Hepatoblastoma

A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)

Also Known As:

Networked: 1403 relevant articles (63 outcomes, 197 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Neoplasm Metastasis (Metastasis)
3.	Sarcoma (Soft Tissue Sarcoma)
4.	Rhabdomyosarcoma
5.	Ewing's Sarcoma (Sarcoma, Ewing)

Experts

1.	Warmann, Steven W: 16 articles (02/2015 - 07/2005)
2.	Fuchs, Jörg: 15 articles (02/2015 - 07/2002)
3.	von Schweinitz, Dietrich: 14 articles (12/2015 - 10/2003)
4.	Perilongo, Giorgio: 12 articles (08/2013 - 02/2003)
5.	Armeanu-Ebinger, Sorin: 11 articles (02/2015 - 12/2010)
6.	Czauderna, Piotr: 11 articles (02/2014 - 05/2005)
7.	Malogolowkin, Marcio H: 10 articles (02/2014 - 06/2006)
8.	Katzenstein, Howard M: 10 articles (11/2013 - 08/2002)
9.	Hiyama, Eiso: 9 articles (12/2015 - 06/2002)
10.	Finegold, Milton J: 9 articles (08/2014 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hepatoblastoma:

1.	Cisplatin (Platino)FDA LinkGeneric 07/01/2015 - "The aim of the present study was to determine whether treatment with sepantronium bromide (YM155), a novel small molecule inhibitor of survivin, enhanced the sensitivity of CDDP to hepatoblastoma cells, leading to the therapeutic efficacy of cisplatin. " 06/20/2006 - "Results from this and other therapeutic trials suggested that cisplatin was the most active agent against hepatoblastoma. " 07/01/2015 - "Cisplatin (CDDP) is a chemotherapeutic drug that is often used for the treatment of hepatoblastoma. " 07/01/2015 - "Antitumor activity of YM155, a selective survivin suppressant, in combination with cisplatin in hepatoblastoma." 06/01/2014 - "Human hepatoblastoma HepG2 cells were treated with concentrations of cisplatin ranging from 1 to 5 μg/mL. Cell survival and proliferation were evaluated using a tetrazolium dye (MTT) assay. "
2.	Doxorubicin (Adriamycin)FDA LinkGeneric 08/01/1980 - "Adriamycin alone, or in combination with other agents, has proven effective in primary and metastatic childhood hepatoblastoma. " 08/01/2011 - "With the goal of minimizing long-term toxicities, our institution treated hepatoblastoma with continuous infusion of doxorubicin and cisplatinum (PLADO), rather than short infusion or bolus dosing as used in other treatment protocols. " 10/22/2009 - "Doxorubicin can be safely omitted from the treatment of standard-risk hepatoblastoma. " 05/10/2008 - "Redefining the role of doxorubicin for the treatment of children with hepatoblastoma." 05/01/2008 - "[Inhibitory effect of adriamycin combined P21CIP1 gene transfection on proliferation of human hepatoblastoma cell line HepG2]."
3.	irinotecan (Camptosar)FDA LinkGeneric 07/01/2013 - "[Preliminary study on the efficacy of irinotecan in the treatment of childhood relapsed hepatoblastoma]." 12/01/2012 - "Efficacy of irinotecan single drug treatment in children with refractory or recurrent hepatoblastoma--a phase II trial of the childhood liver tumour strategy group (SIOPEL)." 12/01/2012 - "Exploration of the role of irinotecan in the initial treatment of hepatoblastoma is warranted." 12/01/2012 - "Irinotecan has a significant anti-tumour activity and acceptable toxicity in patients with relapsed hepatoblastoma and therefore should be considered for the treatment of these patients. " 12/01/2012 - "To assess the clinical activity of irinotecan as single drug in children with refractory or recurrent hepatoblastoma. "
4.	alpha-Fetoproteins (AFP)IBA 10/01/2014 - "The purpose of this study was to determine the utility of surveillance CT scans compared to serum alpha-fetoprotein (AFP) levels for the detection of hepatoblastoma relapse. " 12/01/2001 - "This study supports the use of AFP monitoring to modify treatment in hepatoblastoma responding to therapy with less toxic drugs and the use of nonstandard therapy when suboptimal responses are obtained." 01/01/1987 - "Morphometric, immunohistochemical, and electron-microscopic studies were undertaken in an attempt to identify the types of hepatoblastoma cellular elements responsible for the synthesis of alpha-fetoprotein (AFP), and to see how they may relate to serum AFP levels and the metastatic spread and prognosis of the hepatoblastoma. " 01/01/1987 - "[Hepatoblastoma cells producing alpha-fetoprotein: morphometric, immunohistochemical and electron microscopic studies]." 10/01/2014 - "We recommend using serial serum AFP levels as the preferred method of surveillance in children with AFP-positive hepatoblastoma, reserving imaging for the early postoperative period, for children at high risk of relapse, and for determination of the anatomical site of clinically suspected recurrence. "
