Prostaglandin E Receptors (Prostaglandin E Receptor)

Cell surface receptors which bind prostaglandins with a high affinity and trigger intracellular changes which influence the behavior of cells. Prostaglandin E receptors prefer prostaglandin E2 to other endogenous prostaglandins. They are subdivided into EP1, EP2, and EP3 types based on their effects and their pharmacology.

Also Known As:

Networked: 136 relevant articles (4 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Narumiya, Shuh: 12 articles (07/2015 - 07/2002)
2.	Narumiya, S: 9 articles (07/2011 - 04/2000)
3.	Maruyama, Takayuki: 8 articles (02/2010 - 07/2002)
4.	Sugimoto, Y: 8 articles (02/2010 - 04/2000)
5.	Sugimoto, Yukihiko: 6 articles (04/2015 - 04/2002)
6.	Ma, Xinrong: 6 articles (01/2014 - 03/2006)
7.	Kundu, Namita: 6 articles (01/2014 - 03/2006)
8.	Fulton, Amy M: 5 articles (04/2012 - 03/2006)
9.	Maruyama, T: 5 articles (08/2004 - 04/2000)
10.	Ushikubi, F: 5 articles (09/2001 - 04/2000)

Related Diseases

1.	Endometriosis (Adenomyosis) 08/04/2015 - "The objective of the present study was to determine the effects of pharmacological inhibition of PGE2 receptors, EP2 and EP4, on molecular and cellular aspects of the pathogenesis of endometriosis and associated clinical symptoms. " 08/04/2015 - "Molecular and preclinical basis to inhibit PGE2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis." 03/01/2014 - "Prostaglandin-endoperoxidase synthase (PTGS)1, PTGS2, prostaglandin E receptor (PTGER)1, PTGER2, PTGER3, and PTGER4 mRNA levels in endometrium of disease-free women and in eutopic and ectopic endometrium of endometriosis-affected women. "
2.	Infection 06/01/2011 - "Paraventricular nucleus of the hypothalamus (PVH), parabrachial nucleus (PBN), and nucleus tractus solitarius (NTS) neurons also express PGE receptors and are activated during systemic pathogen infection. " 01/01/1999 - "Modulation of the prostaglandin E receptor: a possible mechanism for infection-induced preterm labor." 11/01/2006 - "In this review, we first briefly summarize current views on the mechanism of sensing microbial infection by the nervous system, and the roles of prostaglandin E2 (PGE2) and its receptors in fever; then we focus on the neural circuits underlying fever generation, particularly their relationship with the distribution of PGE2 receptors within the CNS. " 04/17/2014 - "Targeted PGE2 suppression via genetic ablation of microsomal prostaglandin E-synthase 1 (mPGES-1) or by the pharmacological inhibition of PGE2 receptors EP2 and EP4 substantially improved survival against lethal IAV infection whereas PGE2 administration reversed this phenotype. "
3.	Premature Obstetric Labor (Premature Labor) 02/01/2010 - "Elucidating the regulation of PGE2 receptors may facilitate improved approaches to the prevention and treatment of preterm labor." 02/01/2012 - "PGE receptors, EP1 and EP3, may each mediate contractions, and represent potential therapeutic targets in the management of preterm labor. " 01/01/1999 - "Modulation of the prostaglandin E receptor: a possible mechanism for infection-induced preterm labor."
4.	Ischemia 01/01/2006 - "Together, these results suggest that modulation of PGE2 receptors that increase cAMP levels and activate extracellular-regulated kinases 1/2 caused by treatment with 1-OHPGE1 can be protective against neuronal injury induced by focal ischemia." 07/01/2009 - "Expression of prostaglandin PGE2 receptors under conditions of aging and stress and the protective effect of the EP2 agonist butaprost on retinal ischemia."
5.	Neoplasms (Cancer) 07/15/2015 - "Deficiency of PGE receptor subtype EP2 selectively reduced, and deficiency of EP1 and EP3 enhanced, the tumor formation. " 01/01/2014 - "The PGE2 receptors EP1-4 regulate tumor cell growth, invasion and migration in different tumor entities but EP expression in BCA remains to be determined. " 07/01/2010 - "We previously reported that the PGE receptor EP3 is expressed in bone marrow (BM) derived cells, enriched in stromal tissue, and enhances the potential for tumor angiogenesis. " 12/01/2005 - "Prostaglandin E receptor EP3 deficiency modifies tumor outcome in mouse two-stage skin carcinogenesis." 09/01/1991 - "PGE2 receptors were examined on both unfractionated and monocyte-macrophage-depleted splenocytes of normal or tumor-bearing C3H/HeJ mice (at 25 days following s.c. "

Related Drugs and Biologics

1.	Dinoprostone (PGE2)
2.	Cyclooxygenase 2 (Cyclooxygenase-2)
3.	Messenger RNA (mRNA)
4.	prostaglandin-E synthase
5.	Phosphotransferases (Kinase)
6.	Prostaglandins E (PGE)
7.	ONO 8711
8.	Azoxymethane
9.	Complementary DNA (cDNA)
10.	Matrix Metalloproteinases

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Castration