Pneumovirus Infections

Infections with viruses of the genus PNEUMOVIRUS, family PARAMYXOVIRIDAE. This includes RESPIRATORY SYNCYTIAL VIRUS INFECTIONS, an important cause of respiratory disease in humans.

Also Known As:

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Porcine Reproductive and Respiratory Syndrome (PRRS)
2.	Pneumonia (Pneumonitis)
3.	Inflammation
4.	Infection
5.	Asthma (Bronchial Asthma)

Experts

1.	Rosenberg, Helene F: 6 articles (10/2014 - 08/2003)
2.	Domachowske, Joseph B: 6 articles (02/2012 - 08/2003)
3.	Bonville, Cynthia A: 4 articles (02/2012 - 08/2003)
4.	Phipps, Simon: 2 articles (05/2015 - 05/2013)
5.	Foster, Paul S: 2 articles (10/2014 - 05/2013)
6.	Bem, Reinout A: 2 articles (01/2010 - 01/2009)
7.	Bos, Albert P: 2 articles (01/2010 - 01/2009)
8.	van Woensel, Job B M: 2 articles (01/2010 - 01/2009)
9.	Easton, Andrew J: 2 articles (08/2004 - 08/2003)
10.	Engwerda, Christian R: 1 article (05/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pneumovirus Infections:

1.	CCR1 ReceptorsIBA 08/01/2004 - "Functional antagonism of chemokine receptor CCR1 reduces mortality in acute pneumovirus infection in vivo."
2.	Granzymes (Granzyme)IBA 01/15/2010 - "Expression of granzyme A and B is detected in effector lymphocytes in mouse lungs in response to pneumovirus infection. " 01/15/2010 - "Mice deficient for granzyme A and the granzyme B cluster have unchanged virus titers in the lungs but show a significantly delayed clinical response to fatal pneumovirus infection, a feature that is associated with delayed neutrophil recruitment, diminished activation of caspase-3, and reduced lung permeability. "
3.	Caspase 3 (Caspase-3)IBA 01/15/2010 - "Mice deficient for granzyme A and the granzyme B cluster have unchanged virus titers in the lungs but show a significantly delayed clinical response to fatal pneumovirus infection, a feature that is associated with delayed neutrophil recruitment, diminished activation of caspase-3, and reduced lung permeability. "
4.	Toll-Like Receptor 7IBA 05/01/2013 - "Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice."
5.	Toll-Like Receptor 4IBA 03/01/2006 - "Suppression of pattern-recognition receptor TLR4 sensing does not alter lung responses to pneumovirus infection."
6.	Pattern Recognition ReceptorsIBA 06/01/2013 - "Host-Viral Interactions: Role of Pattern Recognition Receptors (PRRs) in Human Pneumovirus Infections."
7.	CytokinesIBA 10/15/2014 - "Production and differentiation of myeloid cells driven by proinflammatory cytokines in response to acute pneumovirus infection in mice."
8.	LeukotrienesIBA 02/01/2006 - "We observed substantial virus replication in our mouse model of pneumovirus infection and significant accumulation of cysteinyl leukotrienes in lung tissue, the latter detected at levels that correlate directly with granulocyte recruitment to the airways. "
9.	Ribonucleases (Ribonuclease)IBA 08/01/2003 - "Diminished expression of an antiviral ribonuclease in response to pneumovirus infection in vivo."
10.	Interferon Type IIBA 05/01/2015 - "Coinfection with Blood-Stage Plasmodium Promotes Systemic Type I Interferon Production during Pneumovirus Infection but Impairs Inflammation and Viral Control in the Lung."

Therapies and Procedures

1.	Artificial Respiration (Mechanical Ventilation) 01/01/2009 - "Mechanical ventilation enhances lung inflammation and caspase activity in a model of mouse pneumovirus infection."