Myogenin

A myogenic regulatory factor that controls myogenesis. Myogenin is induced during differentiation of every skeletal muscle cell line that has been investigated, in contrast to the other myogenic regulatory factors that only appear in certain cell types.

Networked: 294 relevant articles (3 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Barr, Frederic G: 6 articles (05/2014 - 12/2002)
2.	Teot, Lisa A: 5 articles (05/2014 - 11/2004)
3.	Parham, David M: 5 articles (05/2014 - 11/2004)
4.	Bridge, Julia A: 5 articles (05/2014 - 09/2002)
5.	Seethala, Raja R: 4 articles (03/2015 - 03/2006)
6.	Zhang, Paul J: 4 articles (01/2011 - 12/2002)
7.	Qualman, Stephen J: 4 articles (07/2008 - 11/2004)
8.	Thompson, Lester D R: 3 articles (12/2015 - 09/2011)
9.	Magro, Gaetano: 3 articles (05/2015 - 01/2008)
10.	Wang, Jian: 3 articles (06/2014 - 12/2012)

Related Diseases

1.	Rhabdomyosarcoma 09/01/2008 - "Rhabdomyosarcoma subtyping by immunohistochemical assessment of myogenin: tissue array study and review of the literature." 12/01/2015 - "Rhabdomyosarcoma is defined by skeletal muscle differentiation which can be suggested by routine histology and confirmed by immunohistochemistry for the skeletal muscle-specific markers myogenin or myoD1. " 01/01/2015 - "The Expression of c-Myb Correlates with the Levels of Rhabdomyosarcoma-specific Marker Myogenin." 01/01/2011 - "Rhabdomyosarcoma: molecular analysis of Igf2, MyoD1 and Myogenin expression." 09/01/2008 - "Myogenin immunostaining has been described as a useful marker of the alveolar subtype of rhabdomyosarcoma and as a tool for distinguishing it from the more common embryonal subtype. "
2.	Alveolar Rhabdomyosarcoma 06/01/2013 - "Compared with ALK-negative alveolar rhabdomyosarcomas, ALK-positive ones are presented with metastatic spread more frequently and showed a greater extent of myogenin reactivity. " 01/01/2014 - "A paradoxical feature of alveolar rhabdomyosarcoma (ARMS), a prevalent soft tissue sarcoma in children arising from cells with a myogenic phenotype, is the inability of these cells to undergo terminal differentiation despite the expression of MYOGENIN. " 01/01/2013 - "However, the recognition of new variants of embryonal rhabdomyosarcoma (ERMS), shifts in the diagnostic criteria of alveolar rhabdomyosarcoma (ARMS), the increasing use of myogenin immunohistochemistry and recognition of the distinct biologic properties associated with fusion status all raised questions about the continued use of this classification system in the diagnosis and treatment of patients with RMS. " 03/01/2008 - "To assess the value of myogenin staining in the diagnosis of micrometastases in alveolar rhabdomyosarcoma, the authors examined 36 lymph nodes from children bearing this tumor. " 02/01/2000 - "In contrast, we propose that alveolar rhabdomyosarcomas either originate from a late block in myogenesis (after expression of myogenin) or that the pathological mechanisms involved in these neoplasms also induce strong expression of this protein."
3.	Neoplasms (Cancer) 09/01/2001 - "Previous studies have focused on expression of myogenin and MyoD1 in small round cell tumors. " 09/01/2000 - "In this study, we evaluated myogenin expression using the monoclonal myf-4 antibody (Novocastra Labs) on FFPE in a large number of pediatric tumors in order to define the clinical utility of this marker. " 04/01/2015 - "The tumor was strongly positive for CD99, NSE, and chromogranin; No reaction was seen for CD10, CD45 and myogenin. " 11/01/2013 - "Immunocytochemistry for myogenin diffusely and strongly highlighted the nuclei of the tumor cells in six (86%) of seven cases of metastatic RMS; specifically, the five alveolar RMS and one embryonal RMS cases. " 12/01/2012 - "However, the tumor cells were GFAP (+), INI-1 (+), and myogenin (-). "
4.	Atrophy 05/01/2003 - "To construct eukaryotic expression vector of rat myogenin gene for further study on its functions in skeletal muscle denervated atrophy and repair. " 10/01/2010 - "Thus, myogenin plays a dual role as both a regulator of muscle development and an inducer of neurogenic atrophy. " 10/01/2010 - "Deletion of myogenin from adult mice diminishes expression of MuRF1 and atrogin-1 in denervated muscle and confers resistance to atrophy. " 10/01/2010 - "We show that myogenin, an essential regulator of muscle development, controls neurogenic atrophy. " 01/01/2006 - "Soleus atrophy was similar in the SI and denervated groups at each time point, although increases in whole-muscle expression of myogenin and, to a lesser degree, MyoD were lower (P < 0.05) in SI than denervated soleus muscles. "
5.	Muscular Atrophy (Muscle Atrophy) 05/01/1999 - "Neither myogenin nor MyoD appear to play a critical role in the muscular atrophy that occurs during weightlessness." 08/01/2011 - "Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle." 10/01/2010 - "Conversely, forced expression of myogenin in skeletal muscle of HDAC mutant mice restores muscle atrophy following denervation. " 09/03/2009 - "In this study, we found that myogenin in differentiated myoblasts is destabilized by muscle atrophy-inducing dexamethasone and that MAFbx (muscle atrophy F-box protein) is increased in atrophying myotubes. " 03/01/2015 - "From this result, we know that, in stress conditions, μ-calpain may be involved in the muscle atrophy through the suppression of myogenin and MyoD. "

Related Drugs and Biologics

1.	Desmin
2.	Antibodies
3.	Messenger RNA (mRNA)
4.	Vimentin
5.	myogenic factor 6
6.	Synaptophysin
7.	Proteins (Proteins, Gene)
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9.	Myosin Heavy Chains (Myosin Heavy Chain)
10.	Myoglobin

Related Therapies and Procedures

1.	Denervation
2.	Resistance Training
3.	Transplantation (Transplant Recipients)
4.	Drug Therapy (Chemotherapy)
5.	Neck Dissection (Radical Neck Dissection)