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Malignant Mixed Tumor (Tumor, Malignant Mixed)

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A malignant tumor composed of more than one type of neoplastic tissue. (Dorland, 27th ed)

Also Known As:

Tumor, Malignant Mixed; Mixed Tumor, Malignant; Malignant Mixed Tumors; Mixed Tumors, Malignant; Tumors, Malignant Mixed

Networked: 34 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Neoplasms: 649836
- Neoplasms by Histologic Type: 1
  - Complex and Mixed Neoplasms
    - Malignant Mixed Tumor: 34

Related Diseases

1.	Synovial Sarcoma (Synovioma)
2.	Neoplasm Metastasis (Metastasis)
3.	Neoplasms (Cancer)
4.	Adenoid Cystic Carcinoma (Cylindroma)
5.	Cavernous Hemangioma (Cavernous Angioma)

Experts

1.	Liu, Baoan: 1 article (01/2015)
2.	Su, Zhansan: 1 article (01/2015)
3.	Li, Zhi: 1 article (01/2015)
4.	Elkhamary, Sahar M: 1 article (01/2014)
5.	Al-Mutlaq, Mohammed: 1 article (01/2014)
6.	Alkatan, Hind M: 1 article (01/2014)
7.	Al-Harkan, Dora Hamad: 1 article (01/2014)
8.	Maktabi, Azza: 1 article (01/2014)
9.	Wisell, Joshua: 1 article (12/2011)
10.	Hristov, Alexandra C: 1 article (12/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Malignant Mixed Tumor:

1.	Nasopharyngeal carcinomaIBA 11/01/2011 - "Of 2 patients with malignant mixed tumors, 1 survived disease free after a follow-up of 4 years,and another was still alive with disease after a follow-up of 3 years; Of 2 patients with synovial sarcomas, 1 survived disease free for a follow-up of 3 years, the other one survived disease free after a follow-up of 2 years; 1 patient of nasopharyngeal carcinoma with metastasis in the parapharyngeal space had post-operative radical radiotherapy and survived disease free after a follow-up of 5 years. " 01/01/2011 - "Ten cases with nasopharyngeal tumors were recruited in this study, of them, 3 cases with residual nasopharyngeal carcinoma after chemoradiotherapy, 2 cases with cavernous angioma, 2 cases with benign mixed tumor, 1 malignant mixed tumor, 1 adenoid cystic carcinoma, and 1 chordoma. "
2.	2-methylcyclopentadienyl manganese tricarbonyl (MMT)IBA 05/01/1977 - "Forty-seven cases of malignant mixed tumor (MMT) arising in major and minor salivary glands are presented. " 01/01/2014 - "We had 2 cases of malignant mixed tumor (MMT) one of which arising in a recurrent tumor. " 05/15/1980 - "Six cases of a rare entity, lacrimal gland malignant mixed tumor (MMT), or carcinoma arising in benign mixed tumor (BMT), are presented. " 06/01/1992 - "The authors studied a subset of benign and malignant mixed tumors (BMT and MMT) and found that 12 of 15 (80%) MMT diffusely and strongly expressed TAG-72, 2 of 15 MMT (13%) expressed TAG-72 focally, and 1 MMT (7%) was nonreactive. "
3.	VimentinIBA 05/01/1986 - "Four cases of malignant mixed tumor (carcinoma in pleomorphic adenomas) were studied for ultrastructural appearance and for the presence of cytokeratins and vimentin. " 01/01/1995 - "The true malignant mixed tumor exhibited variable positivity for two keratins, vimentin, proliferating cell nuclear antigen, Ki67, and p53. " 09/01/1989 - "The fibrosarcomas were positive only for vimentin, while the following expressed both desmin and cytokeratin: epithelial-like cells in one adenoma, three complex adenomas, the myoepithelioma-like tumor, the single comedo carcinoma, two complex carcinomas, the single lobular carcinoma, one malignant mixed tumor, and three osteosarcomas. "
4.	Proliferating Cell Nuclear Antigen (PCNA)IBA 03/01/2000 - "PCNA index was highest in malignant tumors (adenocarcinoma: 27.0%; malignant mixed tumor: 15.7%), followed by benign tumors (adenoma: 4.4%; benign mixed tumor: 5.3%), hyperplasia (2.1%), and normal mammary gland (0.9%). " 01/01/1995 - "The true malignant mixed tumor exhibited variable positivity for two keratins, vimentin, proliferating cell nuclear antigen, Ki67, and p53. "
5.	Keratins (Keratin)IBA 09/01/1989 - "Additionally, cytokeratin positive cells were scattered interstitially in one single adenoma, most complex adenomas, some benign mixed tumors, complex carcinomas, and in the malignant mixed tumors. " 01/01/1995 - "The true malignant mixed tumor exhibited variable positivity for two keratins, vimentin, proliferating cell nuclear antigen, Ki67, and p53. " 09/01/1989 - "The fibrosarcomas were positive only for vimentin, while the following expressed both desmin and cytokeratin: epithelial-like cells in one adenoma, three complex adenomas, the myoepithelioma-like tumor, the single comedo carcinoma, two complex carcinomas, the single lobular carcinoma, one malignant mixed tumor, and three osteosarcomas. "
6.	DNA (Deoxyribonucleic Acid)IBA 09/01/1992 - "DNA ploidy levels and cell proliferation rates were compared with those of conventional benign mixed tumors and also with malignant mixed tumors. " 03/01/1992 - "DNA-content was quantitatively determined in 2 monomorphic adenomas, 16 mixed tumors and 3 malignant mixed tumors by image analysis technique. "
7.	Bone Morphogenetic Protein 6IBA 11/01/2001 - "No significant immunoreactivity for BMP-6 was observed in most of the malignant mammary tumors; only one malignant mixed tumor was examined. "
8.	Telomerase (Telomerase Reverse Transcriptase)IBA 03/01/2000 - "In contrast, all normal mammary glands, hyperplasias, and malignant mixed tumors were negative for telomerase. "
9.	Complementary DNA (cDNA)IBA 07/15/2004 - "Amplification of MGC2177, PLAG1, PSMC6P, and LYN in a malignant mixed tumor of salivary gland detected by cDNA microarray with tyramide signal amplification."
10.	Cadherins (E-Cadherin)IBA 08/01/2002 - "In addition to histologic grading, Ki67 is a useful prognostic marker in the evaluation of malignant mixed tumor while p53 and E-cadherin appear to be of limited value."

