Endolymphatic Hydrops

An accumulation of ENDOLYMPH in the inner ear (LABYRINTH) leading to buildup of pressure and distortion of intralabyrinthine structures, such as COCHLEA and SEMICIRCULAR CANALS. It is characterized by SENSORINEURAL HEARING LOSS; TINNITUS; and sometimes VERTIGO.

Also Known As:

Networked: 328 relevant articles (18 outcomes, 40 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Vertigo (Positional Vertigo)
2.	Meniere Disease (Menieres Disease)
3.	Hypertension (High Blood Pressure)
4.	Sudden Hearing Loss (Sudden Deafness)
5.	Deafness (Deaf Mutism)

Experts

1.	Naganawa, Shinji: 26 articles (11/2015 - 01/2008)
2.	Nakashima, Tsutomu: 26 articles (08/2015 - 04/2002)
3.	Sone, Michihiko: 25 articles (11/2015 - 01/2008)
4.	Takeda, Taizo: 12 articles (03/2014 - 07/2002)
5.	Yamazaki, Masahiro: 11 articles (01/2014 - 01/2010)
6.	Kawai, Hisashi: 11 articles (01/2014 - 01/2010)
7.	Teranishi, Masaaki: 10 articles (08/2015 - 02/2009)
8.	Kakigi, Akinobu: 10 articles (03/2014 - 07/2002)
9.	Takeda, Setsuko: 7 articles (03/2014 - 08/2003)
10.	Bokura, Kiminori: 7 articles (01/2014 - 01/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Endolymphatic Hydrops:

