Endolymphatic Hydrops

An accumulation of ENDOLYMPH in the inner ear (LABYRINTH) leading to buildup of pressure and distortion of intralabyrinthine structures, such as COCHLEA and SEMICIRCULAR CANALS. It is characterized by SENSORINEURAL HEARING LOSS; TINNITUS; and sometimes VERTIGO.

Also Known As:

Networked: 541 relevant articles (36 outcomes, 68 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Meniere Disease (Menieres Disease)
2.	Vertigo (Positional Vertigo)
3.	Syncope (Fainting)
4.	Hypertension (High Blood Pressure)
5.	Edema (Dropsy)

Experts

1.	Naganawa, Shinji: 48 articles (07/2022 - 01/2008)
2.	Sone, Michihiko: 43 articles (07/2022 - 01/2008)
3.	Nakashima, Tsutomu: 28 articles (03/2017 - 04/2002)
4.	Kawai, Hisashi: 19 articles (07/2022 - 01/2010)
5.	Yoshida, Tadao: 18 articles (07/2022 - 03/2012)
6.	Kitahara, Tadashi: 15 articles (04/2022 - 04/2009)
7.	Teranishi, Masaaki: 15 articles (08/2021 - 02/2009)
8.	Takeda, Taizo: 15 articles (01/2020 - 07/2002)
9.	Kakigi, Akinobu: 13 articles (01/2020 - 07/2002)
10.	Yamazaki, Masahiro: 12 articles (01/2014 - 01/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Endolymphatic Hydrops:

1.	Glycerol (Glycerine)FDA LinkGeneric 01/01/2021 - "Conclusion: The significant reduction in enhanced eye velocity during head impulse testing following oral glycerol is consistent with the hypothesis that the enhanced eye velocity in vHIT may be caused by endolymphatic hydrops." 06/01/2001 - "In conclusion, clinical use of OAE, especially DPOAE, as a test complementary to pure-tone audiometry during the glycerol test is very useful and will improve the diagnosis of endolymphatic hydrops." 02/01/1981 - "Temporary improvement in the hearing level and discrimination from the glycerin test in endolymphatic hydrops could be explained by this potential mechanism of endolymph volume reduction." 01/01/1984 - "The glycerol effect for endolymphatic hydrops is well known for an improvement in pure tone threshold three hours after glycerol administration. " 01/01/2004 - "The present study re-confirms the potentiality of DPOAEs associated with glycerol test in diagnosing endolymphatic hydrops precociously. "
2.	GadoliniumIBA 01/01/2021 - "This study included 1,842 ears from 934 patients who underwent 3-T magnetic resonance imaging with gadolinium to investigate the presence of endolymphatic hydrops. " 01/29/2019 - "[Magnetic resonance imaging study of endolymphatic hydrops based on 3D-FLAIR sequence after single-dose intravenous gadolinium injection]." 07/01/2015 - "Studies describing endolymphatic hydrops in Menière disease after off-label intratympanic gadolinium-based contrast have been limited by long acquisition times. " 02/01/2012 - "Recent studies reported on the use of MRI after intratympanic gadolinium injection to demonstrate endolymphatic hydrops in vivo. " 08/01/2023 - "The possibility of endolymphatic hydrops was suspected, which was confirmed by inner ear magnetic resonance gadolinium imaging. "
3.	Gentamicins (Gentamicin)FDA LinkGeneric 07/01/2000 - "The significant reduction in the SP/AP ratio in the gentamicin-treated Ménière's group supports the hypothesis that gentamicin improves the electrophysiologic function of the cochlea, possibly by reducing the severity of the associated endolymphatic hydrops." 01/01/2018 - "The study indicates that the endolymphatic hydrops degree has a negative interference on the delivery of gentamicin into the inner ear following middle ear application." 01/01/2018 - "In animals with endolymphatic hydrops, lower concentrations of gentamicin were observed after 20 or 120 minutes of exposure and in both types of administration, when compared to controls. " 01/01/2018 - "Perilymph gentamicin concentrations and correlation with endolymphatic hydrops in an animal model were assessed. " 01/01/2018 - "Gentamicin delivery to the inner ear: Does endolymphatic hydrops matter?"
4.	Furosemide (Lasix)FDA LinkGeneric 09/01/2020 - "Comparison of furosemide-loading cervical vestibular-evoked myogenic potentials with magnetic resonance imaging for the evaluation of endolymphatic hydrops." 12/01/2017 - "The presence of endolymphatic hydrops can be suggested by improving the amplitude of vestibular-evoked myogenic potential (VEMP) after furosemide administration (furosemide loading VEMP [FVEMP]). " 12/01/2017 - "Revision of a furosemide-loading vestibular-evoked myogenic potential protocol for detecting endolymphatic hydrops." 03/01/2016 - "There was no evidence of endolymphatic hydrops modification 1 hour after intravenously administered frusemide. " 11/01/2005 - "Vestibular evoked myogenic potentials were also measured after furosemide administration in six patients in the endolymphatic hydrops group. "
5.	Contrast MediaIBA 01/01/2021 - "Results: Based on our experience of endolymphatic hydrops imaging (EHI), which was established in cooperation between our departments of radiology and otorhinolaryngology in 2017, we have exclusively used intratympanic application of a contrast agent prior to magnetic resonance imaging, as this approach provides high quality imaging results. " 12/29/2020 - "Evaluation of endolymphatic hydrops is possible as the contrast agent selectively penetrates the perilymph, and endolymph is visualized as contrast defects. " 01/01/2020 - "Recent two MRI methods using a contrast agent can only depict the low-resolution imaging of endolymphatic hydrops. " 09/01/2019 - "Intravenous contrast agent-enhanced magnetic resonance imaging of the endolymphatic space (ELS) of the inner ear permits direct, in-vivo, non-invasive visualization of labyrinthine structures and thus verification of endolymphatic hydrops (ELH). " 01/01/2022 - "This paper presents an expert consensus on MRI of endolymphatic hydrops in the following aspects: indications and contra-indications for patient selection, methods of contrast-agent administration (intravenous or intratympanic), MRI sequence selection, the specific scanning parameter settings, and standard image evaluation methods and their advantages and disadvantages. "
