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Chloride Channels (Chloride Channel)

Subscribe to New Research on Chloride Channels

Cell membrane glycoproteins that form channels to selectively pass chloride ions. Nonselective blockers include FENAMATES; ETHACRYNIC ACID; and TAMOXIFEN.

Also Known As:

Chloride Channel; Calcium-Activated Chloride Channels; Chloride Ion Channels; Chlorine Channels; Ion Channel, Chloride; Calcium Activated Chloride Channels; Channel, Chloride; Channel, Chloride Ion; Channels, Calcium-Activated Chloride; Channels, Chloride; Channels, Chloride Ion; Channels, Chlorine; Chloride Channels, Calcium-Activated; Chloride Ion Channel; Ion Channels, Chloride

Networked: 1146 relevant articles (20 outcomes, 56 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Carrier Proteins: 11456
    - Membrane Transport Proteins: 165
      - Ion Channels: 3653
        Chloride Channels: 1146
        GABA-A Receptors: 2016
        Cystic Fibrosis Transmembrane Conductance Regulator: 1580
        Glycine Receptors: 275
        rat CLIC1 protein: 21
        CLC-5 chloride channel: 17
        glutamate-gated chloride channels: 14
        ClC-2 chloride channels: 7
        ClC-3 channel: 6
        CLC-1 channel: 5
        Arabidopsis ATCLC-A protein
        Arabidopsis ClCe protein
        C elegans clh-1 protein
        C elegans clh-2 protein
        C elegans clh-3 protein
        C elegans clh-4 protein
        C elegans clh-6 protein
        C elegans EXC-4 protein
        C elegans MOD-1 protein
        Drosophila bestrophin-1
        Drosophila bestrophin-2
        Drosophila bestrophin-3
        Drosophila CLIC protein
        Drosophila DM-HisCl-alpha2 protein
        Drosophila ora transientless protein
        E coli ClC protein
        Haemonchus contortus HG4 protein
        human ANO5 protein
        human BEST1 protein
        human BEST2 protein
        human BEST3 protein
        human BEST4 protein
        human BSND protein
        human CLCA1 protein
        human CLCA2 protein
        human CLCA3P protein
        human CLCA4 protein
        human CLCC1 protein
        human CLCN4 protein
        human CLCN6 protein
        human CLCN7 protein
        human CLCNKA protein
        human CLCNKB protein
        human CLIC1 protein
        human CLIC2 protein
        human CLIC3 protein
        human CLIC4 protein
        human CLIC5 protein
        human CLIC6 protein
        human TTYH3 protein
        mouse Best-2 protein
        mouse Best4 protein
        mouse CLC5 protein
        mouse Clca1 protein
        mouse Clca2 protein
        mouse Clca3 protein
        mouse CLCA4 protein
        mouse CLCA5 protein
        mouse Clca6 protein
        mouse Clcc1 protein
        mouse Clcn4-1 protein
        mouse Clcn6 protein
        mouse Clcn7 protein
        mouse Clcnka protein
        mouse Clcnkb protein
        mouse CLIC protein
        mouse Clic1 protein
        mouse CLIC5 protein
        mouse CLIC6 protein
        mouse TMEM16A protein
        mouse TMEM16B protein
        mouse Vmd2L1 protein
        Nicotiana tabacum CLC-Nt1 protein
        Oryctolagus cuniculus parchorin protein
        rat ANO1 protein
        rat bestrophin-1 protein
        rat CLC-6 protein
        rat CLCA protein
        rat Clca4 protein
        rat Clcn7 protein
        rat Clcnk1 protein
        rat Clcnkb protein
        rat Clic4 protein
        rat CLIC6 protein
        rat Mclc protein
        S cerevisiae GEF1 protein
        Torpedo californica CLC-0 chloride channel protein
        Xenopus clcnka protein
        Xenopus CLIC1 protein
        Xenopus TMEM16A protein
  - Membrane Proteins: 5300
    - Membrane Glycoproteins: 1848
      - Ion Channels: 3653
        Chloride Channels: 1146
        GABA-A Receptors: 2016
        Cystic Fibrosis Transmembrane Conductance Regulator: 1580
        Glycine Receptors: 275
        rat CLIC1 protein: 21
        CLC-5 chloride channel: 17
        glutamate-gated chloride channels: 14
        ClC-2 chloride channels: 7
        ClC-3 channel: 6
        CLC-1 channel: 5
        Arabidopsis ATCLC-A protein
        Arabidopsis ClCe protein
        C elegans clh-1 protein
        C elegans clh-2 protein
        C elegans clh-3 protein
        C elegans clh-4 protein
        C elegans clh-6 protein
        C elegans EXC-4 protein
        C elegans MOD-1 protein
        Drosophila bestrophin-1
        Drosophila bestrophin-2
        Drosophila bestrophin-3
        Drosophila CLIC protein
        Drosophila DM-HisCl-alpha2 protein
        Drosophila ora transientless protein
        E coli ClC protein
        Haemonchus contortus HG4 protein
