Myogenic Regulatory Factors

A family of muscle-specific transcription factors which bind to DNA in control regions and thus regulate myogenesis. All members of this family contain a conserved helix-loop-helix motif which is homologous to the myc family proteins. These factors are only found in skeletal muscle. Members include the myoD protein (MYOD PROTEIN); MYOGENIN; myf-5, and myf-6 (also called MRF4 or herculin).

Also Known As:

Networked: 78 relevant articles (0 outcomes, 13 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Carvalho, Robson Francisco: 5 articles (01/2016 - 12/2008)
2.	Okoshi, Katashi: 3 articles (01/2014 - 04/2010)
3.	Castillero, Estíbaliz: 3 articles (07/2012 - 10/2009)
4.	López-Calderón, Asunción: 3 articles (07/2012 - 10/2009)
5.	López-Menduiña, María: 3 articles (07/2012 - 10/2009)
6.	Martín, Ana Isabel: 3 articles (07/2012 - 10/2009)
7.	Padovani, Carlos Roberto: 3 articles (06/2011 - 12/2008)
8.	Chatzigeorgiou, Antonios: 2 articles (04/2021 - 07/2020)
9.	Koutsilieris, Michael: 2 articles (04/2021 - 07/2020)
10.	Moustogiannis, Athanasios: 2 articles (04/2021 - 07/2020)

Related Diseases

1.	Heart Failure 06/01/2011 - "Heart failure (HF) is characterized by limited exercise tolerance, skeletal muscle atrophy, a shift toward fast muscle fiber, and myogenic regulatory factor (MRF) changes. " 12/01/2010 - "Chronic heart failure-induced skeletal muscle atrophy, necrosis, and changes in myogenic regulatory factors." 01/01/2016 - "The purpose of this study was to investigate the effects of physical training (PT) on phenotypic features (fibre-type content) and myogenic regulatory factors (MyoD and myogenin) in rat skeletal muscle during the transition from cardiac hypertrophy to heart failure. " 04/01/2010 - "This study evaluated the effects of growth hormone (GH) on morphology and myogenic regulatory factors (MRF) gene expression in skeletal muscle of rats with ascending aortic stenosis (AAS) induced chronic heart failure. " 08/10/2013 - "In this study we tested the hypothesis that skeletal muscle phenotype changes are related to myogenic regulatory factors and myostatin/follistatin expression in spontaneously hypertensive rats (SHR) with heart failure. "
2.	Atrophy 07/01/2020 - "This study investigated the effects of different loading protocols on the expression of myogenic regulatory factors, anabolic, atrophy and pro-apoptotic factors in skeletal myotubes. " 06/01/2011 - "Heart failure (HF) is characterized by limited exercise tolerance, skeletal muscle atrophy, a shift toward fast muscle fiber, and myogenic regulatory factor (MRF) changes. " 10/01/2013 - "In fish, the GH induces muscle growth by modulating the expression of several genes belonging to the myostatin (MSTN), atrophy, GH, and IGF systems as well as myogenic regulatory factors (MRFs). " 01/01/2015 - "Temporal study following burn injury in young rats is associated with skeletal muscle atrophy, inflammation and altered myogenic regulatory factors." 12/01/2010 - "Chronic heart failure-induced skeletal muscle atrophy, necrosis, and changes in myogenic regulatory factors."
3.	Hypertrophy 10/01/2023 - "Overall, the results obtained from our current study revealed that extreme heat exposure (41 °C) may promote skeletal muscle hypertrophy by regulating myogenic regulatory factors and IGF-1-mediated mTOR pathway in bovine myocytes." 12/03/2021 - "These results indicate that the FSI-I-I gene mediates skeletal muscle hypertrophy through an MSTN-related signaling pathway and the expression of myogenic regulatory factors. " 09/01/2014 - "Muscle hypertrophy in heavy weight Japanese quail line: delayed muscle maturation and continued muscle growth with prolonged upregulation of myogenic regulatory factors." 01/01/2013 - "The importance of this pathway linked to the modulation of myogenic regulatory factors expression in rat skeletal muscle undergoing hypertrophy following resistance exercise, has not been investigated. " 12/01/2008 - "It grows by hypertrophy and hyperplasia, events regulated by differential expression of myogenic regulatory factors (MRFs). "
4.	Muscular Atrophy (Muscle Atrophy) 01/01/2015 - "The purpose of this study was to investigate the temporal effects of extensive experimental BI in the skeletal muscle distant from lesion, through morphological analysis, expression of genes related to muscle atrophy, inflammation and the myogenic regulatory factors. " 01/01/2012 - "In skeletal muscle, SREBP-1 proteins regulate the expression of hundreds of genes, and we previously showed that their overexpression induced muscle atrophy together with a combined lack of expression of myogenic regulatory factors. " 08/01/2003 - "Inhibitors of differentiation (Id) proteins are repressors of myogenic regulatory factors and have been implicated in apoptosis and muscle atrophy during aging. " 02/01/2016 - "Our results demonstrate that myostatin propeptide gene delivery, especially the mutant-type of MSPPD75A, attenuates muscle atrophy through myogenic regulatory factors and acetylcholine receptor regulation. " 02/01/2016 - "Further studies have indicated the implications of the ubiquitin-proteasome and PI3K/Akt/FoxO signaling pathways and myogenic regulatory factors in miRNA-mediated muscle atrophy. "
5.	Inflammation (Inflammations) 01/01/2015 - "The purpose of this study was to investigate the temporal effects of extensive experimental BI in the skeletal muscle distant from lesion, through morphological analysis, expression of genes related to muscle atrophy, inflammation and the myogenic regulatory factors. " 03/01/2023 - "Whereas CGA supplementation in oxidized fish oil diets partially counteracted the negative effects of the oxidized fish oil on I. punctatus in terms of increasing the growth performance, improving the intestinal mucosal structure, alleviating hepatic oxidative stress and intestinal inflammation, recompiling the myogenic regulatory factors expression and improving skin color. " 08/01/2012 - "Surprisingly, the recovery of muscle mass and fiber CSA following myotoxic injury was impaired in AT(1A)(-/-) mice, in part by impaired myoblast fusion, prolonged collagen infiltration and inflammation, and delayed expression of myogenic regulatory factors. " 01/01/2015 - "Temporal study following burn injury in young rats is associated with skeletal muscle atrophy, inflammation and altered myogenic regulatory factors."

Related Drugs and Biologics

1.	Myogenin
2.	Myostatin
3.	Messenger RNA (mRNA)
4.	myogenic factor 6
5.	Proteins (Proteins, Gene)
6.	Insulin-Like Growth Factor I (IGF-1)
7.	Myosin Heavy Chains (Myosin Heavy Chain)
8.	Proteasome Endopeptidase Complex (Proteasome)
9.	Ubiquitin
10.	Protein Isoforms (Isoforms)

Related Therapies and Procedures

1.	Denervation
2.	Electroacupuncture
3.	Acupuncture Points (Acupuncture Point)