Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)

Cell surface proteins that bind glutamate and act through G-proteins to influence second messenger systems. Several types of metabotropic glutamate receptors have been cloned. They differ in pharmacology, distribution, and mechanisms of action.

Also Known As:

Networked: 805 relevant articles (15 outcomes, 104 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Conn, P Jeffrey: 27 articles (01/2016 - 02/2002)
2.	Nicoletti, Ferdinando: 23 articles (02/2015 - 12/2002)
3.	Lindsley, Craig W: 18 articles (01/2016 - 07/2005)
4.	Chen, Suzie: 18 articles (11/2015 - 11/2004)
5.	Battaglia, Giuseppe: 17 articles (02/2015 - 12/2002)
6.	Niswender, Colleen M: 16 articles (01/2016 - 07/2007)
7.	Jones, Carrie K: 14 articles (01/2016 - 01/2005)
8.	Neugebauer, Volker: 14 articles (12/2011 - 06/2002)
9.	Goydos, James S: 10 articles (02/2015 - 03/2007)
10.	Daniels, J Scott: 9 articles (01/2016 - 02/2012)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 02/02/2011 - "In addition, metabotropic glutamate receptor mGlu(2/3) agonists show promise as a new treatment for schizophrenia. " 06/01/2014 - "The objective of this study is to review the available data regarding metabotropic glutamate receptors in the pathology of Schizophrenia. " 05/15/2009 - "Here we report association studies of schizophrenia with polymorphisms in group III metabotropic glutamate receptor genes, GRM4 and GRM7. " 05/15/2009 - "Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia." 01/01/2005 - "Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3. "
2.	Pain (Aches) 01/01/2005 - "Our previous studies showed an important role of group I metabotropic glutamate receptors (mGluRs) in pain-related synaptic plasticity and sensitization of neurons in the central nucleus of the amygdala (CeA). " 02/01/2015 - "Metabotropic glutamate receptors (mGluRs) modulate neurotransmission all along the pain neuraxis. " 01/01/2015 - "Metabotropic glutamate receptors (mGluRs) and their role in modulating pain throughout the peripheral and central nervous system are the focus of this chapter. " 06/01/2014 - "Supraspinal metabotropic glutamate receptor subtype 8: a switch to turn off pain." 02/01/2014 - "Supraspinal metabotropic glutamate receptors: a target for pain relief and beyond."
3.	Anoxia (Hypoxia) 06/01/1996 - "We therefore examined whether the protective effects of metabotropic glutamate receptors during anoxia and NO toxicity were mediated through the cellular pathways of PKC or PKA in primary hippocampal neurons. " 07/01/2011 - "Ca(2+)-mediated signal transduction of group I metabotropic glutamate receptors (ImGluR) was studied in the brain of young (15 days) and old rats (90 days) exposed to severe hypobaric hypoxia on gestation days 14-16. " 11/01/2010 - "Group I metabotropic glutamate receptors (mGluRs) are expressed transiently on developing oligodendrocytes in humans during the perinatal period, and the blood-brain-barrier permeable agonist of group I mGluRs, 1-aminocyclopentane-trans-1,3-dicarboxylic acid (ACPD), reduces white matter damage significantly in a rat model of perinatal hypoxia-ischaemia. " 10/01/2005 - "Sub-neurotoxic neonatal anoxia induces subtle behavioural changes and specific abnormalities in brain group-I metabotropic glutamate receptors in rats." 08/16/2004 - "Endogenous activation of type-5 metabotropic glutamate receptors contributes to the development of hypoxia-induced liver cell injury. "
4.	Seizures (Seizure) 06/01/2014 - "Previous studies have shown that partial inhibition of metabotropic glutamate receptor signaling is sufficient to correct behavioral phenotypes in a mouse model of FX, including audiogenic seizures, open-field hyperactivity and social behavior. " 01/01/2010 - "The present study was undertaken to clarify the effect of group I metabotropic glutamate receptor (mGluR) antagonist, (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) on pentetrazol-induced kindled seizures. " 01/01/1999 - "Progress in the study of metabotropic glutamate receptors (mGluRs) makes clear that activation of these receptors can contribute greatly to seizure discharges and epileptogenesis. " 05/01/2015 - "Antagonists of Metabotropic Glutamate Receptors Prevent the Development of Audiogenic Seizures." 10/01/2014 - "Action of an antagonist of metabotropic glutamate receptors subtype 5 MTEP was studied in a model of complex partial seizures. "
5.	Hyperalgesia 01/01/2015 - "Peripheral group I metabotropic glutamate receptor activation leads to muscle mechanical hyperalgesia through TRPV1 phosphorylation in the rat." 04/01/2010 - "Thus, therapies specifically targeting metabotropic glutamate receptors may improve the treatment of patients with persistent spontaneous nociception and hyperalgesia." 12/06/2006 - "Participation of peripheral group I and II metabotropic glutamate receptors in the development or maintenance of IL-1beta-induced mechanical allodynia in the orofacial area of conscious rats." 10/01/2006 - "Central metabotropic glutamate receptors differentially participate in interleukin-1beta-induced mechanical allodynia in the orofacial area of conscious rats." 11/01/2005 - "Role of peripheral group I and II metabotropic glutamate receptors in IL-1beta-induced mechanical allodynia in the orofacial area of conscious rats."

Related Drugs and Biologics

1.	Glutamic Acid (Glutamate)
2.	metabotropic glutamate receptor 5
3.	N-Methylaspartate (NMDA)
4.	metabotropic glutamate receptor 2
5.	Pilocarpine (Ocusert)
6.	metabotropic glutamate receptor 3 (mGluR3)
7.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
8.	Riluzole
9.	LY 2140023
10.	Serine (L-Serine)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Intraventricular Infusions
4.	Drug Repositioning
5.	Injections