Mesoblastic Nephroma (Congenital Mesoblastic Nephroma)

A solid, unencapsulated tumor of the KIDNEY composed of spindle mesenchymal cells that resemble FIBROBLASTS or muscle cells. The homogeneous mass typically extends into the renal parenchyma and replaces most of the kidney. In most cases, mesoblastic nephroma is benign and occurs in the fetus or newborn, and rarely in the older child or the adult.

Also Known As:

Networked: 98 relevant articles (3 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Wilms Tumor (Wilm's Tumor)
3.	Rhabdoid Tumor (Rhabdoid Tumors)
4.	Renal Cell Carcinoma (Grawitz Tumor)
5.	Neoplasm Metastasis (Metastasis)

Experts

1.	Davis, Jessica L: 3 articles (03/2022 - 01/2018)
2.	Rudzinski, Erin R: 3 articles (03/2022 - 01/2018)
3.	Kis, Adrienn: 2 articles (07/2022 - 03/2015)
4.	Trencsenyi, Gyorgy: 2 articles (07/2022 - 06/2009)
5.	Al-Ibraheemi, Alyaa: 2 articles (03/2022 - 01/2022)
6.	Gupta, Kirti: 2 articles (11/2021 - 11/2021)
7.	Trehan, Amita: 2 articles (11/2021 - 11/2021)
8.	Banfalvi, Gaspar: 2 articles (06/2012 - 06/2009)
9.	Arato, Viktoria: 1 article (07/2022)
10.	Denes, Noemi: 1 article (07/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mesoblastic Nephroma:

1.	Co-Repressor ProteinsIBA 11/01/2021 - "Recent studies have identified internal tandem duplication of BCL6 corepressor (BCOR) gene in CCSKs which coupled with cyclin D1 immunoreactivity, is helpful in differentiating it from its mimics, particularly blastema-rich Wilms tumor (WT), malignant rhabdoid tumor (MRT), and congenital mesoblastic nephroma (CMN). "
2.	Cyclin D1IBA 11/01/2021 - "Recent studies have identified internal tandem duplication of BCL6 corepressor (BCOR) gene in CCSKs which coupled with cyclin D1 immunoreactivity, is helpful in differentiating it from its mimics, particularly blastema-rich Wilms tumor (WT), malignant rhabdoid tumor (MRT), and congenital mesoblastic nephroma (CMN). "
3.	IntegrinsIBA 03/10/2015 - "Orthotopic and heterotopic transplanted mesoblastic nephroma (NeDe) bearing Fischer-344 rats were prepared, on which biodistribution studies and miniPET scans were performed for both (68)Ga-NOTA-c(NGR) and ανβ3 integrin selective (68)Ga-NODAGA-[c(RGD)]2 tracers. " 07/01/2022 - "The aim of this study was to evaluate the alterations in aminopeptidase N (APN/CD13) and αvβ3 integrin receptor expression in serially transplanted mesoblastic nephroma tumor (Ne/De) metastases using 68Gallium (68Ga)-labeled NOTA-cNGR and NODAGA-RGD radiotracers and preclinical positron emission tomography (PET) imaging. "
4.	1- (1,3- carboxypropyl)- 4,7- carboxymethyl- 1,4,7- triazacyclononaneIBA 03/10/2015 - "Orthotopic and heterotopic transplanted mesoblastic nephroma (NeDe) bearing Fischer-344 rats were prepared, on which biodistribution studies and miniPET scans were performed for both (68)Ga-NOTA-c(NGR) and ανβ3 integrin selective (68)Ga-NODAGA-[c(RGD)]2 tracers. " 07/01/2022 - "The aim of this study was to evaluate the alterations in aminopeptidase N (APN/CD13) and αvβ3 integrin receptor expression in serially transplanted mesoblastic nephroma tumor (Ne/De) metastases using 68Gallium (68Ga)-labeled NOTA-cNGR and NODAGA-RGD radiotracers and preclinical positron emission tomography (PET) imaging. "
5.	ReninIBA 11/01/1988 - "Renin in mesoblastic nephroma: an immunohistochemical study." 05/01/2000 - "Histologic analysis identified renin production from either the mesoblastic nephroma or secondarily from compression or ischemia. " 03/01/1993 - "Renin production in congenital mesoblastic nephroma in comparison with that in Wilms' tumor." 01/01/1992 - "Renin activity determination from the tumoral tissue had led to a different interpretation, ie primary hyperreninism: in the case of mesoblastic nephroma, only the non tumoral but compressed tissue contains a large quantity of renin; in the case of nephroblastomas, only the tumoral tissue contains renin. " 06/01/1989 - "These findings suggest that hypertension secondary to increased tumour associated renin production is a feature of congenital mesoblastic nephroma."
6.	Capsules (Microcapsules)IBA 07/01/2022 - "Primary and metastatic mesoblastic nephroma (Ne/De) tumors were induced by subrenal capsule assay (SRCA) in Fischer-344 rats. " 06/01/2009 - "Rat hepatocarcinoma (He/De), mesoblastic nephroma (Ne/De) cells, and in other cases tumor-bearing lymph nodes were transplanted under the renal capsule of F344 rats. " 05/15/1990 - "Myelomonocytic leukemia (My) mesoblastic nephroma (Ne) and hepatocellular carcinoma (He) cells were implanted under the renal capsule of F344, Long-Evans (LE) and BDIX rats. " 01/01/2023 - "Several studies implementing either Hepatocarcinoma (He/De), Mesoblastic Nephroma (Ne/De), chemically induced Myeloid Leukemia (My1/De), or spontaneous Myeloid Myelomonocytic Leukemia (My2/De) cells under the left renal capsule of rats applying SRCA method were underway to study secondary tumor formation. "
7.	LectinsIBA 04/01/1993 - "Congenital mesoblastic nephroma: an immunohistochemical and lectin study." 07/01/1986 - "Six peroxidase conjugated lectins were used to compare their ability to bind to formalin fixed paraffin embedded tissue sections of childhood renal tumours (Wilms' tumour, mesoblastic nephroma, renal carcinoma, rhabdoid renal tumour, and bone metastasising renal tumour of childhood (BMRTC) with fetal and normal children's kidney. "
8.	Proliferating Cell Nuclear Antigen (PCNA)IBA 02/01/1994 - "The PCNA scores for each tumor were as follows; the renal specimens for the control study (n = 10, a mean +/- SD of 8.04 +/- 3.59%); the nephroblastomas without anaplasia (n = 15, 27.70 +/- 7.59%); the nephroblastomas with anaplasia (n = 3, 36.89 +/- 1.17%); the sarcomatous renal tumors (n = 5, 27.75 +/- 5.02); the renal cell carcinomas (n = 2, 28.31 +/- 0.86%), a congenital mesoblastic nephroma and a juxtaglomerular cell tumor (10.05 and 10.80%, respectively). " 04/01/1999 - "To describe a case of congenital mesoblastic nephroma (CMN) treated by radical nephrectomy with no evidence of relapses after five years in spite of an unusual positivity for proliferating cellular nuclear antigen (PCNA). "
9.	CD13 Antigens (Alanine Aminopeptidase)IBA 07/01/2022 - "The aim of this study was to evaluate the alterations in aminopeptidase N (APN/CD13) and αvβ3 integrin receptor expression in serially transplanted mesoblastic nephroma tumor (Ne/De) metastases using 68Gallium (68Ga)-labeled NOTA-cNGR and NODAGA-RGD radiotracers and preclinical positron emission tomography (PET) imaging. "
10.	1,4,7- triazacyclononane- N,N',N''- triacetic acid (NOTA)IBA 07/01/2022 - "The aim of this study was to evaluate the alterations in aminopeptidase N (APN/CD13) and αvβ3 integrin receptor expression in serially transplanted mesoblastic nephroma tumor (Ne/De) metastases using 68Gallium (68Ga)-labeled NOTA-cNGR and NODAGA-RGD radiotracers and preclinical positron emission tomography (PET) imaging. "

