Oxytocin Receptors (Oxytocin Receptor)

Cell surface proteins that bind oxytocin with high affinity and trigger intracellular changes which influence the behavior of cells. Oxytocin receptors in the uterus and the mammary glands mediate the hormone's stimulation of contraction and milk ejection. The presence of oxytocin and oxytocin receptors in neurons of the brain probably reflects an additional role as a neurotransmitter.

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Networked: 195 relevant articles (4 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bussolati, G: 7 articles (04/2004 - 03/2000)
2.	Cassoni, P: 7 articles (04/2004 - 03/2000)
3.	Chini, Bice: 4 articles (01/2014 - 07/2005)
4.	Chini, B: 4 articles (04/2004 - 03/2001)
5.	Watanabe, Yuichiro: 3 articles (03/2015 - 12/2012)
6.	Someya, Toshiyuki: 3 articles (03/2015 - 12/2012)
7.	Egawa, Jun: 3 articles (03/2015 - 12/2012)
8.	Busnelli, Marta: 3 articles (01/2014 - 10/2010)
9.	Nishimori, Katsuhiko: 3 articles (05/2011 - 06/2008)
10.	Geenen, Vincent: 3 articles (01/2011 - 08/2002)

Related Diseases

1.	Premature Obstetric Labor (Premature Labor) 09/01/2000 - "These results indicate that the combination of an inhibitor of prostaglandin endoperoxidase H synthase type 2 with an oxytocin receptor antagonist is more effective in inhibition of preterm labor than is treatment with a prostaglandin endoperoxidase H synthase type 2 inhibitor alone. " 07/01/2007 - "These results provide further evidence that selective oxytocin receptor antagonism may offer an effective treatment for preterm labor." 07/01/2015 - "Retosiban is a small molecule oxytocin receptor antagonist that is under evaluation in clinical studies for treatment of spontaneous preterm labor. " 07/01/2003 - "We conclude that compound 1 is a potent, selective, and orally active nonpeptide oxytocin receptor antagonist, which is a suitable candidate for evaluation as a potential tocolytic agent for the management of preterm labor." 07/20/2001 - "Understanding of the molecular determinants responsible for antagonist binding to the oxytocin receptor should provide important insights that facilitate rational design of potential therapeutic agents for the treatment of preterm labor. "
2.	Autistic Disorder (Autism) 05/03/2010 - "Oxytocin receptor (OXTR) does not play a major role in the aetiology of autism: genetic and molecular studies." 01/01/2006 - "Our study of 314 autism families highlights the importance of further analyses on 3p24-26 locus involving comprehensive molecular genetic analyses of oxytocin receptor gene (OXTR), a positional and functional candidate gene for autism." 10/01/2014 - "Here, we have examined the neuroanatomical basis of ALTs and their association with the oxytocin receptor gene (OXTR) rs2254298A, a known risk allele for autism in Asian populations which has also been implicated in limbic-paralimbic brain structures. " 01/01/2014 - "Region specific up-regulation of oxytocin receptors in the opioid oprm1 (-/-) mouse model of autism." 01/01/2013 - "AR-dependent gene overactivation in conjunction with a DNMT mechanism for methylating oxytocin receptors could produce high arousal inputs to the amygdala resulting in aberrant socialization, a prime characteristic of autism. "
3.	Pervasive Child Development Disorders 08/01/2009 - "Associations of oxytocin receptor gene (OXTR) variants and autism spectrum disorders (ASD) have been reported in earlier studies; in one of the studies associations with IQ and daily living skills were found additionally. " 10/01/2008 - "Evidence both from animal and human studies suggests that common polymorphisms in the oxytocin receptor (OXTR) gene are likely candidates to confer risk for autism spectrum disorders (ASD). " 12/01/2015 - "Research supports an association between genetic variation in the oxytocin receptor gene (OXTR) and autism spectrum disorders (ASD). " 12/01/2015 - "Genetic variation in the oxytocin receptor gene is associated with a social phenotype in autism spectrum disorders." 05/01/2015 - "The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: a meta-analysis."
4.	Neoplasms (Cancer) 03/01/2015 - "For cancers in organs rich in oxytocin receptors (uterus, breast, and brain), the corresponding SIRs were 1.02 (0.87-1.19) and 1.13 (1.09-1.17), respectively. " 09/21/2009 - "We also report here the conjugation of one of them to Lys(8)-oxytocin and radiolabeling with (111)In(iii) to obtain a new radiopharmaceutical product with potential applications in the diagnosis of tumors over-expressing oxytocin receptors." 01/01/2007 - "The RGS2 gene, but not the oxytocin receptor, was also shown to be over-expressed in the majority of breast cancers, identifying the product of this gene, or the pathway(s) it regulates, as potentially significant therapeutic targets." 07/01/2005 - "Oxytocin receptor signaling in myoepithelial and cancer cells." 04/20/2004 - "In some cases, OT exhibits an oxytocin receptor (OTR)-mediated antiproliferative effect on cancer cells. "
5.	Obesity 07/01/2015 - "Until now, little is known about regulation of oxytocin receptor in metabolically active tissues in obesity. " 12/01/2013 - "We tested the hypothesis that myometrial oxytocin receptor (OXTR) gene and protein expression are affected by obesity in pregnancy. " 06/01/2013 - "Oxytocin receptor, but not connexin-43, expression is related to BMI, suggesting an alteration in oxytocin receptor expression or function related to obesity." 06/11/2008 - "Oxytocin receptor-deficient mice developed late-onset obesity." 01/01/2015 - "We present evidence from human and animal studies of interactions between obesity and parturition signaling in all elements of the birth process, including: delayed cervical ripening, prostaglandin insensitivity, amniotic membrane strengthening, decreased myometrial oxytocin receptor expression, decreased myocyte action potential initiation and contractility, decreased myocyte gap junction formation, and impaired myocyte neutralization of reactive oxygen species. "

Related Drugs and Biologics

1.	atosiban
2.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
3.	Oxytocin (Pitocin)
4.	Messenger RNA (mRNA)
5.	Nifedipine (Adalat)
6.	Calcium Channel Blockers (Blockers, Calcium Channel)
7.	Indomethacin (Indometacin)
8.	Ritodrine (Yutopar)
9.	Adrenergic beta-Agonists (beta-Adrenergic Agonists)
10.	Magnesium

Related Therapies and Procedures

1.	Tocolysis
2.	Cervical Cerclage
3.	Ovariectomy (Oophorectomy)
4.	Bed Rest (Bedrest)
5.	Spinal Injections