Mesoblastic Nephroma (Congenital Mesoblastic Nephroma)

A solid, unencapsulated tumor of the KIDNEY composed of spindle mesenchymal cells that resemble FIBROBLASTS or muscle cells. The homogeneous mass typically extends into the renal parenchyma and replaces most of the kidney. In most cases, mesoblastic nephroma is benign and occurs in the fetus or newborn, and rarely in the older child or the adult.
Also Known As:
Congenital Mesoblastic Nephroma; Nephroma, Mesoblastic; Congenital Mesoblastic Nephromas; Mesoblastic Nephroma, Congenital; Mesoblastic Nephromas, Congenital; Nephroma, Congenital Mesoblastic; Nephromas, Congenital Mesoblastic; Nephromas, Mesoblastic
Networked: 74 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Renal Cell Carcinoma (Grawitz Tumor)
3. Wilms Tumor (Wilm's Tumor)
4. Clear Cell Sarcoma
5. Neuroblastoma


1. Roh, Cheong-Rae: 1 article (09/2015)
2. Choi, Suk-Joo: 1 article (09/2015)
3. Oh, Soo-Young: 1 article (09/2015)
4. Kim, Jung-Sun: 1 article (09/2015)
5. Do, A Young: 1 article (09/2015)
6. Kim, Jong-Hwa: 1 article (09/2015)
7. Gun, Feryal: 1 article (11/2013)
8. Esmer, Aytul Corbacioglu: 1 article (11/2013)
9. Ziylan, Orhan: 1 article (11/2013)
10. Kilicaslan, Isin: 1 article (11/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mesoblastic Nephroma:
1. ReninIBA
2. tranilast (N 5')IBA
05/01/1983 - "These included congenital mesoblastic nephroma (n = 5), fetal rhabdomyomatous nephroblastoma (n = 2), cystic partially differentiated nephroblastoma (n = 3), nephroblastoma with focal or diffuse anaplasia (n = 2), clear cell sarcoma or bone metastasizing renal tumor of childhood (n = 4), rhabdoid tumor (n = 2) and rhabdomyosarcomatous nephroblastoma (n = 3). "
12/01/2009 - "Cases studied included Wilms tumor (n=24), nephroblastomatosis (n=6), renal cell carcinoma (n=19), renal clear cell sarcoma (n=9), mesoblastic nephroma (n=9), neuroblastoma (n=11), malignant rhabdoid tumor (n=8 including 2 renal), Ewing sarcoma (n=16 including 1 renal, 7 soft tissue, and 8 bone), intra-abdominal desmoplastic small round cell tumor (n=5), and rhabdomyosarcoma (n=8, all extrarenal). "
12/01/2006 - "Histologic diagnoses were neuroblastoma (n = 5; 31.2 %), teratoma/ germ cell tumor (n = 4; 25 %), soft tissue sarcoma (one fibrosarcoma of the thigh and two hemangiopericytoma of the back and heart; 18.8 %), and one case each of mesoblastic nephroma, cerebral tumor (ependymoblastoma), melanoma (associated with giant congenital melanocytic nevi), and acute leukemia (associated with Down syndrome). "
02/01/1994 - "The PCNA scores for each tumor were as follows; the renal specimens for the control study (n = 10, a mean +/- SD of 8.04 +/- 3.59%); the nephroblastomas without anaplasia (n = 15, 27.70 +/- 7.59%); the nephroblastomas with anaplasia (n = 3, 36.89 +/- 1.17%); the sarcomatous renal tumors (n = 5, 27.75 +/- 5.02); the renal cell carcinomas (n = 2, 28.31 +/- 0.86%), a congenital mesoblastic nephroma and a juxtaglomerular cell tumor (10.05 and 10.80%, respectively). "
03/01/2006 - "Pathological examination of resected tumors revealed hepatoblastoma (n=11), mesenchymal hamartoma (n = 5), hepatocellular carcinoma (n = 4), hemangioendothelioma (n=1), malignant mesenchymal tumor (n = 1), hemangioma (n = 1), cyst adenoma (n = 1), and metastasis of cellular mesoblastic nephroma (n = 1). "
3. Proliferating Cell Nuclear Antigen (PCNA)IBA
4. renal OncocytomaIBA
5. Messenger RNA (mRNA)IBA
6. ParaffinIBA
10/01/1994 - "Fluorescence in situ hybridization utilizing a probe for the alpha satellite repeat sequence on chromosome 11 was used to detect variations in the number of chromosomes 11 in 24 formalin-fixed, paraffin-embedded congenital mesoblastic nephromas. "
01/01/2000 - "Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors."
01/01/2000 - "We report the development of a reverse transcriptase polymerase chain reaction assay that reliably detects the ETV6-NTRK3 chimeric RNA characteristic of infantile fibrosarcoma and the cellular variant of congenital mesoblastic nephroma (CMN) in formalin-fixed, paraffin-embedded tissue blocks. "
07/01/1986 - "Six peroxidase conjugated lectins were used to compare their ability to bind to formalin fixed paraffin embedded tissue sections of childhood renal tumours (Wilms' tumour, mesoblastic nephroma, renal carcinoma, rhabdoid renal tumour, and bone metastasising renal tumour of childhood (BMRTC) with fetal and normal children's kidney. "
01/01/1986 - "Using a peroxidase-antiperoxidase staining procedure, formalin fixed paraffin embedded sections of fetal and normal kidney; benign (mesoblastic nephroma); and malignant tumours (Wilms' tumour, clear cell renal carcinoma, rhabdoid renal tumour, and bone metastasising renal tumour of childhood (BMRTC] were examined for their reactivity with antisera to fibronectin, laminin, and epithelial membrane antigen. "
7. Formaldehyde (Formol)FDA Link
8. DNA (Deoxyribonucleic Acid)IBA
9. RNA (Ribonucleic Acid)IBA
10. Fibronectins (Fibronectin)IBA

Therapies and Procedures

1. Nephrectomy
2. Drug Therapy (Chemotherapy)
3. Oral Administration