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Sodium Selenite (Selenite)

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Selenious acid, disodium salt. It is used therapeutically to supply the trace element selenium.

Also Known As:

Selenite; Na salt (2:1) of Sodium Selenite; Na salt of Sodium Selenite; diselenious acid, di-Na salt of Sodium Selenite; mono-Na salt of Sodium Selenite; pentahydrate of Sodium Selenite; Selenite pentahydrate, Sodium; Selenite, Sodium; Sodium Selenite pentahydrate; diselenious acid, di Na salt of Sodium Selenite; mono Na salt of Sodium Selenite; Selenious acid, disodium salt

Networked: 823 relevant articles (51 outcomes, 190 trials/studies)

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Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Selenium Compounds: 135
  - Sodium Selenite: 823
    - haynesite
- Sodium Compounds: 14
  - Sodium Selenite: 823
    - haynesite

Experts

1.	Yang, Yang: 21 articles (11/2014 - 12/2004)
2.	Xu, Caimin: 18 articles (11/2014 - 12/2002)
3.	Abraham, Annie: 13 articles (12/2015 - 12/2006)
4.	Björnstedt, Mikael: 13 articles (06/2015 - 05/2002)
5.	Jiang, Qian: 10 articles (08/2013 - 10/2008)
6.	Sahasranamam, V: 10 articles (07/2013 - 12/2006)
7.	Sasikala, V: 9 articles (07/2013 - 03/2009)
8.	Li, Zhushi: 9 articles (01/2013 - 10/2008)
9.	Shi, Kejian: 8 articles (11/2014 - 06/2010)
10.	Rooban, B N: 8 articles (07/2013 - 03/2009)

Related Diseases

1.	Cataract (Cataracts) 09/01/2010 - "Oxidative stress has long been recognized as an important mediator in the pathogenesis of cataract and the goal of this study was to determine the efficacy of isorhamnetin-3-glucoside (IR3G) in alleviating the toxicity induced by sodium selenite in in vitro culture condition. " 01/01/2010 - "There was also a significant (p < 0.05) increase in protein content (total protein = 59.36% and soluble protein = 105.78%) in animals treated with Embelica officinalis, indicating improvement in cataractogenic condition in the selenite induced cataract model. " 10/01/2010 - "The aim of this study was to investigate the protective effects of the flavonoid fraction of Moringa oleifera leaves (FMO) on selenite cataract in vivo. " 09/01/1988 - "Remarkably, selenite cortical cataract spontaneously cleared after several months, restoring essentially normal cells to the epithelium and outer and mid-cortex. " 09/01/2014 - "Cataract-induced by sodium selenite in suckling rats is one of the suitable animal models to study the basic mechanism of human cataract formation. "
2.	Neoplasms (Cancer) 01/01/2004 - "However, the cytoprotective activity of selenite may also reduce the efficacy of chemotherapeutic drugs on tumor cells. " 11/01/2000 - "In the present experiments, we evaluated the efficacy of mammary cancer protection by this compound in rats fed either a selenite-deficient (< 0.01 ppm Se) or selenite-adequate (0.1 ppm Se) diet. " 01/01/2014 - "Our previous study confirmed that selenite, an anti-tumour agent, triggered apoptosis through the production of ROS in multiple types of cancer cells. " 01/01/2013 - "Previous studies demonstrated that selenite induced cancer-cell apoptosis through multiple mechanisms; however, effects of selenite on microtubules in leukemic cells have not been demonstrated. " 07/01/2011 - "In this paper, human cervical cancer HeLa cells were investigated by MTT assay and morphological observation to get appropriate selenite concentrations for proteomic study. "
3.	Lymphedema (Milroy Disease) 09/01/2005 - "A significant reduction of lymphedema occurred in the sodium selenite-treated group. " 06/01/2007 - "Schrauzer, Treatment of secondary lymphedema of the arm with physical decongestive therapy and sodium selenite: a review, Am. J. " 05/01/2003 - "Additionally, our results suggest that sodium selenite has a positive effect on secondary-developing lymphedema caused by radiation therapy alone or by irradiation after surgery." 08/01/2000 - "Treatment of secondary lymphedema of the arm with physical decongestive therapy and sodium selenite: a review." 09/15/1997 - "Intensive treatment with decongestive physical therapy in combination with sodium selenite shows significant improvement in the reduction of the volume of the limb and in the histophysiology of secondary lymphedema after mastectomy or Wertheim-operation. "
4.	Body Weight (Weight, Body) 08/01/2000 - "Exposure to 9 ppm of Se as sodium selenite resulted in marked decrease in body weight gain and relative organ weights. " 02/04/2005 - "In the present study, rats were treated with sodium selenite (5 micromol/kg body weight/day, ip) for 4 weeks and the parameters of contractile activity, action potential, L-type Ca2+-current (ICaL), as well as transient outward (Ito), inward rectifier (IK1), and steady state (Iss) K+-currents were investigated. " 06/28/2015 - "First-feeding fry (initial body weight: 91 mg) were fed either a plant- or fishmeal-based diet containing 0·5 or 1·2 mg Se/kg diet supplemented or not with 0·3 mg Se/kg diet supplied as Se-enriched yeast or sodium selenite for 12 weeks at 17°C. " 12/01/2014 - "AFB1Tx group was administered AFB1 intragastrically (0.1 mg/kg body weight) plus sodium selenite (1 mg/kg body weight). " 04/01/2014 - "The results suggest that an administration of 200 mg/kg body weight of C-PC has the ability to prevent/alter the secondary changes reflected in the serum biochemical and histological modifications in rats exposed to sodium selenite. "
5.	Prostatic Neoplasms (Prostate Cancer) 11/01/2008 - "These results suggest that selenite may have potential as a novel therapeutic agent to treat both androgen-dependent and androgen-independent prostate cancer." 05/01/2013 - "This study investigated the mechanism of action of sodium selenite in human prostate cancer PC-3 cells using proteomics. " 12/01/2006 - "Notably and in contrast to previous studies, RWPE-1 cells were significantly more sensitive to selenite than either of the prostate cancer cell lines. " 05/01/2013 - "Comparative proteomics analysis of sodium selenite-induced apoptosis in human prostate cancer cells." 06/01/2010 - "Selenite triggers rapid transcriptional activation of p53, and p53-mediated apoptosis in prostate cancer cells: Implication for the treatment of early-stage prostate cancer."

Related Drugs and Biologics

1.	Selenium
2.	Selenomethionine (Sethotope)
3.	DNA (Deoxyribonucleic Acid)
4.	Ascorbic Acid (Vitamin C)
5.	Cisplatin (Platino)
6.	Luteolin
7.	anthracene
8.	Vitamin E
9.	Antioxidants
10.	selenic acid (selenate)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Chemoprevention
3.	Drug Therapy (Chemotherapy)
4.	Lenses
5.	Radiotherapy