Endometrial Stromal Sarcoma

A highly malignant subset of neoplasms arising from the endometrial stroma. Tumors in this group infiltrate the stroma with a wide range of atypia cells and numerous mitoses. They are capable of widespread metastases (NEOPLASM METASTASIS).

Also Known As:

Networked: 234 relevant articles (13 outcomes, 18 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Leiomyosarcoma
2.	Endometrioid Carcinoma
3.	Neoplasms (Cancer)
4.	Sarcoma (Soft Tissue Sarcoma)
5.	Carcinosarcoma

Experts

1.	Reich, Olaf: 9 articles (07/2007 - 07/2002)
2.	Regauer, Sigrid: 9 articles (07/2007 - 07/2002)
3.	Oliva, Esther: 7 articles (07/2014 - 01/2002)
4.	Regauer, S: 7 articles (01/2011 - 03/2000)
5.	Reich, O: 7 articles (01/2011 - 03/2000)
6.	Lee, Cheng-Han: 5 articles (09/2014 - 10/2012)
7.	Moinfar, Farid: 5 articles (06/2014 - 09/2004)
8.	Zatloukal, Kurt: 5 articles (06/2014 - 09/2004)
9.	Denk, Helmut: 5 articles (06/2014 - 09/2004)
10.	Nucci, Marisa R: 4 articles (01/2016 - 10/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Endometrial Stromal Sarcoma:

1.	Estrogens (Estrogen)FDA Link 12/01/2004 - "After transvaginal trough-cut biopsy of the mass, the diagnosis of low-grade endometrial stromal sarcoma with a high expression of alpha-estrogen receptor was made. " 07/01/2003 - "The goal of this work was to determine whether exposure to estrogen following treatment of low-grade endometrial stromal sarcomas affects clinical outcome. " 01/01/1989 - "Thus, immunohistochemically determined estrogen receptor levels may indicate the aggressiveness of endometrial stromal sarcoma, and might be a guideline in selecting patients for hormonal therapy. " 01/01/1987 - "Endometrial stromal sarcoma: a clinicopathologic study of 11 cases with determination of estrogen and progestin receptor levels in three tumors." 12/01/2013 - "It is prudent not to offer estrogen therapy to survivors of endometrial stromal sarcoma and women with granulosa cell tumors of the ovaries. "
2.	Aromatase (CYP19)IBA 08/01/2007 - "Endometrial stromal sarcoma, an uncommon uterine malignancy, has shown response to hormonal treatments, with multiple case reports of efficacy of aromatase inhibition. " 01/01/2004 - "Aromatase expression in low-grade endometrial stromal sarcomas: an immunohistochemical study." 01/01/2011 - "We examined the polymorphism 1558 C > T in he aromatase gene (CYP19A1) in a series of 20 low-grade endometrial stromal sarcomas. " 01/01/2011 - "Polymorphism 1558 C > T in the aromatase gene (CYP19A1) in low-grade endometrial stromal sarcoma." 01/01/2004 - "Our results demonstrate that most low-grade endometrial stromal sarcomas express aromatase. "
3.	Mifepristone (RU 486)FDA Link 05/01/2009 - ": The objective of this study was to determine the efficacy of mifepristone (RU-486) in women with advanced or recurrent endometrioid adenocarcinoma or low-grade endometrial stromal sarcoma (LGESS). " 05/01/2009 - "Phase 2 trial of mifepristone (RU-486) in advanced or recurrent endometrioid adenocarcinoma or low-grade endometrial stromal sarcoma."
4.	TamoxifenFDA LinkGeneric 01/01/2008 - "High-grade endometrial stromal sarcoma following tamoxifen treatment." 07/01/2006 - "However, only a few cases of endometrial stromal sarcomas have been reported to be linked with tamoxifen usage. " 02/01/2005 - "Is tamoxifen an option for patients with endometrial stromal sarcoma?" 09/01/2003 - "Here we report a woman who developed a high-grade endometrial stromal sarcoma after receiving postmastectomy tamoxifen therapy. " 06/01/1998 - "Only two cases of endometrial stromal sarcoma with sex cord-like features associated with tamoxifen use have been reported previously. "
5.	letrozole (Femara)FDA LinkGeneric 04/01/2010 - "Letrozole has been described as treatment for endometrial stromal sarcoma. " 04/01/2010 - "Treatment of recurrent endometrial stromal sarcoma with letrozole: a case report and literature review." 11/01/2009 - "Hormonal therapy with letrozole prior to surgical management of recurrent metastatic low-grade endometrial stromal sarcoma (LGESS)." 09/01/2007 - "Management of late recurrence of a low-grade endometrial stromal sarcoma (LGESS): treatment with letrozole." 08/01/2001 - "Endometrial stromal sarcoma: objective response to letrozole."
6.	Aromatase InhibitorsIBA 07/01/2012 - "Aromatase inhibitors are a well-tolerated class of medications that are effective in the treatment of endometrial stromal sarcomas. " 07/01/2005 - "Hormonal treatment with aromatase inhibitors for patients with endometrial stromal sarcoma." 11/01/2015 - "There has been no consensus on the indications for the treatment of advanced low-grade endometrial stromal sarcoma (LGESS), and the possible effects of hormonal treatment including progestins and aromatase inhibitors have been reported. " 01/01/2015 - "In low-grade endometrial stromal sarcomas, antihormonal therapies including aromatase inhibitors and progestins have proven activity. " 05/01/2012 - "For endometrial stromal sarcoma(formerly named low-grade ESS), progestins and aromatase inhibitors have been proven beneficial."
7.	Estrogen ReceptorsIBA 11/01/1986 - "Low-grade endometrial stromal sarcomas had higher median estrogen receptors (238.9 fmol/mg) and better survival (all patients alive at 6-12 months) than did high grade (N = 7) endometrial stromal sarcomas (median ER = 6.6 fmol/mg, all dead of disease at 8-27 months). " 08/01/2001 - "Letrozole at a daily dose of 2.5 mg may be effective in low-grade endometrial stromal sarcoma with positive estrogen receptors." 03/01/1992 - "The high-grade endometrial stromal sarcomas were negative for progesterone and estrogen receptors by both methods. " 01/01/2006 - "Morphological characteristics of the thracoscopically resected lung tumors suggested low-grade endometrial stromal sarcoma (ESS), and immunostaining revealed that the tumor cells were positive for progesterone and estrogen receptors, CD10 and vimentin, confirming a diagnosis of ESS. " 03/01/1992 - "Endometrial stromal sarcoma expression of estrogen receptors, progesterone receptors and estrogen-induced srp27 (24K) suggests hormone responsiveness."
8.	Paclitaxel (Taxol)FDA LinkGeneric 04/01/2000 - "Effective treatment of a patient with a high-grade endometrial stromal sarcoma with an accelerated regimen of carboplatin and paclitaxel."
9.	Carboplatin (JM8)FDA LinkGeneric 04/01/2000 - "Effective treatment of a patient with a high-grade endometrial stromal sarcoma with an accelerated regimen of carboplatin and paclitaxel."
10.	DydrogesteroneFDA Link 11/01/2013 - "Dydrogesterone at a daily dose of 10 mg may be effective in treating low-grade endometrial stromal sarcoma. " 11/01/2013 - "Successful use of dydrogesterone as maintenance therapy in recurrent endometrial stromal sarcoma: a case report."