1.	Glycerol (Glycerine)FDA LinkGeneric 05/01/1994 - "A significant reduction of SP/AP amplitude ratios was found to be always associated with prominent SP/AP ratios at the baseline, irrespective of glycerol test results, and only in cases of classic Menière's disease, indicating that this dominant ratio is a very reliable indicator of Menière's disease and endolymphatic hydrops. " 06/01/2001 - "In conclusion, clinical use of OAE, especially DPOAE, as a test complementary to pure-tone audiometry during the glycerol test is very useful and will improve the diagnosis of endolymphatic hydrops." 02/01/1981 - "Temporary improvement in the hearing level and discrimination from the glycerin test in endolymphatic hydrops could be explained by this potential mechanism of endolymph volume reduction." 01/01/1984 - "The glycerol effect for endolymphatic hydrops is well known for an improvement in pure tone threshold three hours after glycerol administration. " 01/01/2004 - "The present study re-confirms the potentiality of DPOAEs associated with glycerol test in diagnosing endolymphatic hydrops precociously. "
2.	GadoliniumIBA 01/01/2010 - "Bilateral intratympanic administration of a gadolinium-based contrast agent (GBCA) in MRI was successfully performed and proved to be beneficial in the semi-quantitative evaluation of endolymphatic hydrops. " 07/01/2015 - "Studies describing endolymphatic hydrops in Menière disease after off-label intratympanic gadolinium-based contrast have been limited by long acquisition times. " 02/01/2012 - "Recent studies reported on the use of MRI after intratympanic gadolinium injection to demonstrate endolymphatic hydrops in vivo. " 02/01/2011 - "The objective of the study was to compare the outcomes of a series of diagnostic parameters in Ménière's disease (MD) patients with the extent of endolymphatic hydrops (EH) as shown by magnetic resonance imaging (MRI) performed after intra-tympanic gadolinium administration using 18 patients (13 males and 5 females, age 25-78 years, median age 54.3 years) with definite MD. " 11/13/2015 - "We performed MR imaging of 40 ears in 20 patients with clinically suspected endolymphatic hydrops 4 hours after intravenous administration of single-dose gadolinium-based contrast material (IV-SD-GBCM). "
3.	Furosemide (Lasix)FDA LinkGeneric 11/01/2005 - "Vestibular evoked myogenic potentials were also measured after furosemide administration in six patients in the endolymphatic hydrops group. " 03/01/2003 - "To investigate whether endolymphatic hydrops in Ménière's Disease could be diagnosed by comparing vestibular evoked myogenic potential (VEMP) before and after furosemide administration (F-VEMP). " 01/01/1994 - "[Changes in vestibular function and furosemide test after experimental endolymphatic hydrops in guinea pigs]." 01/01/1993 - "The positive rate of the furosemide VOR test in patients with endolymphatic hydrops was more than 50%. " 01/01/1993 - "Furosemide VOR test for the detection of endolymphatic hydrops."
4.	Gentamicins (Gentamicin)FDA LinkGeneric 07/01/2000 - "The significant reduction in the SP/AP ratio in the gentamicin-treated Ménière's group supports the hypothesis that gentamicin improves the electrophysiologic function of the cochlea, possibly by reducing the severity of the associated endolymphatic hydrops." 06/01/2012 - "Magnetic resonance imaging fails to show evidence of reduced endolymphatic hydrops in gentamicin treatment of Ménière's disease." 04/01/2002 - "Seven patients who were with or without symptoms for 6-101 months after intratympanic gentamicin therapy for unilateral endolymphatic hydrops were sinusoidally exposed to lateral linear acceleration, and their compensatory eye movements were compared with those of 18 normal controls, using electro-oculography (EOG). " 05/01/1995 - "More vestibulotoxic than cochleotoxic, gentamicin initially disrupts the endolymph-secreting vestibular dark cells, thereby preventing endolymphatic hydrops development. " 09/01/1993 - "Ossicular disruption, experimentally induced early endolymphatic hydrops and gentamycin-induced inner ear damage could be objectively determined histologically and electrophysiologically. "
5.	Dexamethasone (Maxidex)FDA LinkGeneric 01/01/2015 - "The present study showed that intratympanic dexamethasone injection (ITD) is a promising approach for the treatment of contralateral and ipsilateral delayed endolymphatic hydrops (DEH). " 03/01/2008 - "The aim of this study was to investigate the audiological and histopathologic effects of dexamethasone in the treatment of experimentally induced endolymphatic hydrops. " 10/01/2014 - "To observe the effect of tympanic injection of dexamethasone in the guinea pig endolymphatic hydrops and the change CFTR expression, to explore the effect of glucocorticoid treatment endolymphatic and its possible mechanism. " 10/01/2014 - "[Effects of intratympanic injection of dexamethasone on endolymphatic hydrops and changes in guinea pigs inner ear CFTR expression]." 02/01/2009 - "Dexamethasone inner ear perfusion for subclinical endolymphatic hydrops."
6.	gadodiamide (Omniscan)FDA Link 01/01/2013 - "Three-dimensional visualization of endolymphatic hydrops after intravenous administration of single-dose gadodiamide." 01/01/2013 - "Visualization of endolymphatic hydrops in Ménière's disease after intravenous administration of single-dose gadodiamide at 1.5T." 01/01/2010 - "Endolymphatic hydrops could be visualized recently by intratympanic injection of Omniscan diluted 8- or 16-fold with saline using three-dimensional fluid attenuated inversion recovery (3-D FLAIR) MRI. " 12/01/2003 - "To conclude, endolymphatic hydrops can be visualized with high-resolution MRI by means of Gd-DTPA-BMA, and it is possible to quantify the extent of endolymphatic hydrops. " 01/01/2012 - "To visualize endolymph as bright signal after intravenous injection of single-dose gadodiamide, we shortened the inversion time of heavily T(2)-weighted 3-dimensional (3D) fluid-attenuated inversion recovery (FLAIR) to 2050 ms. In 14 patients with suspected Ménière's disease, we observed high signal of vestibular endolymph in all ears, including 6 ears without vestibular endolymphatic hydrops. "
7.	ThiazidesIBA 06/01/2008 - "Furthermore, patients may develop endolymphatic hydrops requiring diuretic therapy, mainly in the form of thiazides. " 07/01/2012 - "In this study, we aimed to investigate whether the symptoms of vertigo related to hypertension resulted from endolymphatic hydrops and the efficacy of the thiazides in the treatment. "
8.	Horseradish PeroxidaseIBA 06/01/1998 - "This paper reports that endolymphatic hydrops causes a significant reduction of retrogradely labeled cell bodies of the ipsilateral trigeminal ganglion following application of horseradish peroxidase in the cochlea. " 08/01/1990 - "This was followed by a light and electron microscopic study on the changes in permeability of the cochlear lateral wall with horseradish peroxidase and a study of the development mechanism of endolymphatic hydrops. "
9.	IsosorbideFDA Link 01/01/2004 - "Time course of dehydrating effects of isosorbide on experimentally induced endolymphatic hydrops in guinea pigs." 01/01/1995 - "Changes in hearing were studied in 145 ears (103 patients) with endolymphatic hydrops before and after an 8-week administration of isosorbide. " 01/01/1995 - "Effect of isosorbide on hearing loss due to endolymphatic hydrops." 01/01/1982 - "For the purpose of improving the repeated attacks of vertigo, Isosorbide as an oral hyperosmotic diuretic was first administered orally to 21 patients with Menière's disease from November 1979 to January 1981 for reducing the endolymphatic hydrops that can be presumed to be of pathogenetic importance. " 11/01/2009 - "A gadodiamide (a kind of GBCA)-enhanced space surrounding the endolymph in the affected side with a 0.50 ratio (which may have represented endolymphatic hydrops) improved after isosorbide therapy to a 0.98 ratio. "
10.	Free Radical ScavengersIBA 06/01/1995 - "These data suggest that oxidative insult is likely to contribute to the pathology associated with endolymphatic hydrops and thus that free radical scavengers might be useful in the treatment of Menière's disease patients. "

