Retinoic Acid Receptors (Retinoic Acid Receptor)

Proteins in the nucleus or cytoplasm that specifically bind RETINOIC ACID or RETINOL and trigger changes in the behavior of cells. Retinoic acid receptors, like steroid receptors, are ligand-activated transcription regulators. Several types have been recognized.

Also Known As:

Networked: 705 relevant articles (17 outcomes, 45 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shudo, Koichi: 10 articles (10/2015 - 07/2007)
2.	Lotan, R: 6 articles (06/2001 - 01/2000)
3.	Katsuki, Hiroshi: 5 articles (10/2015 - 01/2011)
4.	Solt, Laura A: 5 articles (08/2015 - 06/2010)
5.	Lane, Michelle A: 5 articles (01/2014 - 11/2005)
6.	Park, Eun Young: 5 articles (01/2014 - 11/2005)
7.	Benbrook, Doris M: 5 articles (07/2013 - 02/2004)
8.	Chandraratna, R A: 5 articles (08/2001 - 04/2000)
9.	Hisatsune, Akinori: 4 articles (10/2015 - 01/2011)
10.	Kamenecka, Theodore M: 4 articles (08/2015 - 01/2012)

Related Diseases

1.	Leukemia 01/01/2007 - "Presented patient underwent alloSCT in second complete hematological and cytogenetic remission with presence of promyelocytic leukemia-retinoic acid receptor A (PML-RARA) detected in reverse transcription-polymerase chain reaction (RT-PCR) with sensitivity of 10(-2). " 12/01/2015 - "PML-RARα fusion protein was found to be reduced with PHB-overexpression, and following As4S4 treatment, a greater reduction of promyelocytic leukemia-retinoic acid receptor-α (PML-RARα) fusion protein was seen in PHB-overexpression than that in parental cells. " 01/01/2015 - "Moreover, the combination of low concentrations of As4S4 and As3+ enhanced degradation of the promyelocytic leukemia-retinoic acid receptor α oncoprotein. " 01/01/2015 - "The 3.2 μM Se(4+) enhanced As(3+)-induced differentiation by promoting the degradation of promyelocytic leukemia protein-retinoic acid receptor-α (PML-RARα) oncoprotein, but 1.0 μM Se(4+) did not have this effect. " 10/01/2014 - "Role of UTX in retinoic acid receptor-mediated gene regulation in leukemia."
2.	Neoplasms (Cancer) 01/01/2007 - "Recent discoveries may help to reveal the molecular basis of the tumor suppressive action of this retinoic acid receptor subtype and provide new tools for its analysis and, possibly, therapeutic exploitation. " 10/01/2005 - "Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists." 12/01/2001 - "In previous studies, we have shown that retinoic acid receptors (RARs) -alpha and -gamma are down-regulated during skin tumor progression. " 08/01/2015 - "Retinoic acid receptor β (RARβ), one member of the RAR receptor family, is considered as a tumor suppressor. " 03/01/2015 - "Retinoic acid receptor-related orphan receptor α (RORα) is a nuclear receptor and can regulate several lipid metabolism genes in certain cancers. "
3.	Acute Promyelocytic Leukemia 08/01/2013 - "Genetics and molecular biology: the role of retinoic acid receptor genes in acute promyelocytic leukemia." 07/15/2013 - "The PML gene is frequently fused to the retinoic acid receptor α (RARα) gene in acute promyelocytic leukemia (APL), generating a characteristic PML-RARα oncogenic chimera. " 02/21/2013 - "Acute promyelocytic leukemia is characterized by the rearrangement of the retinoic acid receptor α (RARA) gene and its fusion with other genes. " 03/01/2007 - "Designed ATRA analogue active against ATRA-resistant acute promyelocytic leukemia cells having a single nucleotide substitution in their retinoic acid receptor." 05/01/2004 - "Acute promyelocytic leukemia (APL) is characterized by a translocation t(15:17) that fuses the retinoic acid receptor gene with the promyelocytic gene, which blocks differentiation to normal granulocytes. "
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 08/01/1997 - "Tazarotene is a retinoic acid receptor-specific retinoid with demonstrated efficacy in the topical treatment of psoriasis. " 10/01/1997 - "Tazarotene therapy regulates gene transcription via interaction with specific nuclear retinoic acid receptors (RARs), thereby modulating the three key pathogenic factors in psoriasis. " 12/01/1996 - "Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoic acid receptor-specific retinoid: insight into the mechanism of retinoid action in psoriasis." 12/01/1996 - "Tazarotene (AGN 190168), a retinoic acid receptor (RAR)-specific retinoid, is effective in the treatment of psoriasis, a hyperproliferative and inflammatory skin disease. " 02/01/2009 - "Tazarotene (Tazorac, Avage, Allergan, Inc., Irvine, CA, USA) is a synthetic retinoic acid receptor- betagamma topical retinoid approved for the treatment of plaque psoriasis and acne vulgaris. "
5.	Inflammation 06/06/2013 - "We show that loss of retinoic-acid-receptor-related orphan receptor-γt-positive (RORγt(+)) ILCs was associated with dysregulated adaptive immune cell responses against commensal bacteria and low-grade systemic inflammation. " 09/21/2012 - "Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation." 12/01/1991 - "Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation." 03/01/2011 - "To determine whether synthetic retinoic acid receptor (RAR)-α/β-specific agonist Am80 reduces inflammation in experimental autoimmune uveoretinitis (EAU). " 06/01/2009 - "The nuclear receptor-type transcription factor retinoic acid receptor-related orphan receptor alpha (RORalpha) is a multifunctional molecule involved in tissue development and cellular function, such as inflammation, metabolism, and differentiation; however, the role of RORalpha during adipocyte differentiation has not yet been fully understood. "

Related Drugs and Biologics

1.	Tretinoin (Retinoic Acid)
2.	retinoic acid receptor alpha
3.	Transcription Factors (Transcription Factor)
4.	Am 80 (tamibarotene)
5.	tazarotene (Tazorac)
6.	Proteins (Proteins, Gene)
7.	Histones (Histone)
8.	Proteasome Endopeptidase Complex (Proteasome)
9.	Hemoglobins (Hemoglobin)
10.	Fibrinogen (Factor I)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Chemoprevention
4.	Electrodes (Electrode)