Glycine Receptors (Glycine Receptor)

Cell surface receptors that bind GLYCINE with high affinity and trigger intracellular changes which influence the behavior of cells. Glycine receptors in the CENTRAL NERVOUS SYSTEM have an intrinsic chloride channel and are usually inhibitory.

Also Known As:

Networked: 275 relevant articles (6 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Vincent, Angela: 12 articles (06/2015 - 08/2011)
2.	Waters, Patrick: 8 articles (08/2014 - 08/2011)
3.	Harvey, Robert J: 7 articles (02/2015 - 05/2004)
4.	Woodhall, Mark: 7 articles (08/2014 - 12/2012)
5.	Vincent, A: 5 articles (04/2014 - 10/2008)
6.	Dalmau, Josep: 4 articles (02/2015 - 04/2010)
7.	Lynch, Joseph W: 4 articles (08/2014 - 01/2006)
8.	Schofield, P R: 4 articles (09/2010 - 02/2001)
9.	Jiang, Zheng-Lin: 3 articles (08/2015 - 04/2007)
10.	Wang, Guo-Hua: 3 articles (08/2015 - 04/2007)

Related Diseases

1.	Seizures (Seizure) 12/01/2012 - "Since reduced function of glycine receptors causes seizures, we hypothesized that TXA and EACA inhibit the activity of glycine receptors. " 01/17/2003 - "These results indicate that Fe(2+) decreases I(tau) in acutely dissociated rat hippocampal neurons and the inhibition of glycine receptors by Fe(2+) might be one possible approach through which Fe(2+) induces seizures." 01/01/1987 - "Strychnine, a drug which induces convulsions by blocking glycine receptors was equally effective in producing convulsions in both male and female adult mice. " 11/08/1996 - "With the exception of substitution at C-8, modified HBADs generally have a lower affinity at NMDA receptor glycine sites than the parent compound 3. Mouse maximum electroshock-induced seizure studies show that the three HBADs selected for testing have in vivo potency with the 6,8-dimethyl analog (52) being the most potent (ED50 = 3.9 mg/kg, iv)." 12/01/2012 - "Tranexamic acid concentrations associated with human seizures inhibit glycine receptors."
2.	Pain (Aches) 04/09/2015 - "Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptor α1 for the treatment of pain." 01/01/2015 - "Glycine receptors (GlyRs) belong to the superfamily of pentameric cys-loop receptor-operated channels and are involved in numerous physiological functions, including movement, vision, and pain. " 01/01/2015 - "These results indicated that TXA produces pain by inhibiting GABAA and glycine receptors in the spinal dorsal horn. " 12/17/2013 - "This review summarizes the roles of ionotropic inhibition in the regulation of nociception, and explores recent evidence that the potentiation of GABAA or glycine receptor activity or the enhancement of inhibitory drive can reverse pathological pain." 10/16/2013 - "Inflammatory pain sensitization is initiated by prostaglandin-induced phosphorylation of α3 glycine receptors (GlyRs) that are specifically located in inhibitory synapses on spinal pain sensory neurons. "
3.	Hyperalgesia 07/01/2009 - "Their anti-allodynia effects are mediated by the inhibition of GlyTs following activation of spinal glycine receptor alpha3. " 11/01/2004 - "The present data suggest that this allodynia could arise due to blockade of tonic GABAA and glycine-receptor mediated inhibition in the deep dorsal horn. " 11/01/2004 - "Intrathecal administration of both GABAA and glycine receptor antagonists has been shown elsewhere to induce tactile allodynia. " 07/01/1994 - "The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord." 02/01/2001 - "There is anatomic evidence for changes in these transmitter systems after nerve injuries, and blocking either GABAA or glycine receptors has been shown to produce allodynia-like behavior in awake normal animals. "
4.	Parkinson Disease (Parkinson's Disease) 09/01/2014 - "Activation of N-methyl-D-aspartate receptor glycine site temporally ameliorates neuropsychiatric symptoms of Parkinson's disease with dementia."
5.	Dementia (Dementias) 09/01/2014 - "Activation of N-methyl-D-aspartate receptor glycine site temporally ameliorates neuropsychiatric symptoms of Parkinson's disease with dementia."

Related Drugs and Biologics

1.	N-Methylaspartate (NMDA)
2.	Strychnine
3.	Serine (L-Serine)
4.	Picrotoxin
5.	Taurine
6.	Baclofen
7.	Muscimol
8.	7-chlorokynurenic acid
9.	Phenobarbital (Luminal)
10.	Pentobarbital (Nembutal)

Related Therapies and Procedures

1.	Ligation
2.	Electrocoagulation (Electrocautery)
3.	Anesthesia
4.	Sutures (Suture)
5.	Injections