Member 7 Tumor Necrosis Factor Receptor Superfamily

A member of the tumor necrosis factor receptor superfamily found on most T-LYMPHOCYTES. Activation of the receptor by CD70 ANTIGEN results in the increased proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

Also Known As:

Networked: 28 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bao, Li: 1 article (01/2020)
2.	Chu, Bin: 1 article (01/2020)
3.	Fang, Lijuan: 1 article (01/2020)
4.	Gao, Shan: 1 article (01/2020)
5.	Liu, Xi: 1 article (01/2020)
6.	Lu, Minqiu: 1 article (01/2020)
7.	Shi, Lei: 1 article (01/2020)
8.	Wang, Yutong: 1 article (01/2020)
9.	Xiang, Qiuqing: 1 article (01/2020)
10.	Chen, Li-Juan: 1 article (08/2017)

Related Diseases

1.	Juvenile Arthritis (Juvenile Idiopathic Arthritis) 11/01/1987 - "Increased prevalence of late stage T cell activation antigen (VLA-1) in active juvenile chronic arthritis." 11/01/1987 - "The presence of activated T cells as judged from the reaction with monoclonal antibodies (MoAb) against (a) a late stage T cell activation antigen (VLA-1), (b) the interleukin 2 (IL2) receptor (CD25), and (c) four different HLA class II molecules (HLA-DR, DRw52, DQ, and DP) was studied in 15 patients with active juvenile chronic arthritis (JCA), 10 patients with JCA in remission, and 11 age matched, healthy controls. "
2.	Psoriasis (Pustulosis Palmaris et Plantaris) 03/01/2007 - "Because antigen presenting is necessary for T-cell activation, antigen-presenting cells should be involved in the pathogenesis of psoriasis. " 01/01/1991 - "Quantitation of soluble CD27, a T-cell activation antigen, and soluble interleukin-2 receptor in serum from patients with psoriasis."
3.	Multiple Myeloma 01/01/2020 - "CD27 antigen negative expression indicates poor prognosis in newly diagnosed multiple myeloma." 08/01/2017 - "To explore the expression of CD27 antigen in patients with multiple myeloma(MM), and its clinical diagnostic value, as well as the correlation of CD27 with clinical features and genetic abnormalities. " 08/01/2017 - "[Diagnostic Value of CD27 Antigen in Patients with Multiple Myeloma]."
4.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 05/01/1995 - "Serum levels of soluble forms of T cell activation antigens CD27 and CD25 in systemic lupus erythematosus in relation with lymphocytes count and disease course." 09/01/1989 - "The expression of a new activation antigen, T cell lineage specific activation antigen (TLiSA1) on peripheral blood T cells from 16 rheumatoid arthritis (RA) and 8 systemic lupus erythematosus (SLE) patients and synovial fluid T cells from RA patients was determined in the context of T cell activation. "
5.	Infections 06/15/1998 - "The role of the T-cell activation antigen CD26 was evaluated in viral entry and infection of CD4(+)/CXCR4(+) cells by the lymphotropic HIV-1 Lai isolate. " 11/01/1996 - "Using these hybrids it is demonstrated that expression of CD4 and CD26, the T cell activation antigen dipeptidyl peptidase IV recently proposed as a CD4 cofactor necessary for HIV-1 infection, are not sufficient for HIV-1 entry. "

Related Drugs and Biologics

1.	Interleukin-2 Receptors (IL 2 Receptor)
2.	Monoclonal Antibodies
3.	Interleukin-2 (IL2)
4.	HLA-DR Antigens (HLA-DR)
5.	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)
6.	Antigens
7.	Sorting Nexins
8.	Integrin alpha1beta1
9.	Integrin alpha2beta1
10.	GTP Phosphohydrolases (GTPases)

Related Therapies and Procedures

1.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
2.	Therapeutics