        human ANO5 protein
        human BEST1 protein
        human BEST2 protein
        human BEST3 protein
        human BEST4 protein
        human BSND protein
        human CLCA1 protein
        human CLCA2 protein
        human CLCA3P protein
        human CLCA4 protein
        human CLCC1 protein
        human CLCN4 protein
        human CLCN6 protein
        human CLCN7 protein
        human CLCNKA protein
        human CLCNKB protein
        human CLIC1 protein
        human CLIC2 protein
        human CLIC3 protein
        human CLIC4 protein
        human CLIC5 protein
        human CLIC6 protein
        human TTYH3 protein
        mouse Best-2 protein
        mouse Best4 protein
        mouse CLC5 protein
        mouse Clca1 protein
        mouse Clca2 protein
        mouse Clca3 protein
        mouse CLCA4 protein
        mouse CLCA5 protein
        mouse Clca6 protein
        mouse Clcc1 protein
        mouse Clcn4-1 protein
        mouse Clcn6 protein
        mouse Clcn7 protein
        mouse Clcnka protein
        mouse Clcnkb protein
        mouse CLIC protein
        mouse Clic1 protein
        mouse CLIC5 protein
        mouse CLIC6 protein
        mouse TMEM16A protein
        mouse TMEM16B protein
        mouse Vmd2L1 protein
        Nicotiana tabacum CLC-Nt1 protein
        Oryctolagus cuniculus parchorin protein
        rat ANO1 protein
        rat bestrophin-1 protein
        rat CLC-6 protein
        rat CLCA protein
        rat Clca4 protein
        rat Clcn7 protein
        rat Clcnk1 protein
        rat Clcnkb protein
        rat Clic4 protein
        rat CLIC6 protein
        rat Mclc protein
        S cerevisiae GEF1 protein
        Torpedo californica CLC-0 chloride channel protein
        Xenopus clcnka protein
        Xenopus CLIC1 protein
        Xenopus TMEM16A protein
    - Membrane Transport Proteins: 165
      - Ion Channels: 3653
        Chloride Channels: 1146
        GABA-A Receptors: 2016
        Cystic Fibrosis Transmembrane Conductance Regulator: 1580
        Glycine Receptors: 275
        rat CLIC1 protein: 21
        CLC-5 chloride channel: 17
        glutamate-gated chloride channels: 14
        ClC-2 chloride channels: 7
        ClC-3 channel: 6
        CLC-1 channel: 5
        Arabidopsis ATCLC-A protein
        Arabidopsis ClCe protein
        C elegans clh-1 protein
        C elegans clh-2 protein
        C elegans clh-3 protein
        C elegans clh-4 protein
        C elegans clh-6 protein
        C elegans EXC-4 protein
        C elegans MOD-1 protein
        Drosophila bestrophin-1
        Drosophila bestrophin-2
        Drosophila bestrophin-3
        Drosophila CLIC protein
        Drosophila DM-HisCl-alpha2 protein
        Drosophila ora transientless protein
        E coli ClC protein
        Haemonchus contortus HG4 protein
        human ANO5 protein
        human BEST1 protein
        human BEST2 protein
        human BEST3 protein
        human BEST4 protein
        human BSND protein
        human CLCA1 protein
        human CLCA2 protein
        human CLCA3P protein
        human CLCA4 protein
        human CLCC1 protein
        human CLCN4 protein
        human CLCN6 protein
        human CLCN7 protein
        human CLCNKA protein
        human CLCNKB protein
        human CLIC1 protein
        human CLIC2 protein
        human CLIC3 protein
        human CLIC4 protein
        human CLIC5 protein
        human CLIC6 protein
        human TTYH3 protein
        mouse Best-2 protein
        mouse Best4 protein
        mouse CLC5 protein
        mouse Clca1 protein
        mouse Clca2 protein
        mouse Clca3 protein
        mouse CLCA4 protein
        mouse CLCA5 protein
        mouse Clca6 protein
        mouse Clcc1 protein
        mouse Clcn4-1 protein
        mouse Clcn6 protein
        mouse Clcn7 protein
        mouse Clcnka protein
        mouse Clcnkb protein
        mouse CLIC protein
        mouse Clic1 protein
        mouse CLIC5 protein
        mouse CLIC6 protein
        mouse TMEM16A protein
        mouse TMEM16B protein
        mouse Vmd2L1 protein
        Nicotiana tabacum CLC-Nt1 protein
        Oryctolagus cuniculus parchorin protein
        rat ANO1 protein
        rat bestrophin-1 protein
        rat CLC-6 protein
        rat CLCA protein
        rat Clca4 protein
        rat Clcn7 protein
        rat Clcnk1 protein
        rat Clcnkb protein
        rat Clic4 protein
        rat CLIC6 protein
        rat Mclc protein
        S cerevisiae GEF1 protein
        Torpedo californica CLC-0 chloride channel protein
        Xenopus clcnka protein
        Xenopus CLIC1 protein
        Xenopus TMEM16A protein