Therapies and Procedures

1.	Nephrectomy 12/01/1994 - "The benign mesoblastic nephroma, in a one-month-old infant, was cured by nephrectomy alone. " 05/01/2023 - "The patient underwent a left radical nephrectomy, and the pathology results indicated that the mass was consistent with the classic type of congenital mesoblastic nephroma. " 04/01/2021 - "We describe a case of fetal congenital mesoblastic nephroma (CMN) who was diagnosed with ultrasound at 32 weeks of gestation; after delivery, the neonate received left radical nephrectomy, and pathology report confirmed the diagnosis. " 09/01/2015 - "At the end of the first week of life, a right nephrectomy was performed and subsequent pathological examination confirmed a cellular variant of congenital mesoblastic nephroma with a high mitotic count. " 11/01/2013 - "On the forth postnatal day left-sided radical nephrectomy was performed and histopathological examination revealed cellular type congenital mesoblastic nephroma. "
2.	Therapeutics 01/01/1993 - "The authors also stress the importance of differential diagnosis between congenital mesoblastic nephroma and other renal tumours, since therapy and prognosis of these tumours are different. " 03/01/1983 - "Awareness of congenital mesoblastic nephroma will aid in giving proper therapy." 10/01/1982 - "The importance of early and accurate histopathologic diagnosis of the resected specimen to avoid inappropriate post-operative therapy is emphasized, and the peculiar features of congenital mesoblastic nephroma are characterized." 12/01/1982 - "Therapy and outcome in 51 children with mesoblastic nephroma: a report of the National Wilms' Tumor Study." 01/01/2018 - "The growing spectrum of gene fusions associated with infantile fibrosarcoma and congenital mesoblastic nephroma along with the recent availability of targeted therapies directed toward inhibition of NTRK signaling argue for alternate testing strategies beyond ETV6 break-apart FISH. "
3.	Drug Therapy (Chemotherapy) 12/01/2011 - "Congenital mesoblastic nephroma was diagnosed, and the patient received postoperative chemotherapy. " 08/01/2002 - "Complete response of recurrent cellular congenital mesoblastic nephroma to chemotherapy." 04/01/1995 - "Preoperative chemotherapy for mesoblastic nephroma." 10/01/1992 - "Preoperative chemotherapy of cellular congenital mesoblastic nephroma in a 5-month-old infant." 04/01/1995 - "This case illustrates the effective use of a single drug pre-excision chemotherapy which allowed a nephrectomy for extensive stage III mesoblastic nephroma to be carried out safely."
4.	X-Ray Therapy 07/01/1975 - "In view of the occurrence of benign congenital mesoblastic nephroma which is evidently not rare in infancy, and because of the side effects of adjuvant cytotoxic and X-ray therapy, the authors feel that the immediate therapeutic approach to a solid intrarenal tumor in infancy should be surgical only. "
5.	Oral Administration 01/01/1980 - " The rats treated with oral administration of DMNA developed 1 nephroblastoma and 176 mesenchymal tumours similar to mesoblastic nephroma. "