drug Therapy (Chemotherapy) 03/01/2008 - "Our case confirms the findings of previous investigators that if osteoblastoma is removed completely, no recurrence is expected even without adjuvant irradiation and chemotherapy." 01/01/1993 - "More than 90% tumour destruction was histologically demonstrated; tumour bone and osteoid increased after the chemotherapy, and the viable area of the tumour resembled an osteoblastoma. " 01/01/1992 - "Malignant osteoblastoma was, therefore, entertained and the patient was treated as such without aggressive surgery and chemotherapy. " 09/01/1991 - "Osteoblastoma response to chemotherapy." 04/01/1997 - "We report a 13-year-old girl wit recurrent osteoblastoma who, after in complete surgical excision, responded to treatment with radiotherapy and later with chemotherapy. "
3.	Transplants (Transplant) 07/01/2009 - "Total calcanectomy and reconstruction with vascularized iliac bone graft for osteoblastoma: a report of two cases." 10/01/2008 - "Re: metacarpal osteoblastoma treated with non-vascularized fibular graft: 8 years follow-up." 01/01/1962 - "[On the problem of recurrences and on the appearance of a new osteoblastoma in bone grafts]." 01/01/1986 - "It made it possible to diagnose a benign osteoblastoma, the diagnosis of which was doubtful before the transplant between osteosarcoma and chondroblastoma. "
4.	Radiotherapy 01/01/1993 - "The successful use of radiotherapy for osteoblastoma." 04/01/1997 - "We report a 13-year-old girl wit recurrent osteoblastoma who, after in complete surgical excision, responded to treatment with radiotherapy and later with chemotherapy. " 04/01/1997 - "There are few data about the effectiveness of chemotherapy or radiotherapy in the treatment of recurrent osteoblastoma. " 04/01/1997 - "Osteoblastoma response to radiotherapy and chemotherapy." 05/01/1993 - "Twenty-six per cent of cases arose in a pre-existing lesion, 4 cases post-radiotherapy, 3 cases in Paget's disease, 2 cases in bone infarcts and 1 case each in osteoblastoma, osteosarcoma and giant cell tumour. "
5.	Decompression 11/01/2006 - "The patient underwent decompression with resection of the mass which was found to be an aggressive osteoblastoma. " 05/01/2002 - "Following emergency decompression and dorsal stabilization, the pathologic investigation revealed a destructive osteoblastoma. " 07/01/1985 - "The Authors present 9 patients with extradural vertebral lesions: 4 plasmacytomas, 3 metastatic carcinomas, 1 malignant lymphoma and 1 aggressive osteoblastoma treated by simultaneous decompression and stabilization of the spine. " 11/01/1979 - "Osseous tumor was present in four of the five patients (osteoblastoma, metastatic adrenal carcinoma, metastatic renal cell carcinoma, multiple myeloma) and the fifth had spine instability as a result of a posterior decompression for cervical spinal cord glioma. "