5.	Vincristine (Oncovin)FDA LinkGeneric 05/01/2015 - "Formal prospective investigation of the relative risks and benefits of vincristine in hepatoblastoma treatment is warranted to assess the value of continued use of vincristine in this patient population. " 05/01/2015 - "We evaluated the incidence of vincristine-related sensorimotor peripheral, autonomic, and cranial nerve neurological morbidities in 45 consecutive hepatoblastoma patients treated at our institution. " 05/01/2015 - "Further examination of the risk and benefit profile of vincristine relevant to hepatoblastoma clinical care paradigms is thus warranted. " 05/01/2015 - "Vincristine-associated neurological morbidity in the treatment of hepatoblastoma." 08/15/2012 - "A two-year-old African-American girl with stage IV hepatoblastoma arrived at a clinic to receive her fourth dose of vincristine as part of standard induction therapy. "
6.	PlatinumIBA 06/20/2006 - "Intensification of therapy by alternating platinum analogs increased the risk of adverse outcome in children with unresectable or metastatic hepatoblastoma." 06/20/2006 - "Intensified platinum therapy is an ineffective strategy for improving outcome in pediatric patients with advanced hepatoblastoma." 12/15/2009 - "The current study was conducted to determine whether amifostine is effective in reducing the toxicities associated with the administration of platinum-containing regimens in children with hepatoblastoma (HB). " 08/01/2002 - "By contrast, Bamet-D3 [(N'N'' cis-dichloro N(3-3-amminepropylammine)propyl) glycocholamide platinum (II)] was only effective in reducing growth in human hepatoblastoma HepG2 cells. " 01/01/2014 - "At the moment there is no evidence from individual studies in children with osteosarcoma or hepatoblastoma treated with different platinum analogues and dosage schedules which underscores the use of amifostine as an otoprotective intervention as compared to no additional treatment. "
7.	Topotecan (Hycamtin)FDA LinkGeneric 06/01/2008 - "The expression of Bcl-XL, Bcl-XS and p27Kip1 in topotecan-induced apoptosis in hepatoblastoma HepG2 cell line." 06/01/2002 - "Metronome topotecan inhibits growth and neovascularization in experimental hepatoblastoma. " 06/01/2002 - "Topotecan is anti-angiogenic in experimental hepatoblastoma." 11/01/2001 - "From these results, treatment with topotecan appears to be a promising alternative in the pre- and postoperative therapy of patients suffering from human hepatoblastoma" 11/01/2001 - "Successful therapy of subcutaneously growing human hepatoblastoma xenografts with topotecan."
8.	AnthracyclinesIBA 01/01/2014 - "For Wilms' tumour, rhabdomyosarcoma and undifferentiated sarcoma, Ewing's sarcoma, non-Hodgkin lymphoma, hepatoblastoma and AML only one RCT was available for each type and, therefore, no definitive conclusions can be made about the antitumour efficacy of treatment with or without anthracyclines in these tumours. " 01/01/2011 - "For Wilms' tumour, rhabdomyosarcoma/undifferentiated sarcoma, Ewing's sarcoma, non-Hodgkin lymphoma and hepatoblastoma only one RCT was available and, therefore, no definitive conclusions can be made about the antitumour efficacy of treatment with or without anthracyclines in these tumours. " 09/01/1984 - "For hepatoblastomas, chemotherapy should consist of vincristine, cyclophosphamid, adriamycin and actinomycin-D whereas the hepatocellular carcinoma responds best to anthracyclines. "
9.	Proteins (Proteins, Gene)IBA 12/01/2015 - "The aim of this study was to ascertain whether Trx and/or Grx systems mediate the antiproliferative effect of NO on hepatoblastoma cells by modulating the redox-state of key proteins. " 03/01/1989 - "Further cellular investigation of the human hepatoblastoma-derived cell line HepG2: morphology and immunocytochemical studies of hepatic-secreted proteins." 09/01/2014 - "We assessed β-catenin and Yap1 signaling and interactions in hepatoblastoma cell lines ((HuH6, HepG2, HepT1, HC-AFW1, HepG2, and HC-AFW1); proteins were knocked down with small interfering RNAs, and effects on proliferation and cell death were measured. " 07/01/2006 - "Since most proteins involved in coagulation are synthesized by the liver, the hepatoblastoma cell line Hep G2 is introduced, here, as a model system to test nucleic acid based coagulation inhibitors. " 01/01/1999 - "Expression of Bcl-2 family proteins during chemotherapeutic agents-induced apoptosis in the hepatoblastoma HepG2 cell line."