6.	SteroidsIBA 01/01/2020 - "In contrast, the extension of Reissner's membrane and endolymphatic hydrops were observed in the animals in the steroid groups. " 01/01/2020 - "Background: Many clinicians have been empirically using steroids for the treatment of diseases associated with endolymphatic hydrops. " 06/01/2001 - "Hearing results of intratympanic steroid treatment of endolymphatic hydrops." 11/01/1998 - "Although the theoretical basis for intratympanic steroid treatment of endolymphatic hydrops is appealing, we urge close evaluation of the results of specific protocols of intratympanic steroid administration before widespread utilization of this treatment. " 11/01/1998 - "Hearing results of intratympanic steroid treatment of endolymphatic hydrops."
7.	IsosorbideFDA Link 01/01/2023 - "Intratympanic administration of isosorbide resolves endolymphatic hydrops faster than oral ingestion. " 01/01/2004 - "Time course of dehydrating effects of isosorbide on experimentally induced endolymphatic hydrops in guinea pigs." 01/01/1995 - "Changes in hearing were studied in 145 ears (103 patients) with endolymphatic hydrops before and after an 8-week administration of isosorbide. " 11/01/2021 - "Effects of Intratympanic Injection of Isosorbide on the Vestibular Function of Animal Models of Endolymphatic Hydrops." 01/01/2023 - "In the hydrops group, 50% isosorbide slightly reduced endolymphatic hydrops; 65% flattened Reissner's membrane, and 70% slightly concaved it toward the basilar membrane. "
8.	Dexamethasone (Maxidex)FDA LinkGeneric 01/01/2015 - "The present study showed that intratympanic dexamethasone injection (ITD) is a promising approach for the treatment of contralateral and ipsilateral delayed endolymphatic hydrops (DEH). " 03/01/2008 - "The aim of this study was to investigate the audiological and histopathologic effects of dexamethasone in the treatment of experimentally induced endolymphatic hydrops. " 02/01/2009 - "Dexamethasone inner ear perfusion for subclinical endolymphatic hydrops." 03/01/2008 - "Dexamethasone can prevent the audiological and histopathologic findings of experimentally induced endolymphatic hydrops. " 03/01/2008 - "Evaluation of the effect of dexamethasone in experimentally induced endolymphatic hydrops in guinea pigs."
9.	gadodiamide (Omniscan)FDA Link 12/01/2003 - "To conclude, endolymphatic hydrops can be visualized with high-resolution MRI by means of Gd-DTPA-BMA, and it is possible to quantify the extent of endolymphatic hydrops. " 01/01/2018 - "The purpose of this study was to assess the diagnostic performance of 3T MRI after intratympanic injection of gadodiamide for delayed endolymphatic hydrops (DEH), and assess the relationship between endolymphatic hydrops (ELH) and vestibular function in patients diagnosed with DEH and confirmed by 3T MRI. " 01/01/2018 - "Bilateral delayed endolymphatic hydrops evaluated by bilateral intratympanic injection of gadodiamide with 3T-MRI." 01/01/2013 - "Three-dimensional visualization of endolymphatic hydrops after intravenous administration of single-dose gadodiamide." 01/01/2010 - "Endolymphatic hydrops could be visualized recently by intratympanic injection of Omniscan diluted 8- or 16-fold with saline using three-dimensional fluid attenuated inversion recovery (3-D FLAIR) MRI. "
10.	AldosteroneIBA 09/01/2001 - "In animal studies it has been found that exogenous administration of aldosterone resulted in endolymphatic hydrops. " 01/13/2023 - "Dot1l in guinea pig cochlea is inhibited by aldosterone with induction of endolymphatic hydrops. " 12/01/2007 - "The effect of aldosterone on the cochlea is mediated possibly through its action on the genome, and aldosterone may cause ion concentration alterations to induce endolymphatic hydrops." 03/01/2007 - "Low to middle expression grade in endolymphatic hydrops was found in aldosterone group. " 10/01/2002 - "Aldosterone may induce endolymphatic hydrops in both ears."

Therapies and Procedures

1.	Therapeutics 01/01/2021 - "This study aims to explore the long-term efficacy of triple semicircular canal plugging (TSCP) in the treatment of intractable ipsilateral delayed endolymphatic hydrops (DEH), so as to provide an alternative therapy for this disease. " 10/03/2012 - "This article explains why their history (as those suffering from any other vestibular disorder) is often particular, to recall the few knowledge of the disease, how the endolymphatic hydrops was considered as the cause of the disorder, while it is rather an epiphenomenon, and to show how one can believe, wrongly, that a therapy is efficient after a study that seems however at first correctly performed." 07/01/2004 - "The objective of this study was to investigate the effect on experimental endolymphatic hydrops in guinea pigs after hyperbaric therapy. " 01/01/2022 - "The endolymphatic hydrops was detected in all inner ear structures with predominant accumulation in vestibule and semicircular canals by MRI-visualization before therapy. " 09/13/2019 - "There are no widely accepted and effective treatments for endolymphatic hydrops, and identifying potential new and efficacious therapeutics is of high relevance."
2.	Intravenous Administration 01/01/2023 - "For patients with a suspicion of endolymphatic hydrops, 3D-real inversion recovery (IR) images were also obtained at pre-, 10 mins, 4 hours, and 24 hours after intravenous administration (IV) of GBCA. " 06/01/2021 - "In 26 patients with a suspicion of endolymphatic hydrops (21-80 years old), a three-dimensional real inversion recovery (3D-real IR) image was obtained at pre-, and at 5 min, and 4 h post-intravenous administration of a single dose of GBCA (IV-SD-GBCA). " 05/01/2021 - "In 30 patients clinically diagnosed with suspected endolymphatic hydrops, the three-dimensional real inversion recovery (3D-real IR) images were obtained at pre- and 4 h post-intravenous administration of a single dose of GBCA. " 05/01/1975 - "In a previous report it was suggested that intravenous administration of furosemid followed by a comparative caloric test (the furosemid test) could be utilized for detection of endolymphatic hydrops (Kitahara et al., 1973). " 01/01/2011 - "Ten patients suspected of having Ménière's disease underwent hT(2)W 3D FLAIR 4 hours after intravenous administration of single-dose GBCM to evaluate endolymphatic hydrops. "
3.	Intratympanic Injection 01/01/2015 - "Intratympanic injection in delayed endolymphatic hydrops." 01/01/2018 - "The purpose of this study was to assess the diagnostic performance of 3T MRI after intratympanic injection of gadodiamide for delayed endolymphatic hydrops (DEH), and assess the relationship between endolymphatic hydrops (ELH) and vestibular function in patients diagnosed with DEH and confirmed by 3T MRI. " 11/01/2021 - "Effects of Intratympanic Injection of Isosorbide on the Vestibular Function of Animal Models of Endolymphatic Hydrops." 01/01/2018 - "Bilateral delayed endolymphatic hydrops evaluated by bilateral intratympanic injection of gadodiamide with 3T-MRI." 01/01/2018 - "Intratympanic Injections of Dexamethasone in Delayed Endolymphatic Hydrops: A Prospective Clinical Study."
4.	Intravenous Injections 09/01/2021 - "Of 190 patients (91 male and 99 female), that were scanned at 4 h after an intravenous injection of GBCA as a diagnostic examination for endolymphatic hydrops, 6 patients with GBCA leakage were younger than the previously proposed threshold age of 37.3 years for leakage. " 12/01/2020 - "The subjects included 190 patients, that were scanned for 3D-real IR images at 4 hours after intravenous injection of GBCA as a diagnostic test for endolymphatic hydrops. " 01/01/2017 - "Endolymphatic hydrops can be studied on magnetic resonance imaging (MRI) using images acquired 4 h after intravenous injection of Gd-chelate. " 01/01/2021 - "By visualizing the endolymph and perilymph of inner ear in patients with Meniere disease assisted with intravenous injection of double doses of Gd, the grades of endolymphatic hydrops could be assessed. " 01/01/2010 - "We applied hT(2)W-3D-FLAIR to visualize endolymphatic hydrops of Ménière's disease in 3 patients 4 hours after single-dose intravenous injection of GBCM and successfully visualized endolymphatic hydrops in either the cochlea or vestibule in all patients. "
5.	Denervation 08/01/2022 - "Therefore, further studies with a long follow-up period and repeated magnetic resonance imaging are needed to assess the vestibular neurectomy's impact on endolymphatic hydrops. " 08/01/2022 - "Changes in endolymphatic hydrops after vestibular neurectomy observed in magnetic resonance imaging - A pilot study." 08/01/2022 - "Vestibular neurectomy is an effective treatment for intractable vertigo; however, there is no endolymphatic hydrops regression evidence within several months after the surgery. " 08/01/2022 - "The aim was to evaluate endolymphatic hydrops in patients with Ménière's disease before and after vestibular neurectomy to verify if the endolymphatic space dilatation, observed in magnetic resonance imaging, regressed within several months after surgery. " 02/01/1991 - "Parallel evaluations of DPOAEs were performed under essentially identical conditions in rabbit models of several of the human disorders, including noise-induced hearing loss, endolymphatic hydrops, and cochlear neurectomy. "