Experts

1.	Verkman, A S: 23 articles (10/2015 - 01/2003)
2.	Galietta, Luis J V: 18 articles (09/2015 - 05/2005)
3.	Pedemonte, Nicoletta: 11 articles (01/2015 - 05/2005)
4.	Fahlke, Christoph: 10 articles (12/2015 - 09/2002)
5.	Devuyst, Olivier: 10 articles (04/2009 - 04/2003)
6.	Lukacs, Gergely L: 9 articles (10/2015 - 09/2005)
7.	Gruber, Achim D: 9 articles (01/2015 - 11/2004)
8.	Guan, Yong-Yuan: 9 articles (01/2015 - 02/2010)
9.	Guggino, William B: 9 articles (03/2007 - 03/2002)
10.	Norez, Caroline: 8 articles (10/2015 - 02/2004)

Related Diseases

1.	Constipation 02/01/2011 - "Selective C-2 chloride channel activator is more effective than placebo at relieving global IBS symptoms in patients with constipation-predominant IBS. " 01/01/2008 - "It activates specific chloride channels in the gastrointestinal tract to stimulate intestinal fluid secretion, increase gastrointestinal transit, and improve symptoms of constipation. " 01/01/2007 - "Activation of type-2 chloride channels: a novel therapeutic target for the treatment of chronic constipation." 09/01/2011 - "Lubiprostone is a laxative that works by activating the type 2 chloride channel in the gastrointestinal tract and thus has the potential to be especially effective for constipation associated with CF. " 03/01/2010 - "Because it utilizes an alternate chloride channel, lubiprostone may be especially effective for constipation in patients with CF. "
2.	Myotonia 11/27/2012 - "New immunohistochemical method for improved myotonia and chloride channel mutation diagnostics." 10/01/1996 - "Physiologic study of these mutations may lead to better understanding of the pathophysiology of myotonia in these patients and of voltage-gated chloride channel structure/function relationships in skeletal muscles." 04/01/2015 - "Ovine congenital myotonia associated with a mutation in the muscle chloride channel gene." 01/01/2015 - "Impaired surface membrane insertion of homo- and heterodimeric human muscle chloride channels carrying amino-terminal myotonia-causing mutations." 01/01/2015 - "Experimental myotonia induced in rat muscle by ClC-1 chloride channel-inhibited has been shown to be related inversely to extracellular concentrations of Mg(2+) and Ca(2+) ([Mg(2+) ]o and [Ca(2+) ]o) within physiological ranges. "
3.	Cystic Fibrosis (Mucoviscidosis) 01/01/2012 - "CFTR is an epithelial chloride channel that is involved in Cystic Fibrosis (CF) when mutated; thus a better knowledge of its functional interactome may help to understand the pathophysiology of this complex disease. " 11/01/2002 - "Epithelial cell chloride channel activity correlates with improved airway function in cystic fibrosis patients with the major mutant: Delta F508." 09/01/2013 - "Findings from animal studies have provided insight into the pathophysiology of CFRD, and imply that carbohydrate metabolic abnormalities might begin at much younger ages than was previously thought in patients with cystic fibrosis, and might be related to the basic cystic fibrosis chloride channel defect. " 03/17/2011 - "In the present work we study the contribution of the chloride channel of the Cystic Fibrosis Transmembrane Regulator (CFTR) in the postsynaptic inhibition of somatic motoneurons during