Therapies and Procedures

1.	Radiotherapy 07/01/2009 - "In the case of disease spread in uterine sarcomas and malignant mixed tumors, good supportive therapy is a possible therapy option instead of chemo- or radiotherapy. " 05/01/2011 - "Twelve cases including 2 cases of basal cell carcinoma of orbital skin, 2 cases of squamous cell carcinoma of the parotid gland, 2 cases of submandibular gland malignant mixed tumor, 2 cases of metastatic lymph nodes of nasopharyngea carcinoma after radiotherapy, 1 case of squamous cell carcinoma of tongue, and 3 cases of squamous cell carcinoma of occipital skin, and all were classified as TNM stages T3 or T4. " 11/01/2011 - "Of 2 patients with malignant mixed tumors, 1 survived disease free after a follow-up of 4 years,and another was still alive with disease after a follow-up of 3 years; Of 2 patients with synovial sarcomas, 1 survived disease free for a follow-up of 3 years, the other one survived disease free after a follow-up of 2 years; 1 patient of nasopharyngeal carcinoma with metastasis in the parapharyngeal space had post-operative radical radiotherapy and survived disease free after a follow-up of 5 years. "
2.	Neck Dissection (Radical Neck Dissection) 06/01/2007 - "Total excision of the left submandibular gland with radical neck dissection was performed under a diagnosis of a submandibular tumor, probably a malignant mixed tumor. "
3.	Mohs Surgery (Mohs' Micrographic Surgery) 02/01/2011 - "A case of cutaneous malignant mixed tumor treated with mohs micrographic surgery."
4.	Therapeutic Embolization 11/01/1997 - "True malignant mixed tumor (carcinosarcoma) of tonsillar minor salivary gland origin: diagnostic imaging and endovascular therapeutic embolization."
5.	Curettage 01/01/2015 - "Curettage specimens were diagnosed as malignant mixed tumor, considered to be metastatic. "