Lipoprotein Receptors (Lipoprotein Receptor)

Cell surface proteins that bind lipoproteins with high affinity. Lipoprotein receptors in the liver and peripheral tissues mediate the regulation of plasma and cellular cholesterol metabolism and concentration. The receptors generally recognize the apolipoproteins of the lipoprotein complex, and binding is often a trigger for endocytosis.

Also Known As:

Networked: 157 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Krieger, Monty: 5 articles (08/2012 - 06/2003)
2.	Yesilaltay, Ayce: 4 articles (08/2012 - 04/2005)
3.	Herz, Joachim: 3 articles (12/2014 - 11/2010)
4.	Kocher, Olivier: 3 articles (08/2012 - 04/2005)
5.	Murao, Koji: 2 articles (10/2015 - 02/2004)
6.	Imachi, Hitomi: 2 articles (10/2015 - 02/2004)
7.	Zheng, Gang: 2 articles (05/2015 - 12/2005)
8.	Chen, Juan: 2 articles (05/2015 - 12/2005)
9.	Bock, Hans H: 2 articles (12/2014 - 10/2006)
10.	Fleming, Jodie M: 2 articles (01/2014 - 01/2014)

Related Diseases

1.	Dyslipidemias (Dyslipidemia) 02/17/1986 - "The present study was designed to elucidate the role of lipoprotein receptor mechanisms of liver parenchymal cells in the diabetic dyslipoproteinemia. " 01/01/2008 - "A comparable preconditioning effect of wild type mice could be induced in the lipoprotein receptor deficient (LDLR-/-) model for dyslipidemia. " 07/11/1997 - "Pseudo type III dyslipoproteinemia is associated with normal fibroblast lipoprotein receptor activity." 02/17/1986 - "The data presented suggest that significant role of alteration of lipoprotein receptor characteristics in liver parenchymal cells is not played in the diabetic dyslipoproteinemia." 01/01/1984 - "[Lipoprotein receptors and dyslipoproteinemias]."
2.	Hyperlipidemias (Hyperlipidemia) 05/01/2009 - "Liver-specific loss of lipolysis-stimulated lipoprotein receptor triggers systemic hyperlipidemia in mice." 03/01/2007 - "To study on the regulatory mechanism of lipid metabolism disorders in the blood fat of hyperlipemia rat model with Olive Antihyperlipidemia capsule, and do systematic observation on the functions of this medicine on low And high density lipoprotein receptor in rat liver gene expression, and then to clarify the mechanism of action of this medicine on treating hyperlipemia. " 11/01/2012 - "Decreased lipoprotein receptors result from proteinuria and contribute to hyperlipidemia in NS." 01/01/1984 - "Whereas the gene epsilon 2 seems to exert its influence on plasma lipoproteins by an abnormal gene product (E2) that has reduced binding activity to lipoprotein receptors, the mechanism underlying the association of the epsilon 4 gene with hyperlipidemia is presently unclear." 09/12/2008 - "Lipolysis stimulated lipoprotein receptor: a novel molecular link between hyperlipidemia, weight gain, and atherosclerosis in mice."
3.	Myocardial Infarction 08/01/2002 - "Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction." 06/01/2012 - "Our aims were to analyse the effect of hypoxia on low-density lipoprotein receptor-related protein 1 (LRP1) expression in neonatal rat ventricular myocytes (NRVM) and cardiac-derived HL-1 cells and the molecular mechanisms involved in this effect, to determine the role of LRP1 in the very low density lipoprotein (VLDL) uptake by hypoxic cardiomyocytes, and to study the effect of hypoxia on lipoprotein receptor expression and myocardial lipid profile in an in vivo porcine experimental model of acute myocardial infarction. " 11/01/2014 - "Deficiency of the high-density lipoprotein receptor, scavenger receptor class B, type I (SR-BI), in apolipoprotein E knockout or hypomorphic mice, respectively, results in spontaneous or diet-inducible occlusive coronary artery (CA) atherosclerosis, myocardial infarction, and early death. " 08/06/2013 - "Mice lacking both the high-density lipoprotein receptor SR-BI (scavenger receptor class B type I) and ApoE (apolipoprotein E), which promotes clearance of remnant lipoproteins, are a model of severe dyslipidemia and spontaneous myocardial infarction. " 06/10/2003 - "Mice with homozygous null mutations in the high-density lipoprotein receptor SR-BI (scavenger receptor class B, type I) and apolipoprotein E genes fed a low-fat diet exhibit a constellation of pathologies shared with human atherosclerotic coronary heart disease (CHD): hypercholesterolemia, occlusive coronary atherosclerosis, myocardial infarctions, cardiac dysfunction (heart enlargement, reduced systolic function and ejection fraction, and ECG abnormalities), and premature death (mean age 6 weeks). "
4.	Hyperlipoproteinemias 10/01/1998 - "In addition, hyperlipoproteinemias may be improved by transferring functional lipoprotein-receptor genes into hepatocytes of affected individuals. " 01/01/1983 - "The role of lipoprotein receptors in lipid transport and in the pathogenesis of the hyperlipoproteinemias." 04/01/1989 - "The variant apo E3 was defective in its ability to bind to lipoprotein receptors, and this functional defect probably contributes to the expression of type III hyperlipoproteinemia in this family." 01/01/1986 - "Type III hyperlipoproteinemia: a focus on lipoprotein receptor-apolipoprotein E2 interactions." 08/01/1996 - "The defective binding of apolipoprotein (apo) E2 to lipoprotein receptors, an underlying cause of type III hyperlipoproteinemia, results from replacement of Arg 158 with Cys, disrupting the naturally occurring salt bridge between Asp 154 and Arg 158. "
5.	Proteinuria 11/01/2012 - "Decreased lipoprotein receptors result from proteinuria and contribute to hyperlipidemia in NS." 06/01/2013 - "Retraction: Proteinuria decreases tissue lipoprotein receptor levels resulting in altered lipoprotein structure and increasing lipid levels." 11/01/2012 - "Proteinuria decreases tissue lipoprotein receptor levels resulting in altered lipoprotein structure and increasing lipid levels." 07/27/2004 - "Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome."

Related Drugs and Biologics

1.	Lipoproteins (Lipoprotein)
2.	Scavenger Receptors (Scavenger Receptor)
3.	Apolipoproteins
4.	Apolipoproteins E (ApoE)
5.	Phosphatidylcholine-Sterol O-Acyltransferase (Lecithin Cholesterol Acyltransferase)
6.	Sterol O-Acyltransferase
7.	Acyl Coenzyme A (Acyl CoA)
8.	Cholesterol
9.	Apolipoprotein A-I (Apolipoprotein A1)
10.	Amyloid beta-Peptides

Related Therapies and Procedures

1.	Fat-Restricted Diet (Diet, Fat Restricted)
2.	Thrombolytic Therapy