Therapies and Procedures

1.	Decompression 12/01/2013 - "Effects of endolymphatic sac decompression surgery on endolymphatic hydrops." 08/01/1967 - "Automatic repetitive decompression of the saccule in endolymphatic hydrops (tack operation). " 11/01/1965 - "Pharmacologic decompression of the endolymphatic hydrops." 12/01/2013 - "The present findings suggest that complete control of vertigo after endolymphatic sac decompression surgery (ESDS) does not always depend on improved vestibular function or reduced endolymphatic hydrops. " 04/01/2009 - "Decompression effects of erythritol on endolymphatic hydrops."
2.	Hyperbaric Oxygenation 02/01/2007 - "Clinical characteristics of delayed endolymphatic hydrops: long-term results of hearing and efficacy of hyperbaric oxygenation therapy."
3.	Hearing Aids (Hearing Aid) 04/01/1994 - "In patients who have unilateral idiopathic endolymphatic hydrops with intractable, severe episodic vertigo and established sensorineural deafness that cannot be helped by a hearing aid, the Cody tack procedure is the conservative procedure of choice. "
4.	Electrodes (Electrode) 10/01/2015 - "Aim of this study was to explore the clinical value of non-invasive recordings of electrocochleography in comparison to the use of invasive electrodes for the diagnosis of endolymphatic hydrops in patients with suspicious Morbus Menière. " 08/01/2002 - "The left endolymphatic sac was ablated to induce endolymphatic hydrops in fourteen healthy guinea pigs with normal action potential thresholds measured after a sliver ball electrode placed on the round window. " 01/01/1989 - "We have previously shown by chronic implantation of round window electrodes, that after the experimental induction of endolymphatic hydrops by surgical blockade of the endolymphatic canal, in the guinea pig, there is a low/mid-frequency fluctuant hearing loss, followed by a very high frequency loss and after a few months the audiogram is flat. " 09/01/2012 - "Cochleostomy or round window enlargement techniques for cochlear implant electrode insertion result in more abnormal tissue formation in the basal cochlea and are more apt to produce endolymphatic hydrops than round window electrode insertion. "
5.	Solid-State Lasers 06/01/2001 - "KTP laser-assisted TSCA can be performed in the guinea pig model of endolymphatic hydrops without significant loss of hearing. " 06/01/2001 - "Selective vestibular ablation by KTP laser in endolymphatic hydrops." 06/01/2001 - "This study was designed to assess the cochlear effects of potassium titanyl phosphate (KTP) laser-assisted triple semicircular canal ablation (TSCA) in endolymphatic hydrops. "