Therapies and Procedures

1.	Ovariectomy (Oophorectomy) 01/01/2015 - "Complete remission achieved by oophorectomy for recurrent endometrial stromal sarcoma after laparoscopic morcellation." 01/15/2002 - "In our experience, the most effective treatment for patients with endometrial stromal sarcoma is total abdominal hysterectomy and bilateral salpingo-oophorectomy followed by adjuvant radiation therapy, due to the excellent local monitoring possibilities in all stages of disease, and a good disease specific survival in early stages." 04/01/2014 - "A 74-year-old female underwent hysterectomy and bilateral ovariectomy for uterine endometrial stromal sarcoma( ESS), low grade, at another hospital 31 years previously. " 02/01/2004 - "In this report the authors describe a woman with low-grade endometrial stromal sarcoma who was treated with total abdominal hysterectomy and bilateral salpingo-oophorectomy. " 08/01/2001 - "The patient is a 51-year-old woman who presented with low-grade endometrial stromal sarcoma confined to the uterus in 1991 and was treated with total abdominal hysterectomy and bilateral salpingo-oophorectomy. "
2.	Hysterectomy 01/01/2013 - "She had undergone a combination of a hysterectomy and adnexectomy for a low-grade endometrial stromal sarcoma 57 months previously, and undergone adjuvant radiation therapy at the local site. " 01/01/2013 - "A case of extrauterine endometrial stromal sarcoma in the colon diagnosed three decades after hysterectomy for benign disease." 11/01/2010 - "Endometrial stromal sarcoma diagnosed after uterine morcellation in laparoscopic supracervical hysterectomy." 01/01/2009 - "Case 1 was a 68-year-old woman who had three pulmonary nodules 23 years after hysterectomy for low-grade endometrial stromal sarcoma (LGESS). " 01/01/2007 - "Twelve years previously the patient had had a hysterectomy for a low grade endometrial stromal sarcoma, ER and PR positive. "
3.	Drug Therapy (Chemotherapy) 10/01/2010 - "This case suggests that IAP might be effective chemotherapy for patients with high-grade endometrial stromal sarcoma." 02/01/1997 - "The patient was initially diagnosed with a stage IIIA high-grade endometrial stromal sarcoma and had received four cycles of chemotherapy over the past year. " 02/01/1997 - "This case suggests that IAP might be effective chemotherapy for patients with high-grade endometrial stromal sarcoma." 01/01/2006 - "The efficacy of high-dose chemotherapy plus transplantation of autologous hematopoetic stem cells in patients with endometrial stromal sarcomas is unknown. " 02/01/2008 - "To review the survival outcomes in patients with endometrial stromal sarcoma (ESS) in Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, and to discuss prognostic factors and the role of post-operative adjuvant radiotherapy and chemotherapy. "
4.	Adjuvant Radiotherapy 09/01/2015 - "We present the case of a 46-year-old patient who was previously submitted to surgery for an endometrial stromal sarcoma followed by adjuvant radiotherapy; 18 months later she was diagnosed with a pelvic recurrence invading the urinary bladder trigone and the rectosigmoid so she was submitted to a total pelvic exenteration. " 07/01/2015 - "We present the case of a 46-year-old patient who was previously submitted to surgery for an endometrial stromal sarcoma followed by adjuvant radiotherapy; 18 months later she was diagnosed with a pelvic recurrence invading the urinary bladder trigone and the rectosigmoid so she was submitted to a total pelvic exenteration. " 02/01/2008 - "To review the survival outcomes in patients with endometrial stromal sarcoma (ESS) in Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, and to discuss prognostic factors and the role of post-operative adjuvant radiotherapy and chemotherapy. " 12/01/2011 - "Women with leiomyosarcomas and endometrial stromal sarcomas receiving adjuvant radiotherapy have improved local control compared with women undergoing surgery alone. "
5.	Combination Drug Therapy (Combination Chemotherapy) 04/01/1979 - "Complete remission of widely metastatic endometrial stromal sarcoma following combination chemotherapy." 08/01/1985 - "Aggressive endometrial stromal sarcoma responding to medroxyprogesterone following failure of tamoxifen and combination chemotherapy. "