Parathyroid Hormone Receptors

Cell surface proteins that bind PARATHYROID HORMONE with high affinity and trigger intracellular changes which influence the behavior of cells. Parathyroid hormone receptors on BONE; KIDNEY; and gastrointestinal cells mediate the hormone's role in calcium and phosphate homeostasis.

Also Known As:

Networked: 18 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dollberg, Shaul: 2 articles (02/2012 - 04/2010)
2.	Lubetzky, Ronit: 2 articles (02/2012 - 04/2010)
3.	Mandel, Dror: 2 articles (02/2012 - 04/2010)
4.	Alonso, Verónica: 1 article (01/2017)
5.	Ardura, Juan A: 1 article (01/2017)
6.	Esbrit, Pedro: 1 article (01/2017)
7.	Friedman, Peter A: 1 article (01/2017)
8.	Aghazadeh-Habashi, Ali: 1 article (01/2017)
9.	Bhandari, Krishna H: 1 article (01/2017)
10.	Doschak, Michael R: 1 article (01/2017)

Related Diseases

1.	Osteosarcoma (Osteogenic Sarcoma) 11/07/1993 - "Comparison of parathyroid hormone receptors in rat osteosarcoma cells and kidney." 05/01/1990 - "Mechanisms of homologous and heterologous regulation of parathyroid hormone receptors in the rat osteosarcoma cell line UMR-106." 04/01/1988 - "Characterization and agonist-induced down-regulation of parathyroid hormone receptors in clonal rat osteosarcoma cells." 03/15/1988 - "Photoaffinity labeling of parathyroid hormone receptors in clonal rat osteosarcoma cells." 01/01/2001 - "Mutual up-regulation of thyroid hormone and parathyroid hormone receptors in rat osteoblastic osteosarcoma 17/2.8 cells."
2.	Hypercalcemia (Milk Alkali Syndrome) 02/01/2012 - "Parathyroid hormone-related protein (PTHrP) has the ability to activate parathyroid hormone receptors and cause hypercalcemia. " 04/01/2010 - "Parathyroid hormone-related protein (PTHrP) has the ability to activate parathyroid hormone receptors and cause hypercalcemia. " 06/01/1988 - "The data suggest that chronic parathyroid status, as well as hypercalcemia, alters the hypotensive response to parathyroid hormone infusion, presumably by altering the vascular parathyroid hormone receptors or by some other mechanism." 03/01/1983 - "Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors."
3.	Osteoporosis 01/22/2017 - "Parathyroid hormone receptors (PTHR) are widely expressed and PTH is the only anabolic therapy for osteoporosis. " 01/01/2017 - "Synthetic parathyroid hormone (PTH) is clinically indicated for the treatment of osteoporosis, through its anabolic effects on parathyroid hormone receptors (PTHRs), located on osteoblast cells. " 01/01/2016 - "Several growth factors underlying age-related osteoporosis and their signaling pathways have been identified, such as osteoprotegerin (OPG)/receptor activator of nuclear factor B (RANK)/RANK ligand (RANKL), bone morphogenetic protein (BMP), wingless-type MMTV integration site family (Wnt) proteins and signaling through parathyroid hormone receptors. "
4.	Humoral Hypercalcemia Of Malignancy 09/01/1995 - "Peptide antagonists that block parathyroid hormone receptors in vivo would be instrumental in the clinical treatment of humoral hypercalcemia of malignancy. " 01/01/1995 - "PTHrP is a common product of squamous cancers and is the major mediator of the syndrome of humoral hypercalcemia of malignancy (HHM) by its actions through parathyroid hormone receptors in bone and kidney. "
5.	Septic Shock (Toxic Shock Syndrome) 06/01/2013 - "Since Parathyroid hormone receptors and calcium-sensing receptors have been described in immune cells and other cell types, we propose that these effects may have a plethora of other deleterious effects, with important implications to the pathogenesis of septic shock."

Related Drugs and Biologics

1.	Parathyroid Hormone-Related Protein
2.	Parathyroid Hormone (Parathormone)
3.	RANK Ligand
4.	Osteoprotegerin
5.	Wnt Proteins
6.	Anabolic Agents
7.	Calcium-Sensing Receptors
8.	Intercellular Signaling Peptides and Proteins (Growth Factors)
9.	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)
10.	Thyroid Hormones

Related Therapies and Procedures

1.	Therapeutics