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Rho(D) Immune Globulin (RhoGAM)

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Immunizing agent containing IMMUNOGLOBULIN G anti-Rho(D) used for preventing Rh immunization in Rh-negative individuals exposed to Rh-positive red blood cells.

Also Known As:

RhoGAM; Anti D Immunoglobulin; Gamulin Rh; MICRhoGAM; Rho(D) Immune Globulin Intravenous (Human); Rho(D) Immune Human Globulin; Rhophylac; ZLB Bioplasma AG Brand of Rho(D) Immune Globulin; Globulin, Rh Immune; Anti-D-Immunoglobulin; Immune Globulin, Rh; Rh Immune Globulin

Networked: 182 relevant articles (9 outcomes, 14 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Sandler, S G: 6 articles (01/2010 - 03/2000)
2.	Despotovic, Jenny M: 3 articles (11/2013 - 01/2013)
3.	Alioglu, Bulent: 2 articles (07/2013 - 09/2007)
4.	Brady, Jennifer J: 2 articles (11/2012 - 08/2009)
5.	McKenna, Malachi J: 2 articles (11/2012 - 08/2009)
6.	Murray, Barbara F: 2 articles (11/2012 - 08/2009)
7.	Hegarty, John E: 2 articles (11/2012 - 08/2009)
8.	O'Farrelly, Cliona: 2 articles (11/2012 - 08/2009)
9.	Nanda, Kavinderjit S: 2 articles (11/2012 - 08/2009)
10.	Ryan, Elizabeth J: 2 articles (11/2012 - 08/2009)

Related Diseases

1.	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 01/01/2008 - "Rho (D) immune globulin intravenous (IV RhIG, WinRho SDF) has been shown to be a safe treatment for idiopathic thrombocytopenic purpura. " 08/01/2005 - "Efficacy and response to intravenous anti-D immunoglobulin in chronic idiopathic thrombocytopenic purpura." 03/01/1994 - "Anti-D immunoglobulin in the treatment of idiopathic thrombocytopenic purpura." 06/01/1994 - "Successful anti-D immunoglobulin therapy in refractory chronic idiopathic thrombocytopenic purpura showing reduction in thrombocytes even after splenectomy." 08/15/2007 - "Rh immune globulin (WinRho SDF; Cangene, Mississauga, ON, Canada) is an effective treatment for autoimmune thrombocytopenic purpura; however, maintaining a sustained supply for its use in autoimmune thrombocytopenic purpura and its primary indication, hemolytic disease of the newborn, makes the development of alternative reagents desirable. "
2.	Thrombocytopenia (Thrombopenia) 01/01/2013 - "Is anti-D immunoglobulin still a frontline treatment option for immune thrombocytopenia?" 01/01/2002 - "Anti-D immunoglobulin treatment for thrombocytopenia associated with primary antibody deficiency." 01/01/2002 - "Anti-D immunoglobulin may be an effective treatment for antibody deficiency associated thrombocytopenia, even after splenectomy. " 01/01/1989 - "Anti-D immunoglobulin and immune thrombocytopenia--a problem of ethics in blood transfusion practice." 01/01/1988 - "Anti-D immunoglobulin and immune thrombocytopenia--a problem of ethics in blood transfusion practice."
3.	Rh Isoimmunization 11/01/1995 - "The use of anti-D immunoglobulin has dramatically reduced the incidence of rhesus isoimmunization arising from pregnancy. " 10/15/1977 - "A double-blind study of women after first-trimester abortion supports the efficacy of low-dose Rho(D) immune globulin (human) in the prevention of Rh sensitization. " 02/01/1984 - "The test described is sufficiently sensitive to be used for the study of primary Rh isoimmunization and could be clinically applicable for antepartum screening to determine which patients require Rh immune globulin treatment before delivery." 04/01/2006 - "Rhesus isoimmunization remains an important health issue despite the recommendation for anti-D immunoglobulin prophylaxis and injection after sensitizing events. " 11/01/2005 - "Pregnancies complicated by Rh isoimmunization have decreased significantly since the widespread use of Rh immune globulin. "
4.	Fetomaternal Transfusion 01/01/1988 - "Results indicate improved accuracy and precision relative to the standard technique in significantly less time for volumes of fetomaternal hemorrhage requiring more than the standard dose of Rho(D)-immune globulin." 09/01/2005 - "This study evaluated fetomaternal hemorrhage (FMH) in 343 postpartum patients who required prophylaxis of Rh alloimmunization with anti-D immunoglobulin. " 07/01/2015 - "In order to determine the appropriate dose of anti-D immunoglobulin to be administered as a preventive measure against hemolytic disease of the fetus/newborn in the subsequent pregnancy it is necessary to assess the number of fetal red blood cells that infiltrate/penetrate into the maternal circulation as a result of fetomaternal hemorrhage (FMH). " 12/01/2012 - "The result of the acid-elution assay is converted to an estimation of the volume of the fetomaternal hemorrhage, which is the basis for calculating the dose of Rh immune globulin. " 04/01/2012 - "The prevention of Rhesus D alloimmunization through Rh immune globulin (RhIg) administration is the major indication for the accurate detection and quantification of fetomaternal hemorrhage (FMH). "
5.	Neutropenia 09/01/2007 - "Anti-D immunoglobulin-induced prolonged intravascular hemolysis and neutropenia." 03/01/2005 - "Neutropenia (ANC < 1,500/microL), developed during 18 of 64 (28%) treatment courses with IVIG, compared with 0 of 46 (0%) treatment courses with anti-D immunoglobulin (P < 0.001). " 05/01/1994 - "Thrombocytopenia improved temporarily during treatment with corticosteroids, i.v. immunoglobulin G, RhoGAM, and a variety of immunosuppressive agents; however, neutropenia tended to be much more resistant to these therapies. "

Related Drugs and Biologics

1.	Inosine Triphosphate (ITP)
2.	Immunoglobulins (Immunoglobulin)
3.	Immunoglobulin G (IgG)
4.	Adrenal Cortex Hormones (Corticosteroids)
5.	Indicators and Reagents (Reagents)
6.	Immunosuppressive Agents (Immunosuppressants)
7.	RHO(D) antibody (anti-D)
8.	Intravenous Immunoglobulins (IVIG)
9.	Methylprednisolone
10.	Antibodies

Related Therapies and Procedures

1.	Splenectomy
2.	Blood Transfusion (Blood Transfusions)
3.	Fetal Version (External Cephalic Version)
4.	Injections
5.	Cesarean Section (Caesarean Section)