rapid-eye-movement (REM) sleep atonia. " 11/01/2004 - "To determine whether the CLCA gene family of calcium-activated chloride channels is a modulator of the basic defect of cystic fibrosis (CF), an association study was performed with polymorphic microsatellite markers covering a 40-Mbp region spanning the CLCA gene locus on human chromosome 1p in CF patients displaying CF transmembrane conductance regulator (CFTR)-independent residual chloride conductance in gastrointestinal epithelia. "
4.	Hypertension (High Blood Pressure) 10/01/2013 - "Our previous studies have shown that ClC-3 chloride channel is up-regulated with the development of hypertension. " 05/01/2015 - "Calcium-activated chloride channels (CaCCs) have been implicated in hypertension; however, the mechanism underlying their involvement is unknown. " 01/01/2012 - "We investigated a possible association between genetic variations in chloride channel Kb (CLCNKB) gene and essential hypertension (EH) in the Mongolian and Han populations in Inner Mongolia. " 01/01/2012 - "In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: a new drug target for hypertension?" 09/01/2010 - "We hypothesized that inhibition of volume-regulated chloride channel may contribute to the beneficial effects of statins on cerebrovascular remodeling during hypertension. "
5.	Autosomal Dominant Polycystic Kidney (ADPKD) 09/01/2008 - "Our study suggests that KCa3.1 channels play a critical role in transcellular chloride secretion and net fluid transport into the kidney cysts of patients with ADPKD by maintaining the electrochemical driving force for chloride efflux through apical chloride channels. " 12/01/2000 - "Cystic fibrosis (CF) transmembrane conductance regulator (CFTR) is a chloride channel that promotes intracystic fluid secretion, and thus cyst progression, in ADPKD. " 01/01/2013 - "Multiple studies have suggested that fluid secretion across ADPKD cyst-lining cells is driven by the transepithelial secretion of chloride, mediated by the apical cystic fibrosis transmembrane conductance regulator chloride channel (CFTR) and specific basolateral transporters. " 04/01/2014 - "Our findings indicate that steviol slows cyst progression in ADPKD mouse model, in part, through the activation of AMPK which subsequently inhibits CFTR chloride channel expression and inhibits renal epithelial cell proliferation via mTOR/S6K pathway. " 04/01/2014 - "Cyst enlargement in autosomal dominant polycystic kidney disease (ADPKD) is associated with cAMP-activated proliferation of cyst-lining epithelial cells and transepithelial fluid secretion into the cyst lumen via cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel leading to renal failure for which no effective treatment is currently available. "

Related Drugs and Biologics

1.	lubiprostone
2.	Forskolin
3.	Sodium
4.	Calcium Channel Blockers (Blockers, Calcium Channel)
5.	Adenylate Cyclase (Adenylyl Cyclase)
6.	Glycine (Aminoacetic Acid)
7.	4,4'- Diisothiocyanostilbene- 2,2'- Disulfonic Acid (DIDS)
8.	Nitric Oxide Synthase (NO Synthase)
9.	Strychnine
10.	Phospholipases (Phospholipase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Catheters
3.	Electrodes (Electrode)
4.	Chemoprevention
5.	Liver Transplantation