10.	Amifostine (Ethyol)FDA LinkGeneric 12/15/2009 - "The current study was conducted to determine whether amifostine is effective in reducing the toxicities associated with the administration of platinum-containing regimens in children with hepatoblastoma (HB). " 01/01/2014 - "At the moment there is no evidence from individual studies in children with osteosarcoma or hepatoblastoma treated with different platinum analogues and dosage schedules which underscores the use of amifostine as an otoprotective intervention as compared to no additional treatment. " 01/01/2012 - "At the moment there is no evidence from individual studies in children with osteosarcoma and hepatoblastoma treated with different platinum analogues and dosage schedules which underscores the use of amifostine as an otoprotective intervention as compared to no additional treatment. " 12/15/2009 - "Amifostine does not prevent platinum-induced hearing loss associated with the treatment of children with hepatoblastoma: a report of the Intergroup Hepatoblastoma Study P9645 as a part of the Children's Oncology Group."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 03/01/1999 - "Though most patients with nonmetastatic hepatoblastomas can be cured by defining surgical strategies and chemotherapy regimes, new drugs are needed for children with advanced hepatoblastomas. " 07/01/1997 - "This protocol of preoperative chemotherapy appears to be safe and effective for most children who have hepatoblastoma." 01/01/2011 - "In the recent years, surgical resection with pre- and/or postoperative chemotherapy has markedly improved the survival rate of hepatoblastoma patients. " 05/20/2010 - "The primary objective was to determine the efficacy of a newly designed preoperative chemotherapy regimen in an attempt to improve the cure rate of children with high-risk hepatoblastoma. " 06/01/2002 - "However, the better outcome of our patients indicates that multimodal therapy, including high-dose chemotherapy, may improve the outcome of the patients with metastatic hepatoblastoma."
2.	Liver Transplantation 09/15/2002 - "Liver transplantation is an effective treatment for unresectable unifocal or multifocal hepatoblastoma confined to the liver. " 03/01/2012 - "The objective of this study was to review our experience with liver transplantation (OLT) for hepatoblastoma (HB) patients. " 01/01/2004 - "Liver transplantation for hepatoblastoma: results from the International Society of Pediatric Oncology (SIOP) study SIOPEL-1 and review of the world experience." 07/01/2002 - "The purpose of our study was to evaluate the outcome of children who underwent liver transplantation as treatment for unresectable hepatoblastoma. " 12/24/2014 - "Role of liver transplantation in the management of hepatoblastoma in the pediatric population."
3.	Hepatectomy 03/14/2011 - "To evaluate the efficacy of the two-surgeon technique with the liver hanging maneuver (LHM) for hepatectomies in pediatric patients with hepatoblastoma. " 05/01/2015 - "In the first case, the primary hepatoblastoma exhibited intense fluorescence during right hepatectomy, but no fluorescence was detected in the residual liver. " 03/01/2015 - "Erratum: Anaesthetic considerations in an infant with Beckwith-Weidemann syndrome and hepatoblastoma for partial hepatectomy: Erratum." 02/01/2015 - "Anaesthetic considerations in an infant with Beckwith-Weidemann syndrome and hepatoblastoma for partial hepatectomy." 09/01/2014 - "A left lobe hepatectomy was performed and the pathological examination revealed complete excision of a mixed embryonalfetal subtype hepatoblastoma. "
4.	Heterologous Transplantation (Xenotransplantation) 06/01/2006 - "Finally, Gd-labeled LDLs exhibited significant contrast enhancement 24 hours after administration in nude mice with human hepatoblastoma G2 xenografts. " 03/01/2003 - "Xenografts were established in athymic mice by intrarenal injection of cultured human hepatoblastoma cells. " 06/01/2002 - "Xenografts resulted from intrarenal injection of cultured human hepatoblastoma cells in athymic mice. " 04/01/2013 - "Further, small molecule inhibition of FAK led to decreased tumor growth in a nude mouse xenograft model of hepatoblastoma. " 01/01/2011 - "We established a reproducible xenograft model for intrahepatic hepatoblastoma growth with a high tumor incidence. "
5.	Therapeutics 07/01/2015 - "In vitro and in vivo models were used to examine the anticancer efficacy of YM155, either as a monotherapy or in combination with CDDP to identify more effective therapeutics against hepatoblastoma. " 08/15/2014 - "We believe this model may offer a valuable new tool to improve understanding of the cellular etiology and biology of HCC and hepatoblastomas and the development of improved therapeutics for these diseases." 03/01/2007 - "We propose that FOXG1 overexpression may contribute to the maintenance of the undifferentiated state in hepatoblastomas and could be a potential target for molecular therapeutics. "