Connexin 43 (Connexin43)

A 43-kDa peptide which is a member of the connexin family of gap junction proteins. Connexin 43 is a product of a gene in the alpha class of connexin genes (the alpha-1 gene). It was first isolated from mammalian heart, but is widespread in the body including the brain.

Also Known As:

Networked: 1426 relevant articles (51 outcomes, 222 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Green, Colin R: 26 articles (10/2015 - 03/2002)
2.	Naus, Christian C: 23 articles (07/2015 - 08/2004)
3.	Sáez, Juan C: 16 articles (08/2015 - 01/2002)
4.	van Rijen, Harold V M: 15 articles (06/2015 - 03/2004)
5.	de Bakker, Jacques M T: 15 articles (02/2014 - 03/2004)
6.	Shao, Qing: 15 articles (01/2014 - 08/2002)
7.	Laird, Dale W: 15 articles (01/2014 - 08/2002)
8.	van Veen, Toon A B: 14 articles (06/2015 - 04/2005)
9.	Willecke, Klaus: 14 articles (02/2015 - 01/2002)
10.	Lampe, Paul D: 12 articles (09/2015 - 09/2002)

Related Diseases

1.	Myocardial Infarction 01/01/2009 - "Oscillating pressure treatment upregulates connexin43 expression in skeletal myoblasts and enhances therapeutic efficacy for myocardial infarction." 12/01/2006 - "Heavy ion radiation up-regulates Cx43 and ameliorates arrhythmogenic substrates in hearts after myocardial infarction." 05/01/2012 - "An in vivo study was performed such that 2 × 10(6) male (Cx43)Sca-1(+) or (GFP)Sca-1(+) cells were injected into a female rat model of acute myocardial infarction. " 06/01/2015 - "Interestingly, cardiac fibroblasts have been demonstrated to increase Cx43 expression in experimental models of myocardial infarction and functional gap junctions between myocytes and fibroblasts have been reported. " 11/01/2010 - "Relatively little is known, however, about how myocardial infarction (MI) influences expression of Cx43, or how altered Cx43 expression may affect fibroblast function post-MI. "
2.	Fibrosis (Cirrhosis) 06/01/2012 - "Aged ventricles had significantly greater fibrosis and reduced connexin43 gap junction density compared with young hearts. " 07/01/2011 - "Aged hearts had significantly greater LV fibrosis and reduced connexin 43 than adult hearts (P < 0.05). " 04/01/2008 - "The present study demonstrated a decrease in Cx40 and Cx43 expression and increased interstitial fibrosis in PV due to MR. " 01/01/2016 - "These effects were associated with suppression of cardiac fibrosis and restoration of connexin 43 expression in dnNRSF-Tg ventricles. " 06/01/2015 - "The reduced Cx43 expression and increased fibrosis levels in these hearts are likely candidates for the formation of the arrhythmogenic substrate."
3.	Neoplasms (Cancer) 04/01/2013 - "In an osteolytic murine model of ES, the overexpression of Cx43 in ES cells dramatically reduced tumor growth, leading to a significant increase in animal survival. " 12/01/2003 - "In contrast, Cx43 protein analyzed by Western blotting or classic immunohistochemical analyses was present at the beginning of tumor progression, but was dramatically reduced as tumor advanced. " 02/01/2014 - "In this study, we found polarization of Cx43 at the NK/DC and NK/tumor cell-contact sites, accompanied by the formation of functional GJs between NK/DCs and NK/tumor cells, respectively. " 01/01/2014 - "Our results have major implications for past and future studies describing gap junction-independent functions of Cx43 in cancer and other pathological conditions. " 12/10/2013 - "This study suggests that Cx43 exerts tumor suppressive effects in a context-dependent manner where GJ assembly with α-catenin, β-catenin and ZO-2 may be implicated in reducing growth rate, invasiveness, and, malignant phenotype of 2D and 3D cultures of MCF-7 cells, and 3D cultures of MDA-MB-231 cells, by sequestering β-catenin away from nucleus. "
4.	Cardiac Arrhythmias (Arrythmia) 03/11/2014 - "c-Src inhibition improved Cx43 levels and conduction velocity and lowered arrhythmia inducibility after MI, suggesting a new approach for arrhythmia reduction following MI." 05/01/2006 - "Most recently, genetic studies of Cx43 and Cx40 indicate that genetic variations in these genes may predispose to arrhythmia vulnerability in humans. " 08/01/2015 - "These findings demonstrate that the cardioprotective effects of IP on antiventricular arrhythmia and myocardial repair occur through upregulation of PI3K/Akt-mediated connexin 43 and growth factor signaling. " 03/01/2015 - "AAP10 may stimulate the phosphorylation of Cx43 by increasing the total-Cx43 expression and decreasing the NP-Cx43 expression in the ischemic area, so as to decrease ventricular arrhythmia." 01/01/2015 - "The resting [Ca(2+)]i concentration, calcium oscillation, the contents of total Cx43 and non-phosphrylated Cx43 and arrhythmia score were compared among different groups. "
5.	Wounds and Injuries (Trauma) 03/01/2012 - "Twelve hours after scrape wounding, Cx43 AsODN-treated eyes showed a significant reduction in wound area compared with the vehicle alone (1.59±0.37 and 2.29±0.58 mm2, respectively, P<0.01). " 01/01/2011 - "Studies using embryonic fibroblasts from Cx43 knockout (Cx43KO) mice showed Cx43 deficiency caused cell polarity defects as characterized by a failure of the Golgi apparatus and the microtubule organizing center to reorient with the direction of wound closure. " 07/01/2015 - "It was found that connexin 43 deficiency accelerates re-epithelialization and wound closure, increases proliferation and activation of dermal fibroblasts, and enhances the expression of extracellular matrix remodeling mediators. " 07/01/2015 - "Connexin43 hemichannels mediate secondary cellular damage spread from the trauma zone to distal zones in astrocyte monolayers." 03/13/2015 - "Meanwhile, we examined the effects of EPO on NVU injuries including neuronal survival, astrocyte activation and regeneration of endothelial cells as well as whether the effects were Cx43 dependent by using multiple inhibitors. "

Related Drugs and Biologics

1.	Connexin 43 (Connexin43)
2.	Connexins
3.	Messenger RNA (mRNA)
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Carbon Monoxide
6.	Collagen
7.	Oligodeoxyribonucleotides
8.	Glutamic Acid (Glutamate)
9.	Streptozocin (Streptozotocin)
10.	Omega-3 Fatty Acids (Omega 3 Fatty Acids)

Related Therapies and Procedures

1.	Trabeculectomy (Trabeculoplasty)
2.	Therapeutics
3.	Ligation
4.	Drug Therapy (Chemotherapy)
5.	Lasers (Laser)