Leukotriene Receptors (Leukotriene Receptor)

Cell-surface receptors that bind LEUKOTRIENES with high affinity and trigger intracellular changes influencing the behavior of cells. The leukotriene receptor subtypes have been tentatively named according to their affinities for the endogenous leukotrienes LTB4; LTC4; LTD4; and LTE4.

Also Known As:

Leukotriene Receptor; Receptors, Leukotriene; Receptors, Leukotrienes; SRS-A Receptor; Slow Reacting Substance of Anaphylaxis Receptors; Slow Reaction Substance of Anaphylaxis Receptors; Leukotrienes Receptors; Receptor, Leukotriene; Receptor, SRS-A; Receptors, SRS A; SRS A Receptor; SRS A Receptors; Receptors, SRS-A; SRS-A Receptors

Networked: 116 relevant articles (12 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - G-Protein-Coupled Receptors: 4701
        Eicosanoid Receptors: 13
        Leukotriene Receptors: 116
        leukotriene D4 receptor: 432
        Leukotriene B4 Receptors: 181
        cysteinyl leukotriene receptor 2: 45
        leukotriene A receptor
        leukotriene B2 receptor
        leukotriene C4 receptor
        leukotriene E4 receptor

Experts

1.	Bäck, Magnus: 4 articles (04/2009 - 01/2006)
2.	Aigner, Ludwig: 3 articles (12/2021 - 01/2011)
3.	Sjölander, Anita: 3 articles (01/2011 - 01/2003)
4.	Cetinel, Sule: 3 articles (12/2005 - 06/2005)
5.	Gedik, Nursal: 3 articles (12/2005 - 06/2005)
6.	Sener, Göksel: 3 articles (12/2005 - 06/2005)
7.	Yeğen, Berrak C: 3 articles (12/2005 - 06/2005)
8.	Bauer, Hans-Christian: 2 articles (10/2015 - 01/2011)
9.	Couillard-Despres, Sebastien: 2 articles (10/2015 - 01/2011)
10.	Marschallinger, Julia: 2 articles (10/2015 - 01/2011)

Related Diseases

1.	Asthma (Bronchial Asthma) 12/01/2013 - "Chinese medication has a regulatory effect on leukotriene receptor gene expression and the imbalance of Th1/Th2 immune cells during asthma attacks in pediatric patients." 01/01/1996 - "Leukotriene receptors in the airways also mediate a potent bronchoconstriction and this is particularly important in asthma. " 12/01/1995 - "Particularly important in asthma, leukotriene receptors on the airways mediate a potent bronchoconstriction. " 10/01/2001 - "Treatment with leukotriene-receptor antogonists (LTA) showed primarily good results in therapy of ASS-associated asthma. " 06/01/2004 - "Inhibitors of leukotriene receptors represent novel therapy in asthma treatment. "
2.	Burns 08/01/2005 - "In the present study, we investigated whether the leukotriene receptor blocker montelukast is protective against burn-induced remote organ injury. " 06/01/2005 - "In the present study, we investigated whether the leukotriene receptor blocker montelukast is protective against burn-induced injury of the gut. " 08/01/2005 - "Leukotriene receptor blocker montelukast protects against burn-induced oxidative injury of the skin and remote organs." 06/01/2005 - "Burn-induced oxidative injury of the gut is ameliorated by the leukotriene receptor blocker montelukast."
3.	Atherosclerosis 06/01/2008 - "Inflammatory signaling through leukotriene receptors in atherosclerosis." 01/01/2006 - "Taken together, recent evidence suggests that leukotriene receptors may be a potential target in the treatment of atherosclerosis and in the prevention of restenosis after coronary interventions." 01/01/2006 - "The migration and accumulation of inflammatory cells that follow leukotriene receptor activation have been implicated in atherosclerosis initiation and progression. " 01/01/2006 - "Leukotriene receptors in atherosclerosis." 11/01/2015 - "Antileukotrienes decrease experimental atherosclerosis, and recent observational data suggest beneficial clinical effects of leukotriene receptor antagonism in cardiovascular disease prevention. "
4.	Prurigo 05/01/2014 - "In this study, we report on the efficacy of combination therapy of second-generation antihistamine antagonist, fexofenadine hydrochloride, and leukotriene receptor inhibitor, montelukast sodium, for the treatment of 15 prurigo nodularis or pemphigoid nodularis patients, in whom conventional therapy was ineffective. "
5.	Bullous Pemphigoid (Pemphigoid) 05/01/2014 - "In this study, we report on the efficacy of combination therapy of second-generation antihistamine antagonist, fexofenadine hydrochloride, and leukotriene receptor inhibitor, montelukast sodium, for the treatment of 15 prurigo nodularis or pemphigoid nodularis patients, in whom conventional therapy was ineffective. "

Related Drugs and Biologics

1.	montelukast (Singulair)
2.	LY 171883
3.	Leukotrienes
4.	Lipoxygenases
5.	Indomethacin (Indometacin)
6.	Non-Sedating Histamine H1 Antagonists (Histamine H1 Antagonists, Non Sedating)
7.	fexofenadine (Allegra)
8.	Arachidonic Acid (Vitamin F)
9.	Thromboxanes
10.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoprevention
3.	Immunomodulation
4.	Metered Dose Inhalers (Metered Dose Inhaler)
5.	Stents