Complementary DNA (cDNA)

Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.

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Networked: 15028 relevant articles (154 outcomes, 1242 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nakamura, Yusuke: 110 articles (01/2015 - 01/2002)
2.	Katagiri, Toyomasa: 41 articles (10/2010 - 01/2002)
3.	Song, Linsheng: 40 articles (01/2016 - 10/2006)
4.	Tsunoda, Tatsuhiko: 37 articles (08/2012 - 01/2002)
5.	Wang, Lingling: 32 articles (01/2016 - 05/2008)
6.	Daigo, Yataro: 31 articles (07/2014 - 04/2003)
7.	Qiu, Limei: 28 articles (11/2013 - 08/2007)
8.	Furukawa, Yoichi: 28 articles (09/2010 - 01/2002)
9.	Tang, Kexuan: 26 articles (07/2011 - 08/2003)
10.	Sun, Xiaofen: 25 articles (07/2011 - 08/2003)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2004 - "C26 cells, which were transduced with the single-chain IL-27 cDNA and became secreting IL-27 (C26-IL-27), exhibited minimal tumor growth in vivo, and all of the mice inoculated with these cells survived healthily with complete tumor remission. " 01/01/2003 - "Restored expression of Betaig-h3 gene, not DCC gene, by transfecting cDNA into tumor cells resulted in a significant reduction in tumor growth. " 01/01/2005 - "To identify molecular indicators of prognosis for this type of cancer, we used a cDNA microarray consisting of 25,344 human genes to investigate expression profiles of 12 primary breast cancers from patients whose tumors recurred within five years after surgery(5Y-R) and 12 from patients who survived disease-free for more than five years (5Y-F). " 05/01/2015 - "Recurrent tumors were effectively treated with a VSV-cDNA library using cDNA from recurrent B16 tumors. " 05/01/2008 - "This study also demonstrates that the combination of CGH and cDNA microarray is a very useful tool to detect drug resistant targets in cancer treatment."
2.	Infection 10/01/1996 - "To study the role of receptor glycosylation in animals susceptible to infection, we eliminated loop 3 glycosylation sites by mutagenesis of an mCAT-1 cDNA clone, and we expressed wild-type and mutant receptors in mink fibroblasts and Xenopus oocytes. " 01/26/2005 - "The ectopic expression of a 5-UGT cDNA in the tuber improved the plant's defense against pathogen infection. " 11/01/2002 - "Instead, vaccination with either the meta 1 gene alone or in fusion with the monocyte chemotactic protein (MCP)-3 cDNA induced a Th2-type of response that correlated with lack of protection against infection." 01/01/1998 - "In vivo inoculation of this fragment, as cDNA, induced protection against acute infection. " 08/01/1995 - "In addition, we tested whether FACC cDNA transduction could be improved by vector infection supported by autologous stroma. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2004 - "Our approach is based on modern statistical discrimination methods and is shown to be very effective in removing systematic biases present in a previously published breast tumor cDNA microarray data set. " 05/01/2008 - "At the same time, our understanding of the biology of breast cancer has also improved, predominantly as a consequence of data obtained from cDNA microarrays. " 09/14/1990 - "The characterization of the gene and cDNA coding for the H23Ag presented here, may help to elucidate its possible function in human breast cancer." 01/01/2013 - "Several genes with altered expression have been identified by cDNA microarray studies in breast cancer, with the Bcl-2 gene indicated as a likely candidate. " 01/01/2013 - "To study the mechanism involved in this process, we have used MCF-7 breast cancer cell lines transfected with IGF-IR anti-sense cDNA (SX13, MCF-7(SX13)) that resulted in 50% reduction of IGF-IR. "
4.	Neoplasm Metastasis (Metastasis) 10/15/1997 - "MDA-MB-231 cells transfected with the cDNA for human preproPTH-rP secreted a tenfold greater amount of PTH-rP and caused significantly greater bone metastases when inoculated into the left cardiac ventricle of female nude mice compared with parental cells. " 11/15/2011 - "In this study, we compared the expression profiles of AIS with those of EIA showing lymph node metastasis or a fatal outcome, and screened the differentially expressed genes by cDNA microarray. " 06/14/2004 - "In this study, we performed cDNA microarray analysis to profile gene expression patterns in two subtypes of HCC, solitary large HCC (SLHCC) and nodular HCC (NHCC), which differ significantly in the incidence of metastasis. " 11/01/2003 - "In the present study, CO-029 cDNA was stably transfected into a non-metastatic human HCC cell line to investigate whether it could directly promote metastasis. " 08/01/2002 - "The quick and high-throughout method of profiling gene expression by cDNA array provides us overview of key factors that may involved in HCC, and may find the clue of the study of HCC metastasis and molecular targets of anti-metastasis therapy. "
5.	Carcinoma (Carcinomatosis) 07/01/1995 - "Transfection of highly metastatic MDA-MB-435 human breast carcinoma cells with nm23-H1 cDNA resulted in a significant reduction in the metastatic potential in vivo. " 01/01/2013 - "In the present study, we screened for colon carcinoma-specific genes using a cDNA microarray database of colon carcinoma tissues and normal colon tissues, and we found that fermitin family member-1 (FERMT1) is overexpressed in colon carcinoma cells. " 12/01/2011 - "To study the effect of Tbx1 expression on growth and tumorigenic potential of carcinoma cells, we transfected mouse Tbx1 cDNA into a mouse spindle cell carcinoma cell line that did not express endogenous Tbx1. " 01/01/2008 - "This review deals with studies that have used cDNA microarrays and immunohistochemistry to identify a subtype of breast carcinoma known as basal-like carcinoma. " 10/01/2007 - "This study was to construct the recombinant eukaryotic vector expressing E2F-1 cDNA, and explore the effect of E2F-1 overexpression on the proliferation of human gastric carcinoma cell line MKN-45. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Interleukin-2 (IL2)
3.	RNA (Ribonucleic Acid)
4.	Vaccines
5.	Messenger RNA (mRNA)
6.	Antigens
7.	Complementary DNA (cDNA)
8.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
9.	Small Interfering RNA (siRNA)
10.	Dystrophin

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Immunotherapy
4.	Transplants (Transplant)
5.	